{"id":737,"date":"2016-08-05T11:00:20","date_gmt":"2016-08-05T02:00:20","guid":{"rendered":"http:\/\/metabolome.iab.keio.ac.jp\/?page_id=737"},"modified":"2026-03-17T11:36:39","modified_gmt":"2026-03-17T02:36:39","slug":"publications","status":"publish","type":"page","link":"https:\/\/metabolome.iab.keio.ac.jp\/ja\/publications\/","title":{"rendered":"\u7814\u7a76\u696d\u7e3e"},"content":{"rendered":"<h4><a href=\"#y2026\">2026<\/a>|<a href=\"#y2025\">2025<\/a>|<a href=\"#y2024\">2024<\/a>|<a href=\"#y2023\">2023<\/a>|<a href=\"#y2022\">2022<\/a>|<a href=\"#y2021\">2021<\/a>|<a href=\"#y2020\">2020<\/a>|<a href=\"#y2019\">2019<\/a>|<a href=\"#y2018\">2018<\/a>|<a href=\"#y2017\">2017<\/a>|<a href=\"#y2016\">2016<\/a>|<a href=\"#y2015\">2015<\/a>|<a href=\"#y2014\">2014<\/a>|<a href=\"#y2013\">2013<\/a>|<a href=\"#y2012\">2012<\/a>|<a href=\"#y2011\">2011<\/a>|<br \/>\n<a href=\"#y2010\">2010<\/a>|<a href=\"#y2009\">2009<\/a>|<a href=\"#y2008\">2008<\/a>|<a href=\"#y2007\">2007<\/a>|<a href=\"#y2006\">2006<\/a>|<a href=\"#y2005\">2005<\/a>|<a href=\"#y2004\">2004<\/a>|<a href=\"#y2003\">2003<\/a>|<a href=\"#y2002\">2002<\/a>|<a href=\"#y2001\">2001<\/a>|<a href=\"#y2000\">2000<\/a>|<a href=\"#y1999\">1999<\/a>|<a href=\"#y1998\">1998<\/a>|<a href=\"#y1997\">1997<\/a>|<a href=\"#y1995\">1995<\/a>|<a href=\"#y1993\">1993<\/a>|<a href=\"#y1992\">1992<\/a>|<a href=\"#rBooks\">Books<\/a>|<a href=\"#rPatents\">Patents<\/a>|<\/h4>\n<h2>Selected papers<\/h2>\n<ul class=\"list2\">\n<li>Kawano, G., Ikeda, R., Ishihara, D., Shima, T., Sakoda, T., Yamamoto, S., Kochi, Y., Semba, Y., Ashitani, S., Mori, Y., Kato K., Maeda, T., Miyamoto, T., <strong><u>Soga, T.<\/u><\/strong>, Akashi, K., Kikushige, Y., \"Guanine nucleotides drive ribosome biogenesis and glycolytic reprogramming in acute myeloid leukemia stem cells\", <strong><em>Blood <\/em><\/strong>147, 768-782, 2026.<br \/>\n[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41191529\/\">PubMed<\/a>]<\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Yang, C., Arai, M., Fuji Ariyanto, E., Zhang, J., Mirani Lubis D., Ito, R., Xie, S., Nitta, M., Kawashima, F., Ishitsuka, T., Yang, C., Suzuki, T., Komatsu, T., Sagae, H., Jin, H., Takahashi, H., Kobayashi, E., Wei, Y., Liu, B., Choi, H., Wada, Y., Tanaka T., Osawa, T., Kimura, H., Kodama, T., Aburatani, H., Tachibana, M., Shinkai, Y., Inagaki, T., <strong><u>Soga, T.<\/u><\/strong>,\u00a0 Osbome, T.F., Yoneshiro, T., Matsumura, Y., Sakai, J., \u201cGlucose-activated JMJD1A drives visceral adipogenesis via \u03b1-ketoglutarate-dependent chromatin remodeling\u201d <strong><em>Cell Rep. <\/em><\/strong>44, 116060, 2025.<br \/>\n[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40720241\/\">PubMed<\/a>]<\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Pickard, J., Porwollik, S., Caballero-Flores, G., Caruso, R., Fukuda, S., <strong><u>Soga, T.<\/u><\/strong>, Inohara, N., McClelland, M., Nunez, G., \"Dietary amino acids regulate Salmonella colonization via microbiota-dependent mechanisms in the mouse gut\" <strong><em>Nat. Commun. <\/em><\/strong>16, 4225, 2025.<br \/>\n[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40335509\/\">PubMed<\/a>]<\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Nishio, M., Yamaguchi, K., Otani, J., Yuguchi, K., Kohno, D., Sasaki, T., Kitamura, T., Shinohara, M., <strong><u>Soga, T.<\/u><\/strong>, Kawamura, K., Sasaki, A.T., Oshima, M., Hikasa, H., Woo, M., Sasaki, T., Nishina, H., Nakao, K., Maehama, T., Suzuki, A., \"MOB1 deletion in murine mature adipocytes ameliorates obesity and diabetes\" <strong><em>Proc Natl Acad Sci USA,<\/em><\/strong> 122, e2424741122, 2025.<br \/>\n[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40258148\/\">PubMed<\/a>]<\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Morita, K., Hatano, A., Kokaji, T., Sugimoto, H., Tsuchiya, T., Ozaki, H., Egami, R., Li, D., Terakawa, A., Ohno, S., Inoue, H., Inaba, Y., Suzuki, Y., Matsumoto, M., Takahashi, M., Izumi, Y., Bamba, T., Hirayama, A., <strong><u>Soga, T.<\/u><\/strong>, Kuroda, S., \u201cStructural robustness and temporal vulnerability of the starvation-responsive metabolic network in healthy and obese mouse liver\u201d <strong><em>Sci. Signal. <\/em><\/strong>18, eads2547, 2025.<br \/>\n[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40261956\/\">PubMed<\/a>]<\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Jing, Y., Kobayashi, M., Shoulkamy, M.I., Zhou, M., Thi Vu, H., Arakawa, H., Sabit, H., Iwabuchi, S., Quang Vu, C., Kasahara, A., Ueno, M., Tadokoro, Y., Kurayoshi, K., Chen, X., Yan, Y., Arai, S., Hashimoto, S., <strong><u>Soga, T.<\/u><\/strong>, Todo, T., Nakada, M., Hirao, A., \"Lysine-arginine imbalance overcomes therapeutic tolerance governed by the transcription factor E3-lysosome axis in glioblastoma\" <strong><em>Nat. Commun<\/em><\/strong>.16, 2876, 2025.<br \/>\n[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40169552\/\">PubMed<\/a>]<\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Ono, T., Taketomi, Y., Higashi, T., Sato, H., Mochizuki-Ono, C., Nagasaki, Y., Ueta, T., Miyai, T., Tokuoka, S., Oda, Y., Nishito, Y., Ono, T., Taya, C., Arata, S., Watanabe, S., <strong><u>Soga, T.<\/u><\/strong>, Hirabayashi, T., Aihara, M., Murakami, M., \"PNPLA6 regulates retinal homeostasis by choline through phospholipid turnover\" <strong><em>Nat. Commun<\/em><\/strong>.16, 2221., 2025.<br \/>\n[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40082403\/\">PubMed<\/a>]<\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Mizutani, S., Tamaki, A., Shiba, S., Salim, F., Yamada, M., Takamaru, H., Nakajima, T., Yoshida, N., Ikuta, S., Yachida, T., Shibata, T., <strong><u>Soga, T.<\/u><\/strong>, Saito, Y., Fukuda, S., Ishikawa, H., Yamada, T., Yachida, S., \u201cDynamics of the gut microbiome in FAP patients undergoing intensive endoscopic reduction of polyp burden\u201d<strong><em> Gut <\/em><\/strong>74, 335-338, 2025.<br \/>\n[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39089862\/\">PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Steimle, A., Neumann, M., Grant, E.T., Willieme, S., Sciscio, A.D., Parrish, A., Ollert, M., Miyauchi, E., <strong><u>Soga, T.<\/u><\/strong>, Fukuda, S., Ohno, H., Desai, M.S.,\"Gut microbial factors predict disease severity in a mouse model of multiple sclerosis\" <strong><em>Nat. Microbiol.<\/em><\/strong> 9, 2244-2261, 2024.<br \/>\n[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39009690\/\">PubMed<\/a>]<\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Katsuumi, G., Shimizu, I., Suda, M., Yoshida, Y., Furihata, T., Joki, Y., Hsiao, CL., Jiaqi, L., Fujiki, S., Abe, M., Sugimoto, M., <strong><u>Soga, T.<\/u><\/strong>, Minamino, T., \"SGLT2 inhibition eliminates senescent cells and alleviates pathological aging\" <strong><em>Nat. Aging<\/em><\/strong> 4, 926-938, 2024.<br \/>\n[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38816549\/\">PubMed<\/a>]<\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Mae, S., Hattanda, F., Morita, H., Nozaki, A., Katagiri, N., Ogawa, H., Teranaka, K., Nishimura, Y., Kudoh, A., Yamanaka, S., Matsuse, K., Ryosaka, M., Watanabe, A., <strong><u>Soga, T.<\/u><\/strong>, Nishio, S., *Osafune, K., \"Human iPSC-derived renal collecting duct organoid model cystogenesis in ADPKD\" <strong><em>Cell Rep.<\/em><\/strong> 42, 113431, 2023.<br \/>\n[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38039961\/\">PubMed<\/a>]<\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Nomura, M., Oh-uchi, M., Sakamoto, Y., Kudo, K., Yaku, K.,<strong> <u>Soga, T.<\/u><\/strong>, Sugiura, Y., Morita, M., Hayashi, K., Miyahara, S., Sato, T., Yamashita, Y., Ito, S., Kikuchi, N., Sato, I., Saito, R., Yaegashi, N., Fukuhara, T., Yamada, H., Shima, H., Nakayama, K., Hirao, A., Kawasaki, K., Arai, Y., Akamatsu, S., Tanuma, S., Sato, T., Nakagawa, T., Tanuma, N., \"Niacin restriction with NAMPT-inhibition is synthetic lethal to neuroendocrine carcinoma\" <strong><em>Nat. Commun<\/em><\/strong>. 14, 8095, 2023.<br \/>\n[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38092728\/\">PubMed<\/a>]<\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Kojima, Y., Mishiro-Sato, E., Fujishita, T., Satoh, K., Kajino-Sakamoto, R., Oze, I., Nozawa, K., Narita, Y., Ogata, T., Matsuo, K., Muro, K., Taketo, M., <strong><u>Soga, T.<\/u><\/strong>, Aoki, A., \"Decreased liver B vitamin-related enzymes as a metabolic hallmark of cancer cachexia\" <strong><em>Nat. Commun<\/em><\/strong>. 14, 6246, 2023.<br \/>\n[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37803016\/\">PubMed<\/a>]<\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Yabushita, T. Chinen, T., Nishiyama, A., Asada, S., Shimura, R., Isobe, T., Yamamoto, K., Sato, N., Enomoto, Y., Tanaka, Y., Fukuyama, T., Satoh, H., Kato, K., Saitoh, K., Ishikawa, T., <strong><u>Soga, T.,<\/u><\/strong> Nannya, Y., Fukagawa, T., Nakanishi, M., Kitagawa, D., Kitamura, T., Goyama, S., \"Mitotic perturbation is a key mechanism of action of decitabine in myeloid tumor treatment\" <strong><em>Cell Rep.<\/em><\/strong> 42(9), 113098, 2023.<br \/>\n[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37714156\/\">PubMed<\/a>]<\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Kikushige, Y., Miyamoto, T., Kochi, Y., Semba, Y., Ohishi, M., Irifune, H., Hatakeyama, K., Kunisaki, Y., Sugio, T., Sakoda, T., Miyawaki, K., Kato, K., <strong><u>Soga, T.<\/u><\/strong>, Akashi, K., \u201cHuman acute leukemia uses branched-chain amino acid catabolism to maintain stemness through regulating PRC2 function\u201d <strong><em>Blood Adv. <\/em><\/strong>7, 3592-3603, 2023.<br \/>\n[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36044390\/\">PubMed<\/a>]<\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Hibino, S., Eto, S., Hangai, S., Endo, K., Ashitani, S., Sugaya, M., Osawa, T., <strong><u>Soga, T.<\/u><\/strong>, Taniguchi, T., Yanai, H., \"Tumor cell-derived spermidine is an oncometabolite that suppress TCR clustering for intratumoral CD8+ T cell activation\" <strong><em>Proc. Natl. Acad. Sci. USA <\/em><\/strong>120, e2305245120, 2023.<br \/>\n[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37276392\/\">PubMed<\/a>]<\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Tabata, S., Kojima, Y., Sakamoto, T., Igarashi, K., Umetsu, K., Ishikawa, T., Hirayama, A., Kajino-Sakamoto, R., Sakamoto, N., Yasumoto, K., Okano, K., Suzuki, Y., Yachida, S., Aoki, M., <strong><u>Soga, T.<\/u><\/strong>, \"L-2hydroxyglutaric acid rewires amino acid metabolism in colorectal cancer via the mTOR-ATF4 axis\" <strong><em>Oncogene <\/em><\/strong>42<strong><em>,<\/em><\/strong> 1294-1307, 2023.<br \/>\n[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36879117\/\">PubMed<\/a>]<\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Hirabayashi, T., Kawaguchi1, M., Harada, S., Mouri, M., Takamiya, R., Yoshimi, M., Sato, H., Taketomi, Y., Yokoyama, K., Kobayashi, T., Tokuoka, S.M., Kita, Y., Yoda, E., Hara, S., Mikami, K., Nishito, Y., Kikuchi, N., Nakata, R., Kaneko, M., Kiyonari, H., Kasahara, K., Aiba, T., Ohsako, S., Ikeda, K., <strong><u>Soga, T.<\/u><\/strong>, Kurano, M., Yatomi, Y., Murakami, M., \u201cHepatic phosphatidylcholine catabolism driven by PNPLA7 and PNPLA8 supplies endogenous choline to replenish the methionine cycle with methyl groups\u201d <strong><em>Cell Rep<\/em><\/strong>. 42, 111940, 2023.<br \/>\n[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36719796\/\">PubMed<\/a>]<\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Kawamura, G., Kokaji, T., Kawata, K., Sekine, Y., Suzuki, Y., <strong><u>Soga, T<\/u><\/strong>., Ueda, Y., Endo, M., Kuroda, S., Ozawa, T., \u201cOptogenetic decoding of Akt2-regulated metabolic signaling pathways in skeletal muscle cells using transomics analysis\u201d <strong><em>Sci. Signal. <\/em><\/strong>16, eabn0782, 2023.<br \/>\n[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36809024\/\">PubMed<\/a>]<\/li>\n<\/ul>\n<ul class=\"list2\">\n<li><strong><u>Soga, T.<\/u><\/strong>, \u201cAdvances in capillary electrophoresis mass spectrometry for metabolomics\u201d <strong><em>Trends Anal. Chem.<\/em><\/strong>158, 116883, 2023.<br \/>\n[<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0165993622003661\">Publisher<\/a>]<\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Hoshii, T., Perlee, S., Kikuchi, S., Rahmutulla, B, Fukuyo, M., Masuda, T., Ohtsuki, S., <strong><u>Soga, T.<\/u><\/strong>, Nabet, B., Kaneda, A., \"SETD1A regulates transcriptional pause release of heme biosynthesis genes in leukemia\" <strong><em>Cell Rep. <\/em><\/strong>41, 111727, 2022.<br \/>\n[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36450243\/\">PubMed<\/a>]<\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Pan, M., Zorbas, C., Sugaya, M., Ishiguro, K., Kato, M., Nishida, M., Zhang, H.F., Candeias, M.M., Okamoto, A., Ishikawa, T.,<strong><u> Soga, T.<\/u><\/strong>, Aburatani, H., Sakai, J., Matsumura, Y., Suzuki, T., Proud, C.G., Lafontaine, D.L.J., Osawa, T., \"Glutamine deficiency in solid tumor cells confers resistance to ribosomal RNA synthesis inhibitors\" <strong><em>Nat. Commun.<\/em><\/strong> 13, 3706, 2022.<br \/>\n[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35764642\/\">PubMed<\/a>]<\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Saito, Y., Matsuda, S., Ohnishi, N., Endo, K., Ashitani, S., Ohishi, M., Ueno, A., Tomita, M., Ueda, K., <strong><u>Soga, T.<\/u><\/strong>, Muthuswamy, S.K., \u201cPolarity protein SCRIB interacts with SLC3A2 to regulate proliferation and tamoxifen resistance in ER+ breast cancer\u201c <strong><em>Commun. Biol.<\/em><\/strong> 5, 403, 2022.<br \/>\n[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35501367\/\">PubMed<\/a>]<\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Whitburn, J., Rao, S.R., Morris, E.V., Tabata, S., Hirayama, A., <strong><u>Soga, T.<\/u><\/strong>, Edwards, J.R., Kaya, Z., Palmer, C., Hamdy, F.C., Edwards, C.M., \u201cMetabolic profiling of prostate cancer in skeletal microenvironments identifies G6PD as a key mediator of growth and survival\" <strong><em>Sci. Adv.<\/em><\/strong> 8, eabf9096, 2022.<br \/>\n[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35213227\/\">PubMed<\/a>]<\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Heishima, K., Sugito, N., Soga, T., Nishikawa, M., Ito, Y., Honda, R., Kuranaga, Y., Sakai, H., Ito, R., Nakagawa, T., Ueda, H., Akao, Y., \u201cPetasin potently inhibits mitochondrial complex I-based metabolism that suppors tumor growth and metastasis\u201d <strong><em>J. Clin. Invest. <\/em><\/strong>131, e139933, 2021.<br \/>\n[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34623325\/\">PubMed<\/a>]<\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Igarashi, K., Ota, S., Kaneko, M., Hirayama, A., Enomoto, M., Katumata, K., Sugimoto M., <strong><u>Soga, T.<\/u><\/strong>, \"High-throughput Screening of Salivary Polyamine Markers for Discrimination of Colorectal Cancer by Multisegment Injection Capillary Electrophoresis Tandem Mass Spectrometry\" <strong><em>J. Chromatogr. A <\/em><\/strong>1652, 462355, 2021.<br \/>\n[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34233246\/\">PubMed<\/a>]<\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Matsuzaki, F., Uda, S., Yamauchi, Y., Matsumoto, M., <strong><u>Soga, T.<\/u><\/strong>, Maehara, K., Ohkawa, Y., Nakayama, K., Kuroda, S., Kubota, H., \u201cAn extensive and dynamic trans-omic network illustrating prominent regulatory mechanisms in response to insulin in the liver\u201d <strong><em>Cell Rep. <\/em><\/strong>36, 109569, 2021.<br \/>\n[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34433063\/\">PubMed<\/a>]<\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Kozawa, K., Sekai, M., Ohba, K., Ito, S., Sako, H., Maruyama, T., Kakeno, M., Shirai, T., Kuromiya, K., Kamasaki, T., Kohashi, K., Tanaka, S., Ishikawa, S., Sato, N., Asano, S., Suzuki, H., Tanimura, N., Mukai, Y., Gotoh, N., Tanino, M., Tanaka, S., Natsuga, K., <strong><u>Soga, T.<\/u><\/strong>, Nakamura, T., Yabuta, Y., Saitou, M., Ito, T., Matsuura, K., Tsunoda, M., Kikumori, T., Iida, T., Mizutani,Y., Miyai, Y., Kaibuchi, K., Enomoto, A., Fujita, Y., \"The CD44\/COL17A1 pathway promotes the formation of multilayered, transformed epithelia\" <strong><em>Curr. Biol. <\/em><\/strong>31, 3086-3097.e7, 2021.<br \/>\n[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34087104\/\">PubMed<\/a>]<\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Nakasuka, F., Tabata, S., Sakamoto, T., Hirayama, A., Ebi, H., Yamada, T., Umetsu, K., Ohishi, M., Ueno, A., Goto, H., Sugimoto, M., Nishioka, Y., Yamada, Y., Tomita, M., Sasaki, A.T. Yano, S., <strong><u>Soga, T.<\/u><\/strong>, \u201cTGF-\u03b2-dependent reprogramming of amino acid metabolism induces epithelial-mesenchymal transition in non-small cell lung cancers\u201d <strong><em>Commun Biol<\/em><\/strong>. 4, 782, 2021.<br \/>\n[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34168290\/\">PubMed<\/a>]<\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Nishida, H., Okada, M., Yang, L., Takano, T., Tabata, S., <strong><u>Soga, T.<\/u><\/strong>, Ho, D.M., Chung, J., Minami, Y., Yoo, S.K., \"Methionine restriction breaks obligatory coupling of cell proliferation and death by an oncogene Src in Drosophila\" <strong><em>ELife<\/em><\/strong> 10, e59809, 2021.<br \/>\n[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33902813\/\">PubMed<\/a>]<\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Matsuo, T., Isosaka, T., Tang, L., <strong><u>Soga, T.<\/u><\/strong>, Kobayakawa, R., Kobayakawa, K., \u201cArtificial hibernation\/life-protective state induced by thiazoline-related innate fear odors\u201d <strong><em>Commun. 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Chem.<\/em> <\/strong>61, 215-222, 2014.<br \/>\n<a href=\"http:\/\/www.sciencedirect.com\/science\/article\/pii\/S0165993614001265\">[Publisher]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Cheng, K., Lee, B., Masuda, T., Ito, T., Ikeda, K., Hirayama, A., Deng, L., Dong, J., Shimizu, K., <span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, Tomita, M., Palsson, B. O., Robert, M., \u201cGlobal metabolic network reorganization by adaptive mutations allows fast growth of <em>Escherichia coli<\/em> on glycerol\u201d <strong><em>Nat. Commun.<\/em> <\/strong>5, 3233, 2014.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?db=PubMed&amp;cmd=search&amp;term=24481126\" rel=\"nofollow\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Obata, F., Kuranaga, E., Tomioka, K., Ming M., Takeishi, A., Chen, C., <span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, Miura, M., \u201cNecrosis-driven systemic immune response alters SAM metabolism through the FOXO-GNMT axis\u201d <strong><em>Cell Rep.<\/em> <\/strong>7, 821-833, 2014.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?db=PubMed&amp;cmd=search&amp;term=24746817\" rel=\"nofollow\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Adam, J., Yang, M., Bauerschmidt, C., Kitagawa, M., O\u2019Flaherty, L., Maheswaran, P., O\u00a8 zkan, G., Sahgal, N., Baban, D., Kato, K., Saito, K., Iino, K., Igarashi, K., Stratford, M., Pugh, C., Tenant, D., Ludwig, C., Davies, B., Ratcliffe, P. J., El-Bahrawy, M., Ashrafian, H., <span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>,\u00a0 Pollard, P. J., \u201cA Role for Cytosolic Fumarate Hydratase in Urea Cycle Metabolism and Renal Neoplasia\u201d <strong><em>Cell Rep.<\/em> <\/strong>3, 1440-1448, 2013.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?db=PubMed&amp;cmd=search&amp;term=23643539\" rel=\"nofollow\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Ternette N., Yang M., Laroyia M., Kitagawa M., O'Flaherty L., Wolhulter K., Igarashi K., Saito K., Kato K., Fischer R., Berquand A., Kessler B.M., Lappin T., Frizzell N., <span style=\"text-decoration: underline;\"><strong>Soga T.<\/strong><\/span>, Adam J, Pollard P.J., \u201cInhibition of Mitochondrial Aconitase by Succination in Fumarate Hydratase Deficiency\u201d, <strong><em>Cell Rep.<\/em> 3<\/strong>, 689-700. 2013.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?db=PubMed&amp;cmd=search&amp;term=23499446\" rel=\"nofollow\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Takubo, K., Nagamatsu, G., Kobayashi, C. I, Nakamura-Ishizu, A., Kobayashi, H., Ikeda, E., Goda, N., Johnson, R. S, Rahimi, Y., <span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, Hirao, A., Suematsu, M., Suda, T., \u201cRegulation of Glycolysis by Pdk Functions as a Metabolic Checkpoint for Cell Cycle Quiescence in Hematopoietic Stem Cells\u201d <strong><em>Cell Stem Cell<\/em><\/strong> 12, 49-61, 2013.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?db=PubMed&amp;cmd=search&amp;term=23290136\" rel=\"nofollow\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Yang, M., <span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, Pollard, P. J., \u201cOncometabolites: Linking Altered Metabolism with Cancer ? <strong>\u201d <em>J. Clin. Invest.<\/em> <\/strong>123, 3652-3658, 2013.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?db=PubMed&amp;cmd=search&amp;term=23999438\" rel=\"nofollow\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Hoshi, T., Tadokoro, Y., Naka, K., Ooshio, T., Muraguchi, T., Sugiyama, N., <span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, Araki, K., Yamamura, K., Hirao, A., \"mTORC1 is Essential for Leukemia propagation but Not Stem Cell Self-renewal\"<strong> <em>J. Clin. Invest.<\/em><\/strong> 122, 2114-2129, 2012.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?db=PubMed&amp;cmd=search&amp;term=22622041\" rel=\"nofollow\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Kasukawa, T., Sugimoto, M., Hida, A., Minami, Y., Mori, M., Honma, S., Honma, K., Mishima, K., <span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, Ueda, H.R. \"Human blood metabolite timetable indicates internal body time\" <strong><em>Proc. Natl. Acad. Sci. USA<\/em><\/strong> 109, 15036-1504, 2012.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?db=PubMed&amp;cmd=search&amp;term=22927403\" rel=\"nofollow\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Hirayama, A., Tomita, M., <span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, \u201cSheathless capillary electrophoresis-mass spectrometry with a high-sensitivity porous sprayer for cationic metabolome analysis\u201d <strong><em>Analyst<\/em> <\/strong>137, 5026-5033, 2012.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?db=PubMed&amp;cmd=search&amp;term=23000847\" rel=\"nofollow\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Sugimoto, M., Ikeda, S., Niigata, K., Tomita, M., Sato, H., <strong><u>Soga, T.<\/u><\/strong> \u201cMMMDB: Mouse Multiple Tissue Metabolome Database\u201d <strong><em>Nucl. Acids Res.<\/em><\/strong> <strong>40<\/strong> (D1): D809-D814. 2012.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22139941\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li><span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, Sugimoto, M., Honma, M., Mori, M., Igarashi, K., Kashikura, K., Ikeda, S., Hirayama, A., Yamamoto, T., Yoshida, H., Otsuka, M., Tsuji, S., Yatomi, Y., Sakuragawa, T., Watanabe, H., Nihei, K., Saito, T., Kawata, S., Suzuki, H., Tomita, M., Suematsu, M., \u201cSerum Metabolomics Reveals \u03b3-glutamyl Dipeptides as Biomarkers for discrimination among Different Forms of Liver Disease\u201d <strong> <em>J. Hepatol.<\/em><\/strong> 55, 896-905, 2011.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?db=PubMed&amp;cmd=search&amp;term=21334394\" rel=\"nofollow\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Adam, J., Hatipoglu, E., O\u2019Flaherty, L., Ternette, N., Sahgal, N., Lockstone, H., Baban D., Nye, E., Stamp, G.W., Wolhuter, K., Stevens, M., Fischer, R., Carmeliet, P., Maxwell, P.H., Pugh, C.W., Frizzell, N.,<span style=\"text-decoration: underline;\"><strong> Soga, T.<\/strong><\/span>, Kessler, B.M., El-Bahrawy, M., Ratcliffe, P.J., Pollard, P.J. \u201cRenal Cyst Formation in Fh1-Deficient Mice Is Independent of the Hif\/Phd Pathway: Roles for Fumarate in KEAP1 Succination and Nrf2 Signaling\u201d <strong><em>Cancer Cell<\/em> <\/strong>20, 524-537, 2011.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?db=PubMed&amp;cmd=search&amp;term=22014577\" rel=\"nofollow\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Fujiwara, K., Ishihama, Y., Nakahigashi, K.,<span style=\"text-decoration: underline;\"><strong> Soga, T.<\/strong><\/span>, Taguchi, H., \u201dA Systematic Survey of <em>in vivo<\/em> Obligate Shaperonin-dependent Substrates\u201d<strong> <em>EMBO J.<\/em> <\/strong>29, 1552-1564, 2010.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/sites\/entrez?db=pubmed&amp;cmd=search&amp;term=20360681\" rel=\"nofollow\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Kitagawa, M., Ikeda, S., Tashiro, E., <span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, Imoto, M., \u201cMetabolomic Identification of the Target of the Filopodia Protrusion Iinhibitor Glucopiericidin A\u201d<strong> <em>Chem. Biol.<\/em> <\/strong>17, 989-998, 2010.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/sites\/entrez?db=pubmed&amp;cmd=search&amp;term=20851348\" rel=\"nofollow\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Minami, Y., Kasukawa, T., Kakazu, Y., Iigo, M., Sugimoto, M., Ikeda, S., Yasui, A., van der Horst, G., <span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, Ueda, H., \u201dMeasurement of Internal Body Time by Blood Metabolomics\u201d <strong><em>Proc. Natl. Acad. Sci. USA<\/em> <\/strong>106, 9890-9895, 2009.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/sites\/entrez?db=pubmed&amp;cmd=search&amp;term=19487679\" rel=\"nofollow\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Hirayama, A., Kami, K., Sugimoto, M., Sugawara, M., Toki, N., Onozuka, H., Kinoshita, T., Saito, N., Ochiai, A., Tomita, M., Esumi, H., <span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, \"Quantitative Metabolome Profiling of Colon and Stomach Cancer Microenvironment by Capillary Electrophoresis Time-of-flight Mass Spectrometry\", <strong><em>Cancer Res.<\/em><\/strong> 69, 4918-4925, 2009.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/sites\/entrez?db=pubmed&amp;cmd=search&amp;term=19458066\" rel=\"nofollow\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li><span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, Igarashi, K., Itoh, C., Mizobuchi, K., Zimmermann, H., Tomita, M.,\u201dMetabolomic Profiling of Anionic Metabolites by Capillary Electrophoresis Mass Spectrometry\u201d <strong><em>Anal. Chem.<\/em> <\/strong>81, 6165-6174, 2009.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/sites\/entrez?db=pubmed&amp;cmd=search&amp;term=19522513\" rel=\"nofollow\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>\u2020Ishii, N., \u2020Nakahigashi, K., \u2020Baba, T., \u2020Robert, M., \u2020<strong><u>Soga, T.,<\/u><\/strong> \u2020Kanai, A., \u2020Hirasawa, T., Naba, M., Hirai, K., Hoque, A., Ho, P.Y., Kakazu, Y., Sugawara, K., Igarashi, S.,Harada, S., Masuda, T., Sugiyama, N., Togashi, T., Hasegawa, M., Takai, Y., Yugi, K., Arakawa, K., Iwata, N., Toya, Y., Nakayama, Y., Nishioka, T., Shimizu, K., Mori, H., Tomita, M.,\u201dMultiple High-throughput Analyses Monitor the Response of E. coli to Perturbations\u201d, <strong><em>Science<\/em><\/strong> \u00a0<strong>316<\/strong>, 593-597, 2007.(\u2020equally contribution)<br \/>\n<a href=\"http:\/\/www.sciencemag.org\/cgi\/content\/abstract\/1132067\" rel=\"nofollow\">[Science]<\/a> <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?db=pubmed&amp;cmd=search&amp;term=17379776\" rel=\"nofollow\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li><span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, Baran, R., Suematsu M., Ueno, Y., Ikeda, S., Sakurakawa T., Kakazu, Y., Ishikawa, T., Robert, M., Nishioka, T., Tomita, M., \u201cDifferential Metabolomics Reveals Ophthalmic Acid As An Oxidative Stress Biomarker Indicating Hepatic Glutathione Consumption\u201d,<strong> <em>J. Biol. Chem.<\/em> <\/strong>281, 16768-76, 2006.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?db=PubMed&amp;cmd=search&amp;term=16608839\" rel=\"nofollow\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li><span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, Ohashi, Y., Ueno, Y., Naraoka, H., Tomita, M., and Nishioka, T., \u201cQuantitative Metabolome Analysis Using Capillary Electrophoresis Mass Spectrometry\u201d, <strong><em>J. Proteome Res.<\/em> 2<\/strong>.\u3000488-494, 2003.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?db=PubMed&amp;cmd=search&amp;term=14582645\" rel=\"nofollow\"><span style=\"color: #0066cc;\">[PubMed]<\/span><\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li><span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, Ueno, Y., Naraoka, H., Ohashi, Y., Tomita, M., and Nishioka, T., \u201dSimultaneous Determination of Anionic Intermediates for Bacillus subtilis Metabolic Pathways by Capillary Electrophoresis Electrospray Ionization Mass Spectrometry\u201d,<strong> <em>Anal. Chem.<\/em> <\/strong>74, 2233-2239, 2002.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?db=PubMed&amp;cmd=search&amp;term=12038746\" rel=\"nofollow\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li><span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, and Heiger, D. N., \u201dAmino Acid Analysis by Capillary Electrophoresis Electrospray Ionization Mass Spectrometry\u201d, <strong><em>Anal. Chem.<\/em> <\/strong>72 1236-1241, 2000.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?db=PubMed&amp;cmd=search&amp;term=10740865\" rel=\"nofollow\">[PubMed]<\/a><\/li>\n<\/ul>\n<h2 id=\"y2026\">Publications<\/h2>\n<ul class=\"list2\">\n<li><strong>2026<\/strong><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Watanabe, H., Makinoshima, H., Kanauchi, N., Kabasawa, T., Suzuki, J., Takamori, S., Sasage, T., Abe, K., Hoshijima, K., Uchida, T., <strong><u>Soga, T.<\/u><\/strong>, Shiono, S., \"Elevated glucose metabolism via the hexosamine biosynthesis pathway: A metabolic signature of high-fluorodeoxyglucose-uptake lung adenocarcinoma\" <strong><em>Surg. Today, <\/em><\/strong>online, 2026.<br \/>\n[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41806212\/\">PubMed<\/a>]<\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Li, D., Morita, K., Kokaji, T., Hatano, A., Hirayama, A.,<strong><u> Soga, T.<\/u><\/strong>, Suzuki, Y., Matsumoto, M., Tsuchiya, T., Ozaki, H., Ohno, S., Inoue, H., Inaba, Y., Sugimoto, H., Pan, Y., Kuroda, S., \"Global loss of metabolic responsiveness and elevated enzyme in leptin deficient obese mice during starvation\" <strong><em>npj Syst. Biol. Appl.<\/em><\/strong>, online, 2026.<br \/>\n[<a href=\"https:\/\/www.nature.com\/articles\/s41540-026-00678-3\">Publisher<\/a>]<\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Kawano, G., Ikeda, R., Ishihara, D., Shima, T., Sakoda, T., Yamamoto, S., Kochi, Y., Semba, Y., Ashitani, S., Mori, Y., Kato K., Maeda, T., Miyamoto, T., <strong><u>Soga, T.<\/u><\/strong>, Akashi, K., Kikushige, Y., \"Guanine nucleotides drive ribosome biogenesis and glycolytic reprogramming in acute myeloid leukemia stem cells\", <strong><em>Blood <\/em><\/strong>147, 768-782, 2026.<br \/>\n[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41191529\/\">PubMed<\/a>]<\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Kubo, Y., Yamauchi, F., Goshima, N., Ohishi, M., Hasegawa, T., <strong><u>Soga, T.<\/u><\/strong>, Ikeda, M., Aoki, K., \u201cCross-sectional associations between CES-D scores and the salivary metabolome in nonclinical adults\u201d <strong><em>Discov. Ment. Heatlh, <\/em><\/strong>6,<strong><em> \u00a0<\/em><\/strong>15, 2026.<br \/>\n[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41518548\/\">PubMed<\/a>]<\/li>\n<\/ul>\n<h2 id=\"y2025\">Publications<\/h2>\n<ul class=\"list2\">\n<li><strong>2025<\/strong><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Mikawa, T., Kameda, M., Ikari, S., Shibata, E., Liu, S., Miyagawa, S., Ono, K., Ito, T., Yoshizawa, A., Sugimoto, M., Shibuya, S., Shimizu, T., Almunia, J., Ogiso, N., Rev\u00eachon, G., Palazzo, A., Bernard, D., Kanda, H., <strong><u>Soga, T.<\/u><\/strong>, Takubo, K., Morioka, S., Sasaki, J., Sasaki, T., Itamoto, A., Fujii, T., Seno, H., Inagaki, N., Kondoh, H., \u201cAbrogation of aberrant glycolytic interactions eliminates senescent cells and alleviates aging-related dysfunctions\u201d <strong><em>Signal Transduct. Target. The<\/em><\/strong><em>r<\/em>. 10, 402, 2025.<br \/>\n[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41392167\/\">PubMed<\/a>]<\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Miyake, A., Iida, M., Harada, S., Sugiyama, D., Matsumoto, M., Miyagawa, N., Toki, R., Edagawa, S., Hirata, A., Kuwabara, K., Okamura, T., Sato, A., Amano, K., Hirayama, A., Sugimoto, M., <strong><u>Soga, T.<\/u><\/strong>, Tomita, M., Arakawa, K., Kisu, I., Yamagami, W., Takebayashi, T., \u201cLongitudinal study of plasma metabolites during menopause and their associations with later onset of metabolic syndrome\u201d <strong><em>J. Clin. Endocrinol. Metab., <\/em><\/strong>online, dgaf666, 2025..<br \/>\n[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41389027\/\">PubMed<\/a>]<\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Tabata, S., Fujimoto, I., <strong><u>Soga, T.<\/u><\/strong>, Makinoshima, H., \"Context-specific metabolic alterations in HPRT1 knockout cells within a 3D culture system\" <strong><em>Cancer Med. <\/em><\/strong>14, e71452, 2025.<br \/>\n[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41365579\/\">PubMed<\/a>]<\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Aoyama, K., Yamamura, R., Katsurada, T., Shimizu, T., Takahashi, D., Kondo, E., Iwasaki, N., Tamakoshi, A., <strong><u>Soga, T.<\/u><\/strong>, Fukuda, S., Sonoshita, M., Sakamoto, N., \u201cDecreased Fecal Nicotinamide and Increased Bacterial Nicotinamidase Gene Expression in Ulcerative Colitis Patients\u201d <strong><em>Inflamm. Bowel Dis. <\/em><\/strong>31, 2815-2825<strong><em>,<\/em><\/strong>\u00a02025.<br \/>\n[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40357746\/\">PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Sugimura, M., Maeda, K., Shibata, K., Seko, H., Kozaki, Y., Hirayama, A., <strong><u>Soga, T<\/u>.<\/strong>, Ozeki, T., Sato, Y., Kato, N., Kosugi, T., Kadomatsu, K., Maruyama, S., \u201cDysregulated Anaerobic Glycolysis in Podocytes is Relevant to the Progression of Focal Segmental Glomerulosclerosis\u201d <strong><em>Kidney Int. Rep<\/em>. <\/strong>10, 3239-3254, 2025.<br \/>\n[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40980659\/\">PubMed<\/a>]<\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Arai, K., Nishito, Y., Mizuno, H., Motoi, N., Hiraoka, N., Fuse, M., Arai, Y., Shibata, T., Sonobe, Y., Kayukawa, Y., Maruyama, T., Fukuda, H., Mizoguchi, Y., Aikawa, Y., Yoshida, Y., Watanabe, S., Sakamoto, H., Yamashita, M., Kitano, S., Nagata, Y., Mitsumori, R., Ozaki, K., Niida, S., Kanai, Y., Hirayama, A., <strong><u>Soga, T.<\/u><\/strong>, Yoshida, T., Yasuda, K., Ochiai, A., Tsunoda, H., *Aoki, K., \u201cEML4\u2013ALK Rearrangement Creates a Distinctive Myeloid Cell\u2013Dominant Immunosuppressive Microenvironment in Lung Cancer\u201d <strong><em>Cancer Immunol. Res.<\/em><\/strong> 13, 1435-1452, 2025.<br \/>\n[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40627846\/\">PubMed<\/a>]<\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Watanabe, S., Nakayama, M., Yokoo, T., Sanada, S., Ubara, Y., Komatsuda, A., Asanuma, K., Suzuki, Y., Konta, T., Kazama, J. J., Suzuki, T., Fukuda, S., <strong><u>Soga, T.<\/u><\/strong>, Yamada, T., Mizutani, S., Matsumoto, M., Naito, Y., Taguchi, K., Fukami, K., Kashiwagi, H., Kikuchi, K., Suzuki, C., Tokuno, H., Urasato, M., Kujirai, R., Matsumoto, Y., Akiyama, Y., Tomioka, Y., Itai, S., Tongu, Y., Mishima, E., Kawabe, C., Kasahara, T., Ogata, Y., Toyohara, T., Sato, T., Tanaka, T., Abe, T., LUBI-CKD TRIAL Investigators, \u201cLubiprostone in chronic kidney disease: Insights into mitochondrial function and polyamines from a randomized phase 2 clinical trial\u201d<strong><em> Sci. Adv.<\/em><\/strong> 11, eadw3934, 2025.<br \/>\n[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40880481\/\">PubMed<\/a>]<\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Takase, H., Fujisawa, T., Hayashi, R., Makinoshima, H., Suzuki, Y., Soga, T., Fujii, S., \u201c2,3-Pyridinedicarboxylate Is Associated with Shorter Recurrence-Free Survival in Patients with Hypopharyngeal Squamous Cell Carcinoma\u201d <strong><em>Pathobiology<\/em><\/strong>, online, 2025.<br \/>\n[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40875696\/\">PubMed<\/a>]<\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Yang, C., Arai, M., Fuji Ariyanto, E., Zhang, J., Mirani Lubis D., Ito, R., Xie, S., Nitta, M., Kawashima, F., Ishitsuka, T., Yang, C., Suzuki, T., Komatsu, T., Sagae, H., Jin, H., Takahashi, H., Kobayashi, E., Wei, Y., Liu, B., Choi, H., Wada, Y., Tanaka T., Osawa, T., Kimura, H., Kodama, T., Aburatani, H., Tachibana, M., Shinkai, Y., Inagaki, T., <strong><u>Soga, T.<\/u><\/strong>,\u00a0 Osbome, T.F., Yoneshiro, T., Matsumura, Y., Sakai, J., \u201cGlucose-activated JMJD1A drives visceral adipogenesis via \u03b1-ketoglutarate-dependent chromatin remodeling\u201d <strong><em>Cell Rep. <\/em><\/strong>44, 116060, 2025.<br \/>\n[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40720241\/\">PubMed<\/a>]<\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Tongu, Y., Kasahara, T., Matsuhashi, T., Oikawa, Y., Akimoto, R., Luo, Y., Sekine, S., Suzuki, M., Kashiwagi, H., Kanno, S., Tanaka, Y., Sato, K., Okubo, Y., Muto, A., Tokuno, H., Suzuki, C., Kawabe, C., Ishikawa, T., Watanabe, S., Kikuchi, K., Itai, S., Sato, T., Suzuki, T., Igarashi, K., Fukuda, S., <strong><u>Soga, T.<\/u><\/strong>, Murayama, K., Kuranaga, E., Toyohara, T., Abe, T., \u201cMitochondria-Homing Drug Mitochonic Acid 5 Improves Barth Syndrome Myopathy in a Human-Induced Pluripotent Stem Cell Model and Barth Syndrome Drosophila Model\u201d <strong><em>FASEB J.<\/em><\/strong> 39, e70739, 2025.<br \/>\n[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40542649\/\">PubMed<\/a>]<\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Pickard, J., Porwollik, S., Caballero-Flores, G., Caruso, R., Fukuda, S., <strong><u>Soga, T.<\/u><\/strong>, Inohara, N., McClelland, M., Nunez, G., \"Dietary amino acids regulate Salmonella colonization via microbiota-dependent mechanisms in the mouse gut\" <strong><em>Nat. 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Renal Physiol.<\/em><\/strong> 323, F654-F665, 2022.<br \/>\n[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36173728\/\">PubMed<\/a>]<\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Hoshii, T., Perlee, S., Kikuchi, S., Rahmutulla, B, Fukuyo, M., Masuda, T., Ohtsuki, S., <strong><u>Soga, T.<\/u><\/strong>, Nabet, B., Kaneda, A., \"SETD1A regulates transcriptional pause release of heme biosynthesis genes in leukemia\" <strong><em>Cell Rep. <\/em><\/strong>41, 111727, 2022.<br \/>\n[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36450243\/\">PubMed<\/a>]<\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Imajo, M., Norikane, T., Yamamoto, Y., Maeda, Y., Saitoh, K., Kato, K., <strong><u>Soga, T.<\/u><\/strong>, Okano, K., Nishiyama, Y., \"Relationship between [18 F]FDG PET\/CT and metabolomics in patients with colorectal cancer\" <strong><em>Metabolomics <\/em><\/strong>18, 91, 2022.<br \/>\n[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36367606\/\">PubMed<\/a>]<\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Kudo, R., Igarashi, K., <strong><u>Soga, T.<\/u><\/strong>, Ishikawa, T., Saito, Y., \"Comprehensive metabolome analysis of intracellular metabolites in cultured cells\" <strong><em>STAR Protoc.<\/em><\/strong> 3, 101531, 2022.<br \/>\n[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35819883\/\">PubMed<\/a>]<\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Yoshida, Y., Zheng, T., Tanabe, W., Tomoike, F., Hashiya, F., Suzuki, T., Hirota, S., Saiki, Y., Horii, A., Hirayama, A., <strong><u>Soga, T.<\/u><\/strong>, Kimura, Y., Abe, H., \u201cDevelopment of Fluorophosphoramidate as a Biocompatibly Transformable Functional Group and its Application as a Phosphate Prodrug for Nucleoside Analogs\u201d <strong><em>ChemMedChem<\/em><\/strong>. 17, e202200188, 2022.<br \/>\n[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35393747\/\">PubMed<\/a>]<\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Yoshida, Y., Shimizu, I., Shimada, A., Nakahara, K., Yanagisawa, S., Kubo, M., Fukuda, S., Ishii, C., Yamamoto, H., Ishikawa, T., Kano, K., Aoki, J., Katsuumi, G., Suda, M., Ozaki, K., Yoshida, Y., Okuda, S., Ohta, S., Okamoto, S., Minokoshi, Y., Oda, K., Sasaoka, T., Abe, M., Sakimura, K., Kubota, Y., Yoshimura, N., Kajimura, S., Zuriaga, M., Walsh, K., <strong><u>Soga, T.<\/u><\/strong>, Minamino, T., \"Brown adipose tissue dysfunction promotes heart failure via a trimethylamine N-oxide-dependent mechanism\"<strong><em> Sci. Rep. <\/em><\/strong>12, 14883, 2022.<br \/>\n[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36050466\/\">PubMed<\/a>]<\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Kuwabara, H., Katsumata, K., Iwabuthi, A., Udo, R., Tago, T., Kasahara, K., Mazaki, J., Enomoto, M., Ishizaki, T., Soya, R., Kaneko, M., Ota, S., Enomoto, A., <strong><u>Soga, T.<\/u><\/strong>, Tomita, M., Sunamura, M., Tsuchida, A., Sugimoto, M., Nagakawa, Y., \u201cSalivary metabolomics with machine learning for colorectal cancer detection\u201d<strong><em> Cancer Sci.<\/em><\/strong> 113, 3234-3243, 2022.<br \/>\n[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35754317\/\">PubMed<\/a>]<\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Kokaji, T., Eto, M., Hatano, A., Yugi K., Morita, K., Ohno, S., Fujii, M., Hironaka, K., Ito, Y., Egami, R., Uematsu, S., Terakawa, A., Pan, Y., Maehara, H., Li, D., Bai, Y., Tsuchiya, T., Ozaki, H., Inoue, H., Kubota, H., Suzuki, Y., Hirayama, A., <strong><u>Soga, T<\/u><\/strong>., Kuroda, S., \u201cIn vivo transomic analyses of glucose-responsive metabolism in skeletal muscle reveal core differences between the healthy and obese states\u201d <strong><em>Sci. 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Commun.<\/em><\/strong>, 13, 3706, 2022.<br \/>\n[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35764642\/\">PubMed<\/a>]<\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Suzuki, Y., Hayasaka, R., Hasebe, M., Ikeda, S., <strong><u>Soga, T.<\/u><\/strong>, Tomita, M., Hirayama, A., Kuroda, H., \u201cComparative Metabolomics of Small Molecules Specifically Expressed in the Dorsal or Ventral Marginal Zones in Vertebrate Gastrula\u201d <strong><em>Metabolites<\/em><\/strong> 12, 566, 2022.<br \/>\n[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35736498\/\">PubMed<\/a>]<\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Kadonosono, T., Miyamoto, K., Sasaki, S., Matsuo, Y., Kitajima, S., Wang, Q., Endo, M., Nibori, M., Kuchimaru, T., <strong><u>Soga, T.<\/u><\/strong>, Hirota, K., Kizaka-Kondoh, S., \u201cAGE\/RAGE axis regulates reversible transition to quiescent states of ALK-rearranged NSCLC and pancreatic cancer cells in monolayer cultures\u201d <strong><em>Sci. 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Rep.<\/em><\/strong> 11, 589, 2021.<br \/>\n[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33436954\/\">PubMed<\/a>]<\/li>\n<\/ul>\n<ul class=\"list2\">\n<li><strong>2020<\/strong><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Ishikawa, S., Hiraka, T., Kirii, K., Sugimoto, M., Shimamoto, H., Sugano, A., Kitabatake, K., Toyoguchi, Y., Kanoto, M., Nemoto, K., <strong><u>Soga, T.<\/u><\/strong>, Tomita, M., Iino, M., \u201cRelationship between Standard Uptake Values of Positron Emission Tomography\/Computed Tomography and Salivary Metabolites in Oral Cancer: A Pilot Study\u201d<strong><em> J Clin. 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Rep. <\/em><\/strong>10, 19554, 2020.<br \/>\n[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33177599\/\">PubMed<\/a>]<\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Ozawa, H., Hirayama, A., Shoji F., Maruyama, M., Suzuki, K., Yamanaka-Okumura, H., Tatano, H., Morine, Y., <strong><u>Soga, T.<\/u><\/strong>, Shimada, M., Tomita M., \u201cComprehensive Dipeptide Analysis Revealed Cancer-Specific Profile in the Liver of Patients with Hepatocellular Carcinoma and Hepatitis\u201d <strong><em>Metabolites<\/em><\/strong> 10, 442, 2020.<br \/>\n[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33139606\/\">PubMed<\/a>]<\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Hoshino, D., Kawata, K., Kunida, K., Hatano, A., Yugi, K., Wada, T., Fujii, M., Sano, T., Ito, Y., Furuichi, Y., Manabe, Y., Suzuki, Y., Fujii, N.L., <strong><u>Soga, T.<\/u><\/strong>, Kuroda, S., \u201cTrans-omic Analysis Reveals ROS-Dependent Pentose Phosphate Pathway Activation after High-Frequency Electrical Stimulation in C2C12 Myotubes\u201d <strong><em>iScience<\/em><\/strong> 23, 101558, 2020.<br \/>\n[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33083727\/\">PubMed<\/a>]<\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Sugimoto, M., Ota, S., Kaneko, M., Enomoto, A., <strong><u>Soga, T.<\/u><\/strong>, \u201cQuantification of Salivary Charged Metabolites Using Capillary Electrophoresis Time-of-flight-mass Spectrometry\u201d <strong><em>Bio Protoc.<\/em><\/strong> 10, e3797, 2020.<br \/>\n[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33659451\/\">PubMed<\/a>]<\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Ogura, T., Wakayama, M., Ashino, Y., Kadowaki, R., Sato, M., <strong><u>Soga, T.<\/u><\/strong>, Tomita, M., \u201cEffects of feed crops and boiling on chicken egg yolk and white determined by a metabolome analysis\u201d <strong><em>Food Chem<\/em><\/strong>. 327, 127077,\u00a0 2020.<br \/>\n[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32485660\/\">PubMed<\/a>]<\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Hayashi, Y., Mori, M., Igarashi, K., Tanaka, K., Takehara, A., Ito-Matsuoka, Y., Kanai, A., Yaegashi, N., <strong><u>Soga, T.<\/u><\/strong>, Matsui, Y., \u201cProteomic and metabolomic analyses uncover sex-specific regulatory pathways in mouse fetal germline differentiation\u201d <strong><em>Biol. Reprod<\/em><\/strong>. 103, 717-735, 2020.<br \/>\n[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32627815\/\">PubMed<\/a>]<\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Ohno, S., Quek, L.E., Krycer, J.R., Yugi, K., Hirayama, A., Ikeda, S., Shoji, F., Suzuki, K., <strong><u>Soga, T.<\/u><\/strong>, James, D.E., Kuroda, S., \u201cKinetic Trans-omic Analysis Reveals Key Regulatory Mechanisms for Insulin-Regulated Glucose Metabolism in Adipocytes\u201d <strong><em>iScience<\/em><\/strong> 23, 101479, 2020.<br \/>\n[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32891058\/\">PubMed<\/a>]<\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Krycer, J.R., Quek, L-E., Francis, D., Zadoorian, A., Weiss, F.C., Cooke, K.C., Nelson, M.E., Diaz-Vegas, A., Humphrey, S.J., Scalzo, R., Hirayama, A., Ikeda, S., Shoji, F., Suzuki, K. Huynh, K., Giles, Co., Varney, B., Nagarajan, S.R., Hoy, A.J., <strong><u>Soga, T.<\/u><\/strong>, Meikle, P.J., Cooney, G.J., Fazakerley D.J., James, D.E., \"Insulin signalling requires glucose to promote lipid anabolism in adipocytes\" <strong><em>J. Biol. Chem.<\/em><\/strong> 295, 13250-13266, 2020.<br \/>\n[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32723868\/\">PubMed<\/a>]<\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Kikuchi, N., <strong><u>Soga, T.<\/u><\/strong>, Nomura, M., Sato, T., Sakamoto, Y., Tanaka, R., Abe, J., Morita, M., Shima, H., Okada, Y., Tanuma, N., \u201cComparison of the ischemic and non-ischemic lung cancer metabolome reveals hyper activity of the TCA cycle and autophagy\u201d <strong><em>Biochem. Biophys. Res. 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Chem.<\/em><\/strong> 92, 9799-9806, 2020.<br \/>\n[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32538620\/\">PubMed<\/a>]<\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Hirayama, A., Tabata, S., Kudo, R., Hasebe, M., Suzuki, K., Tomita, M., <strong><u>Soga, T.<\/u><\/strong>, \u201cThe use of a double coaxial electrospray ionization sprayer improves the peak resolutions of anionic metabolites in capillary ion chromatography-mass spectrometry\u201d<em><strong> J. Chromatogr. A<\/strong><\/em>\u00a01619, 460914,\u00a0 2020.<br \/>\n[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32008820\/\">PubMed<\/a>]<\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Seong, K.H., Ly, N.H., Katou, Y., Yokota, N., Nakato, R., Murakami, S., Hirayama, A., Fukuda, S., Kang, S., <strong><u>Soga, T.<\/u><\/strong>, Shirahige, K., Ishii, S., \u201cPaternal restraint stress affects offspring metabolism via ATF-2 dependent mechanisms in Drosophila melanogaster germ cells\u201d <em><strong>Commun. Biol. <\/strong><\/em>3, 208, 2020.<br \/>\n[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32367035\/\">PubMed<\/a>]<\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Hamid, SS., Wakayama, M., Ashino, Y., Kadowaki, R., <strong><u>Soga, T.<\/u><\/strong>, Tomita, M., \u201cEffect of blanching on the concentration of metabolites in two parts of Undaria pinnatifida, Wakame (leaf) and Mekabu (sporophyll)\u201d <em><strong>Algal Res.<\/strong><\/em>\u00a047, 101829, 2020.<br \/>\n[<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2211926419305892\">Publisher<\/a>]<\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Tadokoro, H., Hirayama, A., Kudo, R., Hasebe, M., Yoshioka, Y., Matsuzaki, J., Yamamoto, Y., Sugimoto, M., <strong><u>Soga, T.<\/u><\/strong>, Ochiya, T., \u201cAdenosine leakage from perforin-burst extracellular vesicles inhibits perforin secretion by cytotoxic T-lymphocytes\u201d <em><strong>PLoS One<\/strong><\/em>\u00a015, e0231430, 2020.<br \/>\n[<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/32275689\">PubMed<\/a>]<\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Sugimoto, M., Sugawara, T., Obiya, S., Enomoto, A., Kaneko, M., Ota, S., <strong><u>Soga, T.<\/u><\/strong>, Tomita, M., \u201cSensory properties and metabolomic profiles of dry-cured ham during the ripening process\u201d <em><strong>Food Res Int.<\/strong> <\/em>129, 108850, 2020.<br \/>\n[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32036920\/\">PubMed<\/a>]<\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Quek, L.E., Krycer, J.R., Ohno, S., Yugi, K., Fazakerley, D.J., Scalzo, R., Elkington, S.D., Dai, Z., Hirayama, A., Ikeda, S., Shoji, F., Suzuki, K., Locasale, J.W., <strong><u>Soga, T.<\/u><\/strong>, James, D.E., *Kuroda, S., \u201cDynamic 13C Flux Analysis Captures the Reorganization of Adipocyte Glucose Metabolism in Response to Insulin\u201d<em><strong> iScience<\/strong><\/em>\u00a023, 100855, 2020..<br \/>\n[<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/32058966\">PubMed<\/a>]<\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Endoh, M., Baba, M., Endoh, T., Hirayama, A., Nakamura-Ishizu, A., Umemoto, T., Hashimoto, M., Nagashima, K., <strong><u>Soga, T.<\/u><\/strong>, Lang, M., Schmidt, L.S., Linehan, W.M., Suda, T., \u201cA FLCN-TFE3 Feedback Loop Prevents Excessive Glycogenesis and Phagocyte Activation by Regulating Lysosome Activity\u201d <em><strong>Cell Rep.<\/strong> <\/em>30, 1823-1834.e5, 2020.<br \/>\n[<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/32049013\">PubMed<\/a>]<\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Nanto-Hara F., Kanemitsu Y., Fukuda S., Kikuchi K., Asaji K., Saigusa D., Iwasaki T., Ho H.J., Mishima E., Suzuki T., Suzuki C., Tsukimi T., Matsuhashi T., Oikawa Y., Akiyama Y., Kure S., Owada Y., Tomioka Y., <strong><u>Soga, T.<\/u><\/strong>, Ito S., Abe T., \u201cThe guanylate cyclase C agonist linaclotide ameliorates the gut-cardio-renal axis in an adenine-induced mouse model of chronic kidney disease.\u201d <em><strong>Nephrol. Dial. Transplant.<\/strong><\/em> 35, 250-264, 2020.<br \/>\n[<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/31411705\">PubMed<\/a>]<\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Krycer, J.R., Quek, L.E., Francis, D.J., Fazakerley, S.D., Elkington, S., Diaz-Vegas, A., Cooke, K.C., Weiss, F.C., Duan, X., Kurdyukov, S., Zhou, P.X., Tambar, U.K., Hirayama, A., Ikeda, S., Kamei, Y., <strong><u>Soga, T.<\/u><\/strong>, Cooney, G.J., James, D.E., \u201cLactate production is a prioritized feature of adipocyte metabolism\u201d<em><strong> J Biol Chem.<\/strong><\/em>\u00a0295, 83-98, 2020.<br \/>\n[<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/31690627\">PubMed<\/a>]<\/li>\n<\/ul>\n<ul class=\"list2\">\n<li id=\"y2019\">McCarthy, MT., Lin, D., <strong><u>Soga, T.<\/u><\/strong>, Adam, J., O'Callaghan, CA., \u201cInosine pranobex enhances human NK cell cytotoxicity by inducing metabolic activation and NKG2D ligand expression\u201d <b><i>Eur. J. Immunol.<\/i><\/b> 50, 130-137, 2020.<br \/>\n[<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/31434164\">PubMed<\/a>]<\/li>\n<\/ul>\n<ul class=\"list2\">\n<li><strong>2019<\/strong><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Suzuki, A., Onodera, K., Matsui, K., Seki, M., Esumi, H., <strong><u>Soga, T.<\/u><\/strong>, Sugano, S., Kohno, T., Suzuki, Y., Tsuchihara, K., \u201cCharacterization of cancer omics and drug perturbations in panels of lung cancer cells\u201d <strong><em>Sci Rep.<\/em><\/strong> 9, 19529, 2019.<br \/>\n[<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/31863083\">PubMed<\/a>]<\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Annan, DA., Maishi, N., <strong><u>Soga, T.<\/u><\/strong>, Dawood, R. Li, C., Kikuchi, H., Hojo, T., Morimoto, M., Kitamura, T., Alam, MT., Minowa, K., Shinohara, N., Nam, JM., Hida, Y., Hida, K., \"Carbonic anhydrase 2 (CAII) supports tumor blood endothelial cell survival under lactic acidosis in the tumor microenvironment\"<em><strong> Cell Commun. Signal.<\/strong><\/em> 17, 169, 2019.<br \/>\n[<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/31847904\">PubMed<\/a>]<\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Fujiwara, H., Tateishi, K., Misumi, K., Hayashi, A., Igarashi, K, Kato, H., Nakatsuka, T., Suzuki, N., Yamamoto, K., Kudo, Y., Hayakawa, Y., Nakagawa, H., Tanaka, Y., Ijichi, H., Kogure, H, Nakai, Y, Isayama, H., Hasegawa, K., Fukayama, M., <strong><u>Soga, T.<\/u><\/strong>, Koike, K., \u201cMutant IDH1 confers resistance to energy stress in normal biliary cells through PFKP-induced aerobic glycolysis and AMPK activation\u201d <em><strong>Sci. Rep.<\/strong><\/em> 9, 18859, 2019.<br \/>\n[<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/31827136\">PubMed<\/a>]<\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Osada-Oka, M., Goda, N., Saiga, H., Yamamoto, M., Takeda, K., Ozeki, Y., Yamagchi, T., <strong><u>Soga, T.<\/u><\/strong>, Tateishi, Y., Miura, K., Okuzaki, D., Kobayashi, K., Matsumoto, S., \u201cMetabolic adaptation to glycolysis is a basic defense mechanism of macrophages for <em>Mycobacterium tuberculosis<\/em> infection\u201d <b><i>Int. Immunol.<\/i><\/b> 31, 781-793, 2019.<br \/>\n[<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/31201418\">PubMed<\/a>]<\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Harada-Shoji, N., <strong><u>Soga, T.<\/u><\/strong>, Tada, H., Miyashita, M., Harada, M., Watanabe, G., Hamanaka, Y., Sato, A., Suzuki, T., Suzuki, A., Ishida, T. \u201cA metabolic profile of routine needle biopsies identified tumor type specific metabolic signatures for breast cancer stratification: a pilot study\u201d <strong><em>Metabolomics. <\/em><\/strong>15, 147, 2019.<br \/>\n[<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/31686242\">PubMed<\/a>]<\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Louphrasitthiphol P., Ledaki I., Chauhan J., Falletta P., Siddaway R., Buffa FM., Mole DR., <strong><u>Soga T.<\/u><\/strong>, Goding CR., \u201cMITF controls the TCA cycle to modulate the melanoma hypoxia response\u201d <strong><em>Pigment. Cell Melanoma. Res. <\/em><\/strong>32, 792-808, 2019.<br \/>\n[<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/31207090\">PubMed<\/a>]<\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Fukushima, K., Harada, S., Takeuchi, A., Kurihara, A., Iida, M., Fukai, K., Kuwabara, K., Kato, S., Matsumoto, M., Hirata, A., Akiyama, M., Tomita, M., Hirayama, A., Sato, A., Suzuki, C., Sugimoto, M.,<strong> <u>Soga, T.<\/u>,<\/strong> Sugiyama, D., Takebayashi, T., \u201cAssociation between dyslipidemia and plasma levels of branched-chain amino acids in the Japanese population without diabetes mellitus\u201d <strong><em>J. Clini. 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Z., Scheele, C., <strong><u>Soga,<\/u><\/strong> <strong><u>T.<\/u><\/strong>, Minamino, T., \"Gamma-aminobutyric acid signaling in brown adipose tissue promotes systemic metabolic derangement in obesity\" <strong><em>Cell Rep. <\/em><\/strong>24, 2827-2837, 2018.<br \/>\n[<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30208310\">PubMed<\/a>]<\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Tomita, A., Mori, M., Hiwatari, K., Yamaguchi, E., Itoi, T., Sunamura, M., <strong><u>Soga, T.<\/u><\/strong>, Tomita, M., Sugimoto, M., \u201cEffect of storage conditions on salivary polyamines quantified via liquid chromatography-mass spectrometry\u201d <strong><em>Sci. Rep. <\/em><\/strong>8, 12075, 2018.<br \/>\n[<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30104641\">PubMed<\/a>]<\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Doke, T., Ishimoto, T., Hayasaki, T., Ikeda, S., Hasebe, M., Hirayama, A., <strong><u>Soga, T.<\/u><\/strong>,\u00a0 Kato, N., Kosugi, T., Tsuboi, N., Lanaspa, MA., Johnson, RJ., Kadomatsu, K.,\u00a0 Maruyama, S., \u201cLacking ketohexokinase-A exacerbates renal injury in streptozotocin-induced diabetic mice\u201d <strong><em>Metabolism<\/em><\/strong>. 85, 161-170, 2018.<br \/>\n[<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29604362\">PubMed<\/a>]<\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Nishizawa, S., Araki, H., Ishikawa, Y., Kitazawa, S., Hata, A., <strong><u>Soga, T.<\/u><\/strong>, Hara, T. \u201cLow tumor glutathione level as a sensitivity marker for glutamate-cysteine ligase inhibitors\u201d<em><strong> Oncol. Lett.<\/strong> <\/em>15, 8735-8743, 2018.<br \/>\n[<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29928324\">PubMed<\/a>]<\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Hirayama, A., Abe, H., Yamaguchi, N., Tabata, S., Tomita, T., <strong><u>Soga, T.<\/u><\/strong>, \u201cDevelopment of a sheathless CE\u2010ESI\u2010MS interface\u201d <strong><em>Electrophoresis <\/em><\/strong>39, 1382-1389, 2018.<br \/>\n[<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29493797\">PubMed<\/a>]<\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Saito, Y., Morine Y., Iwahashi, S., Ikemoto, T., Imura, S., Yamanaka-Okumura, H., Hirayama, A., <strong><u>Soga, T.<\/u><\/strong>, Tomita, M., Shimada, M., \u201cChanges of Liver Metabolites following Hepatectomy with Ischemia Reperfusion towards Liver Regeneration\u201d <strong><em>Ann. Gastroenterol. Surg. <\/em><\/strong>2, 204-211, 2018.<br \/>\n[<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29863192\">PubMed<\/a>]<\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Tabata, S., Yamamoto, M., Goto, H., Hirayama, A., Ohishi, M., Kuramoto, T., Mitsuhashi, A., Ikeda, R., Haraguchi, M., Kawahara, K., Shinsato, Y., , Minami, K., Saijo, A., Toyoda, Y., Hanibuchi, M., Nishioka, Y., Sone, S., Esumi, H., Tomita, M., <strong><u>Soga, T.<\/u><\/strong>, Furukawa, T., Akiyama, S., \u201cThymidine catabolism promotes NADPH oxidase-derived reactive oxygen species (ROS) signalling in KB and yumoto cells\u201d <strong><em>Sci. Rep. <\/em><\/strong>8, 6760, 2018.<br \/>\n[<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=29713062\">PubMed<\/a>]<\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>McCarthy, MT., Moncayo, G., Hiron, TK., Jakobsen, NA., Valli, A., <strong><u>Soga, T.<\/u><\/strong>, Adam, J., O'Callaghan, CA., \u201cPurine nucleotide metabolism regulates expression of the human immune ligand MICA\u201d<strong><em> J. Biol. Chem. <\/em><\/strong><em>293<\/em>,3913-3924, 2018.<br \/>\n[<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=29279329\">PubMed<\/a>]<\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Morita, M., Sato, T., Nomura, M., Sakamoto, Y., Inoue, Y., Tanaka, R., Ito, S., Kurosawa, K., Yamaguchi, K., Sugiura, Y., Takizaki, H., Yamashita, Y., Katakura, R., Sato, I., Kawai, M., Okada, Y., Watanabe, H., Kondoh, G., Matsumoto, S., Kishimoto, A., Obata, M., Matsumoto, M., Fukuhara, T., Motohashi, H., Suematsu, M., Komatsu, M., Nakayama, KI., Watanabe, T., <strong><u>Soga, T.<\/u><\/strong>, Shima, H., Maemondo, M., Tanuma. N., \u201cPkm1 confers metabolic advantages and promotes cell-autonomous tumor cell growth\u201d <strong><em>Cancer Cell <\/em><\/strong>33<strong><em>, <\/em><\/strong>355-367, 2018.<br \/>\n[<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29533781\">PubMed<\/a>]<\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Nakajima, T., Katsumata, K., Kuwabara, H., Soya, R., Enomoto, M., Ishizaki, T., Tsuchida, A., Mori, M., Hiwatari, K., <strong><u>Soga, T.<\/u><\/strong>, Tomita, M., Sugimoto, M., \"Urinary Polyamine Biomarker Panels with Machine-Learning Differentiated Colorectal Cancers, Benign Disease, and Healthy Controls\" <strong><em>Int. J. Mol. Sci. <\/em><\/strong>19, 756, 2018.<br \/>\n[<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29518931\">PubMed<\/a>]<\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Kim, S., Matsumoto, T., Kagawa, H., Nakamura, M., Hirohata, R., Ueno, A., Ohishi, M., Sakuma, T., <strong><u>Soga, T.<\/u><\/strong>, Yamamoto, T., Woltjen, K., \"Microhomology-assisted scarless genome editing in human iPSCs\" <strong><em>Nat. Commun. <\/em><\/strong>9, 939, 2018.<br \/>\n[<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29507284\">PubMed<\/a>]<\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Oshima, K., Saiki, N., Tanaka, M., Imamura, H. Niwa, A., Tanimura, A., Nagahashi;, A., Hirayama, A., Okita, K., Hotta, A., Kitayama, S., Osawa, M., Kaneko, S., Watanabe, A., Asaka, I., Fujibuchi W., Imai, K., Yabe, H., Kamachi, Y., Hara, J., Kojima, S., Tomita, M., <strong><u>Soga, T.<\/u><\/strong>, Noma, T., Nonoyama, S., Nakahata, T., Saito, M.K., \u201cHuman AK2 links intracellular bioenergetic redistribution to the fate of hematopoietic progenitors\u201d <strong><em>Biochem. Biophys. Res. Commun.<\/em><\/strong>, 497, 719-725, 2018.<br \/>\n[<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29462620\">PubMed<\/a>]<\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Asai, Y., Itoi, T., Sugimoto, M., Sofuni, A., Tsuchiya, T, Tanaka, R., Tonozuka, R., Honjo, M., Mukai, S., Fujita, M., Yamamoto, K., Matsunami, Y., Kurosawa, T., Nagakawa, Y., Kaneko, M., Ota, S., Kawachi, S., Shimazu, M., Soga, T., Tomita, M., Sunamura., M., \u201cElevated Polyamines in Saliva of Pancreatic Cancer\u201d <strong><em>Cancers (Basel).<\/em><\/strong>10<strong><em>,<\/em><\/strong> pii: E43, 2018.<br \/>\n[<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29401744\">PubMed<\/a>]<\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Maeshima, K., Matsuda, T., Shindo, Y., Imamura, H., Tamura, S., Imai, R., Kawakami, S., Nagashima, R., <strong><u>Soga, T.<\/u><\/strong>, Noji, H., Oka, K., Nagai, T., \u201cA Transient Rise in Free Mg2+ Ions Released from ATP-Mg Hydrolysis Contributes to Mitotic Chromosome Condensation\u201d <strong><em>Curr Biol <\/em><\/strong>28<strong><em>,<\/em><\/strong> 444-451, 2018.<br \/>\n[<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=29358072\">PubMed<\/a>]<\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Izuta, Y., Imada, T., Hisamura, R., Oonishi, E., Nakamura. S., Inagaki, E., Ito, M., <strong><u>Soga, T.<\/u><\/strong>, Tsubota, K., \u201cKetone body 3-hydroxybutyrate mimics calorie restriction via Nrf2 activator fumarate in retina\u201d <strong><em>Aging Cell <\/em><\/strong>17, e12699,\u00a0 2018.<br \/>\n[<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29119686\">PubMed<\/a>]<\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Nagata, Y., Hirayama, A., Ikeda, S., Shirahata, A., Shoji, F., Maruyama, M., Kayano, M., Bundo, M., Hattori, K., Yoshida, S., Goto, Y., Urakami, K., <strong><u>Soga, T.<\/u><\/strong>, Ozaki, K., Niida, S., \u201cComparative analysis of cerebrospinal fluid metabolites in Alzheimer\u2019s disease and idiopathic normal pressure hydrocephalus in a Japanese cohort\u201d <strong><em>Biomark. Res.<\/em><\/strong> 6, 5, 2018.<br \/>\n[<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29387418\">PubMed<\/a>]<\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Harada, S., Hirayama, A., Chan, Q., Kurihara, A., Fukai, K., Iida, M., Kato, S., Sugiyama, D., Kuwabara, K., Takeuchi, A., Akiyama, M., Okamura, T., Ebbels, TMD., Elliott, P., Tomita, M., Sato, A., Suzuki, C., Sugimoto, M., <strong><u>Soga, T.<\/u><\/strong>,\u00a0 Takebayashi, T., \u201cReliability of plasma polar metabolite concentrations in a large-scale cohort study using capillary electrophoresis-mass spectrometry\u201d <strong><em>PLoS One<\/em><\/strong> 13, e0191230,\u00a0 2018.<br \/>\n[<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29346414\">PubMed<\/a>]<\/li>\n<\/ul>\n<ul class=\"list2\">\n<li id=\"y2017\">Matsuda, J., Namba, T., Takabatake, Y., Kimura, T., Takahashi, A., Yamamoto, T., Minami, S., Sakai, S., Fujimura, R., Kaimori, J.Y., Matsui, I., Hamano, T., Fukushima, Y., Matsui, K.,<strong><u>Soga, T.<\/u><\/strong>, Isaka, Y., \u201cAntioxidant role of autophagy in maintaining the integrity of glomerular capillaries\u201d <strong><em>Autophagy<\/em><\/strong> 14, 53-65, 2018.<br \/>\n[<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29130363\">PubMed<\/a>]<\/li>\n<\/ul>\n<ul class=\"list2\">\n<li><strong>2017<\/strong><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Krycer, JR., Yugi, K., Hirayama, A., Fazakerley, DJ., Quek, LE., Scalzo, R., Ohno, S., Hodson, MP. Ikeda, S., Shoji, F., Suzuki, K., Domanova, W., Parker, BL.,. Nelson, ME ., Humphrey, SJ., Turner, N., Hoehn, KL., Cooney, GJ., <strong><u>Soga, T.<\/u><\/strong>, Kuroda, S., James, DE. \u201cDynamic metabolomics reveals that insulin primes the adipocyte for glucose metabolism\u201d<strong><em> Cell Rep. <\/em><\/strong>21, 3536\u20133547, 2017.<br \/>\n[<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29262332\">PubMed<\/a>]<\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Sugito, N., Taniguchi, K., Kuranaga, Y., Ohishi, M., <strong><u>Soga, T.<\/u><\/strong>, Ito, Y., Miyachi, M., Kikuchi, K., Hosoi, H., Akao, Y., \u201cCancer-Specific Energy Metabolism in Rhabdomyosarcoma Cells Is Regulated by MicroRNA\u201d <strong><em>Nucleic Acid Ther. <\/em><\/strong>27, 365-377, 2017.<br \/>\n[<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28981396\">PubMed<\/a>]<\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Ikeda, K., Kang, Q., Yoneshiro, T., Camporez, J.P., Maki, H., Homma, M., Shinoda, K., Chen, Y., Lu, X., Maretich, P., Tajima, K., Ajuwon, K.M., <strong><u>Soga, T.<\/u><\/strong>, Kajimura, S., \u201cUCP1-independent signaling involving SERCA2b-mediated calcium cycling regulates beige fat thermogenesis and systemic glucose homestasis\u201d <strong><em>Nat. Med.<\/em><\/strong> 23, 1454\u20131465, 2017.<br \/>\n[<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29131158\">PubMed<\/a>]<\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Jeelani, G., Sato, D., <strong><u>Soga, T.<\/u><\/strong>, Nozaki, T., \"Genetic, metabolomic and transcriptomic analyses of the de novo L-cysteine biosynthetic pathway in the enteric protozoan parasite Entamoeba histolytica\"<strong><em> Sci. Rep. <\/em><\/strong>7, 15649, doi:10.1038\/s41598-017-15923-3, 2017.<br \/>\n[<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=29142277\">PubMed<\/a>]<\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Migita, T., Takayama, K., Urano, T., Obinata, D., Ikeda, K., <strong><u>Soga, T.<\/u><\/strong>, Takahashi, S., Inoue, S., \u201cACSL3 promotes intratumoral steroidogenesis in prostate cancer cells\u201d <strong><em>Cancer Sci. <\/em><\/strong>108, 2011-2021, 2017.<br \/>\n[<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28771887\">PubMed<\/a>]<\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Adam, J., Ramracheya, R., Chibalina, M.V., Ternette, N., Hamilton, A., Tarasov, A.I., Zhang, Q., Rebelato, E., Rorsman, N.J.G., Martin-del-Rio, R., Lewis, A., Ozkan, G., Do, H.W., Spegal, P., Saitoh, K., Kato, K., Igarashi, K., Kessler, B.M., Pugh, C.W., Tamarit-Rodriques, J., Mulder, H., Clark, A., Fizzell, N., <strong><u>Soga, T.<\/u><\/strong>, Ashcroft, F.M., Silver, A., Pollard, P.J., Rorsman, P., \"Fumarate hydratase deletion in pancreatic \u03b2 cells leads to progressive diabetes\"<strong><em> Cell Rep. <\/em><\/strong>20, 3135-3148, 2017.<br \/>\n[<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28954230\">PubMed<\/a>]<\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Satoh, K., Yachida, S., Sugimoto, M., Oshima, M., Nakagawa, T., Akamoto, S., Tabata, S., Saitoh, K., Kato, K., Sato, S., Igarashi, K., Aizawa, Y., Kajino-Sakamoto, R., Kojima, Y., Fujishita, T., Enomoto, A., Hirayama, A., Ishikawa, T., Taketo, M.M., Kushida, Y., Haba, R., Okano, K., Tomita, M., Suzuki, Y., Fukuda, S., Aoki, M., <strong><u>Soga, T.<\/u><\/strong>, \u201cGlobal metabolic reprogramming of colorectal cancer occurs at adenoma stage and is induced by MYC\u201d <strong><em>Proc. Natl. Acad. Sci. USA<\/em><\/strong> 114, E7697-E7706, 2017.<br \/>\n[<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28847964\">PubMed<\/a><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28317223\">]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Mishima, E., Fukuda, S., Mukawa, C., Yuri, A., Kanemitsu, Y., Matsumoto, Y., Akiyama, Y., Fukuda, NN., Tsukamoto, H., Asaji, K., Shima, H., Kikuchi, K., Suzuki, T., Tomioka, Y., <strong><u>Soga, T.<\/u><\/strong>, Ito, S., Abe, T. \u201cEvaluation of the impact of gut microbiota on uremic solute accumulation by CE-TOFMS-based metabolomics approach\u201d <em><strong>Kidney Int<\/strong><\/em><strong>. <\/strong>92, 634-645. 2017.<br \/>\n[<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28396122\">PubMed<\/a><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28317223\">]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Okuma, N., Saita, M., Hoshi, N., <strong><u>Soga, T.<\/u><\/strong>, Tomita, M., Sugimoto, M., Kimoto, K., \u201cEffect of masticatory stimulation on the quantity and quality of saliva and the salivary metabolomic profile\u201d <strong><em>PLoS One<\/em><\/strong> 12, e0183109, 2017.<br \/>\n<span style=\"color: #0066cc;\">[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28813487\/\">PubMed<\/a><\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28317223\"><span style=\"color: #0066cc;\">]<\/span><\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Suda, M., Shimizu, I., Yoshida, Y., Hayashi, Y., Ikegami, R., Katsuumi, G., Wakasugi, T., Yoshida, Y., Okuda, S., <strong><u>Soga, T.<\/u><\/strong>, Minamino, T., \u201cInhibition of dipeptidyl peptidase-4 ameliorates cardiac ischemia and systolic dysfunction by up-regulating the FGF-2\/EGR-1 pathway\u201d <strong><em>PLoS One<\/em><\/strong> 12, e0182422, 2017.<br \/>\n<span style=\"color: #0066cc;\">[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28771625\/\">PubMed<\/a><\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28317223\"><span style=\"color: #0066cc;\">]<\/span><\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Hayashi, Y., Otsuka, K., Ebina, M., Igarashi, K., Takehara, A., Matsumoto, M., Kanai, A., Igarashi, K., <strong><u>Soga, T.<\/u><\/strong>, Matsui, Y., \"Distinct requirements for energy metabolism in mouse primordial germ cells and their reprogramming to embryonic germ cells\" <strong><em>Proc. Natl. Acad. Sci. USA <\/em><\/strong>114, 8289-8294, 2017.<br \/>\n<span style=\"color: #0066cc;\">[<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28716939\">PubMed<\/a><\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28317223\"><span style=\"color: #0066cc;\">]<\/span><\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Toyoda, Y., Kashikura, K., <strong><u>Soga, T.<\/u><\/strong>, Tagawa, Y., \u201cMetabolomics of an in vitro liver model containing primary hepatocytes assembling around an endothelial cell network: comparative study on the metabolic stability and the effect of acetaminophen treatment\u201d <strong><em>J. Toxicol. Sci. <\/em><\/strong>42, 445-454, 2017.<br \/>\n[<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28717103\">PubMed<\/a>]<\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Kitazawa, S., Nishizawa, S., Nakagawa, H., Funata, M., Nishimura, K., <strong><u>Soga, T.<\/u><\/strong>, Hara, T., \u201cCancer with low cathepsin D levels is susceptible to vacuolar (H+)-ATPase inhibition\u201d <strong><em>Cancer Sci. <\/em><\/strong>108, 1185-1193, 2017.<br \/>\n<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28317223\"><span style=\"color: #0066cc;\">[PubMed]<\/span><\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Tanada, Y., Okuda, J., Kato, T., Minamino-Muta, E., Murata, I., <strong><u>Soga, T.<\/u><\/strong>, Shioi, T., Kimura, T., \"The metabolic profile of a rat model of chronic kidney disease\", <strong><em>Peer J. <\/em><\/strong><em>5<\/em>, e3352, 2017.<br \/>\n<span style=\"color: #0066cc;\">[<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28560105\">PubMed<\/a>]<\/span><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Nishihara, T., Inoue, J., Tabata, S., Murakami, S., Ishikawa, T., Saito, N., Fukuda, S., Tomita, M., <strong><u>Soga, T.<\/u><\/strong>, \u201cSynthetic Biomarker Design by Using Analyte-Responsive Acetaminophen\u201d <strong><em>Chembiochem<\/em><\/strong>. 18, 910-913, 2017.<br \/>\n<span style=\"color: #0066cc;\">[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28236354\/\">PubMed<\/a>]<\/span><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Tabata, S., Yamamoto, M., Goto, H., Hirayama, A., Ohishi, M., Kuramoto, T., Mitsuhashi, A., Ikeda, R., Haraguchi, M., Kawahara, K., Shinsato, Y., Minami, K., Saijo, A., Hanibuchi, M., Nishioka, Y., Sone, S., Esumi, H., Tomita, M., <strong><u>Soga, T.<\/u><\/strong>, Furukawa, T., Akiyama, S., \u201cThymidine Catabolism as a Metabolic Strategy for Cancer Survival\u201d <strong><em>Cell Rep. <\/em><\/strong>19, 1313-1321, 2017.<br \/>\n<span style=\"color: #0066cc;\">[<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28514652\">PubMed<\/a>]<\/span><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Yoshitoshi-Uebayashi, E.Y., Toyoda, T., Yasuda, K., Kotaka, M., Nomoto, K., Okita, K., Yasuchika, K., Okamoto, S., Takubo, N., Nishikubo, T., <strong><u>Soga, T.<\/u><\/strong>, Uemoto, S., Osafune, K., \u201cModelling urea-cycle disorder citrullinemia type 1 with disease-specific iPSCs\u201d <strong><em>Biochem Biophys Res Commun. <\/em><\/strong>486 <strong><em>,<\/em><\/strong> 613-619, 2017.<br \/>\n<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28302489\"><span style=\"color: #0066cc;\">[PubMed]<\/span><\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Kon, S., Ishibashi, K., Katoh, H., Kitamoto, S., Shirai, T., Tanaka, S., Kajita, M., Ishikawa, S., Yamauchi, H., Yako, Y., Kamasaki, T., Matsumoto, T., Watanabe, H., Egami, R., Sasaki, A., Nishikawa, A., Kameda, I., Maruyama, T., Narumi, R., Morita, T., Sasaki, Y., Enoki, R., Honma, S., Imamura, H., Oshima, M., <strong><u>Soga, T.<\/u><\/strong>, Miyazaki, J., Duchen, MR.., Nam, J., Onodera, Y., Yoshioka, S., Kikuta, J., Ishii, M., Imajo, M., Nishida, E., Fujioka, Y., Ohba, Y., Sato, T., Fujita, Y.,\"Cell competition with normal epithelial cells promotes apical extrusion of transformed cells through metabolic changes\"<strong><em>Nat. Cell Biol. <\/em><\/strong>19, 530-541, 2017.<br \/>\n<span style=\"color: #0066cc;\">[<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28414314\">PubMed<\/a><\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28317223\"><span style=\"color: #0066cc;\">]<\/span><\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Kitazawa, S., Ebara1, S., Ando, A., Baba, Y., Satomi, Y., <strong><u>Soga, T.<\/u><\/strong>, Hara, T., \u201cSuccinate dehydrogenase B-deficient cancer cells are highly sensitive to bromodomain and extra-terminal inhibitors\u201d <strong><em>Oncotarget <\/em><\/strong>8, 28922-28938, 2017.<br \/>\n<span style=\"color: #0066cc;\">[<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28423651\">PubMed<\/a>]<\/span><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Nijhuis, A., Thompson, H., Adam, J., Paker A., Gammmon, L., Lewis, A., Bundy, J.G., <strong><u>Soga, T.<\/u><\/strong>, Jalaly, A., Propper, D., Jeffery, R., Suraweera, N., McDonald, S., Thaha, M.A., Feakins, R., Lowe, R., Bishop, C., Silver, A., \u201cRemodelling of microRNAs in colorectal cancer by hypoxia alters metabolism profiles and 5-fluorouracil resistance\u201d <strong><em>Hum Mol Genet. <\/em><\/strong>26, 1552-1564, 2017.<br \/>\n<span style=\"color: #0066cc;\">[<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28207045\">PubMed<\/a>]<\/span><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Itoi, T., Sugimoto, M., Umeda, J., Sofuni, A., Tsuchiya, T., Tsuji, S., Tanaka, R., Tonozuka, R., Honjo, M., Moriyasu, F., Kasuya, K., Nagakawa, Y., Abe, Y., Takano, K., Kawachi, S., Shimazu, M., <strong><u>Soga, T.<\/u><\/strong>,\u00a0 Tomita, M.,\u00a0 Sunamura, M., \"Serum Metabolomic Profiles for Human Pancreatic Cancer Discrimination\" <strong><em>Int. J. Mol. Sci.<\/em><\/strong> 18, 767; doi:10.3390\/ijms18040767, 2017.<br \/>\n[<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28375170\"><span style=\"color: #0066cc;\">PubMed<\/span><\/a><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28302489\"><span style=\"color: #0066cc;\">]<\/span><\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Sakata, F., Ito, Y., Mizuno, M., Sawai, A., Suzuki, Y., Tomita, T., Tawada, M., Tanaka, A., Hirayama, A., Sagara, A., Wada, T., Maruyama, S., <strong><u>Soga, T.<\/u><\/strong>, Matsuo, S., Imai, E., Takei, Y., \u201cSodium chloride promotes tissue inflammation via osmotic stimuli in subtotal-nephrectomized mice\u201d, <strong><em>Lab. Invest.<\/em><\/strong> 97, 432-446, 2017<br \/>\n[<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28165470\"><span style=\"color: #0066cc;\">PubMed<\/span><\/a>]<\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Miyamoto, T., Hirayama, A., Sato, Y., Koboyashi, T., Katsuyama, E., Kanagawa, H., Miyamoto, H., Mori, T., Yoshida, S., Fujie, A., Morita, M., Watanabe, R., Tando, T., Miyamoto, K., Tsuji, T., Funayama, A., Nakamura, M., Matsumoto, M., <strong><u>Soga, T.<\/u><\/strong>, Tomita, M., Toyama, Y., \"A serum metabolomics-based profile in low bone mineral density postmenopausal women\" <strong><em>Bone <\/em><\/strong>95<strong><em>, <\/em><\/strong>1-4, doi:10.1016\/j.bone.2016.10.027, 2017.<br \/>\n<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27989648\"><span style=\"color: #0066cc;\">[PubMed]<\/span><\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li id=\"y2016\">Sugimoto, M., Obiya, S., Kaneko, M., Enomoto, A., Honma, M., Wakayama, M., <strong><u>Soga, T.<\/u><\/strong>,\u00a0 Tomita, M., \"Metabolomic profiling as a possible reverse engineering tool for estimating processing conditions of dry-cured hams\", <strong><em>J. Agric. Food Chem<\/em><\/strong>.65, 402-410, 2017.<br \/>\n[<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27951640\">PubMed<\/a>]<\/li>\n<\/ul>\n<ul class=\"list2\">\n<li><strong>2016<\/strong><strong><br \/>\n<\/strong><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Ogawa, T., Tsubakiyama, R., Kanai, M., Koyama , T., Fujii, T., Iefuji, H., <span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, Kume, K., Miyakawa, T., Hirata, D., Mizunuma, M., \u201cStimulating S-adenosyl-L-methionine synthesis extends lifespan via activation of AMPK\u201d <strong><em>Proc. Natl. Acad. Sci. USA <\/em><\/strong>113, 11913-11918, 2016.<br \/>\n<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27698120\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Fukai, K., Harada, S., Iida, M., Kuriara, A., Takeuchi, A., Kuwabara, K., Sugiyama, D., Okamura, T., Akiyama, M., Nishiwaki, Y., Oguma, Y., Suzuki, A., Suzuki, C, Hirayama, A., Sugimoto, M., <strong><u>Soga, T.<\/u><\/strong>, Tomita, M., Takebayashi, T., \u201cMetabolic Profiling of Total Physical Activity and Sedentary Behavior in Community-Dwelling Men\u201d <strong><em>PLoS One<\/em><\/strong>\u00a011, e0164877, 2016.<br \/>\n<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27741291\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Yamano, Y., Sugimoto, M., Hirayama, A., Kume, S., Yamato, M., Jin, G., Tajima, S., Goda, N., Iwai, K., Fukuda, S., Yamaguti, K., Kuratsune, H., <strong><u>Soga, T.<\/u><\/strong>, Watanabe, Y., Kataoka, Y., \u201cIndex markers of chronic fatigue syndrome with dysfunction of TCA and urea cycles\u201d <strong><em>Sci. Rep. <\/em><\/strong>6, 34990, 2016.<br \/>\n[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/27725700\/\">PubMed<\/a>]<\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Hegazy, A.M., Yamada, D., Kobayashi, M., Kohno, S., Ueno, M., Ali, MA., Ohta, K., Tadokoro, Y., Ino, Y., Todo, T., <strong><u>Soga, T.<\/u><\/strong>, Takahashi, C., Hirao, A., \u201cTherapeutic Strategy for Targeting Aggressive Malignant Gliomas by Disrupting Their Energy Balance\u201d <strong><em>J. Biol. Chem. <\/em><\/strong>291, 21496-21509, 2016.<br \/>\n[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/27519418\/\">PubMed<\/a>]<\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Bardella C, Al-Dalahmah O, Krell D, Brazauskas P, Al-Qahtani K, Tomkova M, Adam J, Serres S, Lockstone H, Freeman-Mills L, Pfeffer I, Sibson N, Goldin R, Schuster-B\u00f6eckler B, Pollard, PJ, <strong><u>Soga T<\/u><\/strong>, McCullagh JS, Schofield CJ, Mulholland P, Ansorge O, Kriaucionis S, Ratcliffe PJ, Szele, FG, Tomlinson I, \"Expression of Idh1R132H in the murine subventricular zone stem cell niche recapitulates features of early gliomagenesis\" <strong><em>Cancer Cell<\/em><\/strong> 30, 578-594, 2016.<br \/>\n<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27693047\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Ishikawa, S., Sugimoto, M., Kitabatake, K., Sugano, A., Nakamura, M., Kaneko, M., Ota, S., Hiwatari, K., Enomoto, A., <span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, Tomita, M., Iino, M., \"Identification of salivary metabolomic biomarkers for oral cancer screening\" <strong><em>Sci. Rep.<\/em><\/strong> 6, 31520, 2016.<br \/>\n<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=27539254\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Karigane, D., Kobayashi, H., Morikawa, T., Ootomo, Y., Sakai, M., Nagamatsu, G., Kubota, Y., Goda, N., Matsumoto, M., Nishimura, E. K., <span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, Otsu, K., Suematsu, M., Okamoto, S., Suda, T., Takubo, K., \u201cp38\u03b1 activates purine metabolism to initiate hematopoietic stem\/progenitor cell cycling in response to stress\u201d <strong><em>Cell Stem Cell <\/em><\/strong>19, 192-204, 2016.<br \/>\n<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27345838\"><span style=\"color: #0066cc;\">[PubMed]<\/span><\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Yamanaka, R., Tabata, S., Shindo, Y., Hotta, K., Suzuki, K., <strong><u>Soga, T.<\/u><\/strong>,\u00a0 Oka, K., \"Mitochondrial Mg2+ homeostasis decides cellular energy metabolism and vulnerability to stress\", <strong><em>Sci. Rep<\/em>. <\/strong>6, 30027, 2016.<br \/>\n<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=27458051\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Saito, T., Sugimoto, M., Okumoto, K., Haga, H., Katsumi, T., Mizuno, K., Nishina, T., Sato, S., Igarashi, K., Maki, H., Tomita, M., Ueno, Y., <strong><span style=\"text-decoration: underline;\">Soga, T.<\/span>, <\/strong>\"Serum metabolome profiles characterized by patients with hepatocellular carcinoma associated with hepatitis B and C\" , <strong><em>World J. Gastroenterol.<\/em> <\/strong>22<strong>.<\/strong> 6224-6234, 2016.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27468212\"><span style=\"color: #0066cc;\">[PubMed]<\/span><\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Iida, M., Harada, S., Kurihara, A., Fukai, K., Kuwabara, K., Sugiyama, D., Takeuchi, A., Okamura, T., Akiyama, M., Nishiwaki, Y., Suzuki, A., Hirayama, A., Sugimoto, M., <span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, Tomita, M., Banno, K., Aoki, D., Takebayashi, T., \u201cProfiling of plasma metabolites in postmenopausal women with metabolic syndrome\u201d <em><strong>Menopause<\/strong><\/em> 23, 749-758, 2016.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27070805\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Saito, T., Ichimura, Y., Taguchi, K., Suzuki, T., Mizushima, T., Takagi, K., Hirose, Y., Nagahashi, M., Iso, T., Fukutomi, T., Ohishi, M., Endo, K., Uemura, T., Nishito, Y., Okuda, S., Obata, M., Kouno, T., Imamura, R., Tada, Y., Obata, R., Yasuda, D., Takahashi, K., Fujimura, T., Pi, J., Lee, MS., Ueno, T., Ohe, T., Mashino, T., Wakai, T., Kojima, H., Okabe, T., Nagano, T., Motohashi, H., Waguri, S., <strong><u>Soga, T.<\/u><\/strong>, Yamamoto, M., Tanaka, K., Komatsu, M., \"p62\/Sqstm1 promotes malignancy of HCV-positive hepatocellular carcinoma through Nrf2-dependent metabolic reprogramming\", <strong><em>Nat.Commun. <\/em><\/strong>7, 12030, 2016.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27345495\">[PubMed]<br \/>\n<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Tando, T., Hirayama, A., Furukawa, M., Sato, Y., Kobayashi, T., Funayama1, A., Kanaji, A., Hao, W., Watanabe, R., Morita, M., Oike, T., Miyamoto, K., <strong><u>Soga, T.<\/u><\/strong>, Nomura, M., Yoshimura, A., Tomita, M., Matsumoto, M., Nakamura, M., Toyama, Y., Miyamoto, T. , \"Smad2\/3 are required for immobilization-induced skeletal muscle atrophy\" <strong><em>J. Biol. Chem.<\/em><\/strong> 391, 12184-12194, 2016.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27129272\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Fujita, S., Osuka, S. Shibao, S., Igarashi, K., <strong><u>Soga, T.<\/u><\/strong>,\u00a0 Sampetrean, O., \u201cEffects of fractionated radiation on murine glioma stem cell metabolism\u201d,\u3000<strong><em>Toho J. Med. <\/em><\/strong>2 , 45-52, 2016.<br \/>\n[<a href=\"https:\/\/mylibrary.toho-u.ac.jp\/webopac\/bdyview.do?bodyid=TD85244147&amp;elmid=Body&amp;fname=85244147_cover.pdf\">Publisher<\/a>]<\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Kimura, T., Yasuda, K., Yamamoto, R., <strong><u>Soga, T.<\/u><\/strong>, Rakugi, H., Hayashi, T., Isaka, Y., \"Identification of biomarkers for development of end-stage kidney disease in chronic kidney disease by metabolomic profiling\" <strong><em>Sci. Rep<\/em><\/strong>. 6, 26138, 2016.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27188985\">[PubMed<\/a>]<\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Kemppainen, E., George, J., Garipler, G., Tuomela, T., Kiviranta, E., <strong><u>Soga, T.<\/u><\/strong>, Dunn, C.D., Jacobs, H.T., \u201cMitochondrial Dysfunction Plus High-Sugar Diet Provokes a Metabolic Crisis That Inhibits Growth\u201d <strong><em>PLoS One<\/em><\/strong> 11, e0145836, 2016.<br \/>\n[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/26812173\/\">PubMed<\/a>]<\/li>\n<\/ul>\n<ul class=\"list2\">\n<li id=\"y2015\">Harada S., Takebayashi T., Kurihara A., Akiyama M., Suzuki A., Hatakeyama Y., Sugiyama D., Kuwabara K., Takeuchi A., Okamura T., Nishiwaki Y., Tanaka T., Hirayama A., Sugimoto M., <strong><u>Soga T.<\/u><\/strong>, Tomita M., \u201cMetabolomic profiling reveals novel biomarkers of alcohol intake and alcohol-induced liver injury in community-dwelling men\u201d <strong><em>Environ. Health Prev. Med. <\/em><\/strong>21 , 18-26, 2016.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26459263\">[PubMed]<br \/>\n<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li><strong>2015<\/strong><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Murakami, S., Goto, Y., Ito K., Hayasaka, S., Kurihara, S., <strong><u>Soga, T.<\/u><\/strong>, Tomita, M., Fukuda, S., \u201cThe Consumption of Bicarbonate-Rich Mineral Water Improves Glycemic Control\u201d <strong><em>Evid Based Complement Alternat Med <\/em><\/strong>2015, 824395, 2015.<br \/>\n[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/26798400\/\">PubMed<\/a>]<\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Sakagami, H., Shimada, C., Kanda, Y., Amano, O., Sugimoto, M., Ota S., <strong><u>Soga, T.<\/u><\/strong>, Tomita, M., Sato, A., Tanuma, S., Takao, K., Sugita, Y., \u201cEffects of 3-styrylchromones on metabolic profiles and cell death in oral squamous cell carcinoma cells\u201d <strong><em>Toxicol. Rep.<\/em><\/strong> 2, 1281-1290, 2015.<br \/>\n[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28962471\/\">PubMed<\/a>]<\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Hirayama, A., Sugimoto, M., Suzuki, A., Hatakeyama, Y., Enomoto, A., Harada, S., <strong><u>Soga, T.<\/u><\/strong>, Tomita, M., Takebayashi, T., \"Effects of processing and storage conditions on charged metabolomic profiles in blood\" <strong><em>Electrophoresis <\/em><\/strong>36, 2148\u20132155, 2015.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25820922\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Uetaki, M., Tabata, S., Nakasuka, F., <span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, Tomita, M., \u201cMetabolomic alterations in human cancer cells by vitamin C-induced oxidative stress\u201d <strong><em>Sci. Rep.<\/em> <\/strong>5, 13896, 2015.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26350063\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Nakano, T., Saiki, Y., Kudo, C., Hirayama, A., Mizuguchi, Y., Fujiwara, S., <span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, Sunamura, M., Matsumura, N., Motoi, F., Unno, M., Horii, A., \u201cAcquisition of chemoresistance to gemcitabine is induced by a loss-of-function missense mutation of DCK\u201d <strong><em>Biochem. Biophys. Res. Commun. <\/em><\/strong>464, 1084-1089, 2015.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26196746\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Watanabe, S., Ohbayashi, R., Kanesaki, Y., Saito, N., Chibazakura, T., <strong><u>Soga, T.<\/u><\/strong>, Yoshikawa, H.,\u00a0 \u201cIntensive DNA Replication and Metabolism during the Lag Phase in Cyanobacteria\u201d <strong><em>PLoS One <\/em><\/strong>10, e0136800, 2015.<br \/>\n[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/26331851\/\">PubMed<\/a>]<\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Mishima, E., Fukuda, S., Shima, H., Hirayama, A., Akiyama, Y., Takeuchi, Y., Fukuda, N. N., Suzuki, T., Suzuki, C., Yuri, A., Kikuchi, K., Tomioka, Y., Ito, S., <strong><u>Soga, T.<\/u><\/strong>, Abe, T., \u201cAlteration of the Intestinal Environment by Lubiprostone Is Associated with Amelioration of Adenine-Induced CKD\u201d,<em><strong>J. Am. Soc. Nephrol. <\/strong><\/em>26, 1787-1794, 2015.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25525179\">[PubMed<\/a>]<\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Garcia-Contreras, R., Sugimoto, M., Umemura, N., Kaneko, M., Hatakeyama, Y., <span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, Tomita, M., Scougall-Vilchis, R.J., Contreras-Bulnes, R., Nakajima, H., Sakagami, H., \u201cAlteration of metabolomic profiles by titanium dioxide nanoparticles in human gingivitis model\u201d <strong><em>Biomaterials <\/em><\/strong>57<em>, <\/em>33-40, 2015.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25913073\">[PubMed]<br \/>\n<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Ogawara, Y., Katsumoto, T., Aikawa, Y., Shima, Y., Kagiyama, Y.,<strong><u> Soga, T.<\/u><\/strong>, Matsunaga, H., Seki, T., Araki, K., Kitabayashi, I., \u201cIDH2 and NPM1 mutations cooperate to activate Hoxa9\/Meis1 and hypoxia pathways in acute myeloid leukemia\u201d <strong><em>Cancer Res. <\/em><\/strong>75, 2005-2016, 2015.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25795706\">[PubMed<\/a>]<\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Kishikawa, T., *Otsuka, M., Tan, P.S., Ohno, M., Sun, X., Yoshikawa, T., Shibata, C., Takata, A., Kojima, K., Takehana, K., Ohishi, M., Ota, S., Noyama, T., Kondo, Y., Sato, M., <strong><u>Soga, T.<\/u><\/strong>, Hoshida, Y., Koike, K., \u201cDecreased miR122 in hepatocellular carcinoma leads to chemoresistance with increased arginine\u201d <strong><em>Oncotarget<\/em> <\/strong>6, 8339-8352, 2015<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25826076\">[PubMed<\/a>]<\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Kobayashi, S., Sato, M., Kasakoshi, T., Tsutsui, T., Sugimoto, M., Osaki, M., Okada, F., Igarashi, K., Hiratake, J., Homma, T., Conrad, M., Fujii, J., <strong><u>Soga, T.<\/u><\/strong><strong>,<\/strong> Bannai, S., Sato, H., \u201cCystathionine is a novel substrate of cystine\/glutamate transporter: implications for immune function\u201d<strong><em>J. Biol. Chem.<\/em> <\/strong>290, 8778-8788, 2015.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25713140\">[PubMed]<br \/>\n<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Kume, S., Yamato, M., Tamura, Y., Jin, G., Nakano, M., Miyashige, Y., Eguchi, A., Ogata, Y., Goda, N., Iwai, K., Yamano, E., Watanabe, Y., <strong><u>Soga, T.<\/u><\/strong>, Kataoka, Y., \u201cPotential Biomarkers of Fatigue Identified by Plasma Metabolome Analysis in Rats\u201d <strong><em>PLoS One <\/em><\/strong>10, e0120106<strong>, <\/strong>2015.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25793974\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li id=\"y2014\">Valli, A., Rodriguez, M., Moutsianas, L., Fischer, R., Fedele, V., Huang, H.L., Van Stiphout, R., Jones, D., Mccarthy, M., Vinaxia, M., Igarashi, K., Sato, M., <strong><u>Soga, T.<\/u><\/strong>, Buffa, F., Mccullagh, J., Yanes, O., Harris, A., Kessler. B., \u201cHypoxia Induces a Lipogenic Cancer Cell Phenotype via HIF1\u03b1-Dependent and -Independent Pathways\u201d, <strong><em>Oncotarget<\/em> <\/strong>6<strong>, <\/strong>1920-1941, 2015.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25605240\">[PubMed<\/a>]<\/li>\n<\/ul>\n<ul class=\"list2\">\n<li><strong>2014<\/strong><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Hirayama, A., Igarashi, K., Tomita, M., <span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, \u201cDevelopment of quantitative method for determination of \u03b3-glutamyl peptides by capillary electrophoresis tandem mass spectrometry: An efficient approach avoiding matrix effect\u201d <strong><em>J Chromatogr A<\/em>\u00a0<\/strong>1369, 161-169, 2014.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4222106\/\">[<\/a><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25441083\">PubMed<\/a><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?db=PubMed&amp;cmd=search&amp;term=25240194\" rel=\"nofollow\">]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Tabata, S., Ikeda, R., Yamamoto, M., Shimaoka, S., Mukaida, N., Takeda, Y., Yamada, K., <span style=\"text-decoration: underline;\"><strong>Soga, T<\/strong>.<\/span>, Furukawa, T., Akiyama, S., \u201cThymidine phosphorylase activates NF\u03baB and stimulates the expression of angiogenic and metastatic factors in human cancer cells\u201d <strong><em>Oncotarget<\/em><\/strong> 5, 10473-10485, 2014.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25350954\" rel=\"nofollow\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Jeelani, G., Sato, D., <span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, Watanabe, H., Nozaki, T.,\u00a0 \u201cMass spectrometric analysis of L-cysteine metabolism: physiological role and fate of L-cysteine in the enteric protozoan parasite Entamoeba histolytica\u201d <strong><em>mBio<\/em>. <\/strong>5, e01995-14, 2014.<br \/>\n[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/25370494\/\">PubMed<\/a><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?db=PubMed&amp;cmd=search&amp;term=25240194\" rel=\"nofollow\">]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Xu, F., Sudo, Y., Sanechika, S., Yamashita, J., Shimaguchi, S., Honda, S., Sumi-Ichinose, C., Mori-Kojima, M., Nakata, R., Furuta, T., Sakurai, M., Sugimoto, M.,<span style=\"text-decoration: underline;\"> <strong>Soga, T.<\/strong><\/span>, Kondo, K., Ichinose, H., \u201cDisturbed biopterin and folate metabolism in the Qdpr-deficient mouse\u201d <strong><em>FEBS Lett.<\/em> <\/strong>588, 3924-3931, 2014.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?db=PubMed&amp;cmd=search&amp;term=25240194\" rel=\"nofollow\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Mishima, E., Inoue, C., Saigusa, D., Inoue, R., Ito, K., Suzuki, Y., Jinno, D., Tsukui, Y., Akamatsu, Y., Araki, M., Araki, K., Shimizu, R., Shinke, H., Suzuki, T., Takeuchi, Y., Shima, H., Akiyama, Y., Toyohara, T., Suzuki, C., Saiki, Y., Tominaga, T., Miyagi, S., Kawagisihi, Naoki, <span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, Ohkubo, T., Yamamura, K., Imai, Y., Masuda, S., Sabbisetti, V., Ichimura, T., Mount, D.B., Bonventre, J.V., Ito, S., Tomioka, Y., Itoh, K., Abe, T., \u201cConformational Change in Transfer RNA Is an Early Indicator of Acute Cellular Damage\u201d,<em><strong>J. Am. Soc. Nephrol. <\/strong><\/em>25, 2316-2326, 2014.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24833129\" rel=\"nofollow\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Takeuchi, K., Ohishi, M., Endo, K., Suzumura, K., Naraoka, H., Ohata, T., Seki, J., Miyamae, Y., Honma, M., <span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, \u201cMetabolomic Analysis of the Effects of Omeprazole and Famotidine on Aspirin-induced Gastric Injury\u201d <strong><em>Metabolomics<\/em><\/strong> 10, 995-1004, 2014.<br \/>\n<a href=\"http:\/\/link.springer.com\/article\/10.1007%2Fs11306-014-0627-0\">[Publisher]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Hirayama, A., Wakayama, M., <span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span> , \u201cMetabolome analysis based on capillary electrophoresis-mass spectrometry\u201d <strong><em>Trends Anal. Chem.<\/em> <\/strong>61, 215-222, 2014.<br \/>\n<a href=\"http:\/\/www.sciencedirect.com\/science\/article\/pii\/S0165993614001265\">[Publisher]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Yang, M., Su, H., <span style=\"text-decoration: underline;\"><strong>Soga, T<\/strong>.<\/span>, Kranc, K.R., Pollard, P.J. ,\u201cProlyl hydroxylase domain enzymes: important regulators of cancer metabolism\u201d <strong><em>Hypoxia<\/em> <\/strong>2, 127-142, 2014.<br \/>\n<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27774472\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Nishimura, T., Higuchi1, K., Sai, Y., Sugita, Y., Yoshida, Y., Tomi, M., Wada, M., Wakayama, T., Tamura, A., Tsukita, S., <span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, Nakashima, E., \u201cFetal Growth Retardation and Lack of Hypotaurine in Ezrin Knockout Mice\u201d <strong><em>PLoS One<\/em>\u00a0<\/strong>9, e105423, 2014.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?db=PubMed&amp;cmd=search&amp;term=25144766\" rel=\"nofollow\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Yugi, K., Kubota, H., Toyoshima, Y., Noguchi, R., Kawata, K., Komori, Y., Uda, S., Kunida, K., Tomizawa, Y., Funato, Y., Miki, H., Matsumoto, M., Nakayama, K.I., Kashikura, K., Endo, K., Ikeda, K., <span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, Kuroda, S., \u201cReconstruction of insulin signal flow from phosphoproteome and metabolome data\u201d <strong><em>Cell Rep.<\/em><\/strong> 8, 1171-1183, 2014.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?db=PubMed&amp;cmd=search&amp;term=25131207\" rel=\"nofollow\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Takeuchi, K., Ohishi, M., Endo, K., Suzumura, K., Naraoka, H., Ohata, T., Seki, J., Miyamae, Y., Honma, M., <span style=\"text-decoration: underline;\"><strong>Soga, T<\/strong>.<\/span>, \u201cHydroxyproline, a Serum Biomarker Candidate for Gastric Ulcer in Rats: A Comparison Study of Metabolic Analysis of Gastric Ulcer Models Induced by Ethanol, Stress, and Aspirin\u201d <strong><em>Biomark. Insights<\/em> <\/strong>9, 61-66, 2014.<br \/>\n[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/25125970\/\">PubMed<\/a>]<\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Migita, T., Okabe, S., Ikeda, K., Igarashi, S., Sugawara, S., Tomida, A., Soga, T., Taguchi, R., Seimiya, H., \u201cInhibition of ATP citrate lyase induces triglyceride accumulation with altered fatty acid composition in cancer cells\u201d <strong><em>Int J Cancer<\/em><\/strong> 135, 37-47, 2014.<br \/>\n[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24310723\/\">PubMed<\/a>]<\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Ohka, F., Ito, M., Ranjit, M., Senga, T., Motomura, A., Motomura, K., Saito, K., Kato, K., Kato, Y., Wakabayashi, T.,<span style=\"text-decoration: underline;\"><strong> Soga, T.<\/strong><\/span>, Natsume, A., \u201cQuantitative metabolome analysis profiles activation of glutaminolysis in glioma with IDH1 mutation\u201d<strong> <em>Tumor Biol.<\/em><\/strong> 35, 5911-5920, 2014.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?db=PubMed&amp;cmd=search&amp;term=24590270\" rel=\"nofollow\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Adam, J., Yang, M., <span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, Pollard, P.J., \u201cRare insights into cancer biology\u201d <strong><em>Oncogene<\/em> <\/strong>33, 2547-2556, 2014.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?db=PubMed&amp;cmd=search&amp;term=23812428\" rel=\"nofollow\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Obata, F., Kuranaga, E., Tomioka, K., Ming M., Takeishi, A., Chen, C., <span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, Miura, M., \u201cNecrosis-driven systemic immune response alters SAM metabolism through the FOXO-GNMT axis\u201d <strong><em>Cell Rep.<\/em> <\/strong>7, 821-833, 2014.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?db=PubMed&amp;cmd=search&amp;term=24746817\" rel=\"nofollow\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Sato, D., Sugimoto, M., Akashi, H., Tomita, M., <span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, \"Comparative metabolite profiling of foxglove aphids (<em>Aulacorthum solani<\/em> Kaltenbach) on leaves from resistant and susceptible soybean strains\" <strong><em>Mol. BioSyst.<\/em><\/strong> 10, 909-915, 2014.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?db=PubMed&amp;cmd=search&amp;term=24514152\" rel=\"nofollow\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Sakagami, H., Sugimoto, M., Tanaka, S., Onuma, H., Ota, S., Kaneko, M., <span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, Tomita, M., \u201cMetabolomic profiling of sodium fluoride-induced cytotoxicity in an oral squamous cell carcinoma cell line\u201d <strong><em>Metabolomics<\/em><\/strong> 10, 270-279, 2014.<br \/>\n<a href=\"http:\/\/link.springer.com\/article\/10.1007%2Fs11306-013-0576-z\">[Publisher]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Yamatani, H., Takahashi, K., Yoshida, T., <span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, Kurachi, H., \"Differences in the fatty acid metabolism of visceral adipose tissue in postmenopausal women\", <strong><em>Menopause<\/em> <\/strong>21, 170-176, 2014.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?db=PubMed&amp;cmd=search&amp;term=23760430\" rel=\"nofollow\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li id=\"y2013\">Cheng, K.K., Lee, B.S., Masuda, T., Ito, T., Ikeda, K., Hirayama, A., Deng, L., Dong, J., Shimizu, K., <span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, Tomita, M., Palsson, B.O., Robert, M., \u201cGlobal metabolic network reorganization by adaptive mutations allows fast growth of <em>Escherichia coli<\/em> on glycerol\u201d <strong><em>Nat. Commun.<\/em> <\/strong>5, 3233, 2014.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?db=PubMed&amp;cmd=search&amp;term=24481126\" rel=\"nofollow\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li><strong>2013<\/strong><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Kimura, T., Takahashi, A., Takabatake, Y., Namba, T., Yamamoto, T., Kaimori, J., Matsui, I., Kitamura, H., Niimura, F., Matsusaka, T., <span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, Rakugi, H., *Isaka, Y.,\u00a0 \u201cAutophagy protects kidney proximal tubule epithelial cells from mitochondrial metabolic stress\u201d,<strong> <em>Autophagy<\/em><\/strong>\u00a0 9, 1876-86, 2013.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?db=PubMed&amp;cmd=search&amp;term=24128672\" rel=\"nofollow\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Saito, T., Sugimoto, M., Igarashi, K., Saito, K., Shao, L., Katsumi, T., Tomita, K., Sato, C., Ishii, R., Okumoto, K., Nishise, Y., Watanabe, H., Tomita, M., Ueno, Y., <span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, \"Dynamics of serum metabolites in patients with chronic hepatitis C receiving pegylated interferon plus ribavirin: A metabolomics analysis\",<strong> <em>Metabolism<\/em><\/strong> 62, 1577-1586, 2013.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?db=PubMed&amp;cmd=search&amp;term=23953890\" rel=\"nofollow\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Tsuruoka, M., Hara, J., Hirayama, A., Sugimoto, M., <span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, Shankle, W.R., Tomita , M., \u201cComparative analysis of neurodegenerative dementias based on serum and saliva metabolomics\u201d, <strong><em>Electrophoresis<\/em><\/strong> 34, 2865-2872, 2013.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?db=PubMed&amp;cmd=search&amp;term=23857558\" rel=\"nofollow\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Karasawa, T., Saito, T., Ueno, Y., Sugimoto, M., <span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, \u201cMetabolome analysis of erythrocytes from patients with chronic hepatitis C reveals the etiology of ribavirin-induced hemolysis\u201d <strong><em>Int J Med Sci. <\/em><\/strong>10, 1575-1577, 2013.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?db=PubMed&amp;cmd=search&amp;term=24046534\" rel=\"nofollow\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Yang, M., <span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, Pollard, P.J., \u201cOncometabolites: Linking Altered Metabolism with Cancer ? <strong>\u201d <em>J. Clin. Invest.<\/em> <\/strong>123, 3652-3658, 2013.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?db=PubMed&amp;cmd=search&amp;term=23999438\" rel=\"nofollow\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Ito, T., Sugimoto, M., Toya, Y., Ano, Y., Kurano, N., <span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, Tomita, M., \u201cTime-resolved metabolomics of a novel trebouxiophycean alga using 13CO2 feeding\u201d <strong><em>J Biosci Bioeng.<\/em> <\/strong>116, 408-415, 2013.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?db=PubMed&amp;cmd=search&amp;term=23706992\" rel=\"nofollow\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Nishino, T., Yachie-Kinoshita, A., Hirayama, A., <span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, Suematsu, M., Tomita, M., \u201cDynamic simulation and metabolome analysis of long-term erythrocyte storage in adenine-guanosine solution\u201d <strong><em>PLoS One<\/em>\u00a0<\/strong>8, e71060. 2013.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24205395\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Shimura, D., Nakai, G., Jiao, Q., Osanai, K., Kashikura, K., Endo, K., <strong><u>Soga, T.<\/u><\/strong>, Goda, N., Minamisawa, S., \u201cMetabolomic profiling analysis reveals chamber-dependent metabolite patterns in the mouse heart\u201d <strong><em>Am J Physiol Heart Circ Physiol. <\/em><\/strong>305, H494-505,2013.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23792677\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Okuda, J., Niizuma, S., Shioi, T., Kato, T., Inuzuka, Y., Kawashima, T., Tamaki, Y., Kawamoto, A., Tanada, Y., Iwanaga, Y., Narazaki, M., Matsuda, T., Adachi, S., <span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, Takemura, G., Kondoh, H., Kita, T., Kimura, T., \"Persistent overexpression of phosphoglycerate mutase, a glycolytic enzyme, modifies energy metabolism and reduces stress resistance of heart in mice\", <strong><em>PLoS One<\/em>\u00a0<\/strong>8, e72173, 2013.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?db=PubMed&amp;cmd=search&amp;term=23951293\" rel=\"nofollow\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Uema, N., Ooshio, T., Harada, K., Naito, M., Naka, K., Hoshii, T., Tadokoro, Y., Ohta, K., Ali, M.A., Katano, M., <span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, Nakanuma, Y., Okuda, A., Hirao, A., \u201cAbundant nucleostemin expression supports the undifferentiated properties of germ cell tumors\u201d <strong><em>Am. J. Pathol.<\/em><\/strong> 183, 592-603, 2013.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?db=PubMed&amp;cmd=search&amp;term=23885716\" rel=\"nofollow\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Maekawa, K., Hirayama, A., Iwata Y., Tajima Y., Nishimaki-Mogami T., Sugawara S., Ueno, N., Abe, H., Ishikawa M., Murayama M., Matsuzawa Y., Nakanishi H., Ikeda K., Arita M., Taguchi, R., Minamino N., Wakabayashi, S., <strong><span style=\"text-decoration: underline;\">Soga T.<\/span><\/strong>, Saito, Y., \u201cGlobal metabolomic analysis of heart tissue in a hamster model for dilated cardiomyopathy\u201d<strong> <em>J. Mol. Cell. Cardiol.<\/em><\/strong> 59C, 76-85, 2013.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?db=PubMed&amp;cmd=search&amp;term=23454301\" rel=\"nofollow\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Oyama-Okubo, N., Sakai , T., Ando, T., Nakayama, M., <span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, \u201cMetabolome profiling of floral scent production in <em>Petunia axillaris<\/em>\u201d, <strong><em>Phytochemistry<\/em><\/strong> 90, 37-42, 2013.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?db=PubMed&amp;cmd=search&amp;term=23562394\" rel=\"nofollow\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Adam, J., Yang, M., Bauerschmidt, C., Kitagawa, M., O\u2019Flaherty, L., Maheswaran, P., O\u00a8 zkan, G., Sahgal, N., Baban, D., Kato, K., Saito, K., Iino, K., Igarashi, K., Stratford, M., Pugh, C., Tenant, D., Ludwig, C., Davies, B., Ratcliffe, P. J., El-Bahrawy, M., Ashrafian, H., <span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, Pollard, P. J., \u201cA Role for Cytosolic Fumarate Hydratase in Urea Cycle Metabolism and Renal Neoplasia\u201d <strong><em>Cell Rep.<\/em><\/strong> 3, 1440-1448, 2013.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?db=PubMed&amp;cmd=search&amp;term=23643539\" rel=\"nofollow\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Noguchi, R., Kubota, H., Yugi, K., Toyoshima, Y., Komori, Y., <span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, Kuroda, S., \u201cThe selective control of glycolysis, gluconeogenesis and glycogenesis by temporal insulin patterns\u201d <strong><em>Mol Syst Biol.<\/em> <\/strong>9:664, doi:10.1038\/msb.2013.19, 2013.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?db=PubMed&amp;cmd=search&amp;term=23670537\" rel=\"nofollow\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Migita, T., Okabe, S., Ikeda, K., Igarashi, S., Sugawara, S., Tomida, A., Taguchi, R., <span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, Seimiya, H., \u201cInhibition of ATP citrate lyase induces an anticancer effect via reactive oxygen species: AMPK as a predictive biomarker for therapeutic impact\u201d <strong><em>Am J Pathol.<\/em> <\/strong>182, 1800-1810, 2013.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?db=PubMed&amp;cmd=search&amp;term=23506848\" rel=\"nofollow\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Sato, D., Akashi, H., Sugimoto, M., Tomita, M., <strong><u>Soga, T.<\/u><\/strong>, \u201cMetabolomic profiling of the response of susceptible and resistant soybean strains to foxglove aphid, Aulacorthum solani Kaltenbach\u201d <strong><em>J. Chromatogr. B<\/em><\/strong>\u00a0925, 95-103, 2013.<br \/>\n[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23523883\/\">PubMed<\/a>]<\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Sugimoto, M., Saruta, J., Matsuki, C., To, M., Onuma, H., Kaneko, M., <span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, Tomita, M., Tsukinoki, K., \u201cPhysiological and environmental parameters associated with mass spectrometry-based salivary metabolomic profiles\u201d <strong><em>Metabolomics<\/em><\/strong><span class=\"Apple-converted-space\"> 9, 454-463,2013.<br \/>\n[<a href=\"https:\/\/link.springer.com\/article\/10.1007\/s11306-012-0464-y\">Publisher<\/a>]<\/span><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Kami, K., Fujimori, T., Sato, H., Sato, M., Yamamoto, H., Ohashi, Y., Sugiyama, N., Ishihama, Y., Onozuka, H., Ochiai, A., Esumi, H., <span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, Tomita, M., \"Metabolomic Profiling of Lung and Prostate Tumor Tissues by Capillary Electrophoresis Time-of-flight Mass Spectrometry\" <strong><em>Metabolomics<\/em><\/strong> 9, 444-453, 2013.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?db=PubMed&amp;cmd=search&amp;term=23543897\" rel=\"nofollow\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Ternette N., Yang M., Laroyia M., Kitagawa M., O'Flaherty L., Wolhulter K., Igarashi K., Saito K., Kato K., Fischer R., Berquand A., Kessler B.M., Lappin T., Frizzell N., <span style=\"text-decoration: underline;\"><strong>Soga T.<\/strong><\/span>, Adam J, Pollard P.J., \u201cInhibition of Mitochondrial Aconitase by Succination in Fumarate Hydratase Deficiency\u201d, <strong><em>Cell Rep.<\/em><\/strong> 3, 689-700. 2013.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?db=PubMed&amp;cmd=search&amp;term=23499446\" rel=\"nofollow\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li><strong><span style=\"text-decoration: underline;\">Soga, T.<\/span>, <\/strong>\u201cCancer metabolism: key players in metabolic reprogramming\u201d <strong><em>Cancer Sci.<\/em><\/strong> 104, 275-81, 2013.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?db=PubMed&amp;cmd=search&amp;term=23279446\" rel=\"nofollow\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Ito, T., Tanaka, M., Shinkawa, H., Nakada, T., Ano, Y., Kurano N., <span style=\"text-decoration: underline;\"><strong>Soga T.<\/strong><\/span>, Tomita, M., \u201cMetabolic and morphological changes of an oil accumulating trebouxiophycean alga in nitrogen-deficient conditions\u201d <strong><em>Metabolomics<\/em><\/strong> 9, S178-S187, 2013.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?db=PubMed&amp;cmd=search&amp;term=23463323\" rel=\"nofollow\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Takeuchi, K., Ohishi, M., Ota, S., Suzumura, K., Naraoka, H., Ohata, T., Seki, J., Miyamae, Y., Honma, M., <span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, \"Metabolic Profiling to Identify Potential Serum Biomarkers for gastric ulceration induced by non-steroid anti-inflammatory drugs\"<strong> <em>J. Proteome Res.<\/em><\/strong> 12, 1399-1407 , 2013.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?db=PubMed&amp;cmd=search&amp;term=23336624\" rel=\"nofollow\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Koh, T., Murakami, Y., Tanaka, S., Machino, M., Onuma, H., Kaneko, M., Sugimoto, M., <strong><u>Soga, T.<\/u><\/strong>, Tomita, M., Sakagami, H., \u201cChanges of Metabolic Profiles in an Oral Squamous Cell Carcinoma Cell Line Induced by Eugenol\u201d <strong><em>In Vivo<\/em><\/strong> 27, 233-43, 2013.<br \/>\n[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23422484\/\">PubMed<\/a>]<\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Jeelani, G., Husain, A., Sato, D., <strong><u>Soga, T<\/u><\/strong>., Suematsu, M., Nozaki, T., \u201cBiochemical and functional characterization of novel NADH kinase in the enteric protozoan parasite Entamoeba histolytica\u201d <strong><em>Biochimie<\/em><\/strong> 95, 309-319, 2013.<br \/>\n[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23069387\/\">PubMed<\/a>]<\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Mart\u0131\u00b4nez, P., Ga\u00b4lvez, S., Ohtsuka, N., Budinich, M., Corte\u00b4s, M.P., Serpell, C., Nakahigashi, K., Hirayama, A., Tomita, M., <span style=\"text-decoration: underline;\"><strong>Soga, T<\/strong>.<\/span>, Mart\u0131\u00b4nez, S., Maass, A., Parada, P., \u201cMetabolomic study of Chilean biomining bacteria<em>Acidithiobacillus ferrooxidans<\/em> strain Wenelen and <em>Acidithiobacillus thiooxidans<\/em> strain Licanantay\u201d <strong><em>Metabolomics<\/em> <\/strong>9, 247-257, 2013.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?db=PubMed&amp;cmd=search&amp;term=23335869\" rel=\"nofollow\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li id=\"y2012\">Takubo, K., Nagamatsu, G., Kobayashi, C. I, Nakamura-Ishizu, A., Kobayashi, H., Ikeda, E., Goda, N., Johnson, R. S, Rahimi, Y., <span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, Hirao, A., Suematsu, M., Suda, T., \u201cRegulation of Glycolysis by Pdk Functions as a Metabolic Checkpoint for Cell Cycle Quiescence in Hematopoietic Stem Cells\u201d <strong><em>Cell Stem Cell<\/em><\/strong> 12, 49-61, 2013.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?db=PubMed&amp;cmd=search&amp;term=23290136\" rel=\"nofollow\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li><strong>2012<\/strong><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Yamada, M., Takanashi, K., *Hamatani, T., Hirayama, A., Akutsu, H., Fukunaga, T. Ogawa, S., Sugawara, K., Shinoda, K., <span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, Umezawa, A., Kuji, N., Yoshimura, Y., Tomita, M., \u201cA medium-chain fatty acid as an alternative energy source in mouse preimplantation development\u201d,<strong> <em>Sci. Rep.<\/em> <\/strong>2, 930, doi: 10.1038\/srep00930. 2012.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?db=PubMed&amp;cmd=search&amp;term=23226596\" rel=\"nofollow\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Hirayama, A., Nakashima, E., Sugimoto, M., Akiyama, S., Sato, W., Maruayama, S., Matsuo, S., Tomita, M., Yuzawa, Y., <span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, \u201cMetabolic profiling reveals new serum biomarkers for differentiating diabetic nephropathy\u201d<strong> <em>Anal Bioanal Chem.<\/em> <\/strong>404, 3101-3109, 2012.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?db=PubMed&amp;cmd=search&amp;term=23052862\" rel=\"nofollow\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Yamamotoya, T., Dose, H., Tian, Z., Faur\u00e9, A., Toya, Y., Honma, M., Igarashi, K., Nakahigashi, K.,<strong><u> Soga, T.<\/u><\/strong>, Mori, H., Matsuno, H., \u201cGlycogen is the primary source of glucose during the lag phase of E. coli proliferation\u201d <strong><em>Biochim Biophys Acta.<\/em><\/strong> 1824, 1442-1448, 2012.<br \/>\n[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/22750467\/\">PubMed<\/a>]<\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Kato, T., Niizuma, S., Inuzuka, Y., Kawashima, T., Okuda, J., Kawamoto, A., Tamai, Y., Iwanaga, Y., <span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, Kita, T., Kimura, T., Shioi, T., \u201cAnalysis of Liver Metabolism in a Rat Model of Heart Failure\u201d<strong> <em>Int. J. Cardiol.<\/em> <\/strong>161, 130-136, 2012.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?db=PubMed&amp;cmd=search&amp;term=21839528\" rel=\"nofollow\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Akiyama, Y., Takeuchi, Y., Kikuchi, K., Mishima, E., Yamamoto, Y., Suzuki, C., Toyohara, T., Suzuki, T., Hozawa, A., Ito, S., <span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, Abe, T., \u201cA Metabolomic approach to clarifying the effect of AST-120 on 5\/6 nephrectomized rats by Capillary Electrophoresis with Mass Spectrometry\u201d <strong><em>Toxins<\/em> <\/strong>4, 1309-1322, 2012.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?db=PubMed&amp;cmd=search&amp;term=23202318\" rel=\"nofollow\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Hirayama, A., Tomita, M., <span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, \u201cSheathless capillary electrophoresis-mass spectrometry with a high-sensitivity porous sprayer for cationic metabolome analysis\u201d <strong><em>Analyst<\/em> <\/strong>137, 5026-5033, 2012.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?db=PubMed&amp;cmd=search&amp;term=23000847\" rel=\"nofollow\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Tanaka, S., Taga, H., Maehara, K., *Kaneshima, A., Machino, M., Onuma, H., Kaneko, M., Sakagami, H., Sugimoto, M.,<span style=\"text-decoration: underline;\"><strong> Soga, T.<\/strong><\/span> and Tomita, M., \u201cPilot Study of Changes in Salivary Metabolic Profiles Induced by Template Therapy\u201d<strong><em>In Vivo<\/em>.<\/strong> 26, 1015-1020, 2012.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?db=PubMed&amp;cmd=search&amp;term=23160686\" rel=\"nofollow\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Kami, K., Fujita, Y., Igarashi, S., Koike, S., Sugawara, S., Ikeda, S., Sato, N., Ito, M., *Tanaka, M., Tomita, M., <span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, \"Metabolomic Profiling Rationalized Pyruvate Efficacy in Cybrid Cells Harboring MELAS Mitochondrial DNA Mutations\"<strong> <em>Mitochondrion<\/em> <\/strong>12, 644-53, 2012.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?db=PubMed&amp;cmd=search&amp;term=22884939\" rel=\"nofollow\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Takahashi, M., Miyata, S., Fujii, J., Inai, Y., Ueyama, S., Araki, M., <span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, Fujinawa, R., Nishitani C., Ariki S., Shimizu T., Abe T., Ihara Y., Nishikimi, M., Kozutsumi Y., Taniguchi N., Kuroki, Y., \u201c<em>In vivo<\/em> role of aldehyde reductase\u201d<strong> <em>Biochim Biophys Acta<\/em> <\/strong>1820, 1787-1796, 2012.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?db=PubMed&amp;cmd=search&amp;term=22820017\" rel=\"nofollow\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Imaizumi, Y., Okada, Y., Akamatsu, W., Koike, M., Kuzumaki, N., Hayakawa, H., Nihira, T., Kobayashi, T., Ohyama, M., Sato, S., Takanashi, M., Funayama, M., Hirayama, A., <span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>,\u00a0 Hishiki, T., Suematsu, M., Yagi, T., Ito, D., Kosakai, A., Hayashi, K., Shouji, M., Nakanishi, A., Suzuki, N., Mizuno, Y., Mizushima, N., Amagai, M., Uchiyama, Y., Mochizuki, H., Hattori, N., Okano H.,\u00a0 \u201cMitochondrial dysfunction associated with increased oxidative stress and \u03b1-synuclein accumulation in PARK2 iPSC-derived neurons and postmortem brain tissue\u201d <strong><em>Mol Brain<\/em>.<\/strong> 5:35, 2012.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?db=PubMed&amp;cmd=search&amp;term=23039195\" rel=\"nofollow\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Husain, A., Sato, D., Jeelani, G., <span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, Nozaki, T.,\u00a0 \u201cDramatic Increase in Glycerol Biosynthesis upon Oxidative Stress in the Anaerobic Protozoan Parasite <em>Entamoeba histolytica<\/em>\u201d <strong><em>PLoS Negl. Trop. Dis.<\/em> <\/strong>6, e1831, 2012.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?db=PubMed&amp;cmd=search&amp;term=23029590\" rel=\"nofollow\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Kasukawa, T., Sugimoto, M., Hida, A., Minami, Y., Mori, M., Honma, S., Honma, K., Mishima, K., <span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, Ueda, H.R.\u00a0 \"Human blood metabolite timetable indicates internal body time\" <strong><em>Proc. Natl. Acad. Sci. USA<\/em><\/strong> 109, 15036-1504, 2012.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?db=PubMed&amp;cmd=search&amp;term=22927403\" rel=\"nofollow\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Omori, Y., Ohtani, T., Sakata, Y., Mano, T., Takeda, Y., Tamaki, S., Tsukamoto. Y.,\u3000Kamimura, D., Aizawa, Y., Miwa, T., Komuro, I., <span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, Yamamoto, K. \u201cL-Carnitine Prevents the Development of Ventricular Fibrosis and Heart Failure with Preserved Ejection Fraction in Hypertensive Heart Disease\u201d <strong><em>J. Hypertens.<\/em> <\/strong>30, 1834-44. 2012.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?db=PubMed&amp;cmd=search&amp;term=22796714\" rel=\"nofollow\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Sasidharan, K., <strong><u>Soga, T.<\/u><\/strong>, Tomita, M., Murray, D.B., \u201cA Yeast Metabolite Extraction Protocol Optimised for Time-Series Analyses\u201d<strong><em> PLos One<\/em><\/strong> 7(8), e44283, 2012.<br \/>\n[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/22952947\/\">PubMed<\/a>]<\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Hirata, Y., Ikeda, K., Sudoh, M., Tokunaga, Y., Suzuki, A., Weng, L., Ohta, M., Tobita, Y., Okano, K., Ozeki, K., Kawasaki, K., Tsukuda, T., Katsume, A., Aoki, Y., Umehara, T., Sekiguchi, S., Toyoda, T., Shimotohno, K.,<span style=\"text-decoration: underline;\"><strong> Soga, T.<\/strong><\/span>, Nishijima, M., Taguchi, R., Kohara, M.,\u201cSelf-enhancement of hepatitis C virus replication by promotion of specific sphingolipid biosynthesis.\u201d<strong> <em>PLoS Pathog.<\/em> <\/strong>8, e1002860, 2012.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?db=PubMed&amp;cmd=search&amp;term=22916015\" rel=\"nofollow\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Sugimoto, M., Sakagami, H., Yokote, Y., Onuma, H., Kaneko, M., Mori, M., Sakaguchi, Y., <span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, Tomita, M., \u201cNon-targeted metabolite profiling in activated macrophage secretion \u201d <strong><em>Metabolomics<\/em><\/strong> 8, 624-633, 2012.<br \/>\n<a href=\"http:\/\/link.springer.com\/article\/10.1007\/s11306-011-0353-9\">[Publisher]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Yang, M., <span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, Pollard, P.J., Adam, J., \u201cThe emerging role of fumarate as an oncometabolite\u201d <strong><em>Front. Oncol.<\/em> <\/strong>2, 85, doi: 10.3389\/fonc.2012.00085, 2012.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?db=PubMed&amp;cmd=search&amp;term=22866264\" rel=\"nofollow\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Deguchi, K., Sato, D., Sugimoto, M., Hara, H., Kawasaki, Y., Demura, S., Watanabe, T., Denholme, S. J., Okazaki, H., Ozaki, T., Yamaguchi, T., Takeya, H.,<span style=\"text-decoration: underline;\"> <strong>Soga, T.<\/strong><\/span>, Tomita, M., Takano, Y., \u201cClarification as to why alcoholic beverages have the ability to induce superconductivity in Fe1+dTe1\uff0dxSx\u201d <strong><em>Supercond. Sci. Technol.<\/em><\/strong> 25, doi:10.1088\/0953-2048\/25\/8\/084025, 2012.<br \/>\n[<a href=\"https:\/\/iopscience.iop.org\/article\/10.1088\/0953-2048\/25\/8\/084025\/meta\">Publisher<\/a>]<\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Hoshi, T., Tadokoro, Y., Naka, K., Ooshio, T., Muraguchi, T., Sugiyama, N., <span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, Araki, K., Yamamura, K., Hirao, A., \"mTORC1 is Essential for Leukemia propagation but Not Stem Cell Self-renewal\"<strong> <em>J. Clin. Invest.<\/em><\/strong> 122, 2114-2129, 2012.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?db=PubMed&amp;cmd=search&amp;term=22622041\" rel=\"nofollow\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Jeelani, G., Sato, D., Husain, A., Cadiz, A.E., Sugimoto, M., <strong><u>Soga, T.<\/u><\/strong>, Suematsu, M., Nozaki, T., \u201cMetabolic Profiling of the Protozoan Parasite Entamoeba invadens Revealed Activation of Unpredicted Pathway during Encystation\u201d <strong><em>PLoS One<\/em><\/strong> 7, e37740, 2012.<br \/>\n[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/22662204\/\">PubMed<\/a>]<\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Liu, C., Kurakane, S., Takita, J., Itano R., <span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, Oikawa A.,\u00a0 Igarashi, K., \u201cAntihypertensive Effects of Unripe Persimmon (<em>Diospyros kaki<\/em> L.cv. Hiratanenashi) Fruit and Its Component in Spontaneously Hypertensive Rats\u201d <strong><em>Food Sci. Technol. Res.<\/em> <\/strong>18, 391-398, 2012.<br \/>\n<a href=\"https:\/\/www.jstage.jst.go.jp\/article\/fstr\/18\/3\/18_391\/_article\">[J-stage]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Daimon, M., <strong><u>Soga, T.<\/u><\/strong>, Hozawa, A., Oizumi, T., Kaino, W., Takase, K., Karasawa, S., Jimbu, Y., Wada, K., Kameda, W., Susa, S., Kayama, T., Saito, K., Tomita, M., Kato, T. \u201cSerum glycerophosphate levels are increased in Japanese men with type 2 diabetes\" <em><strong>Int. Med.<\/strong> <\/em>51, 545-551, 2012.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22449660\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Sugimoto, M., Kaneko, M., Onuma, H., Sakaguchi, Y., Mori, M., Abe, S., <span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, Tomita, M., \"Changes in the Charged Metabolite and Sugar Profiles of Pasteurized and Unpasteurized Japanese Sake with Storage\"<strong> <em>J. Agric. Food Chem.<\/em> <\/strong>60, 2586-2593, 2012.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?db=PubMed&amp;cmd=search&amp;term=22352923\" rel=\"nofollow\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Sugimoto, M., Kawakami, M., Robert, M., <span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, Tomita, M. \u201cBioinfomatics Tools for Mass Spectroscopy-Based Metabolomic Data Processing and Analysis\u201d <strong><em>Curr. Bioinf.<\/em> <\/strong>7, 96-108, 2012.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?db=PubMed&amp;cmd=search&amp;term=22438836\" rel=\"nofollow\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Iino, K., Sugimoto, M., <span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, Tomita, M., \u201cProfiling of the Charged Metabolites of Traditional Herbal Medicines Using Capillary Electrophoresis time-of-flight Mass Spectrometry\u201d <strong><em>Metabolomics<\/em><\/strong> 8, 99-108, 2012.<br \/>\n<a href=\"http:\/\/link.springer.com\/article\/10.1007%2Fs11306-011-0290-7\">[Publisher]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Sugimoto, M., Ikeda, S., Niigata, K., Tomita, M., Sato, H., <strong><u>Soga, T.<\/u><\/strong> \u201cMMMDB: Mouse Multiple Tissue Metabolome Database\u201d <strong><em>Nucl. Acids Res.<\/em><\/strong> 40 (D1): D809-D814. 2012.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22139941\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li id=\"y2011\">Toyoda, Y., Tamai, M., Kashikura, K., Kobayashi, S., Fujiyama, Y., <strong><u>Soga, T.,<\/u><\/strong> Tagawa, Y., \u201cAcetaminophen-induced Hepatotoxicity in a Liver Tissue Model Consisting of Primary Hepatocytes Assembling Around an Endothelial Cell Network\u201d<strong><em>Drug Metab. Dispos<\/em><\/strong><em>. <\/em>40<strong>, <\/strong>169-177, 2012.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22010217\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li><strong>2011<\/strong><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Sato, A., <span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, Igarashi, K., Tomita, M., Kanai, A., \u201cGTP-dependent RNA 3'-terminal Phosphate Cyclase from the Hyperthermophilic Archaeon Pyrococcus furiosus\u201d <strong><em>Genes Cells <\/em><\/strong>16<strong><em>,<\/em><\/strong> 1180-1199, 2011<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22074260\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Ochiai, D., Goda, N., Hishiki, T., Kanai, Mai., Senoo-Matsuda, N., <span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, Johnson, R.S., Yoshimura, Y., Suematsu, M., \u201cDisruption of HIF-1\u03b1 in Hepatocytes Impairs Glucose Metabolism in Diet-induced Obesity Mice\u201d <strong><em>Biochem. Biophys. Res. Commun<\/em> <\/strong><span class=\"Apple-converted-space\">415<\/span><span class=\"Apple-converted-space\">, 445-449, 2011.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22051049\">[PubMed]<\/a><\/span><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Adam, J., Hatipoglu, E., O\u2019Flaherty, L., Ternette, N., Sahgal, N., Lockstone, H., Baban D., Nye, E., Stamp, G.W., Wolhuter, K., Stevens, M., Fischer, R., Carmeliet, P., Maxwell, P.H., Pugh, C.W., Frizzell, N.,<span style=\"text-decoration: underline;\"><strong> Soga, T.<\/strong><\/span>, Kessler, B.M., El-Bahrawy, M., Ratcliffe, P.J., Pollard, P.J. \u201cRenal Cyst Formation in Fh1-Deficient Mice Is Independent of the Hif\/Phd Pathway: Roles for Fumarate in KEAP1 Succination and Nrf2 Signaling\u201d <strong><em>Cancer Cell<\/em> <\/strong>20, 524-537, 2011.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?db=PubMed&amp;cmd=search&amp;term=22014577\" rel=\"nofollow\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Gustavsson, C., <span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, Wahlstr\u00f6m, E, Vesterlund, M, Azimi, A., Norstedt, G., Tollet-Egnell, P., \u201cSex-dependent Hepatic Transcripts and Metabolites in the Development of Glucose Intolerance and Insulin Resistance in Zucker Diabetic Fatty Rats\u201d <strong><em>J. Mol. Endcrinol.<\/em> <\/strong>47, 129-143, 2011.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?db=PubMed&amp;cmd=search&amp;term=21673048\" rel=\"nofollow\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Toyohara, T., Suzuki, T., Akiyama, Y., Yoshihara, D., Takeuchi, Y., Mishima, E., Kikuchi, K., Suzuki, C., Tanemoto, M., Ito, S., Nagao, S.,<strong><u> Soga T.<\/u><\/strong>, Abe, T., \u201cMetabolomic profiling of the autosomal dominant polycystic kidney disease rat model\u201d <strong><em>Clin Exp Nephrol. <\/em><\/strong>15, 676\u2013687, 2011.<br \/>\n[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/21695416\/\">PubMed<\/a>]<\/li>\n<\/ul>\n<ul class=\"list2\">\n<li><span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, Sugimoto, M., Honma, M., Mori, M., Igarashi, K., Kashikura, K., Ikeda, S., Hirayama, A., Yamamoto, T., Yoshida, H., Otsuka, M., Tsuji, S., Yatomi, Y., Sakuragawa, T., Watanabe, H., Nihei, K., Saito, T., Kawata, S., Suzuki, H., Tomita, M., Suematsu, M., \u201cSerum Metabolomics Reveals \u03b3-glutamyl Dipeptides as Biomarkers for discrimination among Different Forms of Liver Disease\u201d <strong> <em>J. Hepatol.<\/em><\/strong> 55, 896-905, 2011.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?db=PubMed&amp;cmd=search&amp;term=21334394\" rel=\"nofollow\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Deng, L., Shoji, I., Ogawa, W., Kaneda, S., <strong><span style=\"text-decoration: underline;\">Soga, T.<\/span>,<\/strong> Jiang, D., Ide, Y., Hotta, H., \u201cHepatitis C Virus Infection Promotes Hepatic Gluconeogenesis through an NS5A-Mediated, FoxO1-Dependent Pathway\u201d <strong><em>J. Virol.<\/em><\/strong> 85, 8556-8568, 2011.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?db=PubMed&amp;cmd=search&amp;term=21697492\" rel=\"nofollow\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Suzuki, T., Toyohara, T., Akiyama, Y., Takeuchi, Y., Mishima, E., Suzuki, C., Ito, S.,<span style=\"text-decoration: underline;\"><strong> Soga, T.<\/strong><\/span>, Abe, T., \u201cTranscriptional Regulation of Organic Anion Transporting Polypeptide SLCO4C1 as a New Therapeutic Modality to Prevent Chronic Kidney Disease\u201d <strong><em>J. Pharm. Sci.<\/em> <\/strong>100, 3696-3707, 2011.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?db=PubMed&amp;cmd=search&amp;term=21656517\" rel=\"nofollow\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Hayashi, K., Sasamura, H., Hishiki, T., Suematsu, M., Ikeda, S., <strong><u>Soga, T.,<\/u><\/strong> Itoh, H., \u201cUse of Serum and Urine Metabolome Analysis for the Detection of Metabolic Changes in Patients with Stage 1-2 Chronic Kidney Disease\u201d <strong><em>Nephro-Urol. Mon. <\/em><\/strong>3, 164-171, 2011.<br \/>\n[<a href=\"https:\/\/sites.kowsarpub.com\/num\/articles\/74850.html\">Publisher<\/a>]<\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Kimura, T., Takabatake, Y., Takahashi, A., Kaimori, J., Matsui, I., Namba, T., Kitamura, H., Niimura, F., Matsusaka, T., <span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, Rakugi, H., Isaka, Y., \u201cAutophagy Protects the Proximal Tubule from Degeneration and Acute Ischemic Injury\u201d<strong> <em>J. Am. Soc. Nephrol.<\/em><\/strong> 22, 902-913, 2011.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?db=PubMed&amp;cmd=search&amp;term=21493778\" rel=\"nofollow\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Ogawa, Y., Koike, N., Kurisawa. G., <span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, Tomita, M., Tei, H., \u201cPositive Autoregulation Delays the Expression Phase of Mammalian Clock Gene Per2\u201d <strong><em>PLoS One<\/em><\/strong> 6, e18663, 2011.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?db=PubMed&amp;cmd=search&amp;term=21533189\" rel=\"nofollow\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Ooga, T., Sato, H., Nagashima, A., Sasaki, K., Tomita, M.,<span style=\"text-decoration: underline;\"><strong> Soga, T.<\/strong><\/span>, Ohashi, Y., \u201cMetabolomic Anatomy of an Animal Model Revealing Homeostatic Imbalances in Dyslipidaemia\u201d <strong><em>Mol. Biosyst.<\/em><\/strong> 7, 1217-23, 2011.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?db=PubMed&amp;cmd=search&amp;term=21258713\" rel=\"nofollow\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li id=\"y2010\">Yoshida, S., Imoto, J., Minato, T., Oouchi, R., Kamada, Y., Tomita, M., <span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, Yoshimoto, H., \u201cA Novel Mechanism Regulates H2O and SO2 production in <em>Saccharomyces cerevisiae<\/em>\u201d <strong><em>Yeast<\/em> <\/strong>28, 109-121, 2011.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/sites\/entrez?db=pubmed&amp;cmd=search&amp;term=20936605\" rel=\"nofollow\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li><strong>2010<\/strong><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Husain, A., Sato, D., Jeelani, G., Suematsu, M., <span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, Nozaki, T., \u201cMetabolome Analysis Revealed Increase in S-methylcysteine and Phosphatidylisopropanolamine Synthesis upon L-cysteine Derivatization in The Anaerobic Protozoan Parasite <em>Entamoeba Histolytica<\/em>\u201d<strong> <em>J. Biol. Chem.<\/em> <\/strong>285, 39160-39170, 2010.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/sites\/entrez?db=pubmed&amp;cmd=search&amp;term=20923776\" rel=\"nofollow\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Sugiura, T., Kato, S., Shimizu, T., Wakayama, T., Nakamichi, N., Kubo, Y., Iwata, D., Suzuki, K., <span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, Asano, M., Iseki, S., Tamai, I., Tsuji, A., Kato, Y., \u201cFunctional Expression of Carnitine\/Organic Cation Transporter OCTN1\/SLC22A4 in Mouse Small Intestine and Liver\u201d <strong><em>Drug. Metab. Dispos.<\/em><\/strong> 38, 1665-1672, 2010.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20601551\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Kitagawa, M., Ikeda, S., Tashiro, E., <span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, Imoto, M.,\u00a0 \u201cMetabolomic Identification of the Target of the Filopodia Protrusion Iinhibitor Glucopiericidin A\u201d<strong> <em>Chem. Biol.<\/em> <\/strong>17, 989-998, 2010.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/sites\/entrez?db=pubmed&amp;cmd=search&amp;term=20851348\" rel=\"nofollow\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Toyohara, T., Akiyama, Y., Suzuki, T., Takeuchi, Y., Mishima, E., Tanemoto, M., Momose, A., Toki, N., Sato, H., Nakayama, M., Hozawa, A., Tsuji, I., Ito, S., <span style=\"text-decoration: underline;\"><strong>Soga, T.,<\/strong><\/span> Abe. T. \u201cMetabolomic profiling of uremic solutes in CKD patients\u201d <strong><em>Hypertens. Res.<\/em> <\/strong>33, 944-952, 2010.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/sites\/entrez?db=pubmed&amp;cmd=search&amp;term=20613759\" rel=\"nofollow\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Jeelani, G., Husain, A., Sato, D., Ali, V., Suematsu, M., <span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>,\u00a0 Nozaki, T., \u201cTwo Atypical-cysteine-regulated NADPH-dependent Oxidoreductases Involved in Redox Maintenance, L-cystine and Iron Reduction, and Metronidazole Activation in the Enteric Protozoon <em>Entamoeba Histolytica<\/em>\u201d <strong><em>J. Biol. Chem.<\/em> <\/strong>285, 26889-26899, 2010.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/sites\/entrez?db=pubmed&amp;cmd=search&amp;term=20592025\" rel=\"nofollow\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Toya, Y., Ishii, N., Nakahigashi, K., Hirasawa, T., <span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, Tomita, M., Shimizu, K., \u201c13C-Metabolic Flux Analysis for Batch Culture of <em>Escherrichia coli<\/em> and Its <em>pyk<\/em> and <em>pgi<\/em> Gene Knockout Mutants Based on Mass Isotopomer Distribution of Intracellular Metabolites\u201d, <strong><em>Biotechnol. Prog.<\/em> <\/strong>26, 975-992, 2010.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/sites\/entrez?db=pubmed&amp;cmd=search&amp;term=20730757\" rel=\"nofollow\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Sugimoto, M., Goto, H., Otomo, K., Ito, M., Onuma, H., Suzuki, A., Sugawara, M., Abe, S., Tomita, M., <strong><u>Soga, T.<\/u>, <\/strong>\u201cMetabolomic Profiles and Sensory Attributes of Edamame under Various Storage Duration and Temperature Conditions\u201d <strong><em>J. Agric. Food Chem.<\/em><\/strong> 58, 8418-8425, 2010.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20593783\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Horai, H., Arita, M., Kanaya, S., Nihei, Y., Ikeda, T., Suwa, K., Ojima, Y., Tanaka, K., Tanaka, S., Aoshima, K., Oda, Y., Kakazu, Y., Kusano, M., Tohge, T., Matsuda, F., Sawada, Y., Horai, Y. M., Nakanishi, H., Ikeda, K., Akimoto, N., Maoka, T., Takahashi, H., Ara, T., Sakurai, N., Suzuki, H., Shibata, D., Neumann, S., Iida, T., Tanaka, K., Funatsu, K., Matsuura, F., <span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, Taguchi, R., Saito, K., Nishioka, T., \u201cMassBank: A Public Repository for Sharing Mass Spectral Data for Life Sciences\u201d<strong> <em>J. Mass Spectro.<\/em> <\/strong>45, 703-714, 2010.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/sites\/entrez?db=pubmed&amp;cmd=search&amp;term=20623627\" rel=\"nofollow\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Sugimoto, M., Hirayama, A., Robert, M., Abe, S., <span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, Tomita, M., \u201cPrediction of metabolite identity from accurate mass, migration time prediction and isotopic pattern information in CE-TOFMS data\u201d <strong><em>Electrophoresis<\/em> <\/strong>31, 1-8, 2010.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/sites\/entrez?db=pubmed&amp;cmd=search&amp;term=20568260\" rel=\"nofollow\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Saito, N., Ohashi, Y., <span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, Tomita, M., \u201cUnveiling Cellular Bbiochemical Reactions via Metabolomics-driven Approaches\u201d <strong><em>Curr. Opi. Microbiol.<\/em> <\/strong>13, 358-362, 2010.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/sites\/entrez?db=pubmed&amp;cmd=search&amp;term=20430690\" rel=\"nofollow\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Fujiwara, K., Ishihama, Y., Nakahigashi, K.,<span style=\"text-decoration: underline;\"><strong> Soga, T.<\/strong><\/span>, Taguchi, H., \u201dA Systematic Survey of <em>in vivo<\/em> Obligate Shaperonin-dependent Substrates\u201d<strong> <em>EMBO J.<\/em> <\/strong>29, 1552-1564, 2010.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/sites\/entrez?db=pubmed&amp;cmd=search&amp;term=20360681\" rel=\"nofollow\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Kato, Y., Kubo, Y., Iwata, D., Kato, S., Sudo, T., Sugiura, T., Kagaya, T., Wakayama, T., Hirayama, A., Sugimoto, M., Sugihara, K., Kaneko, S., <span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, Asano, M., Tomita, M., Matsui, T., Wada, M., Tsuji, A. \u201cGene knockout and metabolome analysis of carnitine\/organic cation transporter OCTN1\u201d<strong> <em>Pharm. Res.<\/em> <\/strong>27, 832-840, 2010.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/sites\/entrez?db=pubmed&amp;cmd=search&amp;term=20224991\" rel=\"nofollow\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Kato, T., Niizuma, S., Inuzuka, Y., Kawashima, T., Okuda, J., Yamaki, Y., Iwanaga, Y., Narazaki, M., Matsuda, T.,<span style=\"text-decoration: underline;\"> <strong>Soga, T.<\/strong><\/span>, Kita, T., Kimura, T., Shioi, T., \u201cAnalysis of Metabolic Remodeling in Compensated Left Ventricular Hypertrophy and Heart Failure\u201d <strong><em>Circ. Heart Fail.<\/em>\u00a0<\/strong>3, 420-430, 2010.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/sites\/entrez?db=pubmed&amp;cmd=search&amp;term=20176713\" rel=\"nofollow\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Nakada, T., <span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, Tomita, M., Nozaki, H., \"Chlorogonium complexum sp. nov. (Volvocales, Chlorophyceae), and morphological evolution of Chlorogonium\" <strong><em>Eur. J. Phycol.<\/em> <\/strong>45, 97-106, 2010.<br \/>\n<a href=\"http:\/\/www.tandfonline.com\/doi\/full\/10.1080\/09670260903383263\">[Publisher]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Sakurakawa, T., Hishiki, T., Ueno, Y., Ikeda, S., <span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, Yachie-Kinoshita, A., Kajimura, M., Suematsu, M., \u201cHypotaurine is an energy-saving hepatoprotective compound against ischemia-reperfusion injury of rat liver\u201d<strong> <em>J. Clin. Biochem. Nutr.<\/em> <\/strong>46, 126-134, 2010.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/sites\/entrez?db=pubmed&amp;cmd=search&amp;term=20216945\" rel=\"nofollow\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Sugimoto, M., Hirayama, A., Ihiskawa, T., Baran, R., Robert, M., Uehara, K., <span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, Tomita, M., \u201cDifferential Metabolomics Software for Capillary Electrophoresis-Mass Spectrometry Data Analysis\u201d<strong> <em>Metabolomics<\/em> <\/strong>6, 27-41, 2010.<br \/>\n<a href=\"http:\/\/link.springer.com\/article\/10.1007%2Fs11306-009-0175-1\">[Publisher]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Sugimoto, M., Wong, D.T., Hirayama, A., <span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, Tomita, M., \u201cCapillary Electrophoresis Mass Spectrometry-based Saliva Metabolomics Identifies Oral, Breast and Pancreatic Cancer-Specific Profiles\u201d <strong><em>Metabolomics<\/em> <\/strong>6, 78-95, 2010.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/sites\/entrez?db=pubmed&amp;cmd=search&amp;term=20300169\" rel=\"nofollow\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Sugimoto, M., Koseki, T., Hirayama, A., Abe, S., Sano, T., Tomita, M., <span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>,\u00a0 \u201cCorrelation between Sensory Evaluation Scores of Japanese Sake and their Metabolome Profiles\u201d<strong> <em>J. Agric. Food Chem.<\/em> <\/strong>58, 374-383, 2010.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/sites\/entrez?db=pubmed&amp;cmd=search&amp;term=19961224\" rel=\"nofollow\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Nakada, T., <span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, Tomita, M., \"Phylogenetic position of a rare loricated green alga, <em>Cephalomonas granulata N. L. Higinb<\/em> (Volvocales, Chlorophyceae)\" <strong><em>Phycol. Res.<\/em> <\/strong>58, 62-68, 2010.<br \/>\n<a href=\"http:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1440-1835.2009.00559.x\/abstract\">[Publisher]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li id=\"y2009\">Sato, D., Kobayashi, S., Yasui, H., Shibata, N., Toru, T., Yamamoto, M., Tokoro, G., Ali, V., <span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, Takeuchi, T., Suematsu, M., Nozaki, T., \u201dCytotoxic Effect of Amide Derivatives of Trifluoromethionine against The Enteric Protozoan Parasite Entamoeba histolytica\u201d <em><strong>Int. J. Antimicrob. Agents.<\/strong><\/em> 35, 56-61, 2010.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/sites\/entrez?db=pubmed&amp;cmd=search&amp;term=19910163\" rel=\"nofollow\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li><strong>2009<\/strong><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Toyohara, T., Suzuki, T., Morimoto, R., Akiyama, Y., Souma, T., Shiwaku, H.O., Takeuchi, Y., Mishima, E., Abe, M., Tanemoto, M., Masuda, S., Kawano, H., Maemura, K., Nakayama, M., Sato, H., Mikkaichi, T., Yamaguchi, H., Fukui, S., Fukumoto, Y., Shimokawa, H., Inui, K., Terasaki, T., Goto, J., Ito, S., Hishinuma, T., Rubera, I., Tauc, M., Fujii-Kuriyama, Y., Yabuuchi, H., Moriyama, Y., <span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, Abe, T., \u201cSLCO4C1 Transporter Eliminates Uremic Toxins and Attenuates Hypertension and Renal Inflammation\u201d <strong><em>J. Am. Soc. Nephrol.<\/em> <\/strong>20, 2546-2555, 2009.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/sites\/entrez?db=pubmed&amp;cmd=search&amp;term=19875811\" rel=\"nofollow\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Nishino, T., Yachie-Kinoshita, A., Hirayama, A., <span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, Suematsu, M., Tomota, M., \u201c<em>In Silico<\/em> Modeling and Metabolome Analysis of Long-stored Erythrocytes to Improve Blood Storage Methods\u201d<strong> <em>J. Biotechnol.<\/em> <\/strong>144, 212-223, 2009.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/sites\/entrez?db=pubmed&amp;cmd=search&amp;term=19695295\" rel=\"nofollow\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Tajima, T., Goda, N., Fujiki, N., Hishiki, T., Nishiyama, Y., Senoo-Matsuda, N., Shimazu, M., <span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, Yoshimura, Y., Johnson, R.S., Suematsu, M., \u201cHIF-1a is necessary to support gluconeogenesis during liver regeneration\u201d<strong><em>Biochem. Bioph. Res.<\/em><\/strong> 387, 789-794, 2009.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/sites\/entrez?db=pubmed&amp;cmd=search&amp;term=19643083\" rel=\"nofollow\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Nakahigashi, K., Toya, Y., Ishii, N., <span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, Hasegawa, M., Watanabe, H., Takai, Y., Honma, M., Mori, H., Tomita, M., \u201cSystematic phenome analysis of <em>Escherichia coli<\/em> multiple knockout mutants reveals hidden reactions in central carbon metabolism\u201d <strong><em>Mol. Syst. Biol.<\/em> <\/strong>5, 306, doi:10.1038\/msb.2009.65<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/sites\/entrez?db=pubmed&amp;cmd=search&amp;term=19756045\" rel=\"nofollow\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Iuchi, Y., Okada, F., Takamiya, R., Kibe, N., Tsunoda, S., Nakajima, O., Toyoda, K., Nagae, R., Suematsu, M., <span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, Uchida, K., Fujii, J. \u201cRescue of anemia and autoimmune responses in SOD1-deficient mice by transgenic expression of human SOD1 in erythrocytes\u201d \u201d <strong><em>Biochem. J.<\/em> <\/strong>422, 313-320, 2009.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/sites\/entrez?db=pubmed&amp;cmd=search&amp;term=19515016\" rel=\"nofollow\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li><span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, Igarashi, K., Itoh, C., Mizobuchi, K., Zimmermann, H., Tomita, M.,\u201dMetabolomic Profiling of Anionic Metabolites by Capillary Electrophoresis Mass Spectrometry\u201d <strong><em>Anal. Chem.<\/em><\/strong> 81, 6165-6174, 2009.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/sites\/entrez?db=pubmed&amp;cmd=search&amp;term=19522513\" rel=\"nofollow\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Minami, Y., Kasukawa, T., Kakazu, Y., Iigo, M., Sugimoto, M., Ikeda, S., Yasui, A., van der Horst, G., <span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, *Ueda, H., \u201dMeasurement of Internal Body Time by Blood Metabolomics\u201d <strong><em>Proc. Natl. Acad. Sci. USA<\/em> <\/strong>106 9890-9895, 2009.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/sites\/entrez?db=pubmed&amp;cmd=search&amp;term=19487679\" rel=\"nofollow\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Saito, N., Robert, M., Kochi, H., Matsuo, G., Kakazu, Y., <span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, Tomita, M., \u201cMetabolite profiling reveals YihU as a novel hydroxybutyrate dehydrogenase for alternative succinic semialdehyde metabolism in <em>Escherichia coli<\/em>\u201d<strong> <em>J. Biol. Chem.<\/em> <\/strong>109, 16442-16451, 2009.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/sites\/entrez?db=pubmed&amp;cmd=search&amp;term=19372223\" rel=\"nofollow\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Ooga, T., Ohashi, Y., Kuramitsu, S., Koyama, Y., Tomita, M., <span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, Masui, R.,\u201dDegradation of ppGpp by nudix pyrophosphatase modulates the transition of growth phase in the bacterium thermos thermophilus\u201d,<strong> <em>J. Biol. Chem.<\/em> <\/strong>284, 15549-15556, 2009.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/sites\/entrez?db=pubmed&amp;cmd=search&amp;term=19346251\" rel=\"nofollow\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Hirayama, A., Kami, K., Sugimoto, M., Sugawara, M., Toki, N., Onozuka, H., Kinoshita, T., Saito, N., Ochiai, A., Tomita, M., Esumi, H., <span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, \"Quantitative Metabolome Profiling of Colon and Stomach Cancer Microenvironment by Capillary Electrophoresis Time-of-flight Mass Spectrometry\", <strong><em>Cancer Res.<\/em> <\/strong>69, 4918-4925, 2009.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/sites\/entrez?db=pubmed&amp;cmd=search&amp;term=19458066\" rel=\"nofollow\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Kuramori, C., Hase, Y., Hoshikawa, K., Watanabe, K., Nishi, T., Hishiki, T.,<span style=\"text-decoration: underline;\"><strong> Soga, T.<\/strong><\/span>, Nashimoto, A., Kabe, Y., Yamaguchi, Y., Watanabe, H., Kataoka, K., Suematsu, M., Handa, H., \u201cMono-(2-ethylhexyl) phthalate Targets Glycogen Debranching Enzyme and Affects Glycogen Metabolism in Rat Testis\u201d <strong><em>Toxicol. Sci.<\/em> <\/strong>109, 143-151, 2009.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?db=PubMed&amp;cmd=search&amp;term=19240039\" rel=\"nofollow\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li id=\"y2008\">Shintani, T., Iwabuchi, T., <span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, Kato,Y., Yamamoto, T., Takano, N., Hishiki, T., Ueno, Y., Ikeda, S., Sakurakawa, T., Ishikawa, K., Goda, N., Yitagawa, Y., Kajiyama, M., Matsumoto, K., *Suematsu, M., \"Cystathionine \u03b2-synthase as a Carbon Monoxide-sensitive Regulator of Bile Excretion\" <strong><em>Hepatology<\/em> <\/strong>49, 141-150, 2009.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?db=PubMed&amp;cmd=search&amp;term=19085910\" rel=\"nofollow\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li><strong>2008<\/strong><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Sato, S., Arita, M., <span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, Nishioka, T., Tomita, M., \u201cTime-resolved Metabolomics Reveals Metabolic Modulation in Rice Foliage\u201d, <strong><em>BMC Systems Biology<\/em><\/strong> 2, 51,doi:10.1186\/1752-0509-2-51, 2008.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?db=PubMed&amp;cmd=search&amp;term=18564421\" rel=\"nofollow\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Yoshida, S., Imoto, J., Minato, T., Oouchi, R., Sugihara, M., Imai, T., Ishiguro, T., Mizutani, S., Tomita, M., <span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, Yoshimoto, H., \u201cDeveloping Bottom-fermenting Yeast Strains That Produce High SO2 Levels by Integrated Metabolome and Transcriptome Analysis\u201d, <strong><em>Appl. Environ. Microbiol.<\/em> <\/strong>74, 2787-2796, 2008.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?db=PubMed&amp;cmd=search&amp;term=18310411\" rel=\"nofollow\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li id=\"y2007\">Ohashi, Y., Hirayama, A., Ishikawa, T., Nakamura, S., Shimizu, K., Ueno, Y., Tomita, M., <span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, \u201cDepiction of Metabolome Changes in Histidine-starved <em>Escherichia coli<\/em> by CE-TOFMS\u201d, <strong><em>Mol. BioSyst.<\/em> <\/strong>4, 135-147, 2008.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?db=PubMed&amp;cmd=search&amp;term=18213407\" rel=\"nofollow\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li><strong>2007<\/strong><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Hashimoto, M., Ishihama, Y., Tomita, M., <span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, \u201cMicroelectrospray Interface with Coaxial Sheath Flow for High Resolution CE-MS Separation\u201d <strong><em>Rapid Commun. Mass Spectrom.<\/em><\/strong> 21<strong>,<\/strong> 3579-84, 2007.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?db=pubmed&amp;cmd=Retrieve&amp;dopt=AbstractPlus&amp;list_uids=17935119\" rel=\"nofollow\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Monton, M.R.N., <span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, \u201cMetabolome Analysis by Capillary Electrophoresis \u2013 Mass Spectrometry\u201d<strong> <em>J. Chromatogr. A<\/em><\/strong> 1168, 237-46, 2007.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?db=PubMed&amp;cmd=search&amp;term=17376458\" rel=\"nofollow\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Monton, M.R.N., Tomita, M., <span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, Ishihama, Y., \u201cPolymer Entrapment in Polymerized Silicate for Preparing Highly Stable Capillary Coatings in CE and CE-MS\u201d, <strong><em>Anal. Chem.<\/em> <\/strong>79, 7838-44, 2007.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?db=pubmed&amp;cmd=Retrieve&amp;dopt=AbstractPlus&amp;list_uids=17824669&amp;query_hl=4&amp;itool=pubmed_docsum\" rel=\"nofollow\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Toya, Y., Ishii, N., Hirasawa, T., Naba, M., Hirai, K., Sugawara, K., Igarashi, S., Shimizu, K., Tomita, M., <span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, \u201cDirect Measurement of The Isotope Distribution of Intracellular Metabolites Using CE-TOFMS for Efficient Metabolic Flux Analysis\u201d,<strong> <em>J. Chromatogr. A<\/em><\/strong> 1159, 134-41, 2007.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?db=PubMed&amp;cmd=search&amp;term=17462663\" rel=\"nofollow\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li><span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, Ishikawa, T., Igarashi, S., Sugawara, K., Kakazu, Y., Tomita, M.,\u00a0 \"Analysis of nucleotides by pressure-assisted capillary electrophoresis mass spectrometry using silanol mask technique\" <strong>\u00a0<em>J. Chromatogr. A<\/em><\/strong> 1159, 125-33, 2007.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?db=PubMed&amp;cmd=search&amp;term=17543971\" rel=\"nofollow\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Morohashi, M., Shimizu, K., Ohashi, Y., Abe, J., Mori, H., Tomita, M., <span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, \u201cP-BOSS: A new filtering method for treasure hunting in metabolomics.\u201c, <strong><em>J. Chromatogr. A<\/em><\/strong> 1159, 142-48, 2007.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?db=PubMed&amp;cmd=search&amp;term=17400234\" rel=\"nofollow\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Morohashi, M., Ohashi, Y., Tani, S., Ishii, K., Itaya, M., Nanamiya, H., Kawamura, F., Tomita, M., <span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, \u201cModel based definition of population heterogeneity and its effects on metabolism in sporulating Bacillus subtilis\u201d, <strong><em>J. Biochem.<\/em> <\/strong>142<strong>,<\/strong> 183-91, 2007.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?db=PubMed&amp;cmd=search&amp;term=17545249\" rel=\"nofollow\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>\u2020Ishii, N., \u2020Nakahigashi, K., \u2020Baba, T., \u2020Robert, M., \u2020<strong><u>Soga, T.,<\/u><\/strong> \u2020Kanai, A., \u2020Hirasawa, T., Naba, M., Hirai, K., Hoque, A., Ho, P.Y., Kakazu, Y., Sugawara, K., Igarashi, S.,Harada, S., Masuda, T., Sugiyama, N., Togashi, T., Hasegawa, M., Takai, Y., Yugi, K., Arakawa, K., Iwata, N., Toya, Y., Nakayama, Y., Nishioka, T., Shimizu, K., Mori, H., Tomita, M.,\u201dMultiple High-throughput Analyses Monitor the Response of E. coli to Perturbations\u201d, <strong><em>Science<\/em><\/strong> \u00a0<strong>316<\/strong>, 593-597, 2007.(\u2020equally contribution)<br \/>\n<a href=\"http:\/\/www.sciencemag.org\/cgi\/content\/abstract\/1132067\" rel=\"nofollow\">[Science]<\/a> <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?db=pubmed&amp;cmd=search&amp;term=17379776\" rel=\"nofollow\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Kinoshita, A., Tsukada, K., <span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, Hishiki, T., Ueno, Y., Nakayama, Y., Tomita, M., *Suematsu, M., \"Roles of Hemoglobin Allostery in Hypoxia-induced Metabolic Alterations in Erythrocytes: Simulation and Its Demonstration by Metabolome Analysis\", <strong><em>J. Biol. Chem.<\/em><\/strong> 282, 10731-41, 2007.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?db=PubMed&amp;cmd=search&amp;term=17289676\" rel=\"nofollow\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li id=\"y2006\">Baran, R., Robert, M., Suematsu, M.,<span style=\"text-decoration: underline;\"> <strong>Soga, T.<\/strong><\/span>, Tomita, M., \"Visualization of Three-way Comparisons of Omics Data\", <strong><em>BMC Bioinformatics<\/em> <\/strong>8, 72, 2007.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?db=pubmed&amp;cmd=Retrieve&amp;dopt=AbstractPlus&amp;list_uids=17335588&amp;query_hl=4&amp;itool=pubmed_docsum\" rel=\"nofollow\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li><strong>2006<\/strong><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Baran, R., Kochi, H., Saito, N., Suematsu, M.,\u00a0 <span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, Nishioka, T., Robert, M., Tomita, M.,\u00a0 \"MathDAMP: a package for differential analysis of metabolite profiles\", <em>BMC <strong>Bioinformatics<\/strong><\/em> 7, 530, 2006.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?db=pubmed&amp;cmd=Retrieve&amp;dopt=AbstractPlus&amp;list_uids=17166258&amp;query_hl=4&amp;itool=pubmed_docsum\" rel=\"nofollow\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Shinoda K., Sugimoto M., Yachie N., Sugiyama N., Masuda T., Robert M., <span style=\"text-decoration: underline;\"><strong>Soga T.<\/strong><\/span>, Tomita M., \"Prediction of liquid chromatographic retention times of peptides generated by protease digestion of the <em>Escherichia coli<\/em> proteome using artificial neural networks\",<strong> <em>J. Proteome Res.<\/em> <\/strong>5, 3312-3317, 2006.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?db=pubmed&amp;cmd=Retrieve&amp;dopt=AbstractPlus&amp;list_uids=17137332&amp;query_hl=4&amp;itool=pubmed_docsum\" rel=\"nofollow\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Shinoda, K., Yachie, N., Masuda, T., Sugiyama, N., Sugimoto, M.,<span style=\"text-decoration: underline;\"> <strong>Soga, T.<\/strong><\/span>, Tomita, M., \"HybGFS: A hybrid method for genome-fingerprint scanning\", <strong><em>BMC Bioinformatics<\/em> <\/strong>7, 479, 2006.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?db=pubmed&amp;cmd=Retrieve&amp;dopt=AbstractPlus&amp;list_uids=17069662&amp;query_hl=4&amp;itool=pubmed_docsum\" rel=\"nofollow\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Takahashi, H., Hayashi, M., Sato, S., <span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, Nishioka, T., Tomita, M., Kawai-Yamada, M., Uchimiya, H., \u201cEvaluation of Metabolic Alteration in Transgenic Rice Overexpressing Dihydroflavonol-4-reductase\u201d, <strong><em>Ann. Bot.<\/em> <\/strong>98<strong>,<\/strong> 819-825, 2006.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?db=PubMed&amp;cmd=search&amp;term=16849376\" rel=\"nofollow\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Saito, N., Robert, M., Kitamura, S., Baran, R., <span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, Mori, H., Nishioka, T., Tomita, M., \u201cA metabolomics approach for enzyme discovery\",<strong> <em>J. Proteome Res.<\/em><\/strong> 5, 1979-1987, 2006.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?db=PubMed&amp;cmd=search&amp;term=16889420\" rel=\"nofollow\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li id=\"y2005\"><span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>,\u00a0 Baran, R.,\u00a0 Suematsu M., Ueno, Y., Ikeda, S., Sakurakawa T., Kakazu, Y., Ishikawa, T., Robert, M., Nishioka, T.,\u00a0 Tomita, M., \u201cDifferential Metabolomics Reveals Ophthalmic Acid As An Oxidative Stress Biomarker Indicating Hepatic Glutathione Consumption\u201d,<strong> <em>J. Biol. Chem.<\/em> <\/strong>281, 16768-76, 2006.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?db=PubMed&amp;cmd=search&amp;term=16608839\" rel=\"nofollow\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li><strong>2005<\/strong><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Jaros, M., <span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, Van de Goor, T., Gas, B., \u201cConductivity Detection in Capillary Zone Electrophoresis - Inspection by Peak Master\u201d, <strong><em>Electrophoresis<\/em> <\/strong>26, 1948-1953, 2005.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?db=PubMed&amp;cmd=search&amp;term=15818577\" rel=\"nofollow\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Ishii, N., <span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, Nishioka, T., Tomita, M., \u201cMetabolome Analysis and Metabolic Simulation\", <strong><em>Metabolomics<\/em> <\/strong>1, 29-37, 2005.<br \/>\n<a href=\"http:\/\/link.springer.com\/article\/10.1007%2Fs11306-005-1105-5\">[Publisher]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li id=\"y2004\">Sugimoto, M., Kikuchi, S., Arita, M., <span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, Nishioka, T., Tomita, M., \u201cLarge-Scale Prediction of Cationic Metabolites Identity and Migration Time in Capillary Electrophoresis Mass Spectrometry using Artificial Neural Networks\u201d, <strong><em>Anal. Chem.<\/em> <\/strong>77, 78-84, 2005.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?db=PubMed&amp;cmd=search&amp;term=15623281\" rel=\"nofollow\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li><strong>2004<\/strong><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Sato, S., <span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, Nishioka, T., Tomita, M., \u201cSimultaneous Determination of Main Metabolites in Rice Leaves using Capillary Electrophoresis Mass Spectrometry and Capillary Electrophoresis Diode Array Detection\u201d <strong><em>Plant J. <\/em><\/strong>40, 151-163, 2004.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?db=PubMed&amp;cmd=search&amp;term=15361149\" rel=\"nofollow\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Itoh, A., Ohashi, Y., <span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, Mori, H., Nishioka, T., and Tomita, M., \u201cApplication of Capillary Electrophoresis Mass Spectrometry to Synthetic in vitro Glycolysis Studies \u201d, <strong><em>Electrophoresis<\/em> <\/strong>25, 1996-2002, 2004.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?db=PubMed&amp;cmd=search&amp;term=15237399\" rel=\"nofollow\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li id=\"y2003\"><span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, Kakazu, Y., Martin, R., Tomita, M., and Nishioka, T., \u201cQualitative and Quantitative Analysis of Amino Acids by Capillary Electrophoresis Electrospray Ionization Tandem Mass Spectrometry\u201d, <strong><em>Electrophoresis<\/em> <\/strong>25, 1964-1972, 2004.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?db=PubMed&amp;cmd=search&amp;term=15237395\" rel=\"nofollow\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li><strong>2003<\/strong><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li id=\"y2002\"><span style=\"text-decoration: underline;\"><strong id=\"y2002\">Soga, T.<\/strong><\/span>, Ohashi, Y., Ueno, Y., Naraoka, H., Tomita, M., and Nishioka, T., \u201cQuantitative Metabolome Analysis Using Capillary Electrophoresis Mass Spectrometry\u201d, <strong><em>J. Proteome Res.<\/em> <\/strong>2.\u3000488-494, 2003.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?db=PubMed&amp;cmd=search&amp;term=14582645\" rel=\"nofollow\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li><strong>2002<\/strong><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li><span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, Ueno, Y., Naraoka, H., Matsuda, K., Tomita, M., Nishioka, T., \u201dPressure Assisted Capillary Electrophoresis Electrospray Ionization Mass Spectrometry for Analysis of Multivalent Anions\u201d, <strong><em>Anal. Chem.<\/em> <\/strong>74, 6224-6229, 2002.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?db=PubMed&amp;cmd=search&amp;term=12510742\" rel=\"nofollow\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Matsuda, K., Yamaguchi, H., Ueno, Y., <span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, Fujita, Y., Nishioka, T.,\u00a0 \"Combined Metabolome and Transcriptome Analysis of Bacillus subtilis Cells Cultured on Different Carbon Sources\", <strong><em>Genomic Informatics Series<\/em><\/strong> 13, 593-594, 2002.<br \/>\n[<a href=\"https:\/\/www.jstage.jst.go.jp\/article\/gi1990\/13\/0\/13_0_593\/_article\">J-stage<\/a>]<\/li>\n<\/ul>\n<ul class=\"list2\">\n<li id=\"y2001\"><span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, Ueno, Y., Naraoka, H., Ohashi, Y., Tomita, M., and Nishioka, T., \u201dSimultaneous Determination of Anionic Intermediates for Bacillus subtilis Metabolic Pathways by Capillary Electrophoresis Electrospray Ionization Mass Spectrometry\u201d,<strong> <em>Anal. Chem.<\/em> <\/strong>74, 2233-2239, 2002.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?db=PubMed&amp;cmd=search&amp;term=12038746\" rel=\"nofollow\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li><strong>2001<\/strong><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li><span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, Imaizumi, M., \u201dCapillary Electrophoresis Method for the Analysis of Inorganic Anions, Organic Acids, Amino Acids, Nucleotides, Carbohydrates and Other Anionic Compounds\u201d <strong><em>Electrophoresis<\/em> <\/strong>22, 3418-3425, 2001.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?db=PubMed&amp;cmd=search&amp;term=11669520\" rel=\"nofollow\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li id=\"y2000\">Kodama, S., Yamamoto, A., Matsunaga, A., <span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, Hayakawa, K., \u201dDirect Chiral Resolution of Malic Acid in Apple Juice by Ligand-exchange Capillary Electrophoresis Using Copper (II)-L-Tartaric Acid as A Chiral Selector\u201d <strong><em>Electrophoresis<\/em><\/strong> 22, 3286-3290, 2001.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?db=PubMed&amp;cmd=search&amp;term=11589292\" rel=\"nofollow\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li><strong>2000<\/strong><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li><span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, Serwe, M., \u201dDetermination of Carbohydrates in Food Samples by Capillary Electrophoresis with Indirect UV Detection\u201d, <strong><em>Food Chem.<\/em> <\/strong>69, 339-344, 2000.<br \/>\n[<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0308814600000443\">Publisher<\/a>]<\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Kodama, S., Yamamoto, A., Matsunaga, A., <span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, Minoura, K.,\u00a0 \"Direct Chiral Resolution of Lactic Acid in Food Products by Capillary Electrophoresis\u201d, <strong><em>J. Chromatogr. A<\/em><\/strong> 875, 371-377, 2000.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?db=PubMed&amp;cmd=search&amp;term=10839157\" rel=\"nofollow\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li><span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, Heiger, D.N., \u201dAmino Acid Analysis by Capillary Electrophoresis Electrospray Ionization Mass Spectrometry\u201d, <strong><em>Anal. Chem.<\/em> <\/strong>72<span class=\"Apple-converted-space\"> ,<\/span>1236-1241, 2000.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?db=PubMed&amp;cmd=search&amp;term=10740865\" rel=\"nofollow\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li id=\"y1999\"><span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, Tajima, I., and Heiger, D.N., \u201cCapillary Electrophoresis for the Determination of Forensic Anions in Adulterated Foods and Beverages\u201d,<strong> <em>Am. Lab.<\/em> <\/strong>32<span class=\"Apple-converted-space\"> ,<\/span>124-128, 2000.<\/li>\n<\/ul>\n<ul class=\"list2\">\n<li><strong>1999<\/strong><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Tsunoda, M., Kato, M., Fukushima, T., Santa, T., Homma, H., Yani, H., <span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, Imai, K.,\u201dDetermination of Aspartic Acid Enantiomers in Bio-samples by Capillary Electrophoresis\u201d, <strong><em>Biomed. Chromatogr.<\/em> <\/strong>13 335-339, 1999.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?db=PubMed&amp;cmd=search&amp;term=10425023\" rel=\"nofollow\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li><span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, Ross, G.A., \u201cSimultaneous Determination of Inorganic Anions, Organic Acids, Amino Acids and Carbohydrates by Capillary Electrophoresis\u201d,<strong> <em>J. Chromatogr. A<\/em> <\/strong>837 231-239, 1999.<br \/>\n<a href=\"http:\/\/www.sciencedirect.com\/science\/article\/pii\/S0021967399000928\">[Publisher]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li id=\"y1998\"><span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, Ross, G.A., \u201cSimultaneous Determination of Inorganic Anions, Organic Acids and Metal Cations by Capillary Electrophoresis\u201d,<strong> <em>J. Chromatogr. A<\/em><\/strong> 834 ,65-71, 1999<br \/>\n[<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S002196739800692X\">Publisher<\/a>]<\/li>\n<\/ul>\n<ul class=\"list2\">\n<li><strong>1998<\/strong><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li><span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, Heiger, D.N., \u201cSimultaneous Determination of Monosaccharides in Glycoproteins by Capillary Electrophoresis\u201d,<strong> <em>Anal. Biochem.<\/em> <\/strong>261,73-78, 1998.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?db=PubMed&amp;cmd=search&amp;term=9683514\" rel=\"nofollow\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li id=\"y1997\">Jegle, U., Serwe, M., <span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, \u201dKapillarelektrophorese-eine Pr\u00e4destinierte Technik f\u00fcr die Analyse von Kationen und Anionen in Elektrolyten f\u00fcr die Galvanische und Chemische Metallisierung\u201d, <strong><em>Galvanotechnik<\/em>,<\/strong> 89 1478-1485, 1998.<\/li>\n<\/ul>\n<ul class=\"list2\">\n<li><strong>1997<\/strong><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li><span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, Ross, G.A., \u201cCapillary Electrophoretic Determination of Inorganic and Organic Anions using 2,6-Pyridinedicarboxylic Acid: Effect of Electrolyte\u2019s Complexing Ability\u201d,<strong> <em>J. Chromatogr. A<\/em> <\/strong>767, 223-230, 1997.<br \/>\n<a href=\"http:\/\/www.sciencedirect.com\/science\/article\/pii\/S0021967396010552\">[Publisher]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li><span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, Wakaura, M., \u201cDetermination of Inorganic and Organic Anions in Beer and Wort by Capillary Electrophoresis\u201d,<strong> <em>J. Am. Soc. Brew. Chem.<\/em> <\/strong>55,44-46, 1997.<br \/>\n<a href=\"http:\/\/www.asbcnet.org\/publications\/journal\/vol\/Abstracts\/0420-03a.htm\">[Publisher]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li id=\"y1995\">Jegle, U., Grimm, R., Godel, H., Schuster, R., Ross, G. A., <span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, \u201dPoly(vinyl alcohol)-Coated Capillaries \u2013 A Solution for Many Application Areas in Capillary Electrophoresis\u201d, <strong><em>LCGC International<\/em> <\/strong>10 176-188, 1997.<\/li>\n<\/ul>\n<ul class=\"list2\">\n<li><strong>1995<\/strong><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li><span style=\"text-decoration: underline;\"><strong id=\"y1993\">Soga, T.<\/strong><\/span>, Inoue, Y., Ross, G. A., \u201cAnalysis of Halides, Oxyhalides and Metal Oxoacids by Capillary Electrophoresis with Suppressed Electroosmotic Flow\u201d,<strong> <em>J. Chromatogr. A<\/em><\/strong> 718, 421-428, 1995.<br \/>\n<a href=\"http:\/\/www.sciencedirect.com\/science\/article\/pii\/0021967395007040\">[Publisher]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li><strong>1993<\/strong><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li><span style=\"text-decoration: underline;\"><strong id=\"y1992\">Soga, T.<\/strong><\/span>, Inoue, Y., \u201cDetermination of Catecholamines in Urine and Plasma by On-line Sample Pretreatment using an Internal Surface Boronic Acid Gel\u201d, <strong><em>J. Chromatogr. Biomed.<\/em> <\/strong>620, 175-181, 1993.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?db=PubMed&amp;cmd=search&amp;term=8300784\" rel=\"nofollow\">[PubMed]<\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li><strong>1992<\/strong><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li><span style=\"text-decoration: underline;\"><strong id=\"rBooks\">Soga, T.<\/strong><\/span>, Inoue, Y., Yamaguchi, K., \u201cDetermination of Carbohydrates by Hydrophilic Interaction Chromatography with Pulsed Amperometric Detection using Postcolumn pH Adjustment\u201d,<strong> <em>J. Chromatogr.<\/em><\/strong><span class=\"Apple-converted-space\"> <strong>A <\/strong><\/span>625, 151-155, 1992.<br \/>\n<a href=\"http:\/\/www.sciencedirect.com\/science\/article\/pii\/002196739285196Z\">[Publisher]<\/a><\/li>\n<\/ul>\n<h2>Books<\/h2>\n<ul class=\"list2\">\n<li>Alterman M.Ed., (Hirayama, A., Ikeda, S., Sato, A., <span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, T., contribution for Chapter 23: Amino Acid Analysis by Capillary Electrophoresis-Mass Spectrometry) \u201c<em><strong>Amino Acid Analysis : Methods and Protocols<\/strong>\u201d, (Methods in Molecular Biology 2030), <\/em>pp.307-313, Humana Press, 2019.<br \/>\n<a href=\"https:\/\/www.amazon.com\/Amino-Acid-Analysis-Protocols-Molecular\/dp\/149399638X\"><span style=\"color: #339966;\">Amazon.com<\/span><\/a> <span style=\"color: #ff6600;\"><span style=\"color: #ff9900;\">[<a style=\"color: #ff9900;\" href=\"https:\/\/link.springer.com\/book\/10.1007\/978-1-4939-9639-1\">Publisher<\/a><\/span>]<\/span><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Komatsu, T., Ceccaldi, H-J., Yoshida, J., Prouzet, P., Henocque, Y. Ed., , (Nakano, T., Shirakawa, H., Yeo, G., Devlin, R.H., <span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, contribution for Part IV Innovative Research: Metabolome profiling of growth hormone transgenic coho salmon by capillary electrophoresis time-of-flight mass spectrometry) \u201c<strong>Oceanography Challenges to Future Earth : Human and Natural Impacts on our Seas<\/strong>\u201d, pp. 223-234, Springer, Cham, 2019.<br \/>\n<a href=\"https:\/\/www.amazon.com\/Oceanography-Challenges-Future-Earth-Natural-dp-3030001377\/dp\/3030001377\/\"><span style=\"color: #339966;\">Amazon.com<\/span><\/a> <span style=\"color: #ff6600;\">[<a href=\"https:\/\/link.springer.com\/book\/10.1007\/978-3-030-00138-4\"><span style=\"color: #ff9900;\">Publisher<\/span><\/a>]<\/span><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Ramautar R. Ed., (Hirayama A, <span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, contribution for \u201cCHAPTER 7: CE-MS for anionic and cationic metabolic profiling: system optimization and applications\u201d) \u201c<strong>Capillary Electrophoresis-Mass Spectrometry for Metabolomics<\/strong>\u201d , pp.134-160, The Royal Society of Chemistry, 2018.<br \/>\n<a href=\"https:\/\/www.amazon.com\/Capillary-Electrophoresis-Mass-Spectrometry-Metabolomics-Developments-dp-178801104X\/dp\/178801104X\/\"><span style=\"color: #339966;\">Amazon.com<\/span><\/a> <span style=\"color: #ff6600;\">[<span style=\"color: #ff9900;\"><a style=\"color: #ff9900;\" href=\"https:\/\/pubs.rsc.org\/en\/content\/ebook\/978-1-78801-104-4\">Publisher<\/a><\/span>]<\/span><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Bjerrum, J. T. Ed., (Wakayama, M., Hirayama, A., <span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, contribution for Chapter 9: Capillary Electrophoresis-Mass Spectrometry) <em><strong>\u201cMetabolomics: Methods and Protocols\u201d <\/strong>(Methods in Molecular Biology 1277) <\/em>, pp.113-122, Humana Press, 2015.<br \/>\n<a href=\"https:\/\/www.amazon.com\/Metabonomics-Methods-Protocols-Molecular-Biology\/dp\/1493923765\/\"><span style=\"color: #339966;\">Amazon.com<\/span><\/a> <a href=\"http:\/\/link.springer.com\/book\/10.1007%2F978-1-4939-2377-9#page-1\"><span style=\"color: #ff6600;\">[Publisher]<\/span><\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Hyotylainen, T., Wiedmer, S., Ed., (Hirayama, A., <span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, contribution for Chapter 6: Capillary Electromigration Techniques in Metabolomics) <em><strong>\u201cChromatographic Methods in Metabolomics\u201d<\/strong> (RSC Chromatography Monographs 18)<\/em>, pp.114-137, RSC Publishing, 2013<br \/>\n<a href=\"https:\/\/www.amazon.com\/Chromatographic-Methods-Metabolomics-Chromatography-Monographs\/dp\/1849736073\/\"><span style=\"color: #339966;\">Amazon.com<\/span><\/a> <a href=\"http:\/\/pubs.rsc.org\/en\/content\/ebook\/978-1-84973-607-7#!divbookcontent\"><span style=\"color: #ff6600;\">[Publisher]<\/span><\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Alterman, M. A., Hunziker, P., Ed. (Hirayama, A., <u><strong>Soga, T.<\/strong>,<\/u> contribution for Chapter 8: Amino Acid Analysis by Capillary Electrophoresis-Mass Spectrometry) <em><strong>\u201cAmino Acid Analysis: Methods and Protocols\u201d<\/strong> (Methods in Molecular Biology 828)<\/em>, pp.77-82, Humana Press, 2012.<br \/>\n<span style=\"color: #0066cc;\"><a href=\"https:\/\/www.amazon.com\/Amino-Acid-Analysis-Protocols-Molecular\/dp\/1617794449\/\"><span style=\"color: #339966;\">Amazon.com<\/span><\/a> <a href=\"http:\/\/link.springer.com\/book\/10.1007%2F978-1-61779-445-2\"><span style=\"color: #ff6600;\">[Publisher]<\/span><\/a> <\/span><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Wang, J., Zhu, H., Ed., (Iino, K., Sugimoto, M., <strong><u>Soga, T.<\/u><\/strong>, Tomita, M., contribution for Metabolomics: A New Omics Technology for Traditional Herbal Medicine Analysis) \u201c<strong><em>Chinese Medicine: Acupuncture, Herbal Medicine and Therapies<\/em><\/strong>\u201d pp. 45-55, Nova Science Publishers, Inc., 2012.<br \/>\n<span style=\"color: #ff6600;\"><span style=\"text-decoration: underline;\"><a href=\"https:\/\/www.amazon.co.jp\/-\/en\/Jianguo-Wang\/dp\/162081529X\/ref=sr_1_1?crid=150TNQC47GB9S&amp;keywords=ISBN%3A+978-1-62081-529-8&amp;qid=1646383383&amp;sprefix=isbn+978-1-62081-529-8%2Caps%2C164&amp;sr=8-1\">Amazon.com<\/a> [<\/span><a href=\"https:\/\/novapublishers.com\/shop\/chinese-medicine-acupuncture-herbal-medicine-and-therapies\/\">Publisher<\/a>]<\/span><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Smolke, C. D., Ed. (Monton, M.R., <span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, contribution for Chapter 14: Monitoring and Measuring the Metabolome)<em><strong> \u201cThe Metabolic Pathway Engineering Handbook: Tools and Applications\u201d<\/strong><\/em> pp.14-1-14-12, CRC Press, 2009.<br \/>\n<a href=\"https:\/\/www.amazon.com\/Metabolic-Pathway-Engineering-Handbook-Applications\/dp\/1420077651?ie=UTF8&amp;*Version*=1&amp;*entries*=0\"><span style=\"color: #339966;\">Amazon.com <\/span><\/a> <a href=\"http:\/\/www.crcnetbase.com\/isbn\/9781420077667\"> <span style=\"color: #ff6600;\"><span style=\"text-decoration: underline;\">[<\/span>Publisher]<\/span><\/a><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Nielsen, J., Jewett, M.C., Ed, (Robert, M., <strong><u>Soga, T.<\/u><\/strong>, Tomita, M., contribution for E. coli metabolomics: capturing the complexity of a \u201csimple\u201d model), \u201c<strong><em>Metabolomics: A Powerful Tool in Systems Biology<\/em><\/strong><em>\u201d (Topics in Current Genetics 18)<\/em>, pp.189-234, Springer, 2007.<br \/>\n<span style=\"color: #339966;\"><a href=\"https:\/\/www.amazon.com\/Metabolomics-Powerful-Systems-Biology-Genetics\/dp\/3540747184\">Amazon.com<\/a> <span style=\"color: #ff6600;\"><span style=\"text-decoration: underline;\">[<\/span><a href=\"https:\/\/link.springer.com\/book\/10.1007\/978-3-540-74719-2\">Publisher<\/a>]<\/span><\/span><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Weckwerth, W., Ed. (<span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, contribution for Chapter 8: Capillary Electrophoresis-Mass Spectrometry for Metabolomics) <em><strong>\u201cMetabolomics: Methods and Protocols\u201d<\/strong> (Methods in Molecular Biology 358)<\/em>, pp.129-137, Humana Press, 2006.<br \/>\n<span style=\"color: #339966;\"><a style=\"color: #339966;\" href=\"http:\/\/www.amazon.com\/Metabolomics-Methods-Protocols-Molecular-Biology\/dp\/1588295613\/\" rel=\"nofollow\">Amazon.com<\/a> <a href=\"http:\/\/link.springer.com\/book\/10.1007%2F978-1-59745-244-1\"><span style=\"color: #ff6600;\"><span style=\"text-decoration: underline;\">[<\/span>Publisher]<\/span> <\/a><\/span><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li>Tomita, M., Nishioka T., Ed. (<span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, contribution for Chapter 2: Development and Application of Capillary Electrophoresis-Mass Spectrometry Methods to Metabolomics) <em><strong>\u201cMetabolomics: The Frontier of Systems Biology\u201d<\/strong> <\/em>pp.7-24, Springer, 2005.<br \/>\n<span style=\"color: #339966;\"><a style=\"color: #339966;\" href=\"http:\/\/www.amazon.com\/Metabolomics-Frontier-Systems-M-Tomita\/dp\/4431251219\/s\" rel=\"nofollow\">Amazon.com<\/a> <a href=\"http:\/\/link.springer.com\/book\/10.1007%2F4-431-28055-3\"><span style=\"color: #ff6600;\"><span style=\"text-decoration: underline;\">[<\/span>Publisher]<\/span><\/a> <\/span><\/li>\n<\/ul>\n<ul class=\"list2\">\n<li id=\"rPatents\">El Rassi, Z., Ed. (<strong><span style=\"text-decoration: underline;\">Soga, T<\/span>.<\/strong>, contribution for Chapter 14: Analysis of Carbohydrates in Food and Beverages by HPLC and CE ) <em><strong>\u201cCarbohydrate Analysis by Modern Chromatography and Electrophoresis\u201d<\/strong>( Journal of Chromatography Library 66)<\/em>, pp.483-502, Elsevier Science Publishers, 2002.<br \/>\n<span style=\"color: #339966;\"><a style=\"color: #339966;\" href=\"http:\/\/www.amazon.com\/Carbohydrate-Analysis-Chromatography-Electrophoresis-Journal\/dp\/0444500618\/\" rel=\"nofollow\">Amazon.com<\/a> <a href=\"http:\/\/www.sciencedirect.com\/science\/bookseries\/03014770\/66\"> <span style=\"color: #ff6600;\"><span style=\"text-decoration: underline;\">[<\/span>Publisher]<\/span> <\/a><\/span><\/li>\n<\/ul>\n<h2>Patents<\/h2>\n<ul>\n<li><span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, Hirayama, A., Abe, H., \u201c<em>Method Of Creating Spray Device For Sheathless CE-MS, Spray Device For Sheathless CE-MS, And Sheathless CE-MS Device\u201d, <\/em>DE Patent No. 112016000855 (2019),\u00a0 PCT\/JP2016\/058131.<\/li>\n<li><strong>Soga, T.<\/strong>, Hirayama, A., Abe, H., \u201c<em>Method Of Creating Spray Device For Sheathless CE-MS, Spray Device For Sheathless CE-MS, And Sheathless CE-MS Device\u201d,<\/em> JP Patent No. 6498497(2019).<\/li>\n<li><span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, Sugimoto, M., Suematsu M., Saito, T., Kawata, S.,<em> \u201cLiver Disease Marker, Method And Apparatus For Measuring Same, And Test Method For Pharmaceutical Preparation\u201d,<\/em> KR Patent No.10-1867808 (2018), PCT\/JP2011\/061340.<\/li>\n<li><span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, Hirayama, A., Abe, H., \u201c<em>Method Of Creating Spray Device For Sheathless CE-MS, Spray Device For Sheathless CE-MS, And Sheathless CE-MS Device\u201d,<\/em> US Patent No. US9,978,573 (2018),\u00a0 PCT\/JP2016\/058131.<\/li>\n<li><span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, Sugimoto, M., Suematsu M., Honma, M., Yamamoto, T., Suzuki, H.,<em> \u201cLiver Disease Marker, Method And Apparatus For Measuring Same, And Test Method For Pharmaceutical Preparation\u201d, <\/em>CN Patent No. ZL201410334142.1 (2017), Division of PCT\/JP2009\/069950.<\/li>\n<li><span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, Sugimoto, M., Suematsu M., Honma, M., Yamamoto, T., Suzuki, H.,<em> \u201cMethod for Measuring Liver Disease Markers And Test Method for Pharmaceutical Preparation\", <\/em>EPC Patent No. EP2381259 (2016), PCT\/JP2009\/069950.<\/li>\n<li><span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, Sugimoto, M., Suematsu M., Saito, T., Kawata, S.,<em> \u201cLiver Disease Marker\u201d,<\/em> JP Patent No.5809136 (2015), PCT\/JP2011\/061340.<\/li>\n<li><span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, Sugimoto, M., Suematsu M., Saito, T., Kawata, S.,<em> \u201cLiver Disease Marker, Method And Apparatus For Measuring Same, And Test Method For Pharmaceutical Preparation\u201d,<\/em> CN Patent No. ZL201180030202.5 (2015), PCT\/JP2011\/061340.<\/li>\n<li><span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, Sugimoto, M., Suematsu M., Honma, M., Yamamoto, T., Suzuki, H.,<em> \u201c<span style=\"font-family: Arial;\">Oxidative stress <\/span>Marker, Method And Apparatus For Measuring Same, And Test Method For Pharmaceutical Preparation\u201d, <\/em>JP Patent No. 5676275 (2015)<em>, <\/em>PCT\/JP2009\/069950.<\/li>\n<li>Abe, T., <span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong> <\/span>,\u201cNovel renal disease marker substance in human\u201d JP Patent No. 5757626 (2015), PCT\/JP2010\/005434.<\/li>\n<li>Abe, T., <span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong> <\/span>,\u201cHuman Renal Disease Marker Substance\u201d US Patent No. US8,709,816 (2014), PCT\/JP2010\/005434.<\/li>\n<li><span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, Sugimoto, M., Suematsu M., Honma, M., Yamamoto, T., Suzuki, H.,<em> \u201cLiver Disease Marker, Method And Apparatus For Measuring Same, And Test Method For Pharmaceutical Preparation\u201d, <\/em>CN Patent No. ZL200980152582.2 (2014), PCT\/JP2009\/069950.<\/li>\n<li><u><strong>Soga, T.<\/strong><\/u><u>,<\/u> Suematsu, M., \u201c<em>Method for Determination of Oxidative Stress<\/em>\u201d, US Patent No. US8,309,056 (2012), Division of PCT\/JP2007\/050517.<\/li>\n<li><u><strong>Soga, T.<\/strong><\/u><u>,<\/u> Suematsu, M., \u201c<em>Method for Determination of Oxidative Stress<\/em>\u201d, JP Patent No. 4840804 (2011).<\/li>\n<li><u><strong>Soga, T.<\/strong><\/u><u>,<\/u> Suematsu, M., \u201c<em>Method for Determination of Oxidative Stress<\/em>\u201d, US Patent No. US7,964,177 (2011), PCT\/JP2007\/050517.<\/li>\n<li><u><strong>Soga, T.<\/strong><\/u><u>,<\/u> Suematsu, M., \u201c<em>Method for Determination of Oxidative Stress<\/em>\u201d, EPC Patent No. EP1975621 (2010),\u3000PCT\/JP2007\/050517.<\/li>\n<li>Tomita, M., Itoh, A., <span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, Ohhashi, N.,<span class=\"Apple-converted-space\"> \"<\/span><em>Method for Identifying Functions and Binding Substances of Gene Products\", <\/em>JP Patent No.4114075 (2008)<em>.<\/em><\/li>\n<li>Tomita, M., Itoh, A., <span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>,<span class=\"Apple-converted-space\"> \"<\/span><em>Method and Kit for Identifying Functions and Binding Substances of Gene Products\"<\/em>, US2007\/0172825, EP1717587, WO\/2005\/078449, PCT\/JP2005\/001858.<\/li>\n<li>Sugimoto, M., <span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, Tomita, M., \"<em>Method for Predicting The Migration Time of Ionic Compounds by Electrophoretic measurement\"<\/em>, US2007\/0256935, PCT\/JP2005\/15325.<\/li>\n<li>Sugimoto, M., <span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, Tomita, M., \"<em>Method for Predicting The Migration Time of Ionic Compounds by Electrophoretic measurement\"<\/em>, JP Patent No.3871689 (2006).<\/li>\n<li><span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>,<span class=\"Apple-converted-space\"> \"<\/span><em>Apparatus and Method for Anion Analysis\"<\/em>, JP Patent 3341765 (2002).<\/li>\n<li><span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>,<span class=\"Apple-converted-space\"> \"<\/span><em>Capillary Electrophoresis Apparatus and Method for Anions, Amino Acids and Carbohydrate Analysis\"<\/em>, JP Patent 3038184 (2000).<\/li>\n<li><span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>,<span class=\"Apple-converted-space\"> \"<\/span><em>Apparatus and Method for Anion Analysis\"<\/em>, JP Patent 2912232 (1999).<\/li>\n<li><span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>,<span class=\"Apple-converted-space\"> \"<\/span><em>Apparatus and Method for Catecholamine Analysis\"<\/em>, JP Patent 2833058 (1998).<\/li>\n<li><span style=\"text-decoration: underline;\"><strong>Soga, T.<\/strong><\/span>, Inoue, Y.,<span class=\"Apple-converted-space\"> \"<\/span><em>Capillary Electrophoresis Apparatus and Its Method\"<\/em>, EP078329<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>2026|2025|2024|2023|2022|2021|2020|2019|2018|2017|2016|2015|2014|2013|2012|2011| 2010|2009|2008|2007|2006|2005 <a href=\"https:\/\/metabolome.iab.keio.ac.jp\/ja\/publications\/\" class=\"more-link\">...<span class=\"screen-reader-text\"> \"\u7814\u7a76\u696d\u7e3e\"<\/span> \u3092\u7d9a\u3051\u3066\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"page-templates\/full-width.php","meta":{"_locale":"ja","_original_post":"65","footnotes":""},"class_list":{"0":"post-737","1":"page","2":"type-page","3":"status-publish","5":"ja","6":"h-entry","7":"hentry","8":"h-as-page"},"_links":{"self":[{"href":"https:\/\/metabolome.iab.keio.ac.jp\/wp-json\/wp\/v2\/pages\/737","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/metabolome.iab.keio.ac.jp\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/metabolome.iab.keio.ac.jp\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/metabolome.iab.keio.ac.jp\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/metabolome.iab.keio.ac.jp\/wp-json\/wp\/v2\/comments?post=737"}],"version-history":[{"count":215,"href":"https:\/\/metabolome.iab.keio.ac.jp\/wp-json\/wp\/v2\/pages\/737\/revisions"}],"predecessor-version":[{"id":1969,"href":"https:\/\/metabolome.iab.keio.ac.jp\/wp-json\/wp\/v2\/pages\/737\/revisions\/1969"}],"wp:attachment":[{"href":"https:\/\/metabolome.iab.keio.ac.jp\/wp-json\/wp\/v2\/media?parent=737"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}