Publications

2021|2020|2019|2018|2017|2016|2015|2014|2013|2012|2011|
2010|2009|2008|2007|2006|2005|2004|2003|2002|2001|2000|1999|1998|1997|1995|1993|1992|Books|Patents|

Selected papers

  • Endoh, M., Baba, M., Endoh, T., Hirayama, A., Nakamura-Ishizu, A., Umemoto, T., Hashimoto, M., Nagashima, K., Soga, T., Lang, M., Schmidt, L.S., Linehan, W.M., Suda, T., “A FLCN-TFE3 Feedback Loop Prevents Excessive Glycogenesis and Phagocyte Activation by Regulating Lysosome Activity” Cell Rep. 30, 1823-1834.e5, 2020.
    [PubMed]
  • Osawa, T., Shimamura, T., Saito, K., Hasegawa, Y., Ishii, N., Nishida, M., Ando, R., Kondo, A., Anwar, M., Tsuchida, R., Hino, S., Sakamoto, A., Igarashi, K., Saitoh, K., Kato, K., Endo, K., Yamano, S., Kanki, Y., Matsumura, Y., Minami, T., Tanaka, T., Anai, M., Wada, Y., Wanibuchi, H., Hayashi, M., Hamada, A., Yoshida, M., Yachida, S., Nakao, M., Sakai, J., Aburatani, H., Shibuya, M., Hanada, K., Miyano, S., Soga T., Kodama, T. , “Phosphoethanolamine Accumulation Protects Cancer Cells under Glutamine Starvation through Downregulation of PCYT2” Cell Rep. 29, 89-103.e7, 2019.
    [PubMed]
  • Yoneshiro M., Brown Z., Chondronikola M., Takahashi H., Goto T., Kawada T., Sidossis L., Szoka FC., McManus MT., Saito M., Soga T., Kajimura S., “BCAA catabolism in brown fat controls energy homeostasis through SLC25A44” Nature 572, 614-619, 2019.
    [PubMed]
  • Kofuji, S., Hirayama, A., Eberhardt, A.O., Kawaguchi R., Sugiura, Y., Sampetrean, O., Ikeda, Y., Warren, M., Sakamoto, N., Kitahara, S., Yohino, H., Yamashita, D., Sumita, K., Wofe, K., Lange, L., Ikeda, S., Shimada, H., Minami, N., Malhotra, A., Morioka, S., Ban, Y., Asano, M., Flanary, V.L., Ramkissoon, A., Chow, L.M.L., Kiyokawa, J., Mahimo, T., Lucey, G., Mareninov, S., Ozawa, T., Onishi, N., Okumura, K., Terakawa, J., Daikoku, T., Wise-Draper, T., Majd, N., Kofuji, K., Sasaki, M., Mori, M., Kanemura, Y., Smith, E.P., Anastasiou, D., Wakimoto, H., Holland, E.C., Yong, W.H., Horbinski, C., Nakano, I., Deberardinis, R.J., Bachoo, R., Mischel, P.S., Yasui, W., Suematsu, M., Saya, H., Soga, T., Grummt, I., Bierhoff, H., Sasaki, AT.,“IMP dehydrogenase-2 drives aberrant nucleolar activity and promotes tumorigenesis in glioblastoma” Nat. Cell Biol. 21, 1003-1014, 2019.
    [PubMed]
  • Yachida, S., Mizutani, S., Shiroma, H., Shiba, S., Nakajima, T., Sakamoto, T., Watanabe, H., Masuda, K., Nishimoto, Y., Kubo, M., Hosoda, F., Rokutan, H., Matsumoto, M., Takamaru, H., Yamada, M., Matsuda, T., Iwasaki, M., Yamaji, T., Yachida, T., Soga, T., Kurokawa, K., Toyoda, A., Ogura, Y., Hayashi, T., Hatakeyama, M., Nakagama, H., Saito, Y., Fukuda, S., Shibata, T., Yamada, T., "Metagenomic and metabolimic analyses reveal distinct stage-specific phenotypes of the gut microbiota in colorectal cancer" Nat. Med., 25, 968-976, 2019.
    [PubMed]
  • Kikuchi, K., Saigusa, D., Kanemitsu, Y., Matsumoto, Y., Thanai, P., Suzuki, N., Mise, K., Yamaguchi, H., Nakamura, T., Asaji, K., Mukawa, C., Tsukamoto, H., Sato, T., Oikawa, Y., Iwasaki, T., Oe, Y., Tsukimi, T., Fukuda, N., Ho, H., Nanto-Hara, F., Ogura, J., Saito, R., Nagao, S., Ohsaki, Y., Shimada, S., Suzuki, T., Toyohara, T., Mishima, E., Shima, H., Akiyama, Y., Akiyama, Y., Ichijo, M., Matsuhashi, T., Matsuo, A., Ogata, Y., Yang, C., Suzuki, C., Breeggemann, M., Heymann, J., Shimizu, M., Ogawa, S., Takahashi, N., Suzuki, T., Owada, Y., Kure, S., Mano, N., Soga T., Wada, T., Kopp, J., Fukuda, S., Hozawa, A., Yamamoto, M., Ito, S., Wada, J., Tomioka, Y., Abe, T., “Gut microbiome-derived phenyl sulfate contributes to albuminuria in diabetic kidney disease” Nat Commun 10, 1835, 2019.
    [PubMed]
  • Saito, T., Kuma, A., Sugiura, Y., Ichimura, Y., Obata, M., Kitamura, H., Okuda, S., Lee, HC., Ikeda, K., Kanegae, Y., Saito, I., Auwerx, J., Motohashi, H., Suematsu, M., Soga, T., Yokomizo, T., Waguri, S., Mizushima, N., Komatsu M., "Autophagy regulates lipid metabolism through selective turnover of NCoR1" Nat. Commun 10, 1567, 2019.
    [PubMed]
  • Ikegami, R., *Shimizu, I., Sato, T., Yoshida, Y., Hayashi, Y., Suda, M., Katsuumi, G., Li, J., Wakasugi, T., Minokoshi, Y., Okamoto, S., Hinoi, E., Nielsen, S., Jespersen, N. Z., Scheele, C., Soga, T., Minamino, T., "Gamma-aminobutyric acid signaling in brown adipose tissue promotes systemic metabolic derangement in obesity" Cell Rep. 24, 2827-2837, 2018.
    [PubMed]
  • Hirayama, A., Abe, H., Yamaguchi, N., Tabata, S., Tomita, T., Soga, T., “Development of a sheathless CE‐ESI‐MS interface” Electrophoresis 39, 1382-1389, 2018.
    [PubMed]
  • Morita, M., Sato, T., Nomura, M., Sakamoto, Y., Inoue, Y., Tanaka, R., Ito, S., Kurosawa, K., Yamaguchi, K., Sugiura, Y., Takizaki, H., Yamashita, Y., Katakura, R., Sato, I., Kawai, M., Okada, Y., Watanabe, H., Kondoh, G., Matsumoto, S., Kishimoto, A., Obata, M., Matsumoto, M., Fukuhara, T., Motohashi, H., Suematsu, M., Komatsu, M., Nakayama, KI., Watanabe, T., Soga, T., Shima, H., Maemondo, M., Tanuma. N., “Pkm1 confers metabolic advantages and promotes cell-autonomous tumor cell growth” Cancer Cell 33, 355-367, 2018.
    [PubMed]
  • Kim, S., Matsumoto, T., Kagawa, H., Nakamura, M., Hirohata, R., Ueno, A., Ohishi, M., Sakuma, T., Soga, T., Yamamoto, T., Woltjen, K., "Microhomology-assisted scarless genome editing in human iPSCs" Nat. Commun. 9, 939, doi:10.1038/s41467-018-03044-y, 2018.
    [PubMed]
  • Maeshima, K., Matsuda, T., Shindo, Y., Imamura, H., Tamura, S., Imai, R., Kawakami, S., Nagashima, R., Soga, T., Noji, H., Oka, K., Nagai, T., “A Transient Rise in Free Mg2+ Ions Released from ATP-Mg Hydrolysis Contributes to Mitotic Chromosome Condensation” Curr Biol 28, 444-451, 2018.
    [PubMed]
  • Satoh, K., Yachida, S., Sugimoto, M., Oshima, M., Nakagawa, T., Akamoto, S., Tabata, S., Saitoh, K., Kato, K., Sato, S., Igarashi, K., Aizawa, Y., Kajino-Sakamoto, R., Kojima, Y., Fujishita, T., Enomoto, A., Hirayama, A., Ishikawa, T., Taketo, M.M., Kushida, Y., Haba, R., Okano, K., Tomita, M., Suzuki, Y., Fukuda, S., Aoki, M., Soga, T., “Global metabolic reprogramming of colorectal cancer occurs at adenoma stage and is induced by MYC” Proc. Natl. Acad. Sci. USA 114, E7697-E7706, 2017.
    [PubMed]
  • Ikeda, K., Kang, Q., Yoneshiro, T., Camporez, J.P., Maki, H., Homma, M., Shinoda, K., Chen, Y., Lu, X., Maretich, P., Tajima, K., Ajuwon, K.M., Soga, T., Kajimura, S., “UCP1-independent signaling involving SERCA2b-mediated calcium cycling regulates beige fat thermogenesis and systemic glucose homestasis” Nat. Med. 23, 1454–1465, 2017.
    [PubMed]
  • Hayashi, Y., Otsuka, K., Ebina, M., Igarashi, K., Takehara, A., Matsumoto, M., Kanai, A., Igarashi, K., Soga, T., Matsui, Y., "Distinct requirements for energy metabolism in mouse primordial germ cells and their reprogramming to embryonic germ cells" Proc. Natl. Acad. Sci. USA 114, 8289-8294, 2017.
    [PubMed]
  • Kon, S., Ishibashi, K., Katoh, H., Kitamoto, S., Shirai, T., Tanaka, S., Kajita, M., Ishikawa, S., Yamauchi, H., Yako, Y., Kamasaki, T., Matsumoto, T., Watanabe, H., Egami, R., Sasaki, A., Nishikawa, A., Kameda, I., Maruyama, T., Narumi, R., Morita, T., Sasaki, Y., Enoki, R., Honma, S., Imamura, H., Oshima, M., Soga, T., Miyazaki, J., Duchen, MR.., Nam, J., Onodera, Y., Yoshioka, S., Kikuta, J., Ishii, M., Imajo, M., Nishida, E., Fujioka, Y., Ohba, Y., Sato, T., Fujita, Y.,"Cell competition with normal epithelial cells promotes apical extrusion of transformed cells through metabolic changes"Nat. Cell Biol. 19, 530-541, 2017.
    [PubMed]
  • Tabata, S., Yamamoto, M., Goto, H., Hirayama, A., Ohishi, M., Kuramoto, T., Mitsuhashi, A., Ikeda, R., Haraguchi, M., Kawahara, K., Shinsato, Y., Minami, K., Saijo, A., Hanibuchi, M., Nishioka, Y., Sone, S., Esumi, H., Tomita, M., Soga, T., Furukawa, T., Akiyama, S., “Thymidine Catabolism as a Metabolic Strategy for Cancer Survival” Cell Rep. 19, 1313-1321, 2017.
    [PubMed]
  • Bardella C, Al-Dalahmah O, Krell D, Brazauskas P, Al-Qahtani K, Tomkova M, Adam J, Serres S, Lockstone H, Freeman-Mills L, Pfeffer I, Sibson N, Goldin R, Schuster-Böeckler B, Pollard, PJ, Soga T, McCullagh JS, Schofield CJ, Mulholland P, Ansorge O, Kriaucionis S, Ratcliffe PJ, Szele, FG, Tomlinson I, "Expression of Idh1R132H in the murine subventricular zone stem cell niche recapitulates features of early gliomagenesis" Cancer Cell 30, 578-594, 2016.
    [PubMed]
  • Ogawa, T., Tsubakiyama, R., Kanai, M., Koyama , T., Fujii, T., Iefuji, H., Soga, T., Kume, K., Miyakawa, T., Hirata, D., Mizunuma, M., “Stimulating S-adenosyl-L-methionine synthesis extends lifespan via activation of AMPK” Proc. Natl. Acad. Sci. USA 113, 11913-11918, 2016.
    [PubMed]
  • Saito, T., Ichimura, Y., Taguchi, K., Suzuki, T., Mizushima, T., Takagi, K., Hirose, Y., Nagahashi, M., Iso, T., Fukutomi, T., Ohishi, M., Endo, K., Uemura, T., Nishito, Y., Okuda, S., Obata, M., Kouno, T., Imamura, R., Tada, Y., Obata, R., Yasuda, D., Takahashi, K., Fujimura, T., Pi, J., Lee, MS., Ueno, T., Ohe, T., Mashino, T., Wakai, T., Kojima, H., Okabe, T., Nagano, T., Motohashi, H., Waguri, S., Soga, T., Yamamoto, M., Tanaka, K., Komatsu, M., "p62/Sqstm1 promotes malignancy of HCV-positive hepatocellular carcinoma through Nrf2-dependent metabolic reprogramming", Nat.Commun. 7, 12030, 2016. DOI: 10.1038/ncomms12030
    [PubMed]
  • Yugi, K., Kubota, H., Toyoshima, Y., Noguchi, R., Kawata, K., Komori, Y., Uda, S., Kunida, K., Tomizawa, Y., Funato, Y., Miki, H., Matsumoto, M., Nakayama, K.I., Kashikura, K., Endo, K., Ikeda, K., Soga, T., Kuroda, S., “Reconstruction of insulin signal flow from phosphoproteome and metabolome data” Cell Rep. 8, 1171-1183, 2014.
    [PubMed]
  • Hirayama, A., Wakayama, M., Soga, T., “Metabolome analysis based on capillary electrophoresis-mass spectrometry” Trends Anal. Chem. 61, 215-222, 2014.
    [Publisher]
  • Cheng, K., Lee, B., Masuda, T., Ito, T., Ikeda, K., Hirayama, A., Deng, L., Dong, J., Shimizu, K., Soga, T., Tomita, M., Palsson, B. O., Robert, M., “Global metabolic network reorganization by adaptive mutations allows fast growth of Escherichia coli on glycerol” Nat. Commun. 5, 3233, 2014.
    [PubMed]
  • Obata, F., Kuranaga, E., Tomioka, K., Ming M., Takeishi, A., Chen, C., Soga, T., Miura, M., “Necrosis-driven systemic immune response alters SAM metabolism through the FOXO-GNMT axis” Cell Rep. 7, 821-833, 2014.
    [PubMed]
  • Adam, J., Yang, M., Bauerschmidt, C., Kitagawa, M., O’Flaherty, L., Maheswaran, P., O¨ zkan, G., Sahgal, N., Baban, D., Kato, K., Saito, K., Iino, K., Igarashi, K., Stratford, M., Pugh, C., Tenant, D., Ludwig, C., Davies, B., Ratcliffe, P. J., El-Bahrawy, M., Ashrafian, H., Soga, T.,  Pollard, P. J., “A Role for Cytosolic Fumarate Hydratase in Urea Cycle Metabolism and Renal Neoplasia” Cell Rep. 3, 1440-1448, 2013.
    [PubMed]
  • Ternette N., Yang M., Laroyia M., Kitagawa M., O'Flaherty L., Wolhulter K., Igarashi K., Saito K., Kato K., Fischer R., Berquand A., Kessler B.M., Lappin T., Frizzell N., Soga T., Adam J, Pollard P.J., “Inhibition of Mitochondrial Aconitase by Succination in Fumarate Hydratase Deficiency”, Cell Rep. 3, 689-700. 2013.
    [PubMed]
  • Takubo, K., Nagamatsu, G., Kobayashi, C. I, Nakamura-Ishizu, A., Kobayashi, H., Ikeda, E., Goda, N., Johnson, R. S, Rahimi, Y., Soga, T., Hirao, A., Suematsu, M., Suda, T., “Regulation of Glycolysis by Pdk Functions as a Metabolic Checkpoint for Cell Cycle Quiescence in Hematopoietic Stem Cells” Cell Stem Cell 12, 49-61, 2013.
    [PubMed]
  • Yang, M., Soga, T., Pollard, P. J., “Oncometabolites: Linking Altered Metabolism with Cancer ? J. Clin. Invest. 123, 3652-3658, 2013.
    [PubMed]
  • Hoshi, T., Tadokoro, Y., Naka, K., Ooshio, T., Muraguchi, T., Sugiyama, N., Soga, T., Araki, K., Yamamura, K., Hirao, A., "mTORC1 is Essential for Leukemia propagation but Not Stem Cell Self-renewal" J. Clin. Invest. 122, 2114-2129, 2012.
    [PubMed]
  • Kasukawa, T., Sugimoto, M., Hida, A., Minami, Y., Mori, M., Honma, S., Honma, K., Mishima, K., Soga, T., Ueda, H.R. "Human blood metabolite timetable indicates internal body time" Proc. Natl. Acad. Sci. USA 109, 15036-1504, 2012.
    [PubMed]
  • Hirayama, A., Tomita, M., Soga, T., “Sheathless capillary electrophoresis-mass spectrometry with a high-sensitivity porous sprayer for cationic metabolome analysis” Analyst 137, 5026-5033, 2012.
    [PubMed]
  • Sugimoto, M., Ikeda, S., Niigata, K., Tomita, M., Sato, H., Soga, T. “MMMDB: Mouse Multiple Tissue Metabolome Database” Nucl. Acids Res. 40 (D1): D809-D814. 2012.
    [PubMed]
  • Soga, T., Sugimoto, M., Honma, M., Mori, M., Igarashi, K., Kashikura, K., Ikeda, S., Hirayama, A., Yamamoto, T., Yoshida, H., Otsuka, M., Tsuji, S., Yatomi, Y., Sakuragawa, T., Watanabe, H., Nihei, K., Saito, T., Kawata, S., Suzuki, H., Tomita, M., Suematsu, M., “Serum Metabolomics Reveals γ-glutamyl Dipeptides as Biomarkers for discrimination among Different Forms of Liver Disease” J. Hepatol. 55, 896-905, 2011.
    [PubMed]
  • Adam, J., Hatipoglu, E., O’Flaherty, L., Ternette, N., Sahgal, N., Lockstone, H., Baban D., Nye, E., Stamp, G.W., Wolhuter, K., Stevens, M., Fischer, R., Carmeliet, P., Maxwell, P.H., Pugh, C.W., Frizzell, N., Soga, T., Kessler, B.M., El-Bahrawy, M., Ratcliffe, P.J., Pollard, P.J. “Renal Cyst Formation in Fh1-Deficient Mice Is Independent of the Hif/Phd Pathway: Roles for Fumarate in KEAP1 Succination and Nrf2 Signaling” Cancer Cell 20, 524-537, 2011.
    [PubMed]
  • Fujiwara, K., Ishihama, Y., Nakahigashi, K., Soga, T., Taguchi, H., ”A Systematic Survey of in vivo Obligate Shaperonin-dependent Substrates” EMBO J. 29, 1552-1564, 2010.
    [PubMed]
  • Kitagawa, M., Ikeda, S., Tashiro, E., Soga, T., Imoto, M., “Metabolomic Identification of the Target of the Filopodia Protrusion Iinhibitor Glucopiericidin A” Chem. Biol. 17, 989-998, 2010.
    [PubMed]
  • Minami, Y., Kasukawa, T., Kakazu, Y., Iigo, M., Sugimoto, M., Ikeda, S., Yasui, A., van der Horst, G., Soga, T., Ueda, H., ”Measurement of Internal Body Time by Blood Metabolomics” Proc. Natl. Acad. Sci. USA 106, 9890-9895, 2009.
    [PubMed]
  • Hirayama, A., Kami, K., Sugimoto, M., Sugawara, M., Toki, N., Onozuka, H., Kinoshita, T., Saito, N., Ochiai, A., Tomita, M., Esumi, H., Soga, T., "Quantitative Metabolome Profiling of Colon and Stomach Cancer Microenvironment by Capillary Electrophoresis Time-of-flight Mass Spectrometry", Cancer Res. 69, 4918-4925, 2009.
    [PubMed]
  • Soga, T., Igarashi, K., Itoh, C., Mizobuchi, K., Zimmermann, H., Tomita, M.,”Metabolomic Profiling of Anionic Metabolites by Capillary Electrophoresis Mass Spectrometry” Anal. Chem. 81, 6165-6174, 2009.
    [PubMed]
  • †Ishii, N., †Nakahigashi, K., †Baba, T., †Robert, M., †Soga, T., †Kanai, A., †Hirasawa, T., Naba, M., Hirai, K., Hoque, A., Ho, P.Y., Kakazu, Y., Sugawara, K., Igarashi, S.,Harada, S., Masuda, T., Sugiyama, N., Togashi, T., Hasegawa, M., Takai, Y., Yugi, K., Arakawa, K., Iwata, N., Toya, Y., Nakayama, Y., Nishioka, T., Shimizu, K., Mori, H., Tomita, M.,”Multiple High-throughput Analyses Monitor the Response of E. coli to Perturbations”, Science  316, 593-597, 2007.(†equally contribution)
    [Science] [PubMed]
  • Soga, T., Baran, R., Suematsu M., Ueno, Y., Ikeda, S., Sakurakawa T., Kakazu, Y., Ishikawa, T., Robert, M., Nishioka, T., Tomita, M., “Differential Metabolomics Reveals Ophthalmic Acid As An Oxidative Stress Biomarker Indicating Hepatic Glutathione Consumption”, J. Biol. Chem. 281, 16768-76, 2006.
    [PubMed]
  • Soga, T., Ohashi, Y., Ueno, Y., Naraoka, H., Tomita, M., and Nishioka, T., “Quantitative Metabolome Analysis Using Capillary Electrophoresis Mass Spectrometry”, J. Proteome Res. 2. 488-494, 2003.
    [PubMed]
  • Soga, T., Ueno, Y., Naraoka, H., Ohashi, Y., Tomita, M., and Nishioka, T., ”Simultaneous Determination of Anionic Intermediates for Bacillus subtilis Metabolic Pathways by Capillary Electrophoresis Electrospray Ionization Mass Spectrometry”, Anal. Chem. 74, 2233-2239, 2002.
    [PubMed]
  • Soga, T., and Heiger, D. N., ”Amino Acid Analysis by Capillary Electrophoresis Electrospray Ionization Mass Spectrometry”, Anal. Chem. 72 1236-1241, 2000.
    [PubMed]

Publications

  • 2021
  • Sato, Y., Tomita, M., Soga, T., Ochiai, A., Makinoshima, H., “Upregulation of thymidylate synthase induces pemetrexed resistance in malignant pleural mesothelioma” Front. Pharmacol. 12, 718675, 2021.
    [Publisher]
  • Nakao, M., Shimizu, I., Katsuumi, G., Yoshida, Y., Suda, M., Hayashi, Y., Ikegami, R., Hsiao, Y. T., Okuda, S., Soga, T., Minamino, T., "Empagliflozin Maintains Capillarization and Improves Cardiac Function in a Murine Model of Left Ventricular Pressure Overload" Sci Rep. 11, 18384, 2021.
    [PubMed]
  • Heishima, K., Sugito, N., Soga, T., Nishikawa, M., Ito, Y., Honda, R., Kuranaga, Y., Sakai, H., Ito, R., Nakagawa, T., Ueda, H., Akao, Y., “Petasin potently inhibits mitochondrial-complex-I-based metabolism that suppors tumor growth and metastasis” J Clin. Invest. 131, e139933, 2021.
    [PubMed]
  • Shindo, H., Harada-Shoji, N., Ebata, A., Sato, M., Soga, T., Miyashita, M., Tada, H., Kawai, M., Kosaka, S., Onuki, K., Usami, S., Furumoto, S., Hayashi, S., Abe, T., Suzuki, T., Ishida, T., Sasano, H., “Targeting Amino Acid Metabolic Reprogramming via L-Type Amino Acid Transporter 1 (LAT1) for Endocrine-Resistant Breast Cancer” Cancers 13, 4375, 2021.
    [PubMed]
  • Igarashi, K., Ota, S., Kaneko, M., Hirayama, A., Enomoto, M., Katumata, K., Sugimoto M., Soga, T., "High-throughput Screening of Salivary Polyamine Markers for Discrimination of Colorectal Cancer by Multisegment Injection Capillary Electrophoresis Tandem Mass Spectrometry" J. Chromatogr. A. 1652, 462355, 2021.
    [PubMed]
  • Matsuzaki, F., Uda, S., Yamauchi, Y., Matsumoto, M., Soga, T., Maehara, K., Ohkawa, Y., Nakayama, K., Kuroda, S., Kubota, H., “An extensive and dynamic trans-omic network illustrating prominent regulatory mechanisms in response to insulin in the liver” Cell rep. 36, 109569, 2021.
    [PubMed]
  • Saito, Y., Soga, T., “Amino acid transporters as emerging therapeutic targets in cancer” Cancer Sci., 112, 2958-2965, 2021.
    [PubMed]
  • Kozawa, K., Sekai, M., Ohba, K., Ito, S., Sako, H., Maruyama, T., Kakeno, M., Shirai, T., Kuromiya, K., Kamasaki, T., Kohashi, K., Tanaka, S., Ishikawa, S., Sato, N., Asano, S., Suzuki, H., Tanimura, N., Mukai, Y., Gotoh, N., Tanino, M., Tanaka, S., Natsuga, K., Soga, T., Nakamura, T., Yabuta, Y., Saitou, M., Ito, T., Matsuura, K., Tsunoda, M., Kikumori, T., Iida, T., Mizutani,Y., Miyai, Y., Kaibuchi, K., Enomoto, A., Fujita, Y., "The CD44/COL17A1 pathway promotes the formation of multilayered, transformed epithelia" Curr. Biol. 31, 3086-3097.e7, 2021.
    [PubMed]
  • Ikeda, Y., Hirayama, A., Kofuji, S., Hirota, Y., Kamata, R., Osaka, N., Fujii, Y., Sasaki, M., Ikeda, S., Smith, E.P., Bachoo, R., Soga, T., Sasaki, A.T., "SI-MOIRAI: A new method to identify and quantify the metabolic fate of nucleotides" J Biochem. online, mvab077, 2021.
    [PubMed]
  • Maruyama, A., Sato, Y., Nakayama, J., Murai, J., Ishikawa, T., Soga, T., Makinoshima, H.,  “De novo deoxyribonucleotide biosynthesis regulates cell growth and tumor progression in small-cell lung carcinoma” Sci. Rep., 11, 13474, 2021.
    [PubMed]
  • Nakasuka, F., Tabata, S., Sakamoto, T., Hirayama, A., Ebi, H., Yamada, T., Umetsu, K., Ohishi, M., Ueno, A., Goto, H., Sugimoto, M., Nishioka, Y., Yamada, Y., Tomita, M., Sasaki, A.T. Yano, S., Soga, T., “TGF-β-dependent reprogramming of amino acid metabolism induces epithelial-mesenchymal transition in non-small cell lung cancers” Commun Biol., 4, 782, 2021.
    [PubMed]
  • Akiyama, Y., Kikuchi, K., Toyohara, T., Mishima, E., Suzuki, C., Suzuki, T., Nakayama, M., Tomioka, Y., Soga, T., Abe, T., “CE-MS-based Identification of Uremic Solutes Specific to Hemodialysis Patients” Toxins (Basil) 13,324, 2021.
    [PubMed]
  • Miyamoto, K., Hirayama, A., Sato, Y., Ikeda, S., Maruyama, M., Soga, T., Tomita, M., Nakamura, M., Matsumoto, M., Yoshimura, N., *Miyamoto, T., “A Metabolomic Profile Predictive of New Osteoporosis or Sarcopenia Development” Metabolites 11, 278, 2021.
    [PubMed]
  • Nishida, H., Okada, M., Yang, L., Takano, T., Tabata, S., Soga, T., Ho, D.M., Chung, J., Minami, Y., Yoo, S.K., "Methionine restriction breaks obligatory coupling of cell proliferation and death by an oncogene Src in Drosophila" eLife 10, e59809, 2021.
    [PubMed]
  • Saito, R., Sugimoto, M., Hirayama, A., Soga, T., Tomita, M., Takebayashi, T., “Quality Assessment of Untargeted Analytical Data in a Large-Scale Metabolomic Study” J. Clin. Med. 10, 1826, 2021.
    [PubMed]
  • Ishibashi, Y., Harada, S., Takeuchi, A., Iida, M., Kurihara, A., Kato, S., Kuwabara, K.,  Hirata, A., Shibuki, T., Okamura, T., Sugiyama, D., Sato, A, Amano, K., Hirayama, A., Sugimoto, M., Soga, T., Tomita, M., Takebayashi, T., "Reliability of urinary charged metabolite concentrations in a large-scale cohort study using capillary electrophoresis-mass spectrometry" Sci. Rep 11, 7407, 2021.
    [PubMed]
  • Hayasaka, R., Tabata, S., Hasebe, M., Ikeda, S., Ohnuma, S., Mori, M., Soga, T., Tomita, M., Hirayama, A., “Metabolomic Analysis of Small Extracellular Vesicles Derived from Pancreatic Cancer Cells Cultured under Normoxia and Hypoxia” Metabolites 11, 215, 2021.
    [PubMed]
  • Hsiao, Y.T., Shimizu, I., Wakasugi, T., Yoshida, Y., Ikegami, R., Hayashi, Y., Suda, M., Katsuumi, G., Nakao, M., Ozawa, T., Izumi, D., Kashimura, T., Ozaki, K., Soga, T., Minamino, T., "Cardiac Mitofusin-1 is Reduced in Non-responding Patients with Idiopathic Dilated Cardiomyopathy" Sci. Rep 11, 6722, 2021.
    [PubMed]
  • Egami, R., Kokaji, T., Hatano, A., Yugi, K., Eto, M., Morita, K., Ohno, S., Fujii, M., Hironaka, K., Uematsu, S., Terakawa, A., Bai, Y., Pan, Y., Tsuchiya, T., Ozaki, H., Inoue, H., Uda, S., Kubota, H., Suzuki, Y., Matsumoto, M., Nakayama, K., Hirayama, A., Soga, T., Kuroda, S., “Trans-Omic Analysis Reveals Obesity-Associated Dysregulation of Inter-Organ Metabolomic Cycles between the Liver and Skeletal Muscle” iScience 24, 102217, 2021.
    [PubMed]
  • Shimizu, T., Kimura, K., Sugihara, E., Yamaguchi-Iwai, S., Nobuse, H., Sampetrean, O., Otsuki, Y., Fukuchi, Y., Saitoh, K., Kato, K., Soga, T., Muto, A., Saya, H., "MEK inhibition preferentially suppresses anchorage-independent growth in osteosarcoma cells and decreases tumors in vivo" J. Orthop. Res., online, 2021.
    [PubMed]
  • Guo, J., Wang, J., Iino, K., Tomita, M., Soga, T., “Quantitative and Molecular Similarity Analyses of the Metabolites of Cold- and Hot-Natured Chinese Herbs” Evid. Based. Complement. Alternat. Med. 2021, 6646507, 2021.
    [PubMed]
  • Guo, J., Satoh, K., Tabata, S., Mori, M., Tomita, M., Soga, T., “Reprogramming of glutamine metabolism via glutamine synthetase silencing induces cisplatin resistance in A2780 ovarian cancer cells” BMC Cancer 21, 174, 2021.
    [PubMed]
  • Shibutami, E., Ishii, R., Harada, S., Kurihara, A., Kuwabara, K., Kato, S., Iida, M., Akiyama, M., Sugiyama, D., Hirayama, A., Sato, A., Amano, K., Sugimoto, M., Soga, T. Tomita, M., Takebayashi, T., “Charged metabolite biomarkers of food intake assessed via plasma metabolomics in a population-based observational study in Japan” PLoS One. 16, e0246456. 2021.
    [PubMed]
  • Matsuo, T., Isosaka, T., Tang, L., Soga, T.,  Kobayakawa, R.,  Kobayakawa, K., “Artificial hibernation/life-protective state induced by thiazoline-related innate fear odors” Commun Biol. 4, 101, 2021.
    [PubMed]
  • Sato, M., Harada-Shoji, N., Toyohara, T., Soga, T., Itoh, M., Miyashita, M., Tada, H., Amari, M., Anzai, N., Furumoto, S., Abe, T., Suzuki, T., Ishida, T., Sasano, H., "L-type amino acid transporter 1 is associated with chemoresistance in breast cancer via the promotion of amino acid metabolism" Sci. Rep 11, 589, 2021.
    [PubMed]
  • 2020
  • Ishikawa, S., Hiraka, T., Kirii, K., Sugimoto, M., Shimamoto, H., Sugano, A., Kitabatake, K., Toyoguchi, Y., Kanoto, M., Nemoto, K., Soga, T., Tomita, M., Iino, M., “Relationship between Standard Uptake Values of Positron Emission Tomography/Computed Tomography and Salivary Metabolites in Oral Cancer: A Pilot Study” J Clin. Med. 9, 3958, 2020.
    [PubMed]
  • Kokaji, T., Hatano, A., Ito, Y. ,Yugi, K., Eto, M., Morita, K., Ohno, S.,Fujii, M., Hironaka, K., Egami, R., Terakawa, A., Tsutchiya, T., Ozaki, H., Inoue, H., Uda, S., Kubota, H., Suzuki, Y., Ikeda, K., Arita, M., Matsumoto, M., Nakayama, K., Hirayama, A., Soga, T., Kuroda, S., "Transomics analysis reveals allosteric and gene regulation axes for altered hepatic glucose-responsive metabolism in obesity" Sci Signal.,13, eaaz1236, 2020
    [PubMed]
  • Ogawa, Y., Miyoshi, C., Obana, N., Yajima, K., Hotta-Hirashima, N., Ikkyu, A., Kanno, S., Soga, T., Fukuda, S., Yanagisawa, M., “Gut microbiota depletion by chronic antibiotic treatment alters the sleep/wake architecture and sleep EEG power spectra in mice” Sci. Rep. 10, 19554, 2020.
    [PubMed]
  • Ozawa, H., Hirayama, A., Shoji F., Maruyama, M., Suzuki, K., Yamanaka-Okumura, H., Tatano, H., Morine, Y., Soga, T., Shimada, M., Tomita M., “Comprehensive Dipeptide Analysis Revealed Cancer-Specific Profile in the Liver of Patients with Hepatocellular Carcinoma and Hepatitis” Metabolites 10, 442, 2020.
    [PubMed]
  • Hoshino, D., Kawata, K., Kunida, K., Hatano, A., Yugi, K., Wada, T., Fujii, M., Sano, T., Ito, Y., Furuichi, Y., Manabe, Y., Suzuki, Y., Fujii, N.L., Soga, T., Kuroda, S., “Trans-omic Analysis Reveals ROS-Dependent Pentose Phosphate Pathway Activation after High-Frequency Electrical Stimulation in C2C12 Myotubes” iScience 23, 101558, 2020.
    [PubMed]
  • Ogura, T., Wakayama, M., Ashino, Y., Kadowaki, R., Sato, M., Soga, T., Tomita, M., “Effects of feed crops and boiling on chicken egg yolk and white determined by a metabolome analysis” Food Chem. 327, 127077,  2020.
    [PubMed]
  • Hayashi, Y., Mori, M., Igarashi, K., Tanaka, K., Takehara, A., Ito-Matsuoka, Y., Kanai, A., Yaegashi, N., Soga, T., Matsui, Y., “Proteomic and metabolomic analyses uncover sex-specific regulatory pathways in mouse fetal germline differentiation” Biol. Reprod. 103, 717-735, 2020.
    [PubMed]
  • Ohno, S., Quek, L.E., Krycer, J.R., Yugi, K., Hirayama, A., Ikeda, S., Shoji, F., Suzuki, K., Soga, T., James, D.E., Kuroda, S., “Kinetic Trans-omic Analysis Reveals Key Regulatory Mechanisms for Insulin-Regulated Glucose Metabolism in Adipocytes” iScience 23, 101479, 2020.
    [PubMed]
  • Krycer, J.R., Quek, L-E., Francis, D., Zadoorian, A., Weiss, F.C., Cooke, K.C., Nelson, M.E., Diaz-Vegas, A., Humphrey, S.J., Scalzo, R., Hirayama, A., Ikeda, S., Shoji, F., Suzuki, K. Huynh, K., Giles, Co., Varney, B., Nagarajan, S.R., Hoy, A.J., Soga, T., Meikle, P.J., Cooney, G.J., Fazakerley D.J., James, D.E., "Insulin signalling requires glucose to promote lipid anabolism in adipocytes" J. Biol. Chem. 295, 13250-13266, 2020.
    [PubMed]
  • Kikuchi, N., Soga, T., Nomura, M., Sato, T., Sakamoto, Y., Tanaka, R., Abe, J., Morita, M., Shima, H., Okada, Y., Tanuma, N., “Comparison of the ischemic and non-ischemic lung cancer metabolome reveals hyper activity of the TCA cycle and autophagy” Biochem. Biophys. Res. Commun. 530, 285-291, 2020.
    [PubMed]
  • Kohno, S., Linn, P., Nagatani, N., Watanabe, Y., Kumar, S., Soga, T., Takahashi, C., “Pharmacologically targetable vulnerability in prostate cancer carrying RB1-SUCLA2 deletion” Oncogene 39, 5690-5707, 2020.
    [PubMed]
  • Saito, Y., Sawa, D., Kinoshita, M., Yamada, A., Kamimura, S., Suekane, A., Ogoh, H., Matsuo, H., Adachi, S., Taga, T., Tomizawa, D., Osato, M., Soga, T., Morishita, K., Moritake, H. “EVI1 triggers metabolic reprogramming associated with leukemogenesis and increases sensitivity to L-asparaginase” Haematologica. 105, 2118-2129, 2020.
    [PubMed]
  • Toriyama, K., Kuwahara, M., Kondoh, H., Mikawa, T., Takemori, N., Konishi, A., Yorozuya, T., Yamada, T., Soga, T., Shiraishi, A., Yamashita, M., “T cell-specific deletion of Pgam1 reveals a critical role for glycolysis in T cell responses” Commun Biol 3, 394, 2020.
    [PubMed]
  • Kosakamoto, H., Yamauchi, T., Akuzawa-Tokita, Y., Nishimura, K., Soga, T., Murakami, T., Mori, H., Yamamoto, K., Miyazaki, R., Koto, A., Miura, M., Obata, F., “Local Necrotic Cells Trigger Systemic Immune Activation via Gut Microbiome Dysbiosis in Drosophila” Cell Rep., 32, 107938. 2020.
    [PubMed]
  • Ozawa, H., Hirayama, A., Ishikawa, T., Kudo, R., Maruyama, M., Shoji, F., Doke, T., Ishimoto, T., Maruyama, S., Soga, T., Tomita, M., “Comprehensive Dipeptide Profiling and Quantitation by Capillary Electrophoresis and Liquid Chromatography Coupled with Tandem Mass Spectrometry” Anal. Chem. 92, 9799-9806, 2020.
    [PubMed]
  • Hirayama, A., Tabata, S., Kudo, R., Hasebe, M., Suzuki, K., Tomita, M., Soga, T., “The use of a double coaxial electrospray ionization sprayer improves the peak resolutions of anionic metabolites in capillary ion chromatography-mass spectrometry” J. Chromatogr. A., 1619, 460914,  2020.
    [PubMed]
  • Seong, K.H., Ly, N.H., Katou, Y., Yokota, N., Nakato, R., Murakami, S., Hirayama, A., Fukuda, S., Kang, S., Soga, T., Shirahige, K., Ishii, S., “Paternal restraint stress affects offspring metabolism via ATF-2 dependent mechanisms in Drosophila melanogaster germ cells” Commun. Biol. 3, 208, 2020.
    [PubMed]
  • Hamid, SS., Wakayama, M., Ashino, Y., Kadowaki, R., Soga, T., Tomita, M., “Effect of blanching on the concentration of metabolites in two parts of Undaria pinnatifida, Wakame (leaf) and Mekabu (sporophyll)” Algal Res., 47, 101829, 2020.
    [Publisher]
  • Tadokoro, H., Hirayama, A., Kudo, R., Hasebe, M., Yoshioka, Y., Matsuzaki, J., Yamamoto, Y., Sugimoto, M., Soga, T., Ochiya, T., “Adenosine leakage from perforin-burst extracellular vesicles inhibits perforin secretion by cytotoxic T-lymphocytes” PLoS One. 15, e0231430, 2020.
    [PubMed]
  • Sugimoto, M., Sugawara, T., Obiya, S., Enomoto, A., Kaneko, M., Ota, S., Soga, T., Tomita, M., “Sensory properties and metabolomic profiles of dry-cured ham during the ripening process” Food Res Int. 129, 108850, 2020.
    [PubMed]
  • Quek, L.E., Krycer, J.R., Ohno, S., Yugi, K., Fazakerley, D.J., Scalzo, R., Elkington, S.D., Dai, Z., Hirayama, A., Ikeda, S., Shoji, F., Suzuki, K., Locasale, J.W., Soga, T., James, D.E., *Kuroda, S., “Dynamic 13C Flux Analysis Captures the Reorganization of Adipocyte Glucose Metabolism in Response to Insulin” iScience, 23, 100855, 2020..
    [PubMed]
  • Endoh, M., Baba, M., Endoh, T., Hirayama, A., Nakamura-Ishizu, A., Umemoto, T., Hashimoto, M., Nagashima, K., Soga, T., Lang, M., Schmidt, L.S., Linehan, W.M., Suda, T., “A FLCN-TFE3 Feedback Loop Prevents Excessive Glycogenesis and Phagocyte Activation by Regulating Lysosome Activity” Cell Rep. 30, 1823-1834.e5, 2020.
    [PubMed]
  • Nanto-Hara F., Kanemitsu Y., Fukuda S., Kikuchi K., Asaji K., Saigusa D., Iwasaki T., Ho H.J., Mishima E., Suzuki T., Suzuki C., Tsukimi T., Matsuhashi T., Oikawa Y., Akiyama Y., Kure S., Owada Y., Tomioka Y., Soga, T., Ito S., Abe T., “The guanylate cyclase C agonist linaclotide ameliorates the gut-cardio-renal axis in an adenine-induced mouse model of chronic kidney disease.” Nephrol. Dial. Transplant. 35, 250-264, 2020.
    [PubMed]
  • Krycer, J.R., Quek, L.E., Francis, D.J., Fazakerley, S.D., Elkington, S., Diaz-Vegas, A., Cooke, K.C., Weiss, F.C., Duan, X., Kurdyukov, S., Zhou, P.X., Tambar, U.K., Hirayama, A., Ikeda, S., Kamei, Y., Soga, T., Cooney, G.J., James, D.E., “Lactate production is a prioritized feature of adipocyte metabolism” J Biol Chem., 295, 83-98, 2020.
    [PubMed]
  • McCarthy, MT., Lin, D., Soga, T., Adam, J., O'Callaghan, CA., “Inosine pranobex enhances human NK cell cytotoxicity by inducing metabolic activation and NKG2D ligand expression” Eur. J. Immunol. 50, 130-137, 2020.
    [PubMed]
  • 2019
  • Suzuki, A., Onodera, K., Matsui, K., Seki, M., Esumi, H., Soga, T., Sugano, S., Kohno, T., Suzuki, Y., Tsuchihara, K., “Characterization of cancer omics and drug perturbations in panels of lung cancer cells” Sci Rep. 9, 19529, 2019.
    [PubMed]
  • Annan, DA., Maishi, N., Soga, T., Dawood, R. Li, C., Kikuchi, H., Hojo, T., Morimoto, M., Kitamura, T., Alam, MT., Minowa, K., Shinohara, N., Nam, JM., Hida, Y., Hida, K., "Carbonic anhydrase 2 (CAII) supports tumor blood endothelial cell survival under lactic acidosis in the tumor microenvironment" Cell Commun. Signal. 17, 169, 2019.
    [PubMed]
  • Fujiwara, H., Tateishi, K., Misumi, K., Hayashi, A., Igarashi, K, Kato, H., Nakatsuka, T., Suzuki, N., Yamamoto, K., Kudo, Y., Hayakawa, Y., Nakagawa, H., Tanaka, Y., Ijichi, H., Kogure, H, Nakai, Y, Isayama, H., Hasegawa, K., Fukayama, M., Soga, T., Koike, K., “Mutant IDH1 confers resistance to energy stress in normal biliary cells through PFKP-induced aerobic glycolysis and AMPK activation” Sci. Rep. 9, 18859, 2019.
    [PubMed]
  • Osada-Oka, M., Goda, N., Saiga, H., Yamamoto, M., Takeda, K., Ozeki, Y., Yamagchi, T., Soga, T., Tateishi, Y., Miura, K., Okuzaki, D., Kobayashi, K., Matsumoto, S., “Metabolic adaptation to glycolysis is a basic defense mechanism of macrophages for Mycobacterium tuberculosis infection” Int. Immunol. 31, 781-793, 2019.
    [PubMed]
  • Harada-Shoji, N., Soga, T., Tada, H., Miyashita, M., Harada, M., Watanabe, G., Hamanaka, Y., Sato, A., Suzuki, T., Suzuki, A., Ishida, T. “A metabolic profile of routine needle biopsies identified tumor type specific metabolic signatures for breast cancer stratification: a pilot study” Metabolomics. 15, 147, 2019.
    [PubMed]
  • Louphrasitthiphol P., Ledaki I., Chauhan J., Falletta P., Siddaway R., Buffa FM., Mole DR., Soga T., Goding CR., “MITF controls the TCA cycle to modulate the melanoma hypoxia response” Pigment. Cell Melanoma. Res. 32, 792-808, 2019.
    [PubMed]
  • Fukushima, K., Harada, S., Takeuchi, A., Kurihara, A., Iida, M., Fukai, K., Kuwabara, K., Kato, S., Matsumoto, M., Hirata, A., Akiyama, M., Tomita, M., Hirayama, A., Sato, A., Suzuki, C., Sugimoto, M., Soga, T., Sugiyama, D., Takebayashi, T., “Association between dyslipidemia and plasma levels of branched-chain amino acids in the Japanese population without diabetes mellitus” J. Clini. Lipidol. 13, 932-939, 2019.
    [PubMed]
  • Hashimoto, N., Nakamichi, N., Nanmo, H., Kimura, K., Masuo, Y., Sakai, Y., Schinkel, A.H., Sato, S., Soga, T., Kato, Y., “Metabolome Analysis Reveals Dermal Histamine Accumulation in Murine Dermatitis Provoked by Genetic Deletion of P-Glycoprotein and Breast Cancer Resistance Protein” Pharm. Res. 36. 158, 2019.
    [PubMed]
  • Nakagawa, M., Nakatani, F., Matsunaga H., Seki T., Endo M., Ogawara Y., Machida Y., Katsumoto T., Yamagata K., Hattori A., Fujita S., Aikawa Y., Ishikawa T., Soga, T., Kawai A., Chuman H., Yokoyama N., Fukushima S., Yahiro K., Kimura A., Shimada E., Hirose T., Fujiwara T., Setsu N., Matsumoto Y., Iwamoto Y., Nakashima Y., Kitabayashi I. “Selective inhibition of mutant IDH1 by DS-1001b ameliorates aberrant histone modifications and impairs tumor activity in chondrosarcoma” Oncogene 38, 6835-6849, 2019.
    [PubMed]
  • Osawa, T., Shimamura, T., Saito, K., Hasegawa, Y., Ishii, N., Nishida, M., Ando, R., Kondo, A., Anwar, M., Tsuchida, R., Hino, S., Sakamoto, A., Igarashi, K., Saitoh, K., Kato, K., Endo, K., Yamano, S., Kanki, Y., Matsumura, Y., Minami, T., Tanaka, T., Anai, M., Wada, Y., Wanibuchi, H., Hayashi, M., Hamada, A., Yoshida, M., Yachida, S., Nakao, M., Sakai, J., Aburatani, H., Shibuya, M., Hanada, K., Miyano, S., Soga, T., Kodama, T., “Phosphoethanolamine Accumulation Protects Cancer Cells under Glutamine Starvation through Downregulation of PCYT2” Cell Rep. 29, 89-103.e7, 2019.
    [PubMed]
  • Hayasaki, T., Ishimoto, T., Doke, T., Hirayama, A., Soga, T., Furuhashi, K., Kato, N., Kosugi, T., Tsuboi, N., Lanaspa, MA., Johnson, RJ., Maruyama, S., Kadomatsu, K., “Fructose Increases the Activity of Sodium Hydrogen Exchanger in Renal Proximal Tubules that is Dependent on Ketohexokinase” J. Nutr. Biochem.71, 54-62, 2019.
    [PubMed]
  • Yoneshiro M., Brown Z., Chondronikola M., Takahashi H., Goto T., Kawada T., Sidossis L., Szoka FC., McManus MT., Saito M., Soga T., Kajimura S., “BCAA catabolism in brown fat controls energy homeostasis through SLC25A44” Nature 572, 614-619, 2019.
    [PubMed]
  • Yatsuoka, W., Ueno, T., Miyano, K., Uezono, Y., Enomoto, A., Kaneko, M., Ota, S., Soga, T., Sugimoto, M., Ushijima, T., “Metabolomic profiling reveals salivary hypotaurine as a potential early detection marker for medication-related osteonecrosis of the jaw” PLoS One 14, e0220712. 2019.
    [PubMed]
  • Kofuji, S., Hirayama, A., Eberhardt, A.O., Kawaguchi R., Sugiura, Y., Sampetrean, O., Ikeda, Y., Warren, M., Sakamoto, N., Kitahara, S., Yohino, H., Yamashita, D., Sumita, K., Wofe, K., Lange, L., Ikeda, S., Shimada, H., Minami, N., Malhotra, A., Morioka, S., Ban, Y., Asano, M., Flanary, V.L., Ramkissoon, A., Chow, L.M.L., Kiyokawa, J., Mahimo, T., Lucey, G., Mareninov, S., Ozawa, T., Onishi, N., Okumura, K., Terakawa, J., Daikoku, T., Wise-Draper, T., Majd, N., Kofuji, K., Sasaki, M., Mori, M., Kanemura, Y., Smith, E.P., Anastasiou, D., Wakimoto, H., Holland, E.C., Yong, W.H., Horbinski, C., Nakano, I., Deberardinis, R.J., Bachoo, R., Mischel, P.S., Yasui, W., Suematsu, M., Saya, H., Soga, T., Grummt, I., Bierhoff, H., Sasaki, AT.,“IMP dehydrogenase-2 drives aberrant nucleolar activity and promotes tumorigenesis in glioblastoma” Nat. Cell Biol. 21, 1003-1014, 2019.
    [PubMed]
  • Valli, A., Morotti, M., Zois, CE., Albers, PK., Soga, T, Feldinger, K., Fischer, R., Frejno, M., McIntyre, A., Bridges, E., Haider, S., Buffa, FM., Baban, D., Rodriguezm, M., Yanes, O., Whittington, HJ., Lake, HA., Zervou, S., Lygate, CA., Kessler, BM., Harris, AL., "Adaptation to HIF1α deletion in hypoxic cancer cells by upregulation of GLUT14 and creatine metabolism", Mol. Cancer Res., 17, 1531-1544, 2019.
    [PubMed]
  • Yachida, S., Mizutani, S., Shiroma, H., Shiba, S., Nakajima, T., Sakamoto, T., Watanabe, H., Masuda, K., Nishimoto, Y., Kubo, M., Hosoda, F., Rokutan, H., Matsumoto, M., Takamaru, H., Yamada, M., Matsuda, T., Iwasaki, M., Yamaji, T., Yachida, T., Soga, T., Kurokawa, K., Toyoda, A., Ogura, Y., Hayashi, T., Hatakeyama, M., Nakagama, H., Saito, Y., Fukuda, S., Shibata, T., Yamada, T., "Metagenomic and metabolimic analyses reveal distinct stage-specific phenotypes of the gut microbiota in colorectal cancer" Nat. Med., 25, 968-976, 2019.
    [PubMed]
  • Hamid, S., Wakayama, M., Ichihara, K., Sakurai, K., Ashino, Y., Kadowaki, R., Soga, T., Tomita, M. “Metabolome profiling of various seaweed species discriminates between brown, red, and green algae” Planta 249, 1921-1947, 2019.
    [PubMed]
  • Takai, T., Tsujino, T., Yoshikawa, Y., Inamoto, T., Sugito, N., Kuranaga, Y., Heishima, K., Soga, T., Hayashi, K., Miyata, K., Kataoka, K., Azuma, H., Akao, Y., "Synthetic miR-143 Exhibited an Anti-Cancer Effect via the Downregulation of K-RAS Networks of Renal Cell Cancer Cells In Vitro and In Vivo" Mol. Ther. 27, 1017-1027, 2019.
    [PubMed]
  • Kikuchi, K., Saigusa, D., Kanemitsu, Y., Matsumoto, Y., Thanai, P., Suzuki, N., Mise, K., Yamaguchi, H., Nakamura, T., Asaji, K., Mukawa, C., Tsukamoto, H., Sato, T., Oikawa, Y., Iwasaki, T., Oe, Y., Tsukimi, T., Fukuda, N., Ho, H., Nanto-Hara, F., Ogura, J., Saito, R., Nagao, S., Ohsaki, Y., Shimada, S., Suzuki, T., Toyohara, T., Mishima, E., Shima, H., Akiyama, Y., Akiyama, Y., Ichijo, M., Matsuhashi, T., Matsuo, A., Ogata, Y., Yang, C., Suzuki, C., Breeggemann, M., Heymann, J., Shimizu, M., Ogawa, S., Takahashi, N., Suzuki, T., Owada, Y., Kure, S., Mano, N., Soga, T., Wada, T., Kopp, J., Fukuda, S., Hozawa, A., Yamamoto, M., Ito, S., Wada, J., Tomioka, Y., Abe, T., “Gut microbiome-derived phenyl sulfate contributes to albuminuria in diabetic kidney disease” Nat Commun 10, 1835, 2019.
    [PubMed]
  • Saito, T., Kuma, A., Sugiura, Y., Ichimura, Y., Obata, M., Kitamura, H., Okuda, S., Lee, HC., Ikeda, K., Kanegae, Y., Saito, I., Auwerx, J., Motohashi, H., Suematsu, M., Soga, T., Yokomizo, T., Waguri, S., Mizushima, N., Komatsu M., "Autophagy regulates lipid metabolism through selective turnover of NCoR1" Nat. Commun 10, 1567, 2019.
    [PubMed]
  • Nishimura, T., Nakata, A., Chen, X., Nishi, K., Meguro-Horike, M., Sasaki, S., Kita, K., Horike, S., Saitoh, K., Kato, K., Igarashi, K., Murayama, T., Kohno, S., Takahashi, C., Mukaida, N., Yano, S., Soga, T., Tojo, A., Gotoh, N., “Cancer stem-like properties and gefitinib resistance are dependent on purine synthetic metabolism mediated by the mitochondrial enzyme MTHFD2” Oncogene 38, 2464-2481, 2019.
    [PubMed]
  • Furukawa, T., Yamasaki, Y., Hara, Y., Otsuki, C., Maki, H., Soga, T., Moriyama, Y., Kuroda, H., “Axis elongation during Xenopus tail-bud stage is regulated by GABA expressed in the anterior-to-mid neural tube” Int. J. Dev. Biol. 63, 37-43, 2019.
    [PubMed]
  • Nakai, G., Shimura, D., Uesugi, K., Kajimura, I., Jiao, Q., Kusakari, Y., Soga, T., Goda, N., Minamisawa, S., “Pyruvate dehydrogenase activation precedes the down-regulation of fatty acid oxidation in monocrotaline-induced myocardial toxicity in mice” Heart Vessels. 34, 545-555, 2019.
    [PubMed]
  • Wakasugi, T., Shimizu, I., Yoshida, Y., Hayashi, Y., Ikegami, R., Suda, M., Katsuumi, G., Nakao, M., Hoyano, M., Kashimura, T., Nakamura, K., Ito, H., Nojiri, T., Soga, T., Minamino, T., “Role of smooth muscle cell p53 in pulmonary arterial hypertension”, PLoS One 14, e0212889, 2019.
    [PubMed]
  • Kawanishi, N., Hoshi, N., Masahiro, S., Enomoto, A., Ota, S., Kaneko, M., Soga, T., Tomita, M., Kimoto, K., “Effects of inter-day and intra-day variation on salivary metabolomic profiles” Clin. Chim Acta. 489, 41-48, 2019.
    [PubMed]
  • Kajiura, D., Yamanaka-Okumura, H., Hirayama, A., Tatano, H., Endo, K., Honma, M., Igarashi, K., Syoji, F., Ikeda, S., Yamaguchi, N., Katayama, T., Morine, Y., Imura, S., Utsunomiya, T., Soga, T., Tomita, M., Shimada, M., “Perioperative serum and urine metabolome analyses in patients with hepatocellular carcinoma undergoing partial hepatectomy” Nutrition 58, 110-119, 2019.
    [PubMed]
  • Maedera, S., Mizuno, T. , Ishiguro, H., Ito, T., Soga, T., Kusuhara, H., “GLUT6 is a lysosomal transporter that is regulated by inflammatory stimuli and modulates glycolysis in macrophages” FEBS Lett. 593, 195-208, 2019.
    [PubMed]
  • Sasaki, K., Sagawa, H., Suzuki, M., Yamamoto, H., Tomita, M., Soga, T., Ohashi, Y.,, “Metabolomics Platform with Capillary Electrophoresis Coupled with High-Resolution Mass Spectrometry for Plasma Analysis” Anal. Chem 91, 1295-1301, 2019.
    [PubMed]
  • Asano, M., Ishii, T., Hirayama, A., Mizuno, M., Suzuki, Y., Sakata, F., Akiyama, S., Maruyama, S., Soga, T., Kinashi, H., Katsuno, T., Ito, Y., “Differences in peritoneal solute transport rates in peritoneal dialysis” Clin. Exp. Nephrol., 23, 122-134, 2019.
    [PubMed]
  • 2018
  • Ishii, C., Nakanishi, Y., Murakami, S., Nozu, R., Ueno, M., Hioki, K., Aw, W., Hirayama, A., Soga, T., Ito, M., Tomita, M., Fukuda, S., “A Metabologenomic Approach Reveals Changes in the Intestinal Environment of Mice Fed on American Diet” Int J Mol Sci. 19, pii: E4079, 2018.
    [PubMed]
  • Miyamoto, T., Hirayama, A., Sato, Y., Koboyashi, T., Katsuyama, E., Kanagawa, H., Fujie, A., Morita, M., Watanabe, R., Tando, T., Miyamoto, K., Tsuji, T., Funayama, A., Soga, T., Tomita, M., Nakamura, M., Matsumoto, M., “Metabolomics-based profiles predictive of low bone mass in menopausal women” Bone Rep. 9, 11-18, 2018.
    [PubMed]
  • Hamid, S.S., Wakayama, M., Soga, T., Tomita, M., “Drying and extraction effects on three edible brown seaweeds for metabolomics” J. Appl. Phycol. 30, 3335-3350, 2018.
    [Publisher]
  • Baba, M., Endoh, M., Ma, W., Toyama, H., Hirayama, A., Nishikawa, K., Takubo, K., Hano, H., Hasumi, H., Umemoto, T., Hashimoto, M., Irie, N., Esumi, C., Kataoka, M., Nakagata, N., Soga, T., Yao, M., Kamba, T., Minami, T., Ishii, M., Suda, T., “Folliculin regulates osteoclastogenesis through metabolic regulation” J. Bone Miner. Res. 33, 1785-1798, 2018.
    [PubMed]
  • Nishihara, T. Kuno, S., Nonaka, H., Tabata, S., Saito, N., Fukuda, S., Tomita, M., Sando, S., Soga, T., “Beta-galactosidase-responsive Synthetic Biomarker for Targeted Tumor Detection” Chem.Comm.(Camb) 4 , 11745-11745, 2018.
    [PubMed]
  • Sato, Y., Matsuda, S., Maruyama, A., Nakayama, J., Miyashita, T., Udagawa, H., Umemura, S., Yanagihara, K., Ochiai, A., Tomita, M., Soga, T., Tsuchihara, K., Makinoshima, H., “Metabolic characterization of antifolate responsiveness and nonresponsiveness in malignant pleural mesothelioma cells” Front. Pharmacol. 9, 1129,  2018.
    [PubMed]
  • Kuranaga, Y., Sugito, N., Shinohara, H., Tsujino, T., Taniguchi, K., Komura, K., Ito, Y., Soga, T., Akao, Y., “SRSF3, a Splicer of the PKM Gene, Regulates Cell Growth and Maintenance of Cancer-Specific Energy Metabolism in Colon Cancer Cells” Int. J. Mol. Sci. 19, E3012, 2018.
    [PubMed]
  • Mishima, E., Fukuda, S., Kanemitsu, Y., Saigusa, D., Mukawa, C., Asaji, K., Matsumoto, Y., Tsukamoto, H., Tachikawa, T., Tsukimi, T., Fukuda, N., Ho, HJ., Kikuchi, K. Suzuki, C., Nanto, F., Suzuki, T., Ito, S., Soga, T., Tomioka, Y., Abe, T., "Canagliflozin reduces plasma uremic toxins and alters the intestinal microbiota composition in a chronic kidney disease mouse model" Am. J. Physiol. Renal. Physiol. 315, F824-F833, 2018.
    [PubMed]
  • Yamamoto, Y., Nakanishi, Y., Murakami, S., Aw, W., Tsukimi, T., Nozu, R., Ueno, M., Hioki, K., Nakahigashi, K., Hirayama, A., Sugimoto, M., Soga, T., Ito, M., Tomita, M., Fukuda, S., “A Metabolomic-Based Evaluation of the Role of Commensal Microbiota throughout the Gastrointestinal Tract in Mice” Microorganisms 6, E101, 2018.
    [PubMed]
  • Kawata, K., Hatano, A., Yugi, K., Kubota, H., Sano, T., Fujii, M., Tomizawa, Y., Kokaji, T., Tanaka, KY., Uda, S., Suzuki, Y., Matsumoto, M., Nakayama, KI., Saitoh, K., Kato, K., Ueno, A., Ohishi, M., Hirayama, A., Soga, T., Kuroda, S., “Trans-omic Analysis Reveals Selective Responses to Induced and Basal Insulin across Signaling, Transcriptional, and Metabolic Networks” iScience. 7, 212-229, 2018.
    [PubMed]
  • Ikegami, R., Shimizu, I., Sato, T., Yoshida, Y., Hayashi, Y., Suda, M., Katsuumi, G., Li, J., Wakasugi, T., Minokoshi, Y., Okamoto, S., Hinoi, E., Nielsen, S., Jespersen, N. Z., Scheele, C., Soga, T., Minamino, T., "Gamma-aminobutyric acid signaling in brown adipose tissue promotes systemic metabolic derangement in obesity" Cell Rep. 24, 2827-2837, 2018.
    [PubMed]
  • Tomita, A., Mori, M., Hiwatari, K., Yamaguchi, E., Itoi, T., Sunamura, M., Soga, T., Tomita, M., Sugimoto, M., “Effect of storage conditions on salivary polyamines quantified via liquid chromatography-mass spectrometry” Sci. Rep. 8, 12075, 2018.
    [PubMed]
  • Doke, T., Ishimoto, T., Hayasaki, T., Ikeda, S., Hasebe, M., Hirayama, A., Soga, T.,  Kato, N., Kosugi, T., Tsuboi, N., Lanaspa, MA., Johnson, RJ., Kadomatsu, K.,  Maruyama, S., “Lacking ketohexokinase-A exacerbates renal injury in streptozotocin-induced diabetic mice” Metabolism. 85, 161-170, 2018.
    [PubMed]
  • Nishizawa, S., Araki, H., Ishikawa, Y., Kitazawa, S., Hata, A., Soga, T., Hara, T. “Low tumor glutathione level as a sensitivity marker for glutamate-cysteine ligase inhibitors” Oncol. Lett. 15, 8735-8743, 2018.
    [PubMed]
  • Hirayama, A., Abe, H., Yamaguchi, N., Tabata, S., Tomita, T., Soga, T., “Development of a sheathless CE‐ESI‐MS interface” Electrophoresis 39, 1382-1389, 2018.
    [PubMed]
  • Saito, Y., Morine Y., Iwahashi, S., Ikemoto, T., Imura, S., Yamanaka-Okumura, H., Hirayama, A., Soga, T., Tomita, M., Shimada, M., “Changes of Liver Metabolites following Hepatectomy with Ischemia Reperfusion towards Liver Regeneration” Ann. Gastroenterol. Surg. 2, 204-211, 2018.
    [PubMed]
  • Tabata, S., Yamamoto, M., Goto, H., Hirayama, A., Ohishi, M., Kuramoto, T., Mitsuhashi, A., Ikeda, R., Haraguchi, M., Kawahara, K., Shinsato, Y., , Minami, K., Saijo, A., Toyoda, Y., Hanibuchi, M., Nishioka, Y., Sone, S., Esumi, H., Tomita, M., Soga, T., Furukawa, T., Akiyama, S., “Thymidine catabolism promotes NADPH oxidase-derived reactive oxygen species (ROS) signalling in KB and yumoto cells” Sci. Rep. 8, 6760, 2018.
    [PubMed]
  • McCarthy, MT., Moncayo, G., Hiron, TK., Jakobsen, NA., Valli, A., Soga, T., Adam, J., O'Callaghan, CA., “Purine nucleotide metabolism regulates expression of the human immune ligand MICA” J. Biol. Chem. 293,3913-3924, 2018.
    [PubMed]
  • Morita, M., Sato, T., Nomura, M., Sakamoto, Y., Inoue, Y., Tanaka, R., Ito, S., Kurosawa, K., Yamaguchi, K., Sugiura, Y., Takizaki, H., Yamashita, Y., Katakura, R., Sato, I., Kawai, M., Okada, Y., Watanabe, H., Kondoh, G., Matsumoto, S., Kishimoto, A., Obata, M., Matsumoto, M., Fukuhara, T., Motohashi, H., Suematsu, M., Komatsu, M., Nakayama, KI., Watanabe, T., Soga, T., Shima, H., Maemondo, M., Tanuma. N., “Pkm1 confers metabolic advantages and promotes cell-autonomous tumor cell growth” Cancer Cell 33, 355-367, 2018.
    [PubMed]
  • Nakajima, T., Katsumata, K., Kuwabara, H., Soya, R., Enomoto, M., Ishizaki, T., Tsuchida, A., Mori, M., Hiwatari, K., Soga, T., Tomita, M., Sugimoto, M., "Urinary Polyamine Biomarker Panels with Machine-Learning Differentiated Colorectal Cancers, Benign Disease, and Healthy Controls" Int. J. Mol. Sci. 19, 756, 2018.
    [PubMed]
  • Kim, S., Matsumoto, T., Kagawa, H., Nakamura, M., Hirohata, R., Ueno, A., Ohishi, M., Sakuma, T., Soga, T., Yamamoto, T., Woltjen, K., "Microhomology-assisted scarless genome editing in human iPSCs" Nat. Commun. 9, 939, 2018.
    [PubMed]
  • Oshima, K., Saiki, N., Tanaka, M., Imamura, H. Niwa, A., Tanimura, A., Nagahashi;, A., Hirayama, A., Okita, K., Hotta, A., Kitayama, S., Osawa, M., Kaneko, S., Watanabe, A., Asaka, I., Fujibuchi W., Imai, K., Yabe, H., Kamachi, Y., Hara, J., Kojima, S., Tomita, M., Soga, T., Noma, T., Nonoyama, S., Nakahata, T., Saito, M.K., “Human AK2 links intracellular bioenergetic redistribution to the fate of hematopoietic progenitors” Biochem. Biophys. Res. Commun., 497, 719-725, 2018.
    [PubMed]
  • Asai, Y., Itoi, T., Sugimoto, M., Sofuni, A., Tsuchiya, T, Tanaka, R., Tonozuka, R., Honjo, M., Mukai, S., Fujita, M., Yamamoto, K., Matsunami, Y., Kurosawa, T., Nagakawa, Y., Kaneko, M., Ota, S., Kawachi, S., Shimazu, M., Soga, T., Tomita, M., Sunamura., M., “Elevated Polyamines in Saliva of Pancreatic Cancer” Cancers (Basel).10, pii: E43, 2018.
    [PubMed]
  • Maeshima, K., Matsuda, T., Shindo, Y., Imamura, H., Tamura, S., Imai, R., Kawakami, S., Nagashima, R., Soga, T., Noji, H., Oka, K., Nagai, T., “A Transient Rise in Free Mg2+ Ions Released from ATP-Mg Hydrolysis Contributes to Mitotic Chromosome Condensation” Curr Biol 28, 444-451, 2018.
    [PubMed]
  • Izuta, Y., Imada, T., Hisamura, R., Oonishi, E., Nakamura. S., Inagaki, E., Ito, M., Soga, T., Tsubota, K., “Ketone body 3-hydroxybutyrate mimics calorie restriction via Nrf2 activator fumarate in retina” Aging Cell 17, e12699,  2018.
    [PubMed]
  • Nagata, Y., Hirayama, A., Ikeda, S., Shirahata, A., Shoji, F., Maruyama, M., Kayano, M., Bundo, M., Hattori, K., Yoshida, S., Goto, Y., Urakami, K., Soga, T., Ozaki, K., Niida, S., “Comparative analysis of cerebrospinal fluid metabolites in Alzheimer’s disease and idiopathic normal pressure hydrocephalus in a Japanese cohort” Biomark. Res. 6, 5, 2018.
    [PubMed]
  • Harada, S., Hirayama, A., Chan, Q., Kurihara, A., Fukai, K., Iida, M., Kato, S., Sugiyama, D., Kuwabara, K., Takeuchi, A., Akiyama, M., Okamura, T., Ebbels, TMD., Elliott, P., Tomita, M., Sato, A., Suzuki, C., Sugimoto, M., Soga, T.,  Takebayashi, T., “Reliability of plasma polar metabolite concentrations in a large-scale cohort study using capillary electrophoresis-mass spectrometry” PLoS One 13, e0191230,  2018.
    [PubMed]
  • Matsuda, J., Namba, T., Takabatake, Y., Kimura, T., Takahashi, A., Yamamoto, T., Minami, S., Sakai, S., Fujimura, R., Kaimori, J.Y., Matsui, I., Hamano, T., Fukushima, Y., Matsui, K.,Soga, T., Isaka, Y., “Antioxidant role of autophagy in maintaining the integrity of glomerular capillaries” Autophagy 14, 53-65, 2018.
    [PubMed]
  • 2017
  • Krycer, JR., Yugi, K., Hirayama, A., Fazakerley, DJ., Quek, LE., Scalzo, R., Ohno, S., Hodson, MP. Ikeda, S., Shoji, F., Suzuki, K., Domanova, W., Parker, BL.,. Nelson, ME ., Humphrey, SJ., Turner, N., Hoehn, KL., Cooney, GJ., Soga, T., Kuroda, S., James, DE. “Dynamic metabolomics reveals that insulin primes the adipocyte for glucose metabolism” Cell Rep. 21, 3536–3547, 2017.
    [PubMed]
  • Sugito, N., Taniguchi, K., Kuranaga, Y., Ohishi, M., Soga, T., Ito, Y., Miyachi, M., Kikuchi, K., Hosoi, H., Akao, Y., “Cancer-Specific Energy Metabolism in Rhabdomyosarcoma Cells Is Regulated by MicroRNA” Nucleic Acid Ther. 27, 365-377, 2017.
    [PubMed]
  • Ikeda, K., Kang, Q., Yoneshiro, T., Camporez, J.P., Maki, H., Homma, M., Shinoda, K., Chen, Y., Lu, X., Maretich, P., Tajima, K., Ajuwon, K.M., Soga, T., Kajimura, S., “UCP1-independent signaling involving SERCA2b-mediated calcium cycling regulates beige fat thermogenesis and systemic glucose homestasis” Nat. Med. 23, 1454–1465, 2017.
    [PubMed]
  • Jeelani, G., Sato, D., Soga, T., Nozaki, T., "Genetic, metabolomic and transcriptomic analyses of the de novo L-cysteine biosynthetic pathway in the enteric protozoan parasite Entamoeba histolytica" Sci. Rep. 7, 15649, doi:10.1038/s41598-017-15923-3, 2017.
    [PubMed]
  • Migita, T., Takayama, K., Urano, T., Obinata, D., Ikeda, K., Soga, T., Takahashi, S., Inoue, S., “ACSL3 promotes intratumoral steroidogenesis in prostate cancer cells” Cancer Sci. 108, 2011-2021, 2017.
    [PubMed]
  • Adam, J., Ramracheya, R., Chibalina, M.V., Ternette, N., Hamilton, A., Tarasov, A.I., Zhang, Q., Rebelato, E., Rorsman, N.J.G., Martin-del-Rio, R., Lewis, A., Ozkan, G., Do, H.W., Spegal, P., Saitoh, K., Kato, K., Igarashi, K., Kessler, B.M., Pugh, C.W., Tamarit-Rodriques, J., Mulder, H., Clark, A., Fizzell, N., Soga, T., Ashcroft, F.M., Silver, A., Pollard, P.J., Rorsman, P., "Fumarate hydratase deletion in pancreatic β cells leads to progressive diabetes" Cell Rep. 20, 3135-3148, 2017.
    [PubMed]
  • Satoh, K., Yachida, S., Sugimoto, M., Oshima, M., Nakagawa, T., Akamoto, S., Tabata, S., Saitoh, K., Kato, K., Sato, S., Igarashi, K., Aizawa, Y., Kajino-Sakamoto, R., Kojima, Y., Fujishita, T., Enomoto, A., Hirayama, A., Ishikawa, T., Taketo, M.M., Kushida, Y., Haba, R., Okano, K., Tomita, M., Suzuki, Y., Fukuda, S., Aoki, M., Soga, T., “Global metabolic reprogramming of colorectal cancer occurs at adenoma stage and is induced by MYC” Proc. Natl. Acad. Sci. USA 114, E7697-E7706, 2017.
    [PubMed]
  • Mishima, E., Fukuda, S., Mukawa, C., Yuri, A., Kanemitsu, Y., Matsumoto, Y., Akiyama, Y., Fukuda, NN., Tsukamoto, H., Asaji, K., Shima, H., Kikuchi, K., Suzuki, T., Tomioka, Y., Soga, T., Ito, S., Abe, T. “Evaluation of the impact of gut microbiota on uremic solute accumulation by CE-TOFMS-based metabolomics approach” Kidney Int. 92, 634-645. 2017.
    [PubMed]
  • Okuma, N., Saita, M., Hoshi, N., Soga, T., Tomita, M., Sugimoto, M., Kimoto, K., “Effect of masticatory stimulation on the quantity and quality of saliva and the salivary metabolomic profile” PLoS One 12, e0183109, 2017.
    [PubMed]
  • Suda, M., Shimizu, I., Yoshida, Y., Hayashi, Y., Ikegami, R., Katsuumi, G., Wakasugi, T., Yoshida, Y., Okuda, S., Soga, T., Minamino, T., “Inhibition of dipeptidyl peptidase-4 ameliorates cardiac ischemia and systolic dysfunction by up-regulating the FGF-2/EGR-1 pathway” PLoS One 12, e0182422, 2017.
    [PubMed]
  • Hayashi, Y., Otsuka, K., Ebina, M., Igarashi, K., Takehara, A., Matsumoto, M., Kanai, A., Igarashi, K., Soga, T., Matsui, Y., "Distinct requirements for energy metabolism in mouse primordial germ cells and their reprogramming to embryonic germ cells" Proc. Natl. Acad. Sci. USA , 114, 8289-8294, 2017.
    [PubMed]
  • Toyoda, Y., Kashikura, K., Soga, T., Tagawa, Y., “Metabolomics of an in vitro liver model containing primary hepatocytes assembling around an endothelial cell network: comparative study on the metabolic stability and the effect of acetaminophen treatment” J. Toxicol. Sci. 42, 445-454, 2017.
    [PubMed]
  • Kitazawa, S., Nishizawa, S., Nakagawa, H., Funata, M., Nishimura, K., Soga, T., Hara, T., “Cancer with low cathepsin D levels is susceptible to vacuolar (H+)-ATPase inhibition” Cancer Sci. 108, 1185-1193, 2017.
    [PubMed]
  • Tanada, Y., Okuda, J., Kato, T., Minamino-Muta, E., Murata, I., Soga, T., Shioi, T., Kimura, T., "The metabolic profile of a rat model of chronic kidney disease", Peer J.5, e3352, 2017.
    [PubMed]
  • Nishihara, T., Inoue, J., Tabata, S., Murakami, S., Ishikawa, T., Saito, N., Fukuda, S., Tomita, M., Soga, T., “Synthetic Biomarker Design by Using Analyte-Responsive Acetaminophen” Chembiochem. 18, 910-913, 2017.
    [PubMed]
  • Tabata, S., Yamamoto, M., Goto, H., Hirayama, A., Ohishi, M., Kuramoto, T., Mitsuhashi, A., Ikeda, R., Haraguchi, M., Kawahara, K., Shinsato, Y., Minami, K., Saijo, A., Hanibuchi, M., Nishioka, Y., Sone, S., Esumi, H., Tomita, M., Soga, T., Furukawa, T., Akiyama, S., “Thymidine Catabolism as a Metabolic Strategy for Cancer Survival” Cell Rep. 19, 1313-1321, 2017.
    [PubMed]
  • Yoshitoshi-Uebayashi, E.Y., Toyoda, T., Yasuda, K., Kotaka, M., Nomoto, K., Okita, K., Yasuchika, K., Okamoto, S., Takubo, N., Nishikubo, T., Soga, T., Uemoto, S., Osafune, K., “Modelling urea-cycle disorder citrullinemia type 1 with disease-specific iPSCs” Biochem Biophys Res Commun. 486 , 613-619, 2017.
    [PubMed]
  • Kon, S., Ishibashi, K., Katoh, H., Kitamoto, S., Shirai, T., Tanaka, S., Kajita, M., Ishikawa, S., Yamauchi, H., Yako, Y., Kamasaki, T., Matsumoto, T., Watanabe, H., Egami, R., Sasaki, A., Nishikawa, A., Kameda, I., Maruyama, T., Narumi, R., Morita, T., Sasaki, Y., Enoki, R., Honma, S., Imamura, H., Oshima, M., Soga, T., Miyazaki, J., Duchen, MR.., Nam, J., Onodera, Y., Yoshioka, S., Kikuta, J., Ishii, M., Imajo, M., Nishida, E., Fujioka, Y., Ohba, Y., Sato, T., Fujita, Y.,"Cell competition with normal epithelial cells promotes apical extrusion of transformed cells through metabolic changes"Nat. Cell Biol. 19, 530-541, 2017.
    [PubMed]
  • Kitazawa, S., Ebara1, S., Ando, A., Baba, Y., Satomi, Y., Soga, T., Hara, T., “Succinate dehydrogenase B-deficient cancer cells are highly sensitive to bromodomain and extra-terminal inhibitors” Oncotarget 8, 28922-28938, 2017.
    [PubMed]
  • Nijhuis, A., Thompson, H., Adam, J., Paker A., Gammmon, L., Lewis, A., Bundy, J.G., Soga, T., Jalaly, A., Propper, D., Jeffery, R., Suraweera, N., McDonald, S., Thaha, M.A., Feakins, R., Lowe, R., Bishop, C., Silver, A., “Remodelling of microRNAs in colorectal cancer by hypoxia alters metabolism profiles and 5-fluorouracil resistance” Hum Mol Genet. 26, 1552-1564, 2017.
    [PubMed]
  • Itoi, T., Sugimoto, M., Umeda, J., Sofuni, A., Tsuchiya, T., Tsuji, S., Tanaka, R., Tonozuka, R., Honjo, M., Moriyasu, F., Kasuya, K., Nagakawa, Y., Abe, Y., Takano, K., Kawachi, S., Shimazu, M., Soga, T.,  Tomita, M.,  Sunamura, M., "Serum Metabolomic Profiles for Human Pancreatic Cancer Discrimination" Int. J. Mol. Sci. 18, 767; doi:10.3390/ijms18040767, 2017.
    [PubMed]
  • Sakata, F., Ito, Y., Mizuno, M., Sawai, A., Suzuki, Y., Tomita, T., Tawada, M., Tanaka, A., Hirayama, A., Sagara, A., Wada, T., Maruyama, S., Soga, T., Matsuo, S., Imai, E., Takei, Y., “Sodium chloride promotes tissue inflammation via osmotic stimuli in subtotal-nephrectomized mice”, Lab. Invest. 97, 432-446, 2017
    [PubMed]
  • Miyamoto, T., Hirayama, A., Sato, Y., Koboyashi, T., Katsuyama, E., Kanagawa, H., Miyamoto, H., Mori, T., Yoshida, S., Fujie, A., Morita, M., Watanabe, R., Tando, T., Miyamoto, K., Tsuji, T., Funayama, A., Nakamura, M., Matsumoto, M., Soga, T., Tomita, M., Toyama, Y., "A serum metabolomics-based profile in low bone mineral density postmenopausal women" Bone 95, 1-4, doi:10.1016/j.bone.2016.10.027, 2017.
    [PubMed]
  • Sugimoto, M., Obiya, S., Kaneko, M., Enomoto, A., Honma, M., Wakayama, M., Soga, T.,  Tomita, M., "Metabolomic profiling as a possible reverse engineering tool for estimating processing conditions of dry-cured hams", J. Agric. Food Chem.65, 402-410, 2017.
    [PubMed]
  • 2016
  • Ogawa, T., Tsubakiyama, R., Kanai, M., Koyama , T., Fujii, T., Iefuji, H., Soga, T., Kume, K., Miyakawa, T., Hirata, D., Mizunuma, M., “Stimulating S-adenosyl-L-methionine synthesis extends lifespan via activation of AMPK” Proc. Natl. Acad. Sci. USA 113, 11913-11918, 2016.
    [PubMed]
  • Fukai, K., Harada, S., Iida, M., Kuriara, A., Takeuchi, A., Kuwabara, K., Sugiyama, D., Okamura, T., Akiyama, M., Nishiwaki, Y., Oguma, Y., Suzuki, A., Suzuki, C, Hirayama, A., Sugimoto, M., Soga, T., Tomita, M., Takebayashi, T., “Metabolic Profiling of Total Physical Activity and Sedentary Behavior in Community-Dwelling Men” PLoS One 11, e0164877, 2016.
    [PubMed]
  • Yamano, Y., Sugimoto, M., Hirayama, A., Kume, S., Yamato, M., Jin, G., Tajima, S., Goda, N., Iwai, K., Fukuda, S., Yamaguti, K., Kuratsune, H., Soga, T., Watanabe, Y., Kataoka, Y., “Index markers of chronic fatigue syndrome with dysfunction of TCA and urea cycles” Rep. 6, 34990, 2016.
    [PubMed]
  • Hegazy, A.M., Yamada, D., Kobayashi, M., Kohno, S., Ueno, M., Ali, MA., Ohta, K., Tadokoro, Y., Ino, Y., Todo, T., Soga, T., Takahashi, C., Hirao, A., “Therapeutic Strategy for Targeting Aggressive Malignant Gliomas by Disrupting Their Energy Balance” J. Biol. Chem. 291(41), 21496-21509, 2016.
    [PubMed]
  • Bardella C, Al-Dalahmah O, Krell D, Brazauskas P, Al-Qahtani K, Tomkova M, Adam J, Serres S, Lockstone H, Freeman-Mills L, Pfeffer I, Sibson N, Goldin R, Schuster-Böeckler B, Pollard, PJ, Soga T, McCullagh JS, Schofield CJ, Mulholland P, Ansorge O, Kriaucionis S, Ratcliffe PJ, Szele, FG, Tomlinson I, "Expression of Idh1R132H in the murine subventricular zone stem cell niche recapitulates features of early gliomagenesis" Cancer Cell 30, 578-594, 2016.
    [PubMed]
  • Ishikawa, S., Sugimoto, M., Kitabatake, K., Sugano, A., Nakamura, M., Kaneko, M., Ota, S., Hiwatari, K., Enomoto, A., Soga, T., Tomita, M., Iino, M., "Identification of salivary metabolomic biomarkers for oral cancer screening" Sci. Rep. 6, 31520, 2016.
    [PubMed]
  • Karigane, D., Kobayashi, H., Morikawa, T., Ootomo, Y., Sakai, M., Nagamatsu, G., Kubota, Y., Goda, N., Matsumoto, M., Nishimura, E. K., Soga, T., Otsu, K., Suematsu, M., Okamoto, S., Suda, T., Takubo, K., “p38α activates purine metabolism to initiate hematopoietic stem/progenitor cell cycling in response to stress” Cell Stem Cell 19, 192-204, 2016.
    [PubMed]
  • Yamanaka, R., Tabata, S., Shindo, Y., Hotta, K., Suzuki, K., Soga, T.,  Oka, K., "Mitochondrial Mg2+ homeostasis decides cellular energy metabolism and vulnerability to stress", Sci. Rep. 6, 30027, 2016.
    [PubMed]
  • Saito, T., Sugimoto, M., Okumoto, K., Haga, H., Katsumi, T., Mizuno, K., Nishina, T., Sato, S., Igarashi, K., Maki, H., Tomita, M., Ueno, Y., Soga, T., "Serum metabolome profiles characterized by patients with hepatocellular carcinoma associated with hepatitis B and C" , World J. Gastroenterol. 22. 6224-6234, 2016.
    [PubMed]
  • Iida, M., Harada, S., Kurihara, A., Fukai, K., Kuwabara, K., Sugiyama, D., Takeuchi, A., Okamura, T., Akiyama, M., Nishiwaki, Y., Suzuki, A., Hirayama, A., Sugimoto, M., Soga, T., Tomita, M., Banno, K., Aoki, D., Takebayashi, T., “Profiling of plasma metabolites in postmenopausal women with metabolic syndrome” Menopause 23, 749-758, 2016.
    [PubMed]
  • Saito, T., Ichimura, Y., Taguchi, K., Suzuki, T., Mizushima, T., Takagi, K., Hirose, Y., Nagahashi, M., Iso, T., Fukutomi, T., Ohishi, M., Endo, K., Uemura, T., Nishito, Y., Okuda, S., Obata, M., Kouno, T., Imamura, R., Tada, Y., Obata, R., Yasuda, D., Takahashi, K., Fujimura, T., Pi, J., Lee, MS., Ueno, T., Ohe, T., Mashino, T., Wakai, T., Kojima, H., Okabe, T., Nagano, T., Motohashi, H., Waguri, S., Soga, T., Yamamoto, M., Tanaka, K., Komatsu, M., "p62/Sqstm1 promotes malignancy of HCV-positive hepatocellular carcinoma through Nrf2-dependent metabolic reprogramming", Nat.Commun. 7, 12030, 2016.
    [PubMed]
  • Tando, T., Hirayama, A., Furukawa, M., Sato, Y., Kobayashi, T., Funayama1, A., Kanaji, A., Hao, W., Watanabe, R., Morita, M., Oike, T., Miyamoto, K., Soga, T., Nomura, M., Yoshimura, A., Tomita, M., Matsumoto, M., Nakamura, M., Toyama, Y., Miyamoto, T. , "Smad2/3 are required for immobilization-induced skeletal muscle atrophy" J. Biol. Chem. 391, 12184-12194, 2016.
    [PubMed]
  • Fujita, S., Osuka, S. Shibao, S., Igarashi, K., Soga, T.,  Sampetrean, O., “Effects of fractionated radiation on murine glioma stem cell metabolism”, Toho J. Med. 2 , 45-52, 2016.
    [Publisher]
  • Kimura, T., Yasuda, K., Yamamoto, R., Soga, T., Rakugi, H., Hayashi, T., Isaka, Y., "Identification of biomarkers for development of end-stage kidney disease in chronic kidney disease by metabolomic profiling" Sci. Rep. 6, 26138, 2016.
    [PubMed]
  • Kemppainen, E., George, J., Garipler, G., Tuomela, T., Kiviranta, E., Soga, T., Dunn, C.D., Jacobs, H.T., “Mitochondrial Dysfunction Plus High-Sugar Diet Provokes a Metabolic Crisis That Inhibits Growth” PLoS One 11(1), e0145836, 2016.
    [PubMed]
  • Harada S., Takebayashi T., Kurihara A., Akiyama M., Suzuki A., Hatakeyama Y., Sugiyama D., Kuwabara K., Takeuchi A., Okamura T., Nishiwaki Y., Tanaka T., Hirayama A., Sugimoto M., Soga T., Tomita M., “Metabolomic profiling reveals novel biomarkers of alcohol intake and alcohol-induced liver injury in community-dwelling men” Environ. Health Prev. Med. 21 , 18-26, 2016.
    [PubMed]
  • 2015
  • Murakami, S., Goto, Y., Ito K., Hayasaka, S., Kurihara, S., Soga, T., Tomita, M., Fukuda, S., “The Consumption of Bicarbonate-Rich Mineral Water Improves Glycemic Control” Evid Based Complement Alternat Med 2015, 824395, 2015.
    [PubMed]
  • Sakagami, H., Shimada, C., Kanda, Y., Amano, O., Sugimoto, M., Ota S., Soga, T., Tomita, M., Sato, A., Tanuma, S., Takao, K., Sugita, Y., “Effects of 3-styrylchromones on metabolic profiles and cell death in oral squamous cell carcinoma cells” Toxicol. Rep. 2, 1281-1290, 2015.
    [PubMed]
  • Hirayama, A., Sugimoto, M., Suzuki, A., Hatakeyama, Y., Enomoto, A., Harada, S., Soga, T., Tomita, M., Takebayashi, T., "Effects of processing and storage conditions on charged metabolomic profiles in blood" Electrophoresis 36, 2148–2155, 2015.
    [PubMed]
  • Uetaki, M., Tabata, S., Nakasuka, F., Soga, T., Tomita, M., “Metabolomic alterations in human cancer cells by vitamin C-induced oxidative stress” Sci. Rep. 5, 13896, 2015.
    [PubMed]
  • Nakano, T., Saiki, Y., Kudo, C., Hirayama, A., Mizuguchi, Y., Fujiwara, S., Soga, T., Sunamura, M., Matsumura, N., Motoi, F., Unno, M., Horii, A., “Acquisition of chemoresistance to gemcitabine is induced by a loss-of-function missense mutation of DCK” Biochem. Biophys. Res. Commun. 464, 1084-1089, 2015.
    [PubMed]
  • Watanabe, S., Ohbayashi, R., Kanesaki, Y., Saito, N., Chibazakura, T., Soga, T., Yoshikawa, H.,  “Intensive DNA Replication and Metabolism during the Lag Phase in Cyanobacteria” PLoS One 10, e0136800, 2015.
    [PubMed]
  • Mishima, E., Fukuda, S., Shima, H., Hirayama, A., Akiyama, Y., Takeuchi, Y., Fukuda, N. N., Suzuki, T., Suzuki, C., Yuri, A., Kikuchi, K., Tomioka, Y., Ito, S., Soga, T., Abe, T., “Alteration of the Intestinal Environment by Lubiprostone Is Associated with Amelioration of Adenine-Induced CKD”,J. Am. Soc. Nephrol. 26, 1787-1794, 2015.
    [PubMed]
  • Garcia-Contreras, R., Sugimoto, M., Umemura, N., Kaneko, M., Hatakeyama, Y., Soga, T., Tomita, M., Scougall-Vilchis, R.J., Contreras-Bulnes, R., Nakajima, H., Sakagami, H., “Alteration of metabolomic profiles by titanium dioxide nanoparticles in human gingivitis model” Biomaterials 57, 33-40, 2015.
    [PubMed]
  • Ogawara, Y., Katsumoto, T., Aikawa, Y., Shima, Y., Kagiyama, Y., Soga, T., Matsunaga, H., Seki, T., Araki, K., Kitabayashi, I., “IDH2 and NPM1 mutations cooperate to activate Hoxa9/Meis1 and hypoxia pathways in acute myeloid leukemia” Cancer Res. 75, 2005-2016, 2015.
    [PubMed]
  • Kishikawa, T., *Otsuka, M., Tan, P.S., Ohno, M., Sun, X., Yoshikawa, T., Shibata, C., Takata, A., Kojima, K., Takehana, K., Ohishi, M., Ota, S., Noyama, T., Kondo, Y., Sato, M., Soga, T., Hoshida, Y., Koike, K., “Decreased miR122 in hepatocellular carcinoma leads to chemoresistance with increased arginine” Oncotarget 6, 8339-8352, 2015
    [PubMed]
  • Kobayashi, S., Sato, M., Kasakoshi, T., Tsutsui, T., Sugimoto, M., Osaki, M., Okada, F., Igarashi, K., Hiratake, J., Homma, T., Conrad, M., Fujii, J., Soga, T., Bannai, S., Sato, H., “Cystathionine is a novel substrate of cystine/glutamate transporter: implications for immune function”J. Biol. Chem. 290, 8778-8788, 2015.
    [PubMed]
  • Kume, S., Yamato, M., Tamura, Y., Jin, G., Nakano, M., Miyashige, Y., Eguchi, A., Ogata, Y., Goda, N., Iwai, K., Yamano, E., Watanabe, Y., Soga, T., Kataoka, Y., “Potential Biomarkers of Fatigue Identified by Plasma Metabolome Analysis in Rats” PLoS One 10, e0120106, 2015.
    [PubMed]
  • Valli, A., Rodriguez, M., Moutsianas, L., Fischer, R., Fedele, V., Huang, H.L., Van Stiphout, R., Jones, D., Mccarthy, M., Vinaxia, M., Igarashi, K., Sato, M., Soga, T., Buffa, F., Mccullagh, J., Yanes, O., Harris, A., Kessler. B., “Hypoxia Induces a Lipogenic Cancer Cell Phenotype via HIF1α-Dependent and -Independent Pathways”, Oncotarget 6, 1920-1941, 2015.
    [PubMed]
  • 2014
  • Hirayama, A., Igarashi, K., Tomita, M., Soga, T., “Development of quantitative method for determination of γ-glutamyl peptides by capillary electrophoresis tandem mass spectrometry: An efficient approach avoiding matrix effect” J Chromatogr A. 1369, 161-169, 2014.
    [PubMed]
  • Tabata, S., Ikeda, R., Yamamoto, M., Shimaoka, S., Mukaida, N., Takeda, Y., Yamada, K., Soga, T., Furukawa, T., Akiyama, S., “Thymidine phosphorylase activates NFκB and stimulates the expression of angiogenic and metastatic factors in human cancer cells” Oncotarget 5, 10473-10485, 2014.
    [PubMed]
  • Jeelani, G., Sato, D., Soga, T., Watanabe, H., Nozaki, T.,  “Mass spectrometric analysis of L-cysteine metabolism: physiological role and fate of L-cysteine in the enteric protozoan parasite Entamoeba histolytica” mBio. 5, e01995-14, 2014.
    [PubMed]
  • Xu, F., Sudo, Y., Sanechika, S., Yamashita, J., Shimaguchi, S., Honda, S., Sumi-Ichinose, C., Mori-Kojima, M., Nakata, R., Furuta, T., Sakurai, M., Sugimoto, M., Soga, T., Kondo, K., Ichinose, H., “Disturbed biopterin and folate metabolism in the Qdpr-deficient mouse” FEBS Lett. 588, 3924-3931, 2014.
    [PubMed]
  • Mishima, E., Inoue, C., Saigusa, D., Inoue, R., Ito, K., Suzuki, Y., Jinno, D., Tsukui, Y., Akamatsu, Y., Araki, M., Araki, K., Shimizu, R., Shinke, H., Suzuki, T., Takeuchi, Y., Shima, H., Akiyama, Y., Toyohara, T., Suzuki, C., Saiki, Y., Tominaga, T., Miyagi, S., Kawagisihi, Naoki, Soga, T., Ohkubo, T., Yamamura, K., Imai, Y., Masuda, S., Sabbisetti, V., Ichimura, T., Mount, D.B., Bonventre, J.V., Ito, S., Tomioka, Y., Itoh, K., Abe, T., “Conformational Change in Transfer RNA Is an Early Indicator of Acute Cellular Damage”,J. Am. Soc. Nephrol. 25, 2316-2326, 2014.
    [PubMed]
  • Takeuchi, K., Ohishi, M., Endo, K., Suzumura, K., Naraoka, H., Ohata, T., Seki, J., Miyamae, Y., Honma, M., Soga, T., “Metabolomic Analysis of the Effects of Omeprazole and Famotidine on Aspirin-induced Gastric Injury” Metabolomics 10, 995-1004, 2014.
    [Publisher]
  • Hirayama, A., Wakayama, M., Soga, T. , “Metabolome analysis based on capillary electrophoresis-mass spectrometry” Trends Anal. Chem. 61, 215-222, 2014.
    [Publisher]
  • Yang, M., Su, H., Soga, T., Kranc, K.R., Pollard, P.J. ,“Prolyl hydroxylase domain enzymes: important regulators of cancer metabolism” Hypoxia 2, 127-142, 2014.
    [PubMed]
  • Nishimura, T., Higuchi1, K., Sai, Y., Sugita, Y., Yoshida, Y., Tomi, M., Wada, M., Wakayama, T., Tamura, A., Tsukita, S., Soga, T., Nakashima, E., “Fetal Growth Retardation and Lack of Hypotaurine in Ezrin Knockout Mice”PLoS One 9, e105423, 2014.
    [PubMed]
  • Yugi, K., Kubota, H., Toyoshima, Y., Noguchi, R., Kawata, K., Komori, Y., Uda, S., Kunida, K., Tomizawa, Y., Funato, Y., Miki, H., Matsumoto, M., Nakayama, K.I., Kashikura, K., Endo, K., Ikeda, K., Soga, T., Kuroda, S., “Reconstruction of insulin signal flow from phosphoproteome and metabolome data” Cell Rep. 8, 1171-1183, 2014.
    [PubMed]
  • Takeuchi, K., Ohishi, M., Endo, K., Suzumura, K., Naraoka, H., Ohata, T., Seki, J., Miyamae, Y., Honma, M., Soga, T., “Hydroxyproline, a Serum Biomarker Candidate for Gastric Ulcer in Rats: A Comparison Study of Metabolic Analysis of Gastric Ulcer Models Induced by Ethanol, Stress, and Aspirin” Biomark. Insights 9, 61-66, 2014.
    [PubMed]
  • Migita, T., Okabe, S., Ikeda, K., Igarashi, S., Sugawara, S., Tomida, A., Soga, T., Taguchi, R., Seimiya, H., “Inhibition of ATP citrate lyase induces triglyceride accumulation with altered fatty acid composition in cancer cells” Int J Cancer 135, 37-47, 2014.
    [PubMed]
  • Ohka, F., Ito, M., Ranjit, M., Senga, T., Motomura, A., Motomura, K., Saito, K., Kato, K., Kato, Y., Wakabayashi, T., Soga, T., Natsume, A., “Quantitative metabolome analysis profiles activation of glutaminolysis in glioma with IDH1 mutation” Tumor Biol. 35, 5911-5920, 2014.
    [PubMed]
  • Adam, J., Yang, M., Soga, T., Pollard, P.J., “Rare insights into cancer biology” Oncogene 33, 2547-2556, 2014.
    [PubMed]
  • Obata, F., Kuranaga, E., Tomioka, K., Ming M., Takeishi, A., Chen, C., Soga, T., Miura, M., “Necrosis-driven systemic immune response alters SAM metabolism through the FOXO-GNMT axis” Cell Rep. 7, 821-833, 2014.
    [PubMed]
  • Sato, D., Sugimoto, M., Akashi, H., Tomita, M., Soga, T., "Comparative metabolite profiling of foxglove aphids (Aulacorthum solani Kaltenbach) on leaves from resistant and susceptible soybean strains" Mol. BioSyst. 10, 909-915, 2014.
    [PubMed]
  • Sakagami, H., Sugimoto, M., Tanaka, S., Onuma, H., Ota, S., Kaneko, M., Soga, T., Tomita, M., “Metabolomic profiling of sodium fluoride-induced cytotoxicity in an oral squamous cell carcinoma cell line” Metabolomics 10, 270-279, 2014.
    [Publisher]
  • Yamatani, H., Takahashi, K., Yoshida, T., Soga, T., Kurachi, H., "Differences in the fatty acid metabolism of visceral adipose tissue in postmenopausal women", Menopause 21, 170-176, 2014.
    [PubMed]
  • Cheng, K.K., Lee, B.S., Masuda, T., Ito, T., Ikeda, K., Hirayama, A., Deng, L., Dong, J., Shimizu, K., Soga, T., Tomita, M., Palsson, B.O., Robert, M., “Global metabolic network reorganization by adaptive mutations allows fast growth of Escherichia coli on glycerol” Nat. Commun. 5, 3233, 2014.
    [PubMed]
  • 2013
  • Kimura, T., Takahashi, A., Takabatake, Y., Namba, T., Yamamoto, T., Kaimori, J., Matsui, I., Kitamura, H., Niimura, F., Matsusaka, T., Soga, T., Rakugi, H., *Isaka, Y.,  “Autophagy protects kidney proximal tubule epithelial cells from mitochondrial metabolic stress”, Autophagy  9, 1876-86, 2013.
    [PubMed]
  • Saito, T., Sugimoto, M., Igarashi, K., Saito, K., Shao, L., Katsumi, T., Tomita, K., Sato, C., Ishii, R., Okumoto, K., Nishise, Y., Watanabe, H., Tomita, M., Ueno, Y., Soga, T., "Dynamics of serum metabolites in patients with chronic hepatitis C receiving pegylated interferon plus ribavirin: A metabolomics analysis", Metabolism 62, 1577-1586, 2013.
    [PubMed]
  • Tsuruoka, M., Hara, J., Hirayama, A., Sugimoto, M., Soga, T., Shankle, W.R., Tomita , M., “Comparative analysis of neurodegenerative dementias based on serum and saliva metabolomics”, Electrophoresis 34, 2865-2872, 2013.
    [PubMed]
  • Karasawa, T., Saito, T., Ueno, Y., Sugimoto, M., Soga, T., “Metabolome analysis of erythrocytes from patients with chronic hepatitis C reveals the etiology of ribavirin-induced hemolysis” Int J Med Sci. 10, 1575-1577, 2013.
    [PubMed]
  • Yang, M., Soga, T., Pollard, P.J., “Oncometabolites: Linking Altered Metabolism with Cancer ? J. Clin. Invest. 123, 3652-3658, 2013.
    [PubMed]
  • Ito, T., Sugimoto, M., Toya, Y., Ano, Y., Kurano, N., Soga, T., Tomita, M., “Time-resolved metabolomics of a novel trebouxiophycean alga using 13CO2 feeding” J Biosci Bioeng. 116, 408-415, 2013.
    [PubMed]
  • Nishino, T., Yachie-Kinoshita, A., Hirayama, A., Soga, T., Suematsu, M., Tomita, M., “Dynamic simulation and metabolome analysis of long-term erythrocyte storage in adenine-guanosine solution” PLoS One 8, e71060. 2013.
    [PubMed]
  • Shimura, D., Nakai, G., Jiao, Q., Osanai, K., Kashikura, K., Endo, K., Soga, T., Goda, N., Minamisawa, S., “Metabolomic profiling analysis reveals chamber-dependent metabolite patterns in the mouse heart” Am J Physiol Heart Circ Physiol. 305, H494-505,2013.
    [PubMed]
  • Okuda, J., Niizuma, S., Shioi, T., Kato, T., Inuzuka, Y., Kawashima, T., Tamaki, Y., Kawamoto, A., Tanada, Y., Iwanaga, Y., Narazaki, M., Matsuda, T., Adachi, S., Soga, T., Takemura, G., Kondoh, H., Kita, T., Kimura, T., "Persistent overexpression of phosphoglycerate mutase, a glycolytic enzyme, modifies energy metabolism and reduces stress resistance of heart in mice", PLoS One 8, e72173, 2013.
    [PubMed]
  • Uema, N., Ooshio, T., Harada, K., Naito, M., Naka, K., Hoshii, T., Tadokoro, Y., Ohta, K., Ali, M.A., Katano, M., Soga, T., Nakanuma, Y., Okuda, A., Hirao, A., “Abundant nucleostemin expression supports the undifferentiated properties of germ cell tumors” Am. J. Pathol. 183, 592-603, 2013.
    [PubMed]
  • Maekawa, K., Hirayama, A., Iwata Y., Tajima Y., Nishimaki-Mogami T., Sugawara S., Ueno, N., Abe, H., Ishikawa M., Murayama M., Matsuzawa Y., Nakanishi H., Ikeda K., Arita M., Taguchi, R., Minamino N., Wakabayashi, S., Soga T., Saito, Y., “Global metabolomic analysis of heart tissue in a hamster model for dilated cardiomyopathy” J. Mol. Cell. Cardiol. 59C, 76-85, 2013.
    [PubMed]
  • Oyama-Okubo, N., Sakai , T., Ando, T., Nakayama, M., Soga, T., “Metabolome profiling of floral scent production in Petunia axillaris”, Phytochemistry 90, 37-42, 2013.
    [PubMed]
  • Adam, J., Yang, M., Bauerschmidt, C., Kitagawa, M., O’Flaherty, L., Maheswaran, P., O¨ zkan, G., Sahgal, N., Baban, D., Kato, K., Saito, K., Iino, K., Igarashi, K., Stratford, M., Pugh, C., Tenant, D., Ludwig, C., Davies, B., Ratcliffe, P. J., El-Bahrawy, M., Ashrafian, H., Soga, T., Pollard, P. J., “A Role for Cytosolic Fumarate Hydratase in Urea Cycle Metabolism and Renal Neoplasia” Cell Rep. 3, 1440-1448, 2013.
    [PubMed]
  • Noguchi, R., Kubota, H., Yugi, K., Toyoshima, Y., Komori, Y., Soga, T., Kuroda, S., “The selective control of glycolysis, gluconeogenesis and glycogenesis by temporal insulin patterns” Mol Syst Biol. 9:664, doi:10.1038/msb.2013.19, 2013.
    [PubMed]
  • Migita, T., Okabe, S., Ikeda, K., Igarashi, S., Sugawara, S., Tomida, A., Taguchi, R., Soga, T., Seimiya, H., “Inhibition of ATP citrate lyase induces an anticancer effect via reactive oxygen species: AMPK as a predictive biomarker for therapeutic impact” Am J Pathol. 182, 1800-1810, 2013.
    [PubMed]
  • Sato, D., Akashi, H., Sugimoto, M., Tomita, M., Soga, T., “Metabolomic profiling of the response of susceptible and resistant soybean strains to foxglove aphid, Aulacorthum solani Kaltenbach” J. Chromatogr. B. 925, 95-103, 2013.
    [PubMed]
  • Sugimoto, M., Saruta, J., Matsuki, C., To, M., Onuma, H., Kaneko, M., Soga, T., Tomita, M., Tsukinoki, K., “Physiological and environmental parameters associated with mass spectrometry-based salivary metabolomic profiles” Metabolomics 9, 454-463,2013.
    [Publisher]
  • Kami, K., Fujimori, T., Sato, H., Sato, M., Yamamoto, H., Ohashi, Y., Sugiyama, N., Ishihama, Y., Onozuka, H., Ochiai, A., Esumi, H., Soga, T., Tomita, M., "Metabolomic Profiling of Lung and Prostate Tumor Tissues by Capillary Electrophoresis Time-of-flight Mass Spectrometry" Metabolomics 9, 444-453, 2013.
    [PubMed]
  • Ternette N., Yang M., Laroyia M., Kitagawa M., O'Flaherty L., Wolhulter K., Igarashi K., Saito K., Kato K., Fischer R., Berquand A., Kessler B.M., Lappin T., Frizzell N., Soga T., Adam J, Pollard P.J., “Inhibition of Mitochondrial Aconitase by Succination in Fumarate Hydratase Deficiency”, Cell Rep. 3, 689-700. 2013.
    [PubMed]
  • Soga, T., “Cancer metabolism: key players in metabolic reprogramming” Cancer Sci. 104, 275-81, 2013.
    [PubMed]
  • Ito, T., Tanaka, M., Shinkawa, H., Nakada, T., Ano, Y., Kurano N., Soga T., Tomita, M., “Metabolic and morphological changes of an oil accumulating trebouxiophycean alga in nitrogen-deficient conditions” Metabolomics 9, S178-S187, 2013.
    [PubMed]
  • Takeuchi, K., Ohishi, M., Ota, S., Suzumura, K., Naraoka, H., Ohata, T., Seki, J., Miyamae, Y., Honma, M., Soga, T., "Metabolic Profiling to Identify Potential Serum Biomarkers for gastric ulceration induced by non-steroid anti-inflammatory drugs" J. Proteome Res. 12, 1399-1407 , 2013.
    [PubMed]
  • Koh, T., Murakami, Y., Tanaka, S., Machino, M., Onuma, H., Kaneko, M., Sugimoto, M., Soga, T., Tomita, M., Sakagami, H., “Changes of Metabolic Profiles in an Oral Squamous Cell Carcinoma Cell Line Induced by Eugenol” In Vivo 27, 233-43, 2013.
    [PubMed]
  • Jeelani, G., Husain, A., Sato, D., Soga, T., Suematsu, M., Nozaki, T., “Biochemical and functional characterization of novel NADH kinase in the enteric protozoan parasite Entamoeba histolytica” Biochimie 95, 309-319, 2013.
    [PubMed]
  • Martı´nez, P., Ga´lvez, S., Ohtsuka, N., Budinich, M., Corte´s, M.P., Serpell, C., Nakahigashi, K., Hirayama, A., Tomita, M., Soga, T., Martı´nez, S., Maass, A., Parada, P., “Metabolomic study of Chilean biomining bacteriaAcidithiobacillus ferrooxidans strain Wenelen and Acidithiobacillus thiooxidans strain Licanantay” Metabolomics 9, 247-257, 2013.
    [PubMed]
  • Takubo, K., Nagamatsu, G., Kobayashi, C. I, Nakamura-Ishizu, A., Kobayashi, H., Ikeda, E., Goda, N., Johnson, R. S, Rahimi, Y., Soga, T., Hirao, A., Suematsu, M., Suda, T., “Regulation of Glycolysis by Pdk Functions as a Metabolic Checkpoint for Cell Cycle Quiescence in Hematopoietic Stem Cells” Cell Stem Cell 12, 49-61, 2013.
    [PubMed]
  • 2012
  • Yamada, M., Takanashi, K., *Hamatani, T., Hirayama, A., Akutsu, H., Fukunaga, T. Ogawa, S., Sugawara, K., Shinoda, K., Soga, T., Umezawa, A., Kuji, N., Yoshimura, Y., Tomita, M., “A medium-chain fatty acid as an alternative energy source in mouse preimplantation development”, Sci. Rep. 2, 930, doi: 10.1038/srep00930. 2012.
    [PubMed]
  • Hirayama, A., Nakashima, E., Sugimoto, M., Akiyama, S., Sato, W., Maruayama, S., Matsuo, S., Tomita, M., Yuzawa, Y., Soga, T., “Metabolic profiling reveals new serum biomarkers for differentiating diabetic nephropathy” Anal Bioanal Chem. 404, 3101-3109, 2012.
    [PubMed]
  • Yamamotoya, T., Dose, H., Tian, Z., Fauré, A., Toya, Y., Honma, M., Igarashi, K., Nakahigashi, K., Soga, T., Mori, H., Matsuno, H., “Glycogen is the primary source of glucose during the lag phase of E. coli proliferation” Biochim Biophys Acta 1824, 1442-1448, 2012.
    [PubMed]
  • Kato, T., Niizuma, S., Inuzuka, Y., Kawashima, T., Okuda, J., Kawamoto, A., Tamai, Y., Iwanaga, Y., Soga, T., Kita, T., Kimura, T., Shioi, T., “Analysis of Liver Metabolism in a Rat Model of Heart Failure” Int. J. Cardiol. 161, 130-136, 2012.
    [PubMed]
  • Akiyama, Y., Takeuchi, Y., Kikuchi, K., Mishima, E., Yamamoto, Y., Suzuki, C., Toyohara, T., Suzuki, T., Hozawa, A., Ito, S., Soga, T., Abe, T., “A Metabolomic approach to clarifying the effect of AST-120 on 5/6 nephrectomized rats by Capillary Electrophoresis with Mass Spectrometry” Toxins 4, 1309-1322, 2012.
    [PubMed]
  • Hirayama, A., Tomita, M., Soga, T., “Sheathless capillary electrophoresis-mass spectrometry with a high-sensitivity porous sprayer for cationic metabolome analysis” Analyst 137, 5026-5033, 2012.
    [PubMed]
  • Tanaka, S., Taga, H., Maehara, K., *Kaneshima, A., Machino, M., Onuma, H., Kaneko, M., Sakagami, H., Sugimoto, M., Soga, T. and Tomita, M., “Pilot Study of Changes in Salivary Metabolic Profiles Induced by Template Therapy”In Vivo. 26, 1015-1020, 2012.
    [PubMed]
  • Kami, K., Fujita, Y., Igarashi, S., Koike, S., Sugawara, S., Ikeda, S., Sato, N., Ito, M., *Tanaka, M., Tomita, M., Soga, T., "Metabolomic Profiling Rationalized Pyruvate Efficacy in Cybrid Cells Harboring MELAS Mitochondrial DNA Mutations" Mitochondrion 12, 644-53, 2012.
    [PubMed]
  • Takahashi, M., Miyata, S., Fujii, J., Inai, Y., Ueyama, S., Araki, M., Soga, T., Fujinawa, R., Nishitani C., Ariki S., Shimizu T., Abe T., Ihara Y., Nishikimi, M., Kozutsumi Y., Taniguchi N., Kuroki, Y., “In vivo role of aldehyde reductase” Biochim Biophys Acta 1820, 1787-1796, 2012.
    [PubMed]
  • Imaizumi, Y., Okada, Y., Akamatsu, W., Koike, M., Kuzumaki, N., Hayakawa, H., Nihira, T., Kobayashi, T., Ohyama, M., Sato, S., Takanashi, M., Funayama, M., Hirayama, A., Soga, T.,  Hishiki, T., Suematsu, M., Yagi, T., Ito, D., Kosakai, A., Hayashi, K., Shouji, M., Nakanishi, A., Suzuki, N., Mizuno, Y., Mizushima, N., Amagai, M., Uchiyama, Y., Mochizuki, H., Hattori, N., Okano H.,  “Mitochondrial dysfunction associated with increased oxidative stress and α-synuclein accumulation in PARK2 iPSC-derived neurons and postmortem brain tissue” Mol Brain. 5:35, 2012.
    [PubMed]
  • Husain, A., Sato, D., Jeelani, G., Soga, T., Nozaki, T.,  “Dramatic Increase in Glycerol Biosynthesis upon Oxidative Stress in the Anaerobic Protozoan Parasite Entamoeba histolyticaPLoS Negl. Trop. Dis. 6, e1831, 2012.
    [PubMed]
  • Kasukawa, T., Sugimoto, M., Hida, A., Minami, Y., Mori, M., Honma, S., Honma, K., Mishima, K., Soga, T., Ueda, H.R.  "Human blood metabolite timetable indicates internal body time" Proc. Natl. Acad. Sci. USA 109, 15036-1504, 2012.
    [PubMed]
  • Omori, Y., Ohtani, T., Sakata, Y., Mano, T., Takeda, Y., Tamaki, S., Tsukamoto. Y., Kamimura, D., Aizawa, Y., Miwa, T., Komuro, I., Soga, T., Yamamoto, K. “L-Carnitine Prevents the Development of Ventricular Fibrosis and Heart Failure with Preserved Ejection Fraction in Hypertensive Heart Disease” J. Hypertens. 30, 1834-44. 2012.
    [PubMed]
  • Sasidharan, K., Soga, T., Tomita, M., Murray, D.B., “A Yeast Metabolite Extraction Protocol Optimised for Time-Series Analyses” PLos One 7(8), e44283, 2012.
    [PubMed]
  • Hirata, Y., Ikeda, K., Sudoh, M., Tokunaga, Y., Suzuki, A., Weng, L., Ohta, M., Tobita, Y., Okano, K., Ozeki, K., Kawasaki, K., Tsukuda, T., Katsume, A., Aoki, Y., Umehara, T., Sekiguchi, S., Toyoda, T., Shimotohno, K., Soga, T., Nishijima, M., Taguchi, R., Kohara, M.,“Self-enhancement of hepatitis C virus replication by promotion of specific sphingolipid biosynthesis.” PLoS Pathog. 8, e1002860, 2012.
    [PubMed]
  • Sugimoto, M., Sakagami, H., Yokote, Y., Onuma, H., Kaneko, M., Mori, M., Sakaguchi, Y., Soga, T., Tomita, M., “Non-targeted metabolite profiling in activated macrophage secretion ” Metabolomics 8, 624-633, 2012.
    [Publisher]
  • Yang, M., Soga, T., Pollard, P.J., Adam, J., “The emerging role of fumarate as an oncometabolite” Front. Oncol. 2, 85, doi: 10.3389/fonc.2012.00085, 2012.
    [PubMed]
  • Deguchi, K., Sato, D., Sugimoto, M., Hara, H., Kawasaki, Y., Demura, S., Watanabe, T., Denholme, S. J., Okazaki, H., Ozaki, T., Yamaguchi, T., Takeya, H., Soga, T., Tomita, M., Takano, Y., “Clarification as to why alcoholic beverages have the ability to induce superconductivity in Fe1+dTe1-xSx” Supercond. Sci. Technol. 25, doi:10.1088/0953-2048/25/8/084025, 2012.
    [Publisher]
  • Hoshi, T., Tadokoro, Y., Naka, K., Ooshio, T., Muraguchi, T., Sugiyama, N., Soga, T., Araki, K., Yamamura, K., Hirao, A., "mTORC1 is Essential for Leukemia propagation but Not Stem Cell Self-renewal" J. Clin. Invest. 122, 2114-2129, 2012.
    [PubMed]
  • Jeelani, G., Sato, D., Husain, A., Cadiz, A.E., Sugimoto, M., Soga, T., Suematsu, M., Nozaki, T., “Metabolic Profiling of the Protozoan Parasite Entamoeba invadens Revealed Activation of Unpredicted Pathway during Encystation” PLoS One 7, e37740, 2012.
    [PubMed]
  • Liu, C., Kurakane, S., Takita, J., Itano R., Soga, T., Oikawa A.,  Igarashi, K., “Antihypertensive Effects of Unripe Persimmon (Diospyros kaki L.cv. Hiratanenashi) Fruit and Its Component in Spontaneously Hypertensive Rats” Food Sci. Technol. Res. 18, 391-398, 2012.
    [J-stage]
  • Daimon, M., Soga, T., Hozawa, A., Oizumi, T., Kaino, W., Takase, K., Karasawa, S., Jimbu, Y., Wada, K., Kameda, W., Susa, S., Kayama, T., Saito, K., Tomita, M., Kato, T. “Serum glycerophosphate levels are increased in Japanese men with type 2 diabetes" Int. Med. 51, 545-551, 2012.
    [PubMed]
  • Sugimoto, M., Kaneko, M., Onuma, H., Sakaguchi, Y., Mori, M., Abe, S., Soga, T., Tomita, M., "Changes in the Charged Metabolite and Sugar Profiles of Pasteurized and Unpasteurized Japanese Sake with Storage" J. Agric. Food Chem. 60, 2586-2593, 2012.
    [PubMed]
  • Sugimoto, M., Kawakami, M., Robert, M., Soga, T., Tomita, M. “Bioinfomatics Tools for Mass Spectroscopy-Based Metabolomic Data Processing and Analysis” Curr. Bioinf. 7, 96-108, 2012.
    [PubMed]
  • Iino, K., Sugimoto, M., Soga, T., Tomita, M., “Profiling of the Charged Metabolites of Traditional Herbal Medicines Using Capillary Electrophoresis time-of-flight Mass Spectrometry” Metabolomics 8, 99-108, 2012.
    [Publisher]
  • Sugimoto, M., Ikeda, S., Niigata, K., Tomita, M., Sato, H., Soga, T. “MMMDB: Mouse Multiple Tissue Metabolome Database” Nucl. Acids Res. 40 (D1): D809-D814. 2012.
    [PubMed]
  • Toyoda, Y., Tamai, M., Kashikura, K., Kobayashi, S., Fujiyama, Y., Soga, T., Tagawa, Y., “Acetaminophen-induced Hepatotoxicity in a Liver Tissue Model Consisting of Primary Hepatocytes Assembling Around an Endothelial Cell Network”Drug Metab. Dispos. 40, 169-177, 2012.
    [PubMed]
  • 2011
  • Sato, A., Soga, T., Igarashi, K., Tomita, M., Kanai, A., “GTP-dependent RNA 3'-terminal Phosphate Cyclase from the Hyperthermophilic Archaeon Pyrococcus furiosus” Genes Cells 16, 1180-1199, 2011
    [PubMed]
  • Ochiai, D., Goda, N., Hishiki, T., Kanai, Mai., Senoo-Matsuda, N., Soga, T., Johnson, R.S., Yoshimura, Y., Suematsu, M., “Disruption of HIF-1α in Hepatocytes Impairs Glucose Metabolism in Diet-induced Obesity Mice” Biochem. Biophys. Res. Commun 415, 445-449, 2011.
    [PubMed]
  • Adam, J., Hatipoglu, E., O’Flaherty, L., Ternette, N., Sahgal, N., Lockstone, H., Baban D., Nye, E., Stamp, G.W., Wolhuter, K., Stevens, M., Fischer, R., Carmeliet, P., Maxwell, P.H., Pugh, C.W., Frizzell, N., Soga, T., Kessler, B.M., El-Bahrawy, M., Ratcliffe, P.J., Pollard, P.J. “Renal Cyst Formation in Fh1-Deficient Mice Is Independent of the Hif/Phd Pathway: Roles for Fumarate in KEAP1 Succination and Nrf2 Signaling” Cancer Cell 20, 524-537, 2011.
    [PubMed]
  • Gustavsson, C., Soga, T., Wahlström, E, Vesterlund, M, Azimi, A., Norstedt, G., Tollet-Egnell, P., “Sex-dependent Hepatic Transcripts and Metabolites in the Development of Glucose Intolerance and Insulin Resistance in Zucker Diabetic Fatty Rats” J. Mol. Endcrinol. 47, 129-143, 2011.
    [PubMed]
  • Toyohara, T., Suzuki, T., Akiyama, Y., Yoshihara, D., Takeuchi, Y., Mishima, E., Kikuchi, K., Suzuki, C., Tanemoto, M., Ito, S., Nagao, S., Soga T., Abe, T., “Metabolomic profiling of the autosomal dominant polycystic kidney disease rat model” Clin Exp Nephrol 15, 676–687, 2011.
    [PubMed]
  • Soga, T., Sugimoto, M., Honma, M., Mori, M., Igarashi, K., Kashikura, K., Ikeda, S., Hirayama, A., Yamamoto, T., Yoshida, H., Otsuka, M., Tsuji, S., Yatomi, Y., Sakuragawa, T., Watanabe, H., Nihei, K., Saito, T., Kawata, S., Suzuki, H., Tomita, M., Suematsu, M., “Serum Metabolomics Reveals γ-glutamyl Dipeptides as Biomarkers for discrimination among Different Forms of Liver Disease” J. Hepatol. 55, 896-905, 2011.
    [PubMed]
  • Deng, L., Shoji, I., Ogawa, W., Kaneda, S., Soga, T., Jiang, D., Ide, Y., Hotta, H., “Hepatitis C Virus Infection Promotes Hepatic Gluconeogenesis through an NS5A-Mediated, FoxO1-Dependent Pathway” J. Virol. 85, 8556-8568, 2011.
    [PubMed]
  • Suzuki, T., Toyohara, T., Akiyama, Y., Takeuchi, Y., Mishima, E., Suzuki, C., Ito, S., Soga, T., Abe, T., “Transcriptional Regulation of Organic Anion Transporting Polypeptide SLCO4C1 as a New Therapeutic Modality to Prevent Chronic Kidney Disease” J. Pharm. Sci. 100, 3696-3707, 2011.
    [PubMed]
  • Hayashi, K., Sasamura, H., Hishiki, T., Suematsu, M., Ikeda, S., Soga, T., Itoh, H., “Use of Serum and Urine Metabolome Analysis for the Detection of Metabolic Changes in Patients with Stage 1-2 Chronic Kidney Disease” Nephro-Urol. Mon. 3, 164-171, 2011.
    [Publisher]
  • Kimura, T., Takabatake, Y., Takahashi, A., Kaimori, J., Matsui, I., Namba, T., Kitamura, H., Niimura, F., Matsusaka, T., Soga, T., Rakugi, H., Isaka, Y., “Autophagy Protects the Proximal Tubule from Degeneration and Acute Ischemic Injury” J. Am. Soc. Nephrol. 22, 902-913, 2011.
    [PubMed]
  • Ogawa, Y., Koike, N., Kurisawa. G., Soga, T., Tomita, M., Tei, H., “Positive Autoregulation Delays the Expression Phase of Mammalian Clock Gene Per2” PLoS One 6, e18663, 2011.
    [PubMed]
  • Ooga, T., Sato, H., Nagashima, A., Sasaki, K., Tomita, M., Soga, T., Ohashi, Y., “Metabolomic Anatomy of an Animal Model Revealing Homeostatic Imbalances in Dyslipidaemia” Mol. Biosyst. 7, 1217-23, 2011.
    [PubMed]
  • Yoshida, S., Imoto, J., Minato, T., Oouchi, R., Kamada, Y., Tomita, M., Soga, T., Yoshimoto, H., “A Novel Mechanism Regulates H2O and SO2 production in Saccharomyces cerevisiaeYeast 28, 109-121, 2011.
    [PubMed]
  • 2010
  • Husain, A., Sato, D., Jeelani, G., Suematsu, M., Soga, T., Nozaki, T., “Metabolome Analysis Revealed Increase in S-methylcysteine and Phosphatidylisopropanolamine Synthesis upon L-cysteine Derivatization in The Anaerobic Protozoan Parasite Entamoeba Histolytica J. Biol. Chem. 285, 39160-39170, 2010.
    [PubMed]
  • Sugiura, T., Kato, S., Shimizu, T., Wakayama, T., Nakamichi, N., Kubo, Y., Iwata, D., Suzuki, K., Soga, T., Asano, M., Iseki, S., Tamai, I., Tsuji, A., Kato, Y., “Functional Expression of Carnitine/Organic Cation Transporter OCTN1/SLC22A4 in Mouse Small Intestine and Liver” Drug Metab Dispos 38, 1665-1672, 2010.
    [PubMed]
  • Kitagawa, M., Ikeda, S., Tashiro, E., Soga, T., Imoto, M.,  “Metabolomic Identification of the Target of the Filopodia Protrusion Iinhibitor Glucopiericidin A” Chem. Biol. 17, 989-998, 2010.
    [PubMed]
  • Toyohara, T., Akiyama, Y., Suzuki, T., Takeuchi, Y., Mishima, E., Tanemoto, M., Momose, A., Toki, N., Sato, H., Nakayama, M., Hozawa, A., Tsuji, I., Ito, S., Soga, T., Abe. T. “Metabolomic profiling of uremic solutes in CKD patients” Hypertens. Res. 33, 944-952, 2010.
    [PubMed]
  • Jeelani, G., Husain, A., Sato, D., Ali, V., Suematsu, M., Soga, T.,  Nozaki, T., “Two Atypical-cysteine-regulated NADPH-dependent Oxidoreductases Involved in Redox Maintenance, L-cystine and Iron Reduction, and Metronidazole Activation in the Enteric Protozoon Entamoeba HistolyticaJ. Biol. Chem. 285, 26889-26899, 2010.
    [PubMed]
  • Toya, Y., Ishii, N., Nakahigashi, K., Hirasawa, T., Soga, T., Tomita, M., Shimizu, K., “13C-Metabolic Flux Analysis for Batch Culture of Escherrichia coli and Its pyk and pgi Gene Knockout Mutants Based on Mass Isotopomer Distribution of Intracellular Metabolites”, Biotechnol. Prog. 26, 975-992, 2010.
    [PubMed]
  • Sugimoto, M., Goto, H., Otomo, K., Ito, M., Onuma, H., Suzuki, A., Sugawara, M., Abe, S., Tomita, M., Soga, T., “Metabolomic Profiles and Sensory Attributes of Edamame under Various Storage Duration and Temperature Conditions” J. Agric. Food Chem. 58, 8418-8425, 2010.
    [PubMed]
  • Horai, H., Arita, M., Kanaya, S., Nihei, Y., Ikeda, T., Suwa, K., Ojima, Y., Tanaka, K., Tanaka, S., Aoshima, K., Oda, Y., Kakazu, Y., Kusano, M., Tohge, T., Matsuda, F., Sawada, Y., Horai, Y. M., Nakanishi, H., Ikeda, K., Akimoto, N., Maoka, T., Takahashi, H., Ara, T., Sakurai, N., Suzuki, H., Shibata, D., Neumann, S., Iida, T., Tanaka, K., Funatsu, K., Matsuura, F., Soga, T., Taguchi, R., Saito, K., Nishioka, T., “MassBank: A Public Repository for Sharing Mass Spectral Data for Life Sciences” J. Mass Spectro. 45, 703-714, 2010.
    [PubMed]
  • Sugimoto, M., Hirayama, A., Robert, M., Abe, S., Soga, T., Tomita, M., “Prediction of metabolite identity from accurate mass, migration time prediction and isotopic pattern information in CE-TOFMS data” Electrophoresis 31, 1-8, 2010.
    [PubMed]
  • Saito, N., Ohashi, Y., Soga, T., Tomita, M., “Unveiling Cellular Bbiochemical Reactions via Metabolomics-driven Approaches” Curr. Opi. Microbiol. 13, 358-362, 2010.
    [PubMed]
  • Fujiwara, K., Ishihama, Y., Nakahigashi, K., Soga, T., Taguchi, H., ”A Systematic Survey of in vivo Obligate Shaperonin-dependent Substrates” EMBO J. 29, 1552-1564, 2010.
    [PubMed]
  • Kato, Y., Kubo, Y., Iwata, D., Kato, S., Sudo, T., Sugiura, T., Kagaya, T., Wakayama, T., Hirayama, A., Sugimoto, M., Sugihara, K., Kaneko, S., Soga, T., Asano, M., Tomita, M., Matsui, T., Wada, M., Tsuji, A. “Gene knockout and metabolome analysis of carnitine/organic cation transporter OCTN1” Pharm. Res. 27, 832-840, 2010.
    [PubMed]
  • Kato, T., Niizuma, S., Inuzuka, Y., Kawashima, T., Okuda, J., Yamaki, Y., Iwanaga, Y., Narazaki, M., Matsuda, T., Soga, T., Kita, T., Kimura, T., Shioi, T., “Analysis of Metabolic Remodeling in Compensated Left Ventricular Hypertrophy and Heart Failure” Circ. Heart Fail., 3, 420-430, 2010.
    [PubMed]
  • Nakada, T., Soga, T., Tomita, M., Nozaki, H., "Chlorogonium complexum sp. nov. (Volvocales, Chlorophyceae), and morphological evolution of Chlorogonium" Eur. J. Phycol. 45, 97-106, 2010.
    [Publisher]
  • Sakurakawa, T., Hishiki, T., Ueno, Y., Ikeda, S., Soga, T., Yachie-Kinoshita, A., Kajimura, M., Suematsu, M., “Hypotaurine is an energy-saving hepatoprotective compound against ischemia-reperfusion injury of rat liver” J. Clin. Biochem. Nutr. 46, 126-134, 2010.
    [PubMed]
  • Sugimoto, M., Hirayama, A., Ihiskawa, T., Baran, R., Robert, M., Uehara, K., Soga, T., Tomita, M., “Differential Metabolomics Software for Capillary Electrophoresis-Mass Spectrometry Data Analysis” Metabolomics 6, 27-41, 2010.
    [Publisher]
  • Sugimoto, M., Wong, D.T., Hirayama, A., Soga, T., Tomita, M., “Capillary Electrophoresis Mass Spectrometry-based Saliva Metabolomics Identifies Oral, Breast and Pancreatic Cancer-Specific Profiles” Metabolomics 6, 78-95, 2010.
    [PubMed]
  • Sugimoto, M., Koseki, T., Hirayama, A., Abe, S., Sano, T., Tomita, M., Soga, T.,  “Correlation between Sensory Evaluation Scores of Japanese Sake and their Metabolome Profiles” J. Agric. Food Chem. 58, 374-383, 2010.
    [PubMed]
  • Nakada, T., Soga, T., Tomita, M., "Phylogenetic position of a rare loricated green alga, Cephalomonas granulata N. L. Higinb (Volvocales, Chlorophyceae)" Phycol. Res. 58, 62-68, 2010.
    [Publisher]
  • Sato, D., Kobayashi, S., Yasui, H., Shibata, N., Toru, T., Yamamoto, M., Tokoro, G., Ali, V., Soga, T., Takeuchi, T., Suematsu, M., Nozaki, T., ”Cytotoxic Effect of Amide Derivatives of Trifluoromethionine against The Enteric Protozoan Parasite Entamoeba histolytica” Int. J. Antimicrob. Agents. 35, 56-61, 2010.
    [PubMed]
  • 2009
  • Toyohara, T., Suzuki, T., Morimoto, R., Akiyama, Y., Souma, T., Shiwaku, H.O., Takeuchi, Y., Mishima, E., Abe, M., Tanemoto, M., Masuda, S., Kawano, H., Maemura, K., Nakayama, M., Sato, H., Mikkaichi, T., Yamaguchi, H., Fukui, S., Fukumoto, Y., Shimokawa, H., Inui, K., Terasaki, T., Goto, J., Ito, S., Hishinuma, T., Rubera, I., Tauc, M., Fujii-Kuriyama, Y., Yabuuchi, H., Moriyama, Y., Soga, T., Abe, T., “SLCO4C1 Transporter Eliminates Uremic Toxins and Attenuates Hypertension and Renal Inflammation” J. Am. Soc. Nephrol. 20, 2546-2555, 2009.
    [PubMed]
  • Nishino, T., Yachie-Kinoshita, A., Hirayama, A., Soga, T., Suematsu, M., Tomota, M., “In Silico Modeling and Metabolome Analysis of Long-stored Erythrocytes to Improve Blood Storage Methods” J. Biotechnol. 144, 212-223, 2009.
    [PubMed]
  • Tajima, T., Goda, N., Fujiki, N., Hishiki, T., Nishiyama, Y., Senoo-Matsuda, N., Shimazu, M., Soga, T., Yoshimura, Y., Johnson, R.S., Suematsu, M., “HIF-1a is necessary to support gluconeogenesis during liver regeneration”Biochem. Bioph. Res. 387, 789-794, 2009.
    [PubMed]
  • Nakahigashi, K., Toya, Y., Ishii, N., Soga, T., Hasegawa, M., Watanabe, H., Takai, Y., Honma, M., Mori, H., Tomita, M., “Systematic phenome analysis of Escherichia coli multiple knockout mutants reveals hidden reactions in central carbon metabolism” Mol. Syst. Biol. 5, 306, doi:10.1038/msb.2009.65
    [PubMed]
  • Iuchi, Y., Okada, F., Takamiya, R., Kibe, N., Tsunoda, S., Nakajima, O., Toyoda, K., Nagae, R., Suematsu, M., Soga, T., Uchida, K., Fujii, J. “Rescue of anemia and autoimmune responses in SOD1-deficient mice by transgenic expression of human SOD1 in erythrocytes” ” Biochem. J. 422, 313-320, 2009.
    [PubMed]
  • Soga, T., Igarashi, K., Itoh, C., Mizobuchi, K., Zimmermann, H., Tomita, M.,”Metabolomic Profiling of Anionic Metabolites by Capillary Electrophoresis Mass Spectrometry” Anal. Chem. 81, 6165-6174, 2009.
    [PubMed]
  • Minami, Y., Kasukawa, T., Kakazu, Y., Iigo, M., Sugimoto, M., Ikeda, S., Yasui, A., van der Horst, G., Soga, T., *Ueda, H., ”Measurement of Internal Body Time by Blood Metabolomics” Proc. Natl. Acad. Sci. USA 106 9890-9895, 2009.
    [PubMed]
  • Saito, N., Robert, M., Kochi, H., Matsuo, G., Kakazu, Y., Soga, T., Tomita, M., “Metabolite profiling reveals YihU as a novel hydroxybutyrate dehydrogenase for alternative succinic semialdehyde metabolism in Escherichia coli J. Biol. Chem. 109, 16442-16451, 2009.
    [PubMed]
  • Ooga, T., Ohashi, Y., Kuramitsu, S., Koyama, Y., Tomita, M., Soga, T., Masui, R.,”Degradation of ppGpp by nudix pyrophosphatase modulates the transition of growth phase in the bacterium thermos thermophilus”, J. Biol. Chem. 284, 15549-15556, 2009.
    [PubMed]
  • Hirayama, A., Kami, K., Sugimoto, M., Sugawara, M., Toki, N., Onozuka, H., Kinoshita, T., Saito, N., Ochiai, A., Tomita, M., Esumi, H., Soga, T., "Quantitative Metabolome Profiling of Colon and Stomach Cancer Microenvironment by Capillary Electrophoresis Time-of-flight Mass Spectrometry", Cancer Res. 69, 4918-4925, 2009.
    [PubMed]
  • Kuramori, C., Hase, Y., Hoshikawa, K., Watanabe, K., Nishi, T., Hishiki, T., Soga, T., Nashimoto, A., Kabe, Y., Yamaguchi, Y., Watanabe, H., Kataoka, K., Suematsu, M., Handa, H., “Mono-(2-ethylhexyl) phthalate Targets Glycogen Debranching Enzyme and Affects Glycogen Metabolism in Rat Testis” Toxicol. Sci. 109, 143-151, 2009.
    [PubMed]
  • Shintani, T., Iwabuchi, T., Soga, T., Kato,Y., Yamamoto, T., Takano, N., Hishiki, T., Ueno, Y., Ikeda, S., Sakurakawa, T., Ishikawa, K., Goda, N., Yitagawa, Y., Kajiyama, M., Matsumoto, K., *Suematsu, M., "Cystathionine β-synthase as a Carbon Monoxide-sensitive Regulator of Bile Excretion" Hepatology 49, 141-150, 2009.
    [PubMed]
  • 2008
  • Sato, S., Arita, M., Soga, T., Nishioka, T., Tomita, M., “Time-resolved Metabolomics Reveals Metabolic Modulation in Rice Foliage”, BMC Systems Biology 2, 51,doi:10.1186/1752-0509-2-51, 2008.
    [PubMed]
  • Yoshida, S., Imoto, J., Minato, T., Oouchi, R., Sugihara, M., Imai, T., Ishiguro, T., Mizutani, S., Tomita, M., Soga, T., Yoshimoto, H., “Developing Bottom-fermenting Yeast Strains That Produce High SO2 Levels by Integrated Metabolome and Transcriptome Analysis”, Appl. Environ. Microbiol. 74, 2787-2796, 2008.
    [PubMed]
  • Ohashi, Y., Hirayama, A., Ishikawa, T., Nakamura, S., Shimizu, K., Ueno, Y., Tomita, M., Soga, T., “Depiction of Metabolome Changes in Histidine-starved Escherichia coli by CE-TOFMS”, Mol. BioSyst. 4, 135-147, 2008.
    [PubMed]
  • 2007
  • Hashimoto, M., Ishihama, Y., Tomita, M., Soga, T., “Microelectrospray Interface with Coaxial Sheath Flow for High Resolution CE-MS Separation” Rapid Commun. Mass Spectrom. 21, 3579-84, 2007.
    [PubMed]
  • Monton, M.R.N., Soga, T., “Metabolome Analysis by Capillary Electrophoresis – Mass Spectrometry” J. Chromatogr. A 1168, 237-46, 2007.
    [PubMed]
  • Monton, M.R.N., Tomita, M., Soga, T., Ishihama, Y., “Polymer Entrapment in Polymerized Silicate for Preparing Highly Stable Capillary Coatings in CE and CE-MS”, Anal. Chem. 79, 7838-44, 2007.
    [PubMed]
  • Toya, Y., Ishii, N., Hirasawa, T., Naba, M., Hirai, K., Sugawara, K., Igarashi, S., Shimizu, K., Tomita, M., Soga, T., “Direct Measurement of The Isotope Distribution of Intracellular Metabolites Using CE-TOFMS for Efficient Metabolic Flux Analysis”, J. Chromatogr. A 1159, 134-41, 2007.
    [PubMed]
  • Soga, T., Ishikawa, T., Igarashi, S., Sugawara, K., Kakazu, Y., Tomita, M.,  "Analysis of nucleotides by pressure-assisted capillary electrophoresis mass spectrometry using silanol mask technique"  J. Chromatogr. A 1159, 125-33, 2007.
    [PubMed]
  • Morohashi, M., Shimizu, K., Ohashi, Y., Abe, J., Mori, H., Tomita, M., Soga, T., “P-BOSS: A new filtering method for treasure hunting in metabolomics.“, J. Chromatogr. A 1159, 142-48, 2007.
    [PubMed]
  • Morohashi, M., Ohashi, Y., Tani, S., Ishii, K., Itaya, M., Nanamiya, H., Kawamura, F., Tomita, M., Soga, T., “Model based definition of population heterogeneity and its effects on metabolism in sporulating Bacillus subtilis”, J. Biochem. 142, 183-91, 2007.
    [PubMed]
  • †Ishii, N., †Nakahigashi, K., †Baba, T., †Robert, M., †Soga, T., †Kanai, A., †Hirasawa, T., Naba, M., Hirai, K., Hoque, A., Ho, P.Y., Kakazu, Y., Sugawara, K., Igarashi, S.,Harada, S., Masuda, T., Sugiyama, N., Togashi, T., Hasegawa, M., Takai, Y., Yugi, K., Arakawa, K., Iwata, N., Toya, Y., Nakayama, Y., Nishioka, T., Shimizu, K., Mori, H., Tomita, M.,”Multiple High-throughput Analyses Monitor the Response of E. coli to Perturbations”, Science  316, 593-597, 2007.(†equally contribution)
    [Science] [PubMed]
  • Kinoshita, A., Tsukada, K., Soga, T., Hishiki, T., Ueno, Y., Nakayama, Y., Tomita, M., *Suematsu, M., "Roles of Hemoglobin Allostery in Hypoxia-induced Metabolic Alterations in Erythrocytes: Simulation and Its Demonstration by Metabolome Analysis", J. Biol. Chem. 282, 10731-41, 2007.
    [PubMed]
  • Baran, R., Robert, M., Suematsu, M., Soga, T., Tomita, M., "Visualization of Three-way Comparisons of Omics Data", BMC Bioinformatics 8, 72, 2007.
    [PubMed]
  • 2006
  • Baran, R., Kochi, H., Saito, N., Suematsu, M.,  Soga, T., Nishioka, T., Robert, M., Tomita, M.,  "MathDAMP: a package for differential analysis of metabolite profiles", BMC Bioinformatics 7, 530, 2006.
    [PubMed]
  • Shinoda K., Sugimoto M., Yachie N., Sugiyama N., Masuda T., Robert M., Soga T., Tomita M., "Prediction of liquid chromatographic retention times of peptides generated by protease digestion of the Escherichia coli proteome using artificial neural networks", J. Proteome Res. 5, 3312-3317, 2006.
    [PubMed]
  • Shinoda, K., Yachie, N., Masuda, T., Sugiyama, N., Sugimoto, M., Soga, T., Tomita, M., "HybGFS: A hybrid method for genome-fingerprint scanning", BMC Bioinformatics 7, 479, 2006.
    [PubMed]
  • Takahashi, H., Hayashi, M., Sato, S., Soga, T., Nishioka, T., Tomita, M., Kawai-Yamada, M., Uchimiya, H., “Evaluation of Metabolic Alteration in Transgenic Rice Overexpressing Dihydroflavonol-4-reductase”, Ann. Bot. 98, 819-825, 2006.
    [PubMed]
  • Saito, N., Robert, M., Kitamura, S., Baran, R., Soga, T., Mori, H., Nishioka, T., Tomita, M., “A metabolomics approach for enzyme discovery", J. Proteome Res. 5, 1979-1987, 2006.
    [PubMed]
  • Soga, T.,  Baran, R.,  Suematsu M., Ueno, Y., Ikeda, S., Sakurakawa T., Kakazu, Y., Ishikawa, T., Robert, M., Nishioka, T.,  Tomita, M., “Differential Metabolomics Reveals Ophthalmic Acid As An Oxidative Stress Biomarker Indicating Hepatic Glutathione Consumption”, J. Biol. Chem. 281, 16768-76, 2006.
    [PubMed]
  • 2005
  • Jaros, M., Soga, T., Van de Goor, T., Gas, B., “Conductivity Detection in Capillary Zone Electrophoresis - Inspection by Peak Master”, Electrophoresis 26, 1948-1953, 2005.
    [PubMed]
  • Ishii, N., Soga, T., Nishioka, T., Tomita, M., “Metabolome Analysis and Metabolic Simulation", Metabolomics 1, 29-37, 2005.
    [Publisher]
  • Sugimoto, M., Kikuchi, S., Arita, M., Soga, T., Nishioka, T., Tomita, M., “Large-Scale Prediction of Cationic Metabolites Identity and Migration Time in Capillary Electrophoresis Mass Spectrometry using Artificial Neural Networks”, Anal. Chem. 77, 78-84, 2005.
    [PubMed]
  • 2004
  • Sato, S., Soga, T., Nishioka, T., Tomita, M., “Simultaneous Determination of Main Metabolites in Rice Leaves using Capillary Electrophoresis Mass Spectrometry and Capillary Electrophoresis Diode Array Detection” Plant J. 40, 151-163, 2004.
    [PubMed]
  • Itoh, A., Ohashi, Y., Soga, T., Mori, H., Nishioka, T., and Tomita, M., “Application of Capillary Electrophoresis Mass Spectrometry to Synthetic in vitro Glycolysis Studies ”, Electrophoresis 25, 1996-2002, 2004.
    [PubMed]
  • Soga, T., Kakazu, Y., Martin, R., Tomita, M., and Nishioka, T., “Qualitative and Quantitative Analysis of Amino Acids by Capillary Electrophoresis Electrospray Ionization Tandem Mass Spectrometry”, Electrophoresis 25, 1964-1972, 2004.
    [PubMed]
  • 2003
  • Soga, T., Ohashi, Y., Ueno, Y., Naraoka, H., Tomita, M., and Nishioka, T., “Quantitative Metabolome Analysis Using Capillary Electrophoresis Mass Spectrometry”, J. Proteome Res. 2. 488-494, 2003.
    [PubMed]
  • 2002
  • Soga, T., Ueno, Y., Naraoka, H., Matsuda, K., Tomita, M., Nishioka, T., ”Pressure Assisted Capillary Electrophoresis Electrospray Ionization Mass Spectrometry for Analysis of Multivalent Anions”, Anal. Chem. 74, 6224-6229, 2002.
    [PubMed]
  • Matsuda, K., Yamaguchi, H., Ueno, Y., Soga, T., Fujita, Y., Nishioka, T.,  "Combined Metabolome and Transcriptome Analysis of Bacillus subtilis Cells Cultured on Different Carbon Sources", Genomic Informatics Series 13, 593-594, 2002.
    [J-stage]
  • Soga, T., Ueno, Y., Naraoka, H., Ohashi, Y., Tomita, M., and Nishioka, T., ”Simultaneous Determination of Anionic Intermediates for Bacillus subtilis Metabolic Pathways by Capillary Electrophoresis Electrospray Ionization Mass Spectrometry”, Anal. Chem. 74, 2233-2239, 2002.
    [PubMed]
  • 2001
  • Soga, T., Imaizumi, M., ”Capillary Electrophoresis Method for the Analysis of Inorganic Anions, Organic Acids, Amino Acids, Nucleotides, Carbohydrates and Other Anionic Compounds” Electrophoresis 22, 3418-3425, 2001.
    [PubMed]
  • Kodama, S., Yamamoto, A., Matsunaga, A., Soga, T., Hayakawa, K., ”Direct Chiral Resolution of Malic Acid in Apple Juice by Ligand-exchange Capillary Electrophoresis Using Copper (II)-L-Tartaric Acid as A Chiral Selector” Electrophoresis 22, 3286-3290, 2001.
    [PubMed]
  • 2000
  • Soga, T., Serwe, M., ”Determination of Carbohydrates in Food Samples by Capillary Electrophoresis with Indirect UV Detection”, Food Chem. 69, 339-344, 2000.
    [Publisher]
  • Kodama, S., Yamamoto, A., Matsunaga, A., Soga, T., Minoura, K.,  "Direct Chiral Resolution of Lactic Acid in Food Products by Capillary Electrophoresis”, J. Chromatogr. A 875, 371-377, 2000.
    [PubMed]
  • Soga, T., Heiger, D.N., ”Amino Acid Analysis by Capillary Electrophoresis Electrospray Ionization Mass Spectrometry”, Anal. Chem. 72 ,1236-1241, 2000.
    [PubMed]
  • Soga, T., Tajima, I., and Heiger, D.N., “Capillary Electrophoresis for the Determination of Forensic Anions in Adulterated Foods and Beverages”, Am. Lab. 32 ,124-128, 2000.
  • 1999
  • Tsunoda, M., Kato, M., Fukushima, T., Santa, T., Homma, H., Yani, H., Soga, T., Imai, K.,”Determination of Aspartic Acid Enantiomers in Bio-samples by Capillary Electrophoresis”, Biomed. Chromatogr. 13 335-339, 1999.
    [PubMed]
  • Soga, T., Ross, G.A., “Simultaneous Determination of Inorganic Anions, Organic Acids, Amino Acids and Carbohydrates by Capillary Electrophoresis”, J. Chromatogr. A 837 231-239, 1999.
    [Publisher]
  • Soga, T., Ross, G.A., “Simultaneous Determination of Inorganic Anions, Organic Acids and Metal Cations by Capillary Electrophoresis”, J. Chromatogr. A 834 ,65-71, 1999
    [Publisher]
  • 1998
  • Soga, T., Heiger, D.N., “Simultaneous Determination of Monosaccharides in Glycoproteins by Capillary Electrophoresis”, Anal. Biochem. 261,73-78, 1998.
    [PubMed]
  • Jegle, U., Serwe, M., Soga, T., ”Kapillarelektrophorese-eine Prädestinierte Technik für die Analyse von Kationen und Anionen in Elektrolyten für die Galvanische und Chemische Metallisierung”, Galvanotechnik, 89 1478-1485, 1998.
  • 1997
  • Soga, T., Ross, G.A., “Capillary Electrophoretic Determination of Inorganic and Organic Anions using 2,6-Pyridinedicarboxylic Acid: Effect of Electrolyte’s Complexing Ability”, J. Chromatogr. A 767, 223-230, 1997.
    [Publisher]
  • Soga, T., Wakaura, M., “Determination of Inorganic and Organic Anions in Beer and Wort by Capillary Electrophoresis”, J. Am. Soc. Brew. Chem. 55,44-46, 1997.
    [Publisher]
  • Jegle, U., Grimm, R., Godel, H., Schuster, R., Ross, G. A., Soga, T., ”Poly(vinyl alcohol)-Coated Capillaries – A Solution for Many Application Areas in Capillary Electrophoresis”, LCGC International 10 176-188, 1997.
  • 1995
  • Soga, T., Inoue, Y., Ross, G. A., “Analysis of Halides, Oxyhalides and Metal Oxoacids by Capillary Electrophoresis with Suppressed Electroosmotic Flow”, J. Chromatogr. A 718, 421-428, 1995.
    [Publisher]
  • 1993
  • Soga, T., Inoue, Y., “Determination of Catecholamines in Urine and Plasma by On-line Sample Pretreatment using an Internal Surface Boronic Acid Gel”, J. Chromatogr. Biomed. 620, 175-181, 1993.
    [PubMed]
  • 1992
  • Soga, T., Inoue, Y., Yamaguchi, K., “Determination of Carbohydrates by Hydrophilic Interaction Chromatography with Pulsed Amperometric Detection using Postcolumn pH Adjustment”, J. Chromatogr. A 625, 151-155, 1992.
    [Publisher]

Books

  • Alterman M.Ed., (Hirayama, A., Ikeda, S., Sato, A., Soga, T., T., contribution for Chapter 23: Amino Acid Analysis by Capillary Electrophoresis-Mass Spectrometry) “Amino Acid Analysis : Methods and Protocols”, (Methods in Molecular Biology 2030), pp.307-313, Humana Press, 2019.
    Amazon.com [Publisher]
  • Komatsu, T., Ceccaldi, H-J., Yoshida, J., Prouzet, P., Henocque, Y. Ed., , (Nakano, T., Shirakawa, H., Yeo, G., Devlin, R.H., Soga, T., contribution for Part IV Innovative Research: Metabolome profiling of growth hormone transgenic coho salmon by capillary electrophoresis time-of-flight mass spectrometry) “Oceanography Challenges to Future Earth : Human and Natural Impacts on our Seas”, pp. 223-234, Springer, Cham, 2019.
    Amazon.com [Publisher]
  • Ramautar R. Ed., (Hirayama A, Soga, T., contribution for “CHAPTER 7: CE-MS for anionic and cationic metabolic profiling: system optimization and applications”) “Capillary Electrophoresis-Mass Spectrometry for Metabolomics” , pp.134-160, The Royal Society of Chemistry, 2018.
    Amazon.com [Publisher]
  • Bjerrum, J. T. Ed., (Wakayama, M., Hirayama, A., Soga, T., contribution for Chapter 9: Capillary Electrophoresis-Mass Spectrometry) “Metabolomics: Methods and Protocols” (Methods in Molecular Biology 1277) , pp.113-122, Humana Press, 2015.
    Amazon.com [Publisher]
  • Hyotylainen, T., Wiedmer, S., Ed., (Hirayama, A., Soga, T., contribution for Chapter 6: Capillary Electromigration Techniques in Metabolomics) “Chromatographic Methods in Metabolomics” (RSC Chromatography Monographs 18), pp.114-137, RSC Publishing, 2013
    Amazon.com [Publisher]
  • Alterman, M. A., Hunziker, P., Ed. (Hirayama, A., Soga, T., contribution for Chapter 8: Amino Acid Analysis by Capillary Electrophoresis-Mass Spectrometry) “Amino Acid Analysis: Methods and Protocols” (Methods in Molecular Biology 828), pp.77-82, Humana Press, 2012.
    Amazon.com [Publisher]
  • Wang, J., Zhu, H., Ed., (Iino, K., Sugimoto, M., Soga, T., Tomita, M., contribution for Metabolomics: A New Omics Technology for Traditional Herbal Medicine Analysis) “Chinese Medicine: Acupuncture, Herbal Medicine and Therapies” pp. 45-55, Nova Science Publishers, Inc., 2012.
    [Publisher]
  • Smolke, C. D., Ed. (Monton, M.R., Soga, T., contribution for Chapter 14: Monitoring and Measuring the Metabolome) “The Metabolic Pathway Engineering Handbook: Tools and Applications” pp.14-1-14-12, CRC Press, 2009.
    Amazon.com [Publisher]
  • Nielsen, J., Jewett, M.C., Ed, (Robert, M., Soga, T., Tomita, M., contribution for E. coli metabolomics: capturing the complexity of a “simple” model), “Metabolomics: A Powerful Tool in Systems Biology” (Topics in Current Genetics 18), pp.189-234, Springer, 2007.
    Amazon.com [Publisher]
  • Weckwerth, W., Ed. (Soga, T., contribution for Chapter 8: Capillary Electrophoresis-Mass Spectrometry for Metabolomics) “Metabolomics: Methods and Protocols” (Methods in Molecular Biology 358), pp.129-137, Humana Press, 2006.
    Amazon.com [Publisher]
  • Tomita, M., Nishioka T., Ed. (Soga, T., contribution for Chapter 2: Development and Application of Capillary Electrophoresis-Mass Spectrometry Methods to Metabolomics) “Metabolomics: The Frontier of Systems Biology” pp.7-24, Springer, 2005.
    Amazon.com [Publisher]
  • El Rassi, Z., Ed. (Soga, T., contribution for Chapter 14: Analysis of Carbohydrates in Food and Beverages by HPLC and CE ) “Carbohydrate Analysis by Modern Chromatography and Electrophoresis”( Journal of Chromatography Library 66), pp.483-502, Elsevier Science Publishers, 2002.
    Amazon.com [Publisher]

Patents

  • Soga, T., Hirayama, A., Abe, H., “Method Of Creating Spray Device For Sheathless CE-MS, Spray Device For Sheathless CE-MS, And Sheathless CE-MS Device”, DE Patent No. 112016000855 (2019),  PCT/JP2016/058131.
  • Soga, T., Hirayama, A., Abe, H., “Method Of Creating Spray Device For Sheathless CE-MS, Spray Device For Sheathless CE-MS, And Sheathless CE-MS Device”, JP Patent No. 6498497(2019).
  • Soga, T., Sugimoto, M., Suematsu M., Saito, T., Kawata, S., “Liver Disease Marker, Method And Apparatus For Measuring Same, And Test Method For Pharmaceutical Preparation”, KR Patent No.10-1867808 (2018), PCT/JP2011/061340.
  • Soga, T., Hirayama, A., Abe, H., “Method Of Creating Spray Device For Sheathless CE-MS, Spray Device For Sheathless CE-MS, And Sheathless CE-MS Device”, US Patent No. US9,978,573 (2018),  PCT/JP2016/058131.
  • Soga, T., Sugimoto, M., Suematsu M., Honma, M., Yamamoto, T., Suzuki, H., “Liver Disease Marker, Method And Apparatus For Measuring Same, And Test Method For Pharmaceutical Preparation”, CN Patent No. ZL201410334142.1 (2017), Division of PCT/JP2009/069950.
  • Soga, T., Sugimoto, M., Suematsu M., Honma, M., Yamamoto, T., Suzuki, H., “Method for Measuring Liver Disease Markers And Test Method for Pharmaceutical Preparation", EPC Patent No. EP2381259 (2016), PCT/JP2009/069950.
  • Soga, T., Sugimoto, M., Suematsu M., Saito, T., Kawata, S., “Liver Disease Marker”, JP Patent No.5809136 (2015), PCT/JP2011/061340.
  • Soga, T., Sugimoto, M., Suematsu M., Saito, T., Kawata, S., “Liver Disease Marker, Method And Apparatus For Measuring Same, And Test Method For Pharmaceutical Preparation”, CN Patent No. ZL201180030202.5 (2015), PCT/JP2011/061340.
  • Soga, T., Sugimoto, M., Suematsu M., Honma, M., Yamamoto, T., Suzuki, H.,Oxidative stress Marker, Method And Apparatus For Measuring Same, And Test Method For Pharmaceutical Preparation”, JP Patent No. 5676275 (2015), PCT/JP2009/069950.
  • Abe, T., Soga, T. ,“Novel renal disease marker substance in human” JP Patent No. 5757626 (2015), PCT/JP2010/005434.
  • Abe, T., Soga, T. ,“Human Renal Disease Marker Substance” US Patent No. US8,709,816 (2014), PCT/JP2010/005434.
  • Soga, T., Sugimoto, M., Suematsu M., Honma, M., Yamamoto, T., Suzuki, H., “Liver Disease Marker, Method And Apparatus For Measuring Same, And Test Method For Pharmaceutical Preparation”, CN Patent No. ZL200980152582.2 (2014), PCT/JP2009/069950.
  • Soga, T., Suematsu, M., “Method for Determination of Oxidative Stress”, US Patent No. US8,309,056 (2012), Division of PCT/JP2007/050517.
  • Soga, T., Suematsu, M., “Method for Determination of Oxidative Stress”, JP Patent No. 4840804 (2011).
  • Soga, T., Suematsu, M., “Method for Determination of Oxidative Stress”, US Patent No. US7,964,177 (2011), PCT/JP2007/050517.
  • Soga, T., Suematsu, M., “Method for Determination of Oxidative Stress”, EPC Patent No. EP1975621 (2010), PCT/JP2007/050517.
  • Tomita, M., Itoh, A., Soga, T., Ohhashi, N., "Method for Identifying Functions and Binding Substances of Gene Products", JP Patent No.4114075 (2008).
  • Tomita, M., Itoh, A., Soga, T., "Method and Kit for Identifying Functions and Binding Substances of Gene Products", US2007/0172825, EP1717587, WO/2005/078449, PCT/JP2005/001858.
  • Sugimoto, M., Soga, T., Tomita, M., "Method for Predicting The Migration Time of Ionic Compounds by Electrophoretic measurement", US2007/0256935, PCT/JP2005/15325.
  • Sugimoto, M., Soga, T., Tomita, M., "Method for Predicting The Migration Time of Ionic Compounds by Electrophoretic measurement", JP Patent No.3871689 (2006).
  • Soga, T., "Apparatus and Method for Anion Analysis", JP Patent 3341765 (2002).
  • Soga, T., "Capillary Electrophoresis Apparatus and Method for Anions, Amino Acids and Carbohydrate Analysis", JP Patent 3038184 (2000).
  • Soga, T., "Apparatus and Method for Anion Analysis", JP Patent 2912232 (1999).
  • Soga, T., "Apparatus and Method for Catecholamine Analysis", JP Patent 2833058 (1998).
  • Soga, T., Inoue, Y., "Capillary Electrophoresis Apparatus and Its Method", EP078329