Publications

Selected papers

  • Saito, T., Ichimura, Y., Taguchi, K., Suzuki, T., Mizushima, T., Takagi, K., Hirose, Y., Nagahashi, M., Iso, T., Fukutomi, T., Ohishi, M., Endo, K., Uemura, T., Nishito, Y., Okuda, S., Obata, M., Kouno, T., Imamura, R., Tada, Y., Obata, R., Yasuda, D., Takahashi, K., Fujimura, T., Pi, J., Lee, MS., Ueno, T., Ohe, T., Mashino, T., Wakai, T., Kojima, H., Okabe, T., Nagano, T., Motohashi, H., Waguri, S., Soga, T., Yamamoto, M., Tanaka, K., Komatsu, M., "p62/Sqstm1 promotes malignancy of HCV-positive hepatocellular carcinoma through Nrf2-dependent metabolic reprogramming", Nat.Commun. 7, 12030, 2016. DOI: 10.1038/ncomms12030
    [PubMed]
  • Cheng, K., Lee, B., Masuda, T., Ito, T., Ikeda, K., Hirayama, A., Deng, L., Dong, J., Shimizu, K., Soga, T., Tomita, M., Palsson, B. O. & Robert, M., “Global metabolic network reorganization by adaptive mutations allows fast growth of Escherichia coli on glycerol” Nat. Commun. 5, 3233, 2014.
    [PubMed]
  • Adam, J., Yang, M., Bauerschmidt, C., Kitagawa, M., O’Flaherty, L., Maheswaran, P., O¨ zkan, G., Sahgal, N., Baban, D., Kato, K., Saito, K., Iino, K., Igarashi, K., Stratford, M., Pugh, C., Tenant, D., Ludwig, C., Davies, B., Ratcliffe, P. J., El-Bahrawy, M., Ashrafian, H., Soga, T., and Pollard, P. J. , “A Role for Cytosolic Fumarate Hydratase in Urea Cycle Metabolism and Renal Neoplasia” Cell Rep. 3, 1440-1448, 2013.
    [PubMed]
  • Ternette N., Yang M., Laroyia M., Kitagawa M., O'Flaherty L., Wolhulter K., Igarashi K., Saito K., Kato K., Fischer R., Berquand A., Kessler B.M., Lappin T., Frizzell N., Soga T., Adam J, Pollard P.J., “Inhibition of Mitochondrial Aconitase by Succination in Fumarate Hydratase Deficiency”, Cell Rep. 3, 689-700. 2013.
    [PubMed]
  • Kasukawa, T., Sugimoto, M., Hida, A., Minami, Y., Mori, M., Honma, S., Honma, K., Mishima, K., Soga, T., Ueda, H.R. "Human blood metabolite timetable indicates internal body time" Proc. Natl. Acad. Sci. USA 109, 15036-1504, 2012.
    [PubMed]
  • Hirayama, A., Tomita, M., Soga, T., “Sheathless capillary electrophoresis-mass spectrometry with a high-sensitivity porous sprayer for cationic metabolome analysis” Analyst 137, 5026-5033, 2012.
    [PubMed]
  • Sugimoto, M., Ikeda, S., Niigata, K., Tomita, M., Sato, H., Soga, T. “MMMDB: Mouse Multiple Tissue Metabolome Database” Nucl. Acids Res. 40 (D1): D809-D814. 2012.
    [PubMed]
  • Soga, T., Sugimoto, M., Honma, M., Mori, M., Igarashi, K., Kashikura, K., Ikeda, S., Hirayama, A., Yamamoto, T., Yoshida, H., Otsuka, M., Tsuji, S., Yatomi, Y., Sakuragawa, T., Watanabe, H., Nihei, K., Saito, T., Kawata, S., Suzuki, H., Tomita, M., Suematsu, M., “Serum Metabolomics Reveals γ-glutamyl Dipeptides as Biomarkers for discrimination among Different Forms of Liver Disease” J. Hepatol. 55, 896-905, 2011.
    [PubMed]
  • Adam, J., Hatipoglu, E., O’Flaherty, L., Ternette, N., Sahgal, N., Lockstone, H., Baban D., Nye, E., Stamp, G.W., Wolhuter, K., Stevens, M., Fischer, R., Carmeliet, P., Maxwell, P.H., Pugh, C.W., Frizzell, N., Soga, T., Kessler, B.M., El-Bahrawy, M., Ratcliffe, P.J., Pollard, P.J. “Renal Cyst Formation in Fh1-Deficient Mice Is Independent of the Hif/Phd Pathway: Roles for Fumarate in KEAP1 Succination and Nrf2 Signaling” Cancer Cell 20, 524-537, 2011.
    [PubMed]
  • Fujiwara, K., Ishihama, Y., Nakahigashi, K., Soga, T., Taguchi, H., ”A Systematic Survey of in vivo Obligate Shaperonin-dependent Substrates” EMBO J. 29, 1552-1564, 2010.
    [PubMed]
  • Kitagawa, M., Ikeda, S., Tashiro, E., Soga, T., Imoto, M., “Metabolomic Identification of the Target of the Filopodia Protrusion Iinhibitor Glucopiericidin A” Chem. Biol. 17, 989-998, 2010.
    [PubMed]
  • Minami, Y., Kasukawa, T., Kakazu, Y., Iigo, M., Sugimoto, M., Ikeda, S., Yasui, A., van der Horst, G., Soga, T.,* Ueda, H.,* ”Measurement of Internal Body Time by Blood Metabolomics” Proc. Natl. Acad. Sci. USA 106, 9890-9895, 2009.
    [PubMed]
  • Hirayama, A., Kami, K., Sugimoto, M., Sugawara, M., Toki, N., Onozuka, H., Kinoshita, T., Saito, N., Ochiai, A., Tomita, M., Esumi, H., Soga, T.,* "Quantitative Metabolome Profiling of Colon and Stomach Cancer Microenvironment by Capillary Electrophoresis Time-of-flight Mass Spectrometry", Cancer Res. 69, 4918-4925, 2009.
    [PubMed]
  • Soga, T.,* Igarashi, K., Itoh, C., Mizobuchi, K., Zimmermann, H., Tomita, M.,”Metabolomic Profiling of Anionic Metabolites by Capillary Electrophoresis Mass Spectrometry” Anal. Chem. 81, 6165-6174, 2009.
    [PubMed]
  • Ishii, N.*, Nakahigashi, K.*, Baba, T.*, Robert, M.*, Soga, T.*, Kanai, A.*, Hirasawa, T.*, Naba, M., Hirai, K., Hoque, A.Ho. PY., Kakazu, Y., Sugawara, K., Igarashi, S., Harada, S., Masuda, T., Sugiyama, N., Togashi, T., Hasegawa, M., Takai, Y., Yugi, K., Arakawa, K., Iwata, N., Toya, Y., Nakayama, Y., Nishioka, T., Shimizu, K., Mori, H., Tomita, M., “Multiple High-throughput analyses monitor the response of E. coli to perturbations”, Science 316, 593-7, 2007. (* These authors contributed equally to this work.)
    [Science] [PubMed]
  • Soga, T., Baran, R., Suematsu M., Ueno, Y., Ikeda, S., Sakurakawa T., Kakazu, Y., Ishikawa, T., Robert, M., Nishioka, T., Tomita, M., “Differential Metabolomics Reveals Ophthalmic Acid As An Oxidative Stress Biomarker Indicating Hepatic Glutathione Consumption”, J. Biol. Chem. 281, 16768-76, 2006.
    [PubMed]
  • Soga, T., Ohashi, Y., Ueno, Y., Naraoka, H., Tomita, M., and Nishioka, T., “Quantitative Metabolome Analysis Using Capillary Electrophoresis Mass Spectrometry”, J. Proteome Res. 2. 488-494, 2003.
    [PubMed]
  • Soga, T., Ueno, Y., Naraoka, H., Ohashi, Y., Tomita, M., and Nishioka, T., ”Simultaneous Determination of Anionic Intermediates for Bacillus subtilis Metabolic Pathways by Capillary Electrophoresis Electrospray Ionization Mass Spectrometry”, Anal. Chem. 74, 2233-2239, 2002.
    [PubMed]
  • Soga, T., and Heiger, D. N., ”Amino Acid Analysis by Capillary Electrophoresis Electrospray Ionization Mass Spectrometry”, Anal. Chem. 72 1236-1241, 2000.
    [PubMed]

Publications

  • 2017
  • Kon, S., Ishibashi, K., Katoh, H., Kitamoto, S., Shirai, T., Tanaka, S., Kajita, M., Ishikawa, S., Yamauchi, H., Yako, Y., Kamasaki, T., Matsumoto, T., Watanabe, H., Egami, R., Sasaki, A., Nishikawa, A., Kameda, I., Maruyama, T., Narumi, R., Morita, T., Sasaki, Y., Enoki, R., Honma, S., Imamura, H., Oshima, M., Soga, T., Miyazaki, J., Duchen, MR.., Nam, J., Onodera, Y., Yoshioka, S., Kikuta, J., Ishii, M., Imajo, M., Nishida, E., Fujioka, Y., Ohba, Y., Sato, T., Fujita, Y.,"Cell competition with normal epithelial cells promotes apical extrusion of transformed cells through metabolic changes"Nat. Cell Biol. 19, 530-541, 2017.
    [PubMed]
  • Tanada, Y., Okuda, J., Kato, T., Minamino-Muta, E., Murata, I., Soga, T., Shioi, T., Kimura, T., "The metabolic profile of a rat model of chronic kidney disease", Peer J., online, 2017. Doi: 10.7717/peerj.3352.
    [Publisher]
  • Tabata, S., Yamamoto, M., Goto, H., Hirayama, A., Ohishi, M., Kuramoto, T., Mitsuhashi, A., Ikeda, R., Haraguchi, M., Kawahara, K., Shinsato, Y., Minami, K., Saijo, A., Hanibuchi, M., Nishioka, Y., Sone, S., Esumi, H., Tomita, M., Soga, T., Furukawa, T., Akiyama, S., “Thymidine Catabolism as a Metabolic Strategy for Cancer Survival” Cell Reports 19, 1313-1321, 2017.
    [PubMed]
  • Kitazawa, S., Nishizawa, S., Nakagawa, H., Funata, M., Nishimura, K., Soga, T., Hara, T., “Cancer with low cathepsin D levels is susceptible to V-ATPase inhibition” Cancer Sci., in press, doi: 10.1111/cas.13240, 2017.
    [PubMed]
  • Yoshitoshi-Uebayashi, E.Y., Toyoda, T., Yasuda, K., Kotaka, M., Nomoto, K., Okita, K., Yasuchika, K., Okamoto, S., Takubo, N., Nishikubo, T., Soga, T., Uemoto, S., Osafune, K., “Modelling urea-cycle disorder citrullinemia type 1 with disease-specific iPSCs” Biochem Biophys Res Commun. 486 , 613-619, 2017.
    [PubMed]
  • *Itoi, T., Sugimoto, M., Umeda, J., Sofuni, A., Tsuchiya, T., Tsuji, S., Tanaka, R., Tonozuka, R., Honjo, M., Moriyasu, F., Kasuya, K., Nagakawa, Y., Abe, Y., Takano, K., Kawachi, S., Shimazu, M., Soga, T., Tomita, M., Sunamura, M., "Serum Metabolomic Profiles for Human Pancreatic Cancer Discrimination" Int. J. Mol. Sci. 18, 767; doi:10.3390/ijms18040767, 2017.
    [PubMed]
  • Kitazawa, S., Ebara1, S., Ando, A., Baba, Y., Satomi, Y., Soga, T., Hara, T., “Succinate dehydrogenase B-deficient cancer cells are highly sensitive to bromodomain and extra-terminal inhibitors” Oncotarget 8, 28922-28938, 2017.
    [Publisher]
  • Sakata, F., Ito, Y., Mizuno, M., Sawai, A., Suzuki, Y., Tomita, T., Tawada, M., Tanaka, A., Hirayama, A., Sagara, A., Wada, T., Maruyama, S., Soga, T., Matsuo, S., Imai, E., Takei, Y., “Sodium chloride promotes tissue inflammation via osmotic stimuli in subtotal-nephrectomized mice”, Lab. Invest. 97, 432-446, 2017
    [PubMed]
  • *Miyamoto, T., Hirayama, A., Sato, Y., Koboyashi, T., Katsuyama, E., Kanagawa, H., Miyamoto, H., Mori, T., Yoshida, S., Fujie, A., Morita, M., Watanabe, R., Tando, T., Miyamoto, K., Tsuji, T., Funayama, A., Nakamura, M., Matsumoto, M., Soga, T., Tomita, M., Toyama, Y., "A serum metabolomics-based profile in low bone mineral density postmenopausal women" Bone 95, 1-4, doi:10.1016/j.bone.2016.10.027, 2017.
    [PubMed]
  • Sugimoto, M., Obiya, S., Kaneko, M., Enomoto, A., Honma, M., Wakayama, M., Soga, T., Tomita, M., "Metabolomic profiling as a possible reverse engineering tool for estimating processing conditions of dry-cured hams", J. Agric. Food Chem.65, 402-410, 2017.
    [PubMed]
  • 2016
  • Fukai, K., Harada, S., Iida, M., Kuriara, A., Takeuchi, A., Kuwabara, K., Sugiyama, D., Okamura, T., Akiyama, M., Nishiwaki, Y., Oguma, Y., Suzuki, A., Suzuki, C, Hirayama, A., Sugimoto, M., Soga, T.,c Tomita, M., *Takebayashi, T., “Metabolic Profiling of Total Physical Activity and Sedentary Behavior in Community-Dwelling Men” PLoS ONE 11, e0164877, 2016.
    [PubMed]
  • Bardella C, Al-Dalahmah O, Krell D, Brazauskas P, Al-Qahtani K, Tomkova M, Adam J, Serres S, Lockstone H, Freeman-Mills L, Pfeffer I, Sibson N, Goldin R, Schuster-Böeckler B, Pollard, PJ, Soga T, McCullagh JS, Schofield CJ, Mulholland P, Ansorge O, Kriaucionis S, Ratcliffe PJ, *Szele, FG, *Tomlinson I, "Expression of Idh1R132H in the murine subventricular zone stem cell niche recapitulates features of early gliomagenesis" Cancer Cell 30, 578-594, 2016.
    [PubMed]
  • Ogawa, T., Tsubakiyama, R., Kanai, M., Koyama , T., Fujii, T., Iefuji, H., Soga, T., Kume, K., Miyakawa, T., Hirata, D., *Mizunuma, M., “Stimulating S-adenosyl-L-methionine synthesis extends lifespan via activation of AMPK” Proc. Natl. Acad. Sci. USA 113, 11913-11918, 2016.
    [PubMed]
  • Ishikawa, S., *Sugimoto, M., Kitabatake, K., Sugano, A., Nakamura, M., Kaneko, M., Ota, S., Hiwatari, K., Enomoto, A., Soga, T., Tomita, M., Iino, M.., "Identification of salivary metabolomic biomarkers for oral cancer screening" Sci. Rep. 6, 31520, 2016.
    [PubMed]
  • Yamanaka, R., Tabata, S., Shindo, Y., Hotta, K., Suzuki, K., Soga, T., *Oka, K., "Mitochondrial Mg2+ homeostasis decides cellular energy metabolism and vulnerability to stress", Sci. Rep. 6, 30027, 2016.
    [PubMed]
  • *Saito, T., Sugimoto, M., Okumoto, K., Haga, H., Katsumi, T., Mizuno, K., Nishina, T., Sato, S., Igarashi, K., Maki, H., Tomita, M., Ueno, Y., Soga, T., "Serum metabolome profiles characterized by patients with hepatocellular carcinoma associated with hepatitis B and C" , World J. Gastroenterol. 22. 6224-6234, 2016.
    [PubMed]
  • Saito, T., Ichimura, Y., Taguchi, K., Suzuki, T., Mizushima, T., Takagi, K., Hirose, Y., Nagahashi, M., Iso, T., Fukutomi, T., Ohishi, M., Endo, K., Uemura, T., Nishito, Y., Okuda, S., Obata, M., Kouno, T., Imamura, R., Tada, Y., Obata, R., Yasuda, D., Takahashi, K., Fujimura, T., Pi, J., Lee, MS., Ueno, T., Ohe, T., Mashino, T., Wakai, T., Kojima, H., Okabe, T., Nagano, T., Motohashi, H., Waguri, S., Soga, T., *Yamamoto, M., *Tanaka, K., *Komatsu, M., "p62/Sqstm1 promotes malignancy of HCV-positive hepatocellular carcinoma through Nrf2-dependent metabolic reprogramming", Nat.Commun. 7, 12030, 2016.
    [PubMed]
  • Fujita, S., Osuka, S. Shibao, S., Igarashi, K., Soga, T., *Sampetrean, O., “Effects of fractionated radiation on murine glioma stem cell metabolism”, Toho J. Med. 2 , 45-52, 2016.
    [Publisher]
  • Karigane, D., Kobayashi, H., Morikawa, T., Ootomo, Y., Sakai, M., Nagamatsu, G., Kubota, Y., Goda, N., Matsumoto, M., Nishimura, E. K., Soga, T., Otsu, K., Suematsu, M., Okamoto, S., Suda, T., *Takubo, K., “p38α activates purine metabolism to initiate hematopoietic stem/progenitor cell cycling in response to stress” Cell Stem Cell 19, 192-204, 2016.
    [PubMed]
  • *Kimura, T., Yasuda, K., Yamamoto, R., Soga, T., Rakugi, H., Hayashi, T., Isaka, Y., "Identification of biomarkers for development of end-stage kidney disease in chronic kidney disease by metabolomic profiling" Sci. Rep. 6, 26138, 2016.
    [PubMed]
  • Tando, T., Hirayama, A., Furukawa, M., Sato, Y., Kobayashi, T., Funayama1, A., Kanaji, A., Hao, W., Watanabe, R., Morita, M., Oike, T., Miyamoto, K., Soga, T., Nomura, M., Yoshimura, A., Tomita, M., Matsumoto, M., Nakamura, M., Toyama, Y., *Miyamoto, T. , "Smad2/3 are required for immobilization-induced skeletal muscle atrophy" J. Biol. Chem. 391, 12184-12194, 2016.
    [PubMed]
  • Iida, M., Harada, S., Kurihara, A., Fukai, K., Kuwabara, K., Sugiyama, D., Takeuchi, A., Okamura, T., Akiyama, M., Nishiwaki, Y., Suzuki, A., Hirayama, A., Sugimoto, M., Soga, T., Tomita, M., Banno, K., Aoki, D., *Takebayashi, T., “Profiling of plasma metabolites in postmenopausal women with metabolic syndrome” Menopause 23, 749-758, 2016.
    [PubMed]
  • Harada S., *Takebayashi T., Kurihara A., Akiyama M., Suzuki A., Hatakeyama Y., Sugiyama D., Kuwabara K., Takeuchi A., Okamura T., Nishiwaki Y., Tanaka T., Hirayama A., Sugimoto M., Soga T., Tomita M., “Metabolomic profiling reveals novel biomarkers of alcohol intake and alcohol-induced liver injury in community-dwelling men” Environ. Health Prev. Med. 21 , 18-26, 2016.
    [PubMed]
  • 2015
  • Nakano, T., Saiki, Y., Kudo, C., Hirayama, A., Mizuguchi, Y., Fujiwara, S., Soga, T., Sunamura, M., Matsumura, N., Motoi, F., Unno, M., *Horii, A., “Acquisition of chemoresistance to gemcitabine is induced by a loss-of-function missense mutation of DCK” Biochem. Biophys. Res. Commun. 464, 1084-1089, 2015.
    [PubMed]
  • Uetaki, M., *Tabata, S., Nakasuka, F., Soga, T., Tomita, M., “Metabolomic alterations in human cancer cells by vitamin C-induced oxidative stress” Sci. Rep. 5, 13896, 2015.
    [PubMed]
  • Garcia-Contreras, R., Sugimoto, M., Umemura, N., Kaneko, M., Hatakeyama, Y., Soga, T., Tomita, M., Scougall-Vilchis, R.J., Contreras-Bulnes, R., Nakajima, H., *Sakagami, H., “Alteration of metabolomic profiles by titanium dioxide nanoparticles in human gingivitis model” Biomaterials 57, 33-40, 2015.
    [PubMed]
  • †Hirayama, A., *†Sugimoto, M., Suzuki, A., Hatakeyama, Y., Enomoto, A., Harada, S., Soga, T., Tomita, M., Takebayashi, T., "Effects of processing and storage conditions on charged metabolomic profiles in blood" Electrophoresis 36, 2148–2155, 2015. (†These authors contributed equally)
    [PubMed]
  • Ogawara, Y., Katsumoto, T., Aikawa, Y., Shima, Y., Kagiyama, Y., Soga, T., Matsunaga, H., Seki, T., Araki, K., *Kitabayashi, I., “IDH2 and NPM1 mutations cooperate to activate Hoxa9/Meis1 and hypoxia pathways in acute myeloid leukemia” Cancer Res. 75, 2005-2016, 2015.
    [PubMed]
  • Kobayashi, S., Sato, M., Kasakoshi, T., Tsutsui, T., Sugimoto, M., Osaki, M., Okada, F., Igarashi, K., Hiratake, J., Homma, T., Conrad, M., Fujii, J., Soga, T., Bannai, S., *Sato, H., “Cystathionine is a novel substrate of cystine/glutamate transporter: implications for immune function”J. Biol. Chem. 290, 8778-8788, 2015.
    [PubMed]
  • Kume, S., Yamato, M., Tamura, Y., Jin, G., Nakano, M., Miyashige, Y., Eguchi, A., Ogata, Y., Goda, N., Iwai, K., Yamano, E., Watanabe, Y., Soga, T., *Kataoka, Y., “Potential Biomarkers of Fatigue Identified by Plasma Metabolome Analysis in Rats” PLoS ONE 10, e0120106, 2015.
    [PubMed]
  • Kishikawa, T., *Otsuka, M., Tan, P.S., Ohno, M., Sun, X., Yoshikawa, T., Shibata, C., Takata, A., Kojima, K., Takehana, K., Ohishi, M., Ota, S., Noyama, T., Kondo, Y., Sato, M., Soga, T., Hoshida, Y., Koike, K., “Decreased miR122 in hepatocellular carcinoma leads to chemoresistance with increased arginine” Oncotarget 6, 8339-8352, 2015
    [PubMed]
  • Mishima, E., Fukuda, S., Shima, H., Hirayama, A., Akiyama, Y., Takeuchi, Y., Fukuda, N. N., Suzuki, T., Suzuki, C., Yuri, A., Kikuchi, K., Tomioka, Y., Ito, S., Soga, T., *Abe, T., “Alteration of the Intestinal Environment by Lubiprostone Is Associated with Amelioration of Adenine-Induced CKD”,J. Am. Soc. Nephrol. 26, 1787-1794, 2015.
    [PubMed]
  • *Valli, A., Rodriguez, M., Moutsianas, L., Fischer, R., Fedele, V., Huang, H.L., Van Stiphout, R., Jones, D., Mccarthy, M., Vinaxia, M., Igarashi, K., Sato, M., Soga, T., Buffa, F., Mccullagh, J., Yanes, O., Harris, A., Kessler. B., “Hypoxia Induces a Lipogenic Cancer Cell Phenotype via HIF1α-Dependent and -Independent Pathways”, Oncotarget 6, 1920-1941, 2015.
    [PubMed]
  • 2014
  • Hirayama, A., Igarashi, K., Tomita, M., *Soga, T., “Development of quantitative method for determination of γ-glutamyl peptides by capillary electrophoresis tandem mass spectrometry: An efficient approach avoiding matrix effect” J Chromatogr A. 1369, 161-169, 2014.
    [PubMed]
  • Jeelani, G., Sato, D., Soga, T., Watanabe, H., *Nozaki, T., “Mass spectrometric analysis of L-cysteine metabolism: physiological role and fate of L-cysteine in the enteric protozoan parasite Entamoeba histolytica”mBio. 5, e01995-14, 2014.
    [PubMed]
  • Xu, F., Sudo, Y., Sanechika, S., Yamashita, J., Shimaguchi, S., Honda, S., Sumi-Ichinose, C., Mori-Kojima, M., Nakata, R., Furuta, T., Sakurai, M., Sugimoto, M., Soga, T., Kondo, K., *Ichinose, H., “Disturbed biopterin and folate metabolism in the Qdpr-deficient mouse” FEBS Lett. 588, 3924-3931, 2014.
    [PubMed]
  • Mishima, E., Inoue, C., Saigusa, D., Inoue, R., Ito, K., Suzuki, Y., Jinno, D., Tsukui, Y., Akamatsu, Y., Araki, M., Araki, K., Shimizu, R., Shinke, H., Suzuki, T., Takeuchi, Y., Shima, H., Akiyama, Y., Toyohara, T., Suzuki, C., Saiki, Y., Tominaga, T., Miyagi, S., Kawagisihi, Naoki, Soga, T., Ohkubo, T., Yamamura, K., Imai, Y., Masuda, S., Sabbisetti, V., Ichimura, T., Mount, D.B., Bonventre, J.V., Ito, S., Tomioka, Y., Itoh, K., *Abe, T., “Conformational Change in Transfer RNA Is an Early Indicator of Acute Cellular Damage”,J. Am. Soc. Nephrol. 25, 2316-2326, 2014.
    [PubMed]
  • Tabata, S., Ikeda, R., Yamamoto, M., Shimaoka, S., Mukaida, N., Takeda, Y., Yamada, K., Soga, T., *Furukawa, T., *Akiyama, S., “Thymidine phosphorylase activates NFκB and stimulates the expression of angiogenic and metastatic factors in human cancer cells” Oncotarget 5, 10473-10485, 2014.
    [PubMed]
  • Yang, M., Su, H., Soga, T., Kranc, K.R., Pollard, P.J. ,“Prolyl hydroxylase domain enzymes: important regulators of cancer metabolism” Hypoxia 2, 127-142, 2014.
    [PubMed]
  • Takeuchi, K., Ohishi, M., Endo, K., Suzumura, K., Naraoka, H., Ohata, T., Seki, J., Miyamae, Y., Honma, M., Soga, T., “Hydroxyproline, a Serum Biomarker Candidate for Gastric Ulcer in Rats: A Comparison Study of Metabolic Analysis of Gastric Ulcer Models Induced by Ethanol, Stress, and Aspirin” Biomark. Insights 9, 61-66, 2014.
    [PubMed]
  • Nishimura, T., Higuchi1, K., Sai, Y., Sugita, Y., Yoshida, Y., Tomi, M., Wada, M., Wakayama, T., Tamura, A., Tsukita, S., Soga, T., Nakashima, E., “Fetal Growth Retardation and Lack of Hypotaurine in Ezrin Knockout Mice”PLoS ONE 9, e105423, 2014.
    [PubMed]
  • Yugi, K., Kubota, H., Toyoshima, Y., Noguchi, R., Kawata, K., Komori, Y., Uda, S., Kunida, K., Tomizawa, Y., Funato, Y., Miki, H., Matsumoto, M., Nakayama, K.I., Kashikura, K., Endo, K., Ikeda, K., Soga, T., Kuroda, S., “Reconstruction of insulin signal flow from phosphoproteome and metabolome data” Cell Rep. 8, 1171-1183, 2014.
    [PubMed]
  • Hirayama, A., Wakayama, M., Soga, T. , “Metabolome analysis based on capillary electrophoresis-mass spectrometry” Trends Anal. Chem. 61, 215-222, 2014.
    [Publisher]
  • Cheng, K., Lee, B., Masuda, T., Ito, T., Ikeda, K., Hirayama, A., Deng, L., Dong, J., Shimizu, K., Soga, T., Tomita, M., Palsson, B. O. & Robert, M., “Global metabolic network reorganization by adaptive mutations allows fast growth of Escherichia coli on glycerol” Nat. Commun. 5, 3233, 2014.
    [PubMed]
  • Obata, F., Kuranaga, E., Tomioka, K., Ming M., Takeishi, A., Chen, C., Soga, T., Miura, M., “Necrosis-driven systemic immune response alters SAM metabolism through the FOXO-GNMT axis” Cell Rep. 7, 821-833, 2014.
    [PubMed]
  • Ohka, F., Ito, M., Ranjit, M., Senga, T., Motomura, A., Motomura, K., Saito, K., Kato, K., Kato, Y., Wakabayashi, T., Soga, T., Natsume, A., “Quantitative metabolome analysis profiles activation of glutaminolysis in glioma with IDH1 mutation” Tumor Biol. 35, 5911-5920, 2014.
    [PubMed]
  • Takeuchi, K., Ohishi, M., Endo, K., Suzumura, K., Naraoka, H., Ohata, T., Seki, J., Miyamae, Y., Honma, M., Soga, T., “Metabolomic Analysis of the Effects of Omeprazole and Famotidine on Aspirin-induced Gastric Injury” Metabolomics 10, 995-1004, 2014.
    [Publisher]
  • Sato, D., Sugimoto, M., Akashi, H., Tomita, M., Soga, T., "Comparative metabolite profiling of foxglove aphids (Aulacorthum solani Kaltenbach) on leaves from resistant and susceptible soybean strains" Mol. BioSyst. 10, 909-915, 2014.
    [PubMed]
  • Adam, J., Yang, M., Soga, T., and Pollard, P.J., “Rare insights into cancer biology” Oncogene 33, 2547-2556, 2014.
    [PubMed]
  • Yamatani, H., Takahashi, K., Yoshida, T., Soga, T., Kurachi, H., "Differences in the fatty acid metabolism of visceral adipose tissue in postmenopausal women", Menopause 21, 170-176, 2014.
    [PubMed]
  • Sakagami, H., Sugimoto, M., Tanaka, S., Onuma, H., Ota, S., Kaneko, M., Soga, T., Tomita, M., “Metabolomic profiling of sodium fluoride-induced cytotoxicity in an oral squamous cell carcinoma cell line” Metabolomics 10, 270-279, 2014.
    [Publisher]
  • 2013
  • Soga, T., “Cancer metabolism: key players in metabolic reprogramming” Cancer Sci. 104, 275-81, 2013.
    [PubMed]
  • Adam, J., Yang, M., Bauerschmidt, C., Kitagawa, M., O’Flaherty, L., Maheswaran, P., O¨ zkan, G., Sahgal, N., Baban, D., Kato, K., Saito, K., Iino, K., Igarashi, K., Stratford, M., Pugh, C., Tenant, D., Ludwig, C., Davies, B., Ratcliffe, P. J., El-Bahrawy, M., Ashrafian, H., Soga, T., and Pollard, P. J. , “A Role for Cytosolic Fumarate Hydratase in Urea Cycle Metabolism and Renal Neoplasia” Cell Rep. 3, 1440-1448, 2013.
    [PubMed]
  • Ternette N., Yang M., Laroyia M., Kitagawa M., O'Flaherty L., Wolhulter K., Igarashi K., Saito K., Kato K., Fischer R., Berquand A., Kessler B.M., Lappin T., Frizzell N., Soga T., Adam J, Pollard P.J., “Inhibition of Mitochondrial Aconitase by Succination in Fumarate Hydratase Deficiency”, Cell Rep. 3, 689-700. 2013.
    [PubMed]
  • Takubo, K., Nagamatsu, G., Kobayashi, C. I, Nakamura-Ishizu, A., Kobayashi, H., Ikeda, E., Goda, N., Johnson, R. S, Rahimi, Y., Soga, T., Hirao, A., Suematsu, M., Suda, T., “Regulation of Glycolysis by Pdk Functions as a Metabolic Checkpoint for Cell Cycle Quiescence in Hematopoietic Stem Cells” Cell Stem Cell 12, 49-61, 2013.
    [PubMed]
  • Noguchi, R., Kubota, H., Yugi, K., Toyoshima, Y., Komori, Y., Soga, T., Kuroda, S., “The selective control of glycolysis, gluconeogenesis and glycogenesis by temporal insulin patterns” Mol Syst Biol. 9:664, doi:10.1038/msb.2013.19, 2013.
    [PubMed]
  • Kimura, T., Takahashi, A., Takabatake, Y., Namba, T., Yamamoto, T., Kaimori, J., Matsui, I., Kitamura, H., Niimura, F., Matsusaka, T., Soga, T., Rakugi, H., Isaka, Y., “Autophagy protects kidney proximal tubule epithelial cells from mitochondrial metabolic stress”, Autophagy 9, 1876-86, 2013.
    [PubMed]
  • Karasawa, T., Saito, T., Ueno, Y., Sugimoto, M., Soga, T.,“Metabolome analysis of erythrocytes from patients with chronic hepatitis C reveals the etiology of ribavirin-induced hemolysis” Int J Med Sci. 10, 1575-1577, 2013.
    [PubMed]
  • Saito, T., Sugimoto, M., Igarashi, K., Saito, K., Shao, L., Katsumi, T., Tomita, K., Sato, C., Ishii, R., Okumoto, K., Nishise, Y., Watanabe, H., Tomita, M., Ueno, Y., Soga, T., "Dynamics of serum metabolites in patients with chronic hepatitis C receiving pegylated interferon plus ribavirin: A metabolomics analysis", Metabolism 62, 1577-1586, 2013.
    [PubMed]
  • Okuda, J., Niizuma, S., Shioi, T., Kato, T., Inuzuka, Y., Kawashima, T., Tamaki, Y., Kawamoto, A., Tanada, Y., Iwanaga, Y., Narazaki, M., Matsuda, T., Adachi, S., Soga, T., Takemura, G., Kondoh, H., Kita, T., Kimura, T.,"Persistent overexpression of phosphoglycerate mutase, a glycolytic enzyme, modifies energy metabolism and reduces stress resistance of heart in mice", PLoS ONE 8, e72173, 2013.
    [PubMed]
  • Yang, M., Soga, T., and Pollard, P. J., “Oncometabolites: Linking Altered Metabolism with Cancer ? J. Clin. Invest. 123, 3652-3658, 2013.
    [PubMed]
  • Uema, N., Ooshio, T., Harada, K., Naito, M., Naka, K., Hoshii, T., Tadokoro, Y., Ohta, K., Ali, M.A., Katano, M., Soga, T., Nakanuma, Y., Okuda, A., Hirao, A., “Abundant nucleostemin expression supports the undifferentiated properties of germ cell tumors” Am. J. Pathol. 183, 592-603, 2013.
    [PubMed]
  • Shimura, D., Nakai, G., Jiao, Q., Osanai, K., Kashikura, K., Endo, K., Soga, T., Goda, N., Minamisawa, S., “Metabolomic profiling analysis reveals chamber-dependent metabolite patterns in the mouse heart” Am J Physiol Heart Circ Physiol. 305, H494-505,2013.
    [PubMed]
  • Nishino, T., Yachie-Kinoshita, A., Hirayama, A., Soga, T., Suematsu, M., Tomita, M., “Dynamic simulation and metabolome analysis of long-term erythrocyte storage in adenine-guanosine solution” PLoS ONE 8, e71060. 2013.
    [PubMed]
  • Ito, T., Sugimoto, M., Toya, Y., Ano, Y., Kurano, N., Soga, T., Tomita, M., “Time-resolved metabolomics of a novel trebouxiophycean alga using 13CO2 feeding” J Biosci Bioeng. 116, 408-415, 2013.
    [PubMed]
  • Tsuruoka, M., Hara, J., Hirayama, A., Sugimoto, M., Soga, T., Shankle, W.R., Tomita , M., “Comparative analysis of neurodegenerative dementias based on serum and saliva metabolomics”, Electrophoresis 34, 2865-2872, 2013.
    [PubMed]
  • Maekawa, K.#, Hirayama, A.#, Iwata Y.#, Tajima Y., Nishimaki-Mogami T., Sugawara S., Ueno, N., Abe, H., Ishikawa M., Murayama M., Matsuzawa Y., Nakanishi H., Ikeda K., Arita M., Taguchi, R., Minamino N., Wakabayashi, S., Soga T. *, Saito, Y. *, “Global metabolomic analysis of heart tissue in a hamster model for dilated cardiomyopathy” J. Mol. Cell. Cardiol. 59C, 76-85, 2013. (#Contributed equally to this work)
    [PubMed]
  • Takeuchi, K., Ohishi, M., Ota, S., Suzumura, K., Naraoka, H., Ohata, T., Seki, J., Miyamae, Y., Honma, M., Soga, T., "Metabolic Profiling to Identify Potential Serum Biomarkers for gastric ulceration induced by non-steroid anti-inflammatory drugs" J. Proteome Res. 12, 1399-1407 , 2013.
    [PubMed]
  • Migita, T., Okabe, S., Ikeda, K., Igarashi, S., Sugawara, S., Tomida, A., Taguchi, R., Soga, T., Seimiya, H., “Inhibition of ATP citrate lyase induces an anticancer effect via reactive oxygen species: AMPK as a predictive biomarker for therapeutic impact” Am J Pathol. 182, 1800-1810, 2013.
    [PubMed]
  • Oyama-Okubo, N., Sakai , T., Ando, T., Nakayama, M., Soga, T., “Metabolome profiling of floral scent production in Petunia axillaris”, Phytochemistry 90, 37-42, 2013.
    [PubMed]
  • Martı´nez, P., Ga´lvez, S., Ohtsuka, N., Budinich, M., Corte´s, M.P., Serpell, C., Nakahigashi, K., Hirayama, A., Tomita, M., Soga, T., Martı´nez, S., Maass, A., Parada, P., “Metabolomic study of Chilean biomining bacteriaAcidithiobacillus ferrooxidans strain Wenelen and Acidithiobacillus thiooxidans strain Licanantay” Metabolomics 9, 247-257, 2013.
    [PubMed]
  • Sugimoto, M., Saruta, J., Matsuki, C., To, M., Onuma, H., Kaneko, M., Soga, T., Tomita, M., and Tsukinoki, K., “Physiological and environmental parameters associated with mass spectrometry-based salivary metabolomic profiles” Metabolomics 9, 454-463,2013.
    [PubMed]
  • Ito, T., Tanaka, M., Shinkawa, H., Nakada, T., Ano, Y., Kurano N., Soga T., Tomita, M., “Metabolic and morphological changes of an oil accumulating trebouxiophycean alga in nitrogen-deficient conditions” Metabolomics 9, S178-S187, 2013.
    [PubMed]
  • Kami, K., Fujimori, T., Sato, H., Sato, M., Yamamoto, H., Ohashi, Y., Sugiyama, N., Ishihama, Y., Onozuka, H., Ochiai, A., Esumi, H., Soga, T., Tomita, M., "Metabolomic Profiling of Lung and Prostate Tumor Tissues by Capillary Electrophoresis Time-of-flight Mass Spectrometry" Metabolomics 9, 444-453, 2013.
    [PubMed]
  • 2012
  • Yamada, M., Takanashi, K., *Hamatani, T., Hirayama, A., Akutsu, H., Fukunaga, T. Ogawa, S., Sugawara, K., Shinoda, K., Soga, T., Umezawa, A., Kuji, N., Yoshimura ,Y. and Tomita, M., “A medium-chain fatty acid as an alternative energy source in mouse preimplantation development”, Sci. Rep. 2, 930, doi: 10.1038/srep00930. 2012.
    [PubMed]
  • Tanaka, S., Taga, H., Maehara, K., *Kaneshima, A., Machino, M., Onuma, H., Kaneko, M., Sakagami, H., Sugimoto, M., Soga, T. and Tomita, M., “Pilot Study of Changes in Salivary Metabolic Profiles Induced by Template Therapy”In Vivo. 26, 1015-1020, 2012.
    [PubMed]
  • Hoshi, T., Tadokoro, Y., Naka, K., Ooshio, T., Muraguchi, T., Sugiyama, N., Soga, T., Araki, K., Yamamura, K., Hirao, A., "mTORC1 is Essential for Leukemia propagation but Not Stem Cell Self-renewal" J. Clin. Invest. 122, 2114-2129, 2012.
    [PubMed]
  • Kasukawa, T., Sugimoto, M., Hida, A., Minami, Y., Mori, M., Honma, S., Honma, K., Mishima, K., Soga, T., Ueda, H.R. "Human blood metabolite timetable indicates internal body time" Proc. Natl. Acad. Sci. USA 109, 15036-1504, 2012.
    [PubMed]
  • Imaizumi, Y., Okada, Y., Akamatsu, W., Koike, M., Kuzumaki, N., Hayakawa, H., Nihira, T., Kobayashi, T., Ohyama, M., ,Sato, S., Takanashi, M., Funayama, M., Hirayama, A., Soga, T., Hishiki, T., Suematsu, M., Yagi, T., Ito, D., Kosakai, A., Hayashi, K., Shouji, M., Nakanishi, A., Suzuki, N., Mizuno, Y., Mizushima, N., Amagai, M., Uchiyama, Y., Mochizuki, H., Hattori, N., Okano H.* ,“Mitochondrial dysfunction associated with increased oxidative stress and α-synuclein accumulation in PARK2 iPSC-derived neurons and postmortem brain tissue” Mol Brain. 5:35, 2012.
    [PubMed]
  • Hirata, Y., Ikeda, K., Sudoh, M., Tokunaga, Y., Suzuki, A., Weng, L., Ohta, M., Tobita, Y., Okano, K., Ozeki, K., Kawasaki, K., Tsukuda, T., Katsume, A., Aoki, Y., Umehara, T., Sekiguchi, S., Toyoda, T., Shimotohno, K., Soga, T., Nishijima, M., Taguchi, R., Kohara, M.,“Self-enhancement of hepatitis C virus replication by promotion of specific sphingolipid biosynthesis.” PLoS Pathog. 8, e1002860, 2012.
    [PubMed]
  • Husain, A., Sato, D., Jeelani, G., Soga, T., Nozaki, T., “Dramatic Increase in Glycerol Biosynthesis upon Oxidative Stress in the Anaerobic Protozoan Parasite Entamoeba histolyticaPLoS Negl. Trop. Dis. 6, e1831, 2012.
    [PubMed]
  • Hirayama, A., Tomita, M., and *Soga, T., “Sheathless capillary electrophoresis-mass spectrometry with a high-sensitivity porous sprayer for cationic metabolome analysis” Analyst 137, 5026-5033, 2012.
    [PubMed]
  • Hirayama, A., Nakashima, E., Sugimoto, M., Akiyama, S., Sato, W., Maruayama, S., Matsuo, S., Tomita, M., Yuzawa, Y., Soga, T., “Metabolic profiling reveals new serum biomarkers for differentiating diabetic nephropathy” Anal Bioanal Chem. 404, 3101-3109, 2012.
    [PubMed]
  • Kami, K., Fujita, Y., Igarashi, S., Koike, S., Sugawara, S., Ikeda, S., Sato, N., Ito, M., Tanaka, M., Tomita, M., Soga, T., "Metabolomic Profiling Rationalized Pyruvate Efficacy in Cybrid Cells Harboring MELAS Mitochondrial DNA Mutations" Mitochondrion 12, 644-53, 2012.
    [PubMed]
  • Takahashi, M., Miyata, S., Fujii, J., Inai, Y., Ueyama, S., Araki, M., Soga, T., Fujinawa, R., Nishitani C., Ariki S., Shimizu T., Abe T., Ihara Y., Nishikimi, M., Kozutsumi Y., Taniguchi N., and Kuroki, Y., “In vivo role of aldehyde reductase” Biochim Biophys Acta 1820, 1787-1796, 2012.
    [PubMed]
  • Akiyama, Y., Takeuchi, Y., Kikuchi, K., Mishima, E., Yamamoto, Y., Suzuki, C., Toyohara, T., Suzuki, T., Hozawa, A., Ito, S., Soga, T., Abe, T., “A Metabolomic approach to clarifying the effect of AST-120 on 5/6 nephrectomized rats by Capillary Electrophoresis with Mass Spectrometry” Toxins 4, 1309-1322, 2012.
    [PubMed]
  • Yang, M., Soga, T., Pollard, P.J., Adam, J., “The emerging role of fumarate as an oncometabolite” Front. Oncol. 2, 85, doi: 10.3389/fonc.2012.00085, 2012.
    [PubMed]
  • Omori, Y., Ohtani, T., Sakata, Y., Mano, T., Takeda, Y., Tamaki, S., Tsukamoto. Y., Kamimura, D., Aizawa, Y., Miwa, T., Komuro, I., Soga, T., Yamamoto, K. “L-Carnitine Prevents the Development of Ventricular Fibrosis and Heart Failure with Preserved Ejection Fraction in Hypertensive Heart Disease” J. Hypertens. 30, 1834-44. 2012.
    [PubMed]
  • Deguchi, K., Sato, D., Sugimoto, M., Hara, H., Kawasaki, Y., Demura, S., Watanabe, T., Denholme, S. J., Okazaki, H., Ozaki, T., Yamaguchi, T., Takeya, H., Soga, T., Tomita, M., Takano, Y., “Clarification as to why alcoholic beverages have the ability to induce superconductivity in Fe1+dTe1-xSx” Supercond. Sci. Technol. 25, doi:10.1088/0953-2048/25/8/084025, 2012.
    [arXiv]
  • Liu, C., Kurakane, S., Takita, J., Itano R., Soga, T., Oikawa A., and Igarashi, K., “Antihypertensive Effects of Unripe Persimmon (Diospyros kaki L.cv. Hiratanenashi) Fruit and Its Component in Spontaneously Hypertensive Rats” Food Sci. Technol. Res. 18, 391-398, 2012.
    [J-stage]
  • Kato, T., Niizuma, S., Inuzuka, Y., Kawashima, T., Okuda, J., Kawamoto, A., Tamai, Y., Iwanaga, Y., Soga, T., Kita, T., Kimura, T., Shioi, T., “Analysis of Liver Metabolism in a Rat Model of Heart Failure” Int. J. Cardiol. 161, 130-136, 2012.
    [PubMed]
  • Dimon, M., Soga, T., Hozawa, A., Oizumi, T., Kaino, W., Takase, K., Karasawa, S., Jimbu, Y., Wada, K., Kameda, W., Susa, S., Kayama, T., Saito, K., Tomita, M., Kato, T. “Serum glycerophosphate levels are increased in Japanese men with type 2 diabetes" Int. Med. 51, 545-551, 2012.
    [PubMed]
  • Sugimoto, M., Sakagami, H., Yokote, Y., Onuma, H., Kaneko, M., Mori, M., Sakaguchi, Y., Soga, T., Tomita, M., “Non-targeted metabolite profiling in activated macrophage secretion ” Metabolomics 8, 624-633, 2012.
    [Publisher]
  • Sugimoto, M., Kawakami, M., Robert, M., Soga, T., Tomita, M. “Bioinfomatics Tools for Mass Spectroscopy-Based Metabolomic Data Processing and Analysis” Curr. Bioinf. 7, 96-108, 2012.
    [PubMed]
  • Sugimoto, M., Kaneko, M., Onuma, H., Sakaguchi, Y., Mori, M., Abe, S., Soga, T., Tomita, M., "Changes in the Charged Metabolite and Sugar Profiles of Pasteurized and Unpasteurized Japanese Sake with Storage" J. Agric. Food Chem. 60, 2586-2593, 2012.
    [PubMed]
  • Iino, K., Sugimoto, M., Soga, T., Tomita, M., “Profiling of the Charged Metabolites of Traditional Herbal Medicines Using Capillary Electrophoresis time-of-flight Mass Spectrometry” Metabolomics 8, 99-108, 2012.
    [Publisher]
  • Toyoda, Y., Tamai, M., Kashikura, K., Kobayashi, S., Fujiyama, Y., Soga, T., Tagawa, Y., “Acetaminophen-induced Hepatotoxicity in a Liver Tissue Model Consisting of Primary Hepatocytes Assembling Around an Endothelial Cell Network”Drug Metab. Dispos. 40, 169-177, 2012.
    [PubMed]
  • Sugimoto, M., Ikeda, S., Niigata, K., Tomita, M., Sato, H., Soga, T. “MMMDB: Mouse Multiple Tissue Metabolome Database” Nucl. Acids Res. 40 (D1): D809-D814. 2012.
    [PubMed]
  • 2011
  • Soga, T., Sugimoto, M., Honma, M., Mori, M., Igarashi, K., Kashikura, K., Ikeda, S., Hirayama, A., Yamamoto, T., Yoshida, H., Otsuka, M., Tsuji, S., Yatomi, Y., Sakuragawa, T., Watanabe, H., Nihei, K., Saito, T., Kawata, S., Suzuki, H., Tomita, M., Suematsu, M., “Serum Metabolomics Reveals γ-glutamyl Dipeptides as Biomarkers for discrimination among Different Forms of Liver Disease” J. Hepatol. 55, 896-905, 2011.
    [PubMed]
  • Adam, J., Hatipoglu, E., O’Flaherty, L., Ternette, N., Sahgal, N., Lockstone, H., Baban D., Nye, E., Stamp, G.W., Wolhuter, K., Stevens, M., Fischer, R., Carmeliet, P., Maxwell, P.H., Pugh, C.W., Frizzell, N., Soga, T., Kessler, B.M., El-Bahrawy, M., Ratcliffe, P.J., Pollard, P.J. “Renal Cyst Formation in Fh1-Deficient Mice Is Independent of the Hif/Phd Pathway: Roles for Fumarate in KEAP1 Succination and Nrf2 Signaling” Cancer Cell 20, 524-537, 2011.
    [PubMed]
  • Deng, L., Shoji, I., Ogawa, W., Kaneda, S., Soga, T., Jiang, D., Ide, Y., Hotta, H., “Hepatitis C Virus Infection Promotes Hepatic Gluconeogenesis through an NS5A-Mediated, FoxO1-Dependent Pathway” J. Virol. 85, 8556-8568, 2011.
    [PubMed]
  • Ochiai, D., Goda, N., Hishiki, T., Kanai, Mai., Senoo-Matsuda, N., Soga, T., Johnson, R.S., Yoshimura, Y., Suematsu, M., “Disruption of HIF-1α in Hepatocytes Impairs Glucose Metabolism in Diet-induced Obesity Mice” Biochem. Biophys. Res. Commun 415, 445-449, 2011.
    [PubMed]
  • Sato, A., Soga, T., Igarashi, K., Tomita, M., Kanai, A., “GTP-dependent RNA 3'-terminal Phosphate Cyclase from the Hyperthermophilic Archaeon Pyrococcus furiosus” Genes Cells 16, 1180-1199, 2011
    [PubMed]
  • Suzuki, T., Toyohara, T., Akiyama, Y., Takeuchi, Y., Mishima, E., Suzuki, C., Ito, S., Soga, T., Abe, T., “Transcriptional Regulation of Organic Anion Transporting Polypeptide SLCO4C1 as a New Therapeutic Modality to Prevent Chronic Kidney Disease” J. Pharm. Sci. 100, 3696-3707, 2011.
    [PubMed]
  • Gustavsson, C., Soga, T., Wahlström, E, Vesterlund, M, Azimi, A., Norstedt, G., Tollet-Egnell, P., “Sex-dependent Hepatic Transcripts and Metabolites in the Development of Glucose Intolerance and Insulin Resistance in Zucker Diabetic Fatty Rats” J. Mol. Endcrinol. 47, 129-143, 2011.
    [PubMed]
  • Hayashi, K., Sasamura, H., Hishiki, T., Suematsu, M., Ikeda, S., Soga, T., Itoh, H., “Use of Serum and Urine Metabolome Analysis for the Detection of Metabolic Changes in Patients with Stage 1-2 Chronic Kidney Disease” Nephro-Urol. Mon. 3, 164-171, 2011.
    [Publisher]
  • Kimura, T., Takabatake, Y., Takahashi, A., Kaimori, J., Matsui, I., Namba, T., Kitamura, H., Niimura, F., Matsusaka, T., Soga, T., Rakugi, H., Isaka, Y., “Autophagy Protects the Proximal Tubule from Degeneration and Acute Ischemic Injury” J. Am. Soc. Nephrol. 22, 902-913, 2011.
    [PubMed]
  • Ooga, T., Sato, H., Nagashima, A., Sasaki, K., Tomita, M., Soga, T., Ohashi, Y., “Metabolomic Anatomy of an Animal Model Revealing Homeostatic Imbalances in Dyslipidaemia” Mol. Biosyst. 7, 1217-23, 2011.
    [PubMed]
  • Ogawa, Y., Koike, N., Kurisawa. G., Soga, T., Tomita, M., Tei, H., “Positive Autoregulation Delays the Expression Phase of Mammalian Clock Gene Per2” PLoS ONE 6(4), e18663, 2011.
    [PubMed]
  • Yoshida, S., Imoto, J., Minato, T., Oouchi, R., Kamada, Y., Tomita, M., Soga, T., Yoshimoto, H., “A Novel Mechanism Regulates H2O and SO2 production in Saccharomyces cerevisiaeYeast 28, 109-121, 2011.
    [PubMed]
  • 2010
  • Sugiura, T., Kato, S., Shimizu, T., Wakayama, T., Nakamichi, N., Kubo, Y., Iwata, D., Suzuki, K., Soga, T., Asano, M., Iseki, S., Tamai, I., Tsuji, A. and Kato, Y., “Functional Expression of Carnitine/Organic Cation Transporter OCTN1/SLC22A4 in Mouse Small Intestine and Liver” Drug Metab Dispos 38, 1665-1672, 2010.
    [PubMed]
  • Fujiwara, K., Ishihama, Y., Nakahigashi, K., Soga, T., *Taguchi, H., ”A Systematic Survey of in vivo Obligate Shaperonin-dependent Substrates” EMBO J. 29, 1552-1564, 2010.
    [PubMed]
  • Kitagawa, M., Ikeda, S., Tashiro, E., Soga, T., Imoto, M., “Metabolomic Identification of the Target of the Filopodia Protrusion Iinhibitor Glucopiericidin A” Chem. Biol. 17, 989-998, 2010.
    [PubMed]
  • Husain, A., Sato, D., Jeelani, G., Suematsu, M., Soga, T., Nozaki, T., “Metabolome Analysis Revealed Increase in S-methylcysteine and Phosphatidylisopropanolamine Synthesis upon L-cysteine Derivatization in The Anaerobic Protozoan Parasite Entamoeba Histolytica J. Biol. Chem. 285, 39160-39170, 2010.
    [PubMed]
  • Jeelani, G., Husain, A., Sato, D., Ali, V., Suematsu, M., Soga, T., Nozaki, T., “Two Atypical-cysteine-regulated NADPH-dependent Oxidoreductases Involved in Redox Maintenance, L-cystine and Iron Reduction, and Metronidazole Activation in the Enteric Protozoon Entamoeba HistolyticaJ. Biol. Chem. 285, 26889-26899, 2010.
    [PubMed]
  • Saito, N., Ohashi, Y., Soga, T., Tomita, M., “Unveiling Cellular Bbiochemical Reactions via Metabolomics-driven Approaches” Curr. Opi. Microbiol. 13, 358-362, 2010.
    [PubMed]
  • Sugimoto, M., Hirayama, A., Robert, M., Abe, S., Soga, T., Tomita, M., “Prediction of metabolite identity from accurate mass, migration time prediction and isotopic pattern information in CE-TOFMS data” Electrophoresis 31, 1-8, 2010.
    [PubMed]
  • Toya, Y., Ishii, N., Nakahigashi, K., Hirasawa, T., Soga, T., Tomita, M., Shimizu, K., “13C-Metabolic Flux Analysis for Batch Culture of Escherrichia coli and Its pyk and pgi Gene Knockout Mutants Based on Mass Isotopomer Distribution of Intracellular Metabolites”, Biotechnol. Prog. 26, 975-992, 2010.
    [PubMed]
  • Toyohara, T., Akiyama, Y., Suzuki, T., Takeuchi, Y., Mishima, E., Tanemoto, M., Momose, A., Toki, N., Sato, H., Nakayama, M., Hozawa, A., Tsuji, I., Ito, S., Soga, T. and Abe. T. “Metabolomic profiling of uremic solutes in CKD patients” Hypertens. Res. 33, 944-952, 2010.
    [PubMed]
  • Horai, H., Arita, M., Kanaya, S., Nihei, Y., Ikeda, T., Suwa, K., Ojima, Y., Tanaka, K., Tanaka, S., Aoshima, K., Oda, Y., Kakazu, Y., Kusano, M., Tohge, T., Matsuda, F., Sawada, Y., Horai, Y. M., Nakanishi, H., Ikeda, K., Akimoto, N., Maoka, T., Takahashi, H., Ara, T., Sakurai, N., Suzuki, H., Shibata, D., Neumann, S., Iida, T., Tanaka, K., Funatsu, K., Matsuura, F., Soga, T., Taguchi, R., Saito, K., Nishioka, T., “MassBank: A Public Repository for Sharing Mass Spectral Data for Life Sciences” J. Mass Spectro. 45, 703-714, 2010.
    [PubMed]
  • Sugimoto, M., Goto, H., Otomo, K., Ito, M., Onuma, H., Suzuki, A., Sugawara, M., Abe, S., Tomita, M., Soga, T., “Metabolomic Profiles and Sensory Attributes of Edamame under Various Storage Duration and Temperature Conditions” J. Agric. Food Chem. 58, 8418-8425, 2010.
    [PubMed]
  • Kato, T., Niizuma, S., Inuzuka, Y., Kawashima, T., Okuda, J., Yamaki, Y., Iwanaga, Y., Narazaki, M., Matsuda, T., Soga, T., Kita, T., Kimura, T., Shioi, T., “Analysis of Metabolic Remodeling in Compensated Left Ventricular Hypertrophy and Heart Failure” Circ. Heart Fail., 3, 420-430, 2010.
    [PubMed]
  • Sakurakawa, T., Hishiki, T., Ueno, Y., Ikeda, S., Soga, T., Yachie-Kinoshita, A., Kajimura, M., Suematsu, M., “Hypotaurine is an energy-saving hepatoprotective compound against ischemia-reperfusion injury of rat liver” J. Clin. Biochem. Nutr. 46, 126-134, 2010.
    [PubMed]
  • Kato, Y., Kubo, Y., Iwata, D., Kato, S., Sudo, T., Sugiura, T., Kagaya, T., Wakayama, T., Hirayama, A., Sugimoto, M., Sugihara, K., Kaneko, S., Soga, T., Asano, M., Tomita, M., Matsui, T., Wada, M., Tsuji, A. “Gene knockout and metabolome analysis of carnitine/organic cation transporter OCTN1” Pharm. Res. 27, 832-840, 2010.
    [PubMed]
  • Sugimoto, M., Hirayama, A., Ihiskawa, T., Baran, R., Robert, M., Uehara, K., Soga, T., Tomita, M., “Differential Metabolomics Software for Capillary Electrophoresis-Mass Spectrometry Data Analysis” Metabolomics 6, 27-41, 2010.
    [Publisher]
  • Sugimoto, M., Wong, D., Hirayama, A., Soga, T., Tomita, M., “Capillary Electrophoresis Mass Spectrometry-based Saliva Metabolomics Identifies Oral, Breast and Pancreatic Cancer-Specific Profiles” Metabolomics 6, 78-95, 2010.
    [PubMed]
  • Sato, D., Kobayashi, S., Yasui, H., Shibata, N., Toru, T., Yamamoto, M., Tokoro, G., Ali, V., Soga, T., Takeuchi, T., Suematsu, M., Nozaki, T., ”Cytotoxic Effect of Amide Derivatives of Trifluoromethionine against The Enteric Protozoan Parasite Entamoeba histolytica” Int. J. Antimicrob. Agents. 35, 56-61, 2010.
    [PubMed]
  • Sugimoto, M., Koseki, T., Hirayama, A., Abe, S., Sano, T., Tomita, M., Soga, T., “Correlation between Sensory Evaluation Scores of Japanese Sake and their Metabolome Profiles” J. Agric. Food Chem. 58, 374-383, 2010.
    [PubMed]
  • Nakada, T., Soga, T., Tomita, M., "Phylogenetic position of a rare loricated green alga, Cephalomonas granulata N. L. Higinb (Volvocales, Chlorophyceae)" Phycol. Res. 58, 62-68, 2010.
    [Publisher]
  • Nakada, T., Soga, T., Tomita, M., Nozaki, H., "Chlorogonium complexum sp. nov. (Volvocales, Chlorophyceae), and morphological evolution of Chlorogonium" Eur. J. Phycol. 45, 97-107, 2010.
    [Publisher]
  • 2009
  • Minami, Y., Kasukawa, T., Kakazu, Y., Iigo, M., Sugimoto, M., Ikeda, S., Yasui, A., van der Horst, G., Soga, T.,* Ueda, H.,* ”Measurement of Internal Body Time by Blood Metabolomics” Proc. Natl. Acad. Sci. USA 106 9890-9895, 2009.
    [PubMed]
  • Hirayama, A., Kami, K., Sugimoto, M., Sugawara, M., Toki, N., Onozuka, H., Kinoshita, T., Saito, N., Ochiai, A., Tomita, M., Esumi, H., Soga, T.,* "Quantitative Metabolome Profiling of Colon and Stomach Cancer Microenvironment by Capillary Electrophoresis Time-of-flight Mass Spectrometry", Cancer Res. 69, 4918-4925, 2009.
    [PubMed]
  • Soga, T.,* Igarashi, K., Itoh, C., Mizobuchi, K., Zimmermann, H., Tomita, M.,”Metabolomic Profiling of Anionic Metabolites by Capillary Electrophoresis Mass Spectrometry” Anal. Chem. 81, 6165-6174, 2009.
    [PubMed]
  • Ooga, T., Ohashi, Y.,* Kuramitsu, S., Koyama, Y., Tomita, M., Soga, T., Masui, R.,”Degradation of ppGpp by nudix pyrophosphatase modulates the transition of growth phase in the bacterium thermos thermophilus”, J. Biol. Chem. 284, 15549-15556, 2009.
    [PubMed]
  • Saito, N., Robert, M., Kochi, H., Matsuo, G., Kakazu, Y., Soga, T., Tomita, M., “Metabolite profiling reveals YihU as a novel hydroxybutyrate dehydrogenase for alternative succinic semialdehyde metabolism in Escherichia coli J. Biol. Chem. 109, 16442-16451, 2009.
    [PubMed]
  • Toyohara, T., Suzuki, T., Morimoto, R., Akiyama, Y., Souma, T., Shiwaku, H.O., Takeuchi, Y., Mishima, E., Abe, M., Tanemoto, M., Masuda, S., Kawano, H., Maemura, K., Nakayama, M., Sato, H., Mikkaichi, T., Yamaguchi, H., Fukui, S., Fukumoto, Y., Shimokawa, H., Inui, K., Tetasaki, T., Goto, J., Ito, S., Hishinuma, T., Rubera, I., Tauc, M., Fujii-Kuriyama, Y., Yabuuchi, H., Moriyama, Y., Soga, T., *Abe, T., “SLCO4C1 Transporter Eliminates Uremic Toxins and Attenuates Hypertension and Renal Inflammation” J. Am. Soc. Nephrol. 20, 2546-2555, 2009.
    [PubMed]
  • Nakahigashi, K., Toya, Y., Ishii, N., Soga, T., Hasegawa, M., Watanabe, H., Takai, Y., Honma, M., Mori, H., Tomita, M., “Systematic phenome analysis of Escherichia coli multiple knockout mutants reveals hidden reactions in central carbon metabolism” Mol. Syst. Biol. 5, 306, doi:10.1038/msb.2009.65
    [PubMed]
  • Iuchi, Y., Okada, F., Takamiya, R., Kibe, N., Tsunoda, S., Nakajima, O., Toyoda, K., Nagae, R., Suematsu, M., Soga, T., Uchida, K., Fujii, J. “Rescue of anemia and autoimmune responses in SOD1-deficient mice by transgenic expression of human SOD1 in erythrocytes” ” Biochem. J. 422, 313-320, 2009.
    [PubMed]
  • Tajima, T., Goda, N., Fujiki, N., Hishiki, T., Nishiyama, Y., Senoo-Matsuda, N., Shimazu, M., Soga, T., Yoshimura, Y., Johnson, R.S., Suematsu, M., “HIF-1a is necessary to support gluconeogenesis during liver regeneration”Biochem. Bioph. Res. 387, 789-794, 2009.
    [PubMed]
  • Nishino, T., Yachie-Kinoshita, A., Hirayama, A., Soga, T., Suematsu, M., Tomota, M., “In Silico Modeling and Metabolome Analysis of Long-stored Erythrocytes to Improve Blood Storage Methods” J. Biotechnol. 144, 212-223, 2009.
    [PubMed]
  • Kuramori, C., Hase, Y., Hoshikawa, K., Watanabe, K., Nishi, T., Hishiki, T., Soga, T., Nashimoto, A., Kabe, Y., Yamaguchi, Y., Watanabe, H., Kataoka, K., Suematsu, M., Handa, H., “Mono-(2-ethylhexyl) phthalate Targets Glycogen Debranching Enzyme and Affects Glycogen Metabolism in Rat Testis” Toxicol. Sci. 109, 143-151, 2009.
    [PubMed]
  • Shintani, T., Iwabuchi, T., Soga, T., Kato,Y., Yamamoto, T., Takano, N., Hishiki, T., Ueno, Y., Ikeda, S., Sakurakawa, T., Ishikawa, K., Goda, N., Yitagawa, Y., Kajiyama, M., Matsumoto, K., Suematsu, M.,”Cystathionine β-synthase as a Carbon Monoxide-sensitive Regulator of Bile Excretion” Hepatology 49, 141-150, 2009.
    [PubMed]
  • 2008
  • Yoshida, S., Imoto, J., Minato, T., Oouchi, R., Sugihara, M., Imai, T., Ishiguro, T., Mizutani, S., Tomita, M., Soga, T., Yoshimoto, H., “Developing Bottom-fermenting Yeast Strains That Produce High SO2 Levels by Integrated Metabolome and Transcriptome Analysis”, Appl. Environ. Microbiol. 74, 2787-2796, 2008.
    [PubMed]
  • Sato, S., Arita, M., Soga, T., Nishioka, T., Tomita, M., “Time-resolved Metabolomics Reveals Metabolic Modulation in Rice Foliage”, BMC Systems Biology 2, 51,doi:10.1186/1752-0509-2-51, 2008.
    [PubMed]
  • Ohashi, Y., Hirayama, A., Ishikawa, T., Nakamura, S., Shimizu, K., Ueno, Y., Tomita, M., *Soga, T., “Depiction of Metabolome Changes in Histidine-starved Escherichia coli by CE-TOFMS”, Mol. BioSyst. 4, 135-147, 2008.
    [PubMed]
  • 2007
  • Ishii, N.*, Nakahigashi, K.*, Baba, T.*, Robert, M.*, Soga, T.*, Kanai, A.*, Hirasawa, T.*, Naba, M., Hirai, K., Hoque, A.Ho. PY., Kakazu, Y., Sugawara, K., Igarashi, S., Harada, S., Masuda, T., Sugiyama, N., Togashi, T., Hasegawa, M., Takai, Y., Yugi, K., Arakawa, K., Iwata, N., Toya, Y., Nakayama, Y., Nishioka, T., Shimizu, K., Mori, H., Tomita, M., “Multiple High-throughput analyses monitor the response of E. coli to perturbations”, Science 316, 593-7, 2007. (* These authors contributed equally to this work.)
    [Science] [PubMed]
  • Kinoshita, A., Tsukada, K., Soga, T., Hishiki, T., Ueno, Y., Nakayama, Y., Tomita, M., Suematsu, M.,"Roles of Hemoglobin Allostery in Hypoxia-induced Metabolic Alterations in Erythrocytes: Simulation and Its Demonstration by Metabolome Analysis", J. Biol. Chem. 282, 10731-41, 2007.
    [PubMed]
  • Monton, M. R. N., Tomita, M., *Soga, T., *Ishihama, Y., “Polymer Entrapment in Polymerized Silicate for Preparing Highly Stable Capillary Coatings in CE and CE-MS”, Anal. Chem. 79, 7838-44, 2007.
    [PubMed]
  • Baran, R., Robert, M., Suematsu, M., Soga, T., Tomita, M., "Visualization of Three-way Comparisons of Omics Data", BMC Bioinformatics 8, 72, 2007.
    [PubMed]
  • Hashimoto, M., Ishihama, Y., Tomita, M., Soga, T., “Microelectrospray Interface with Coaxial Sheath Flow for High Resolution CE-MS Separation” Rapid Commun. Mass Spectrom. 21, 3579-84, 2007.
    [PubMed]
  • Monton, M. R. N., Soga, T., “Metabolome Analysis by Capillary Electrophoresis – Mass Spectrometry” J. Chromatogr. A 1168, 237-46, 2007.
    [PubMed]
  • Soga, T., Ishikawa, T., Igarashi, S., Sugawara, K., Kakazu, Y., Tomita, M., ”Analysis of nucleotides by pressure-assisted capillary electrophoresis mass spectrometry using silanol mask technique”, J. Chromatogr. A 1159, 125-33, 2007.
    [PubMed]
  • Toya, Y., Ishii, N., Hirasawa, T., Naba, M., Hirai, K., Sugawara, K., Igarashi, S., Shimizu, K., Tomita, M., Soga, T., “Direct Measurement of The Isotope Distribution of Intracellular Metabolites Using CE-TOFMS for Efficient Metabolic Flux Analysis”, J. Chromatogr. A 1159, 134-41, 2007.
    [PubMed]
  • Morohashi, M., Shimizu, K., Ohashi, Y., Abe, J., Mori, H., Tomita, M., and Soga, T., “P-BOSS: A new filtering method for treasure hunting in metabolomics.“, J. Chromatogr. A 1159, 142-48, 2007.
    [PubMed]
  • Morohashi, M., Ohashi, Y., Tani, S., Ishii, K., Itaya, M., Nanamiya, H., Kawamura, F., Tomita, M., Soga, T., “Model based definition of population heterogeneity and its effects on metabolism in sporulating Bacillus subtilis”, J. Biochem. 142, 183-91, 2007.
    [PubMed]
  • 2006
  • Soga, T., Baran, R., Suematsu M., Ueno, Y., Ikeda, S., Sakurakawa T., Kakazu, Y., Ishikawa, T., Robert, M., Nishioka, T., Tomita, M., “Differential Metabolomics Reveals Ophthalmic Acid As An Oxidative Stress Biomarker Indicating Hepatic Glutathione Consumption”, J. Biol. Chem. 281, 16768-76, 2006.
    [PubMed]
  • Shinoda K., Sugimoto M., Yachie N., Sugiyama N., Masuda T., Robert M., Soga T., Tomita M., "Prediction of liquid chromatographic retention times of peptides generated by protease digestion of the Escherichia coli proteome using artificial neural networks", J. Proteome Res. 5, 3312-3317, 2006.
    [PubMed]
  • Saito, N., Robert, M., Kitamura, S., Baran, R., Soga, T., Mori, H., Nishioka, T., Tomita, M., “A metabolomics approach for enzyme discovery", J. Proteome Res. 5, 1979-1987, 2006.
    [PubMed]
  • Shinoda, K., Yachie, N., Masuda, T., Sugiyama, N., Sugimoto, M., Soga, T., Tomita, M., "HybGFS: A hybrid method for genome-fingerprint scanning", BMC Bioinformatics 7, 479, 2006.
    [PubMed]
  • Baran R., Kochi H., Saito N., Suematsu M., Soga T., Nishioka T., Robert M., Tomita M., "MathDAMP: a package for differential analysis of metabolite profiles", BMC Bioinformatics 7, 530, 2006.
    [PubMed]
  • Takahashi, H., Hayashi, M., Sato, S., Soga, T., Nishioka, T., Tomita, M., Kawai-Yamada, M., Uchimiya, H., “Evaluation of Metabolic Alteration in Transgenic Rice Overexpressing Dihydroflavonol-4-reductase”, Ann. Bot. 98, 819-825, 2006.
    [PubMed]
  • 2005
  • Jaros, M., Soga, T., Van de Goor, T., Gas, B., “Conductivity Detection in Capillary Zone Electrophoresis - Inspection by Peak Master”, Electrophoresis 26, 1948-1953, 2005.
    [PubMed]
  • Sugimoto, M., Kikuchi, S., Arita, M., Soga, T., Nishioka, T., Tomita, M., “Large-Scale Prediction of Cationic Metabolites Identity and Migration Time in Capillary Electrophoresis Mass Spectrometry using Artificial Neural Networks”, Anal. Chem. 77, 78-84, 2005.
    [PubMed]
  • Ishii, N., Soga, T., Nishioka, T., Tomita, M., “Metabolome Analysis and Metabolic Simulation", Metabolomics 1, 29-37, 2005.
    [Publisher]
  • 2004
  • Sato, S., Soga, T., Nishioka, T., Tomita, M., “Simultaneous Determination of Main Metabolites in Rice Leaves using Capillary Electrophoresis Mass Spectrometry and Capillary Electrophoresis Diode Array Detection” Plant J. 40, 151-163, 2004.
    [PubMed]
  • Soga, T., Kakazu, Y., Martin, R., Tomita, M., and Nishioka, T., “Qualitative and Quantitative Analysis of Amino Acids by Capillary Electrophoresis Electrospray Ionization Tandem Mass Spectrometry”, Electrophoresis 25, 1964-1972, 2004.
    [PubMed]
  • Itoh, A., Ohashi, Y., Soga, T., Mori, H., Nishioka, T., and Tomita, M., “Application of Capillary Electrophoresis Mass Spectrometry to Synthetic in vitro Glycolysis Studies ”, Electrophoresis 25, 1996-2002, 2004.
    [PubMed]
  • 2003
  • Soga, T., Ohashi, Y., Ueno, Y., Naraoka, H., Tomita, M., and Nishioka, T., “Quantitative Metabolome Analysis Using Capillary Electrophoresis Mass Spectrometry”, J. Proteome Res. 2. 488-494, 2003.
    [PubMed]
  • 2002
  • Soga, T., Ueno, Y., Naraoka, H., Matsuda, K., Tomita, M., and Nishioka, T., ”Pressure Assisted Capillary Electrophoresis Electrospray Ionization Mass Spectrometry for Analysis of Multivalent Anions”, Anal. Chem. 74, 6224-6229, 2002.
    [PubMed]
  • Soga, T., Ueno, Y., Naraoka, H., Ohashi, Y., Tomita, M., and Nishioka, T., ”Simultaneous Determination of Anionic Intermediates for Bacillus subtilis Metabolic Pathways by Capillary Electrophoresis Electrospray Ionization Mass Spectrometry”, Anal. Chem. 74, 2233-2239, 2002.
    [PubMed]
  • Matsuda, K., Yamaguchi, H., Ueno, Y., Soga, T., Fujita, Y., and Nishioka, T., ”Combined Metabolome and Transcriptome Analysis of Bacillus subtilis Cells Cultured on Different Carbon Sources”, Genomic Informatics Series 13, 593-594, 2002.
  • 2001
  • Soga, T., and Imaizumi, M., ”Capillary Electrophoresis Method for the Analysis of Inorganic Anions, Organic Acids, Amino Acids, Nucleotides, Carbohydrates and Other Anionic Compounds” Electrophoresis 22, 3418-3425, 2001.
    [PubMed]
  • Kodama, S., Yamamoto, A., Matsunaga, A., Soga, T., and Hayakawa, K., ”Direct Chiral Resolution of Malic Acid in Apple Juice by Ligand-exchange Capillary Electrophoresis Using Copper (II)-L-Tartaric Acid as A Chiral Selector” Electrophoresis 22, 3286-3290, 2001.
    [PubMed]
  • 2000
  • Soga, T., Tajima, I., and Heiger, D. N., “Capillary Electrophoresis for the Determination of Forensic Anions in Adulterated Foods and Beverages”, Am. Lab. 32 ,124-128, 2000.
  • Soga, T., and Heiger, D. N., ”Amino Acid Analysis by Capillary Electrophoresis Electrospray Ionization Mass Spectrometry”, Anal. Chem. 72 ,1236-1241, 2000.
    [PubMed]
  • Soga, T., and Serwe, M., ”Determination of Carbohydrates in Food Samples by Capillary Electrophoresis with Indirect UV Detection”, Food Chem. 69, 339-344, 2000.
  • Kodama, S., Yamamoto, A., Matsunaga, A., Soga, T., and Minoura, K., ”Direct Chiral Resolution of Lactic Acid in Food Products by Capillary Electrophoresis”, J. Chromatogr. A 875, 371-377, 2000.
    [PubMed]
  • 1999
  • Soga, T., and Ross, G. A., “Simultaneous Determination of Inorganic Anions, Organic Acids and Metal Cations by Capillary Electrophoresis”, J. Chromatogr. A 834 ,65-71, 1999
    [Publisher]
  • Soga, T., and Ross, G. A., “Simultaneous Determination of Inorganic Anions, Organic Acids, Amino Acids and Carbohydrates by Capillary Electrophoresis”, J. Chromatogr. A 837 231-239, 1999.
    [Publisher]
  • Tsunoda, M., Kato, M., Fukushima, T., Santa, T., Homma, H., Yani, H., Soga, T., and Imai, K.,”Determination of Aspartic Acid Enantiomers in Bio-samples by Capillary Electrophoresis”, Biomed. Chromatogr. 13 335-339, 1999.
    [PubMed]
  • 1998
  • Soga, T., and Heiger, D. N., “Simultaneous Determination of Monosaccharides in Glycoproteins by Capillary Electrophoresis”, Anal. Biochem. 261,73-78, 1998.
    [PubMed]
  • Jegle, U., Serwe, M., and Soga, T., ”Kapillarelektrophorese-eine Pr?destinierte Technik f?r die Analyse von Kationen und Anionen in Elektrolyten f?r die Galvanische und Chemische Metallisierung”, Galvanotechnik, 89 1478-1485, 1998.
  • 1997
  • Soga, T., and Ross, G. A., “Capillary Electrophoretic Determination of Inorganic and Organic Anions using 2,6-Pyridinedicarboxylic Acid: Effect of Electrolyte’s Complexing Ability”, J. Chromatogr. A 767, 223-230, 1997.
    [Publisher]
  • Soga, T., and Wakaura, M., “Determination of Inorganic and Organic Anions in Beer and Wort by Capillary Electrophoresis”, J. Am. Soc. Brew. Chem. 55,44-46, 1997.
    [Publisher]
  • Jegle, U., Grimm, R., Godel, H., Schuster, R., Ross, G. A., and Soga, T., ”Poly(vinyl alcohol)-Coated Capillaries – A Solution for Many Application Areas in Capillary Electrophoresis”, LCGC International 10 176-188, 1997.
  • 1995
  • Soga, T., Inoue, Y., and Ross, G. A., “Analysis of Halides, Oxyhalides and Metal Oxoacids by Capillary Electrophoresis with Suppressed Electroosmotic Flow”, J. Chromatogr. A 718, 421-428, 1995.
    [Publisher]
  • 1993
  • Soga, T., and Inoue, Y., “Determination of Catecholamines in Urine and Plasma by On-line Sample Pretreatment using an Internal Surface Boronic Acid Gel”, J. Chromatogr. Biomed. 620, 175-181, 1993.
    [PubMed]
  • 1992
  • Soga, T., Inoue, Y., and Yamaguchi, K., “Determination of Carbohydrates by Hydrophilic Interaction Chromatography with Pulsed Amperometric Detection using Postcolumn pH Adjustment”, J. Chromatogr. A 625, 151-155, 1992.
    [Publisher]

Books

  • Bjerrum, J. T. Ed., (Wakayama, M., Hirayama, A., Soga, T., contribution for Chapter 9: Capillary Electrophoresis-Mass Spectrometry) “Metabolomics: Methods and Protocols” Methods in Molecular Biology 1277, pp.113-122, Humana Press, 2015.
    Amazon.com [Publisher]
  • Hyotylainen, T., Wiedmer, S., Ed., (Hirayama, A., Soga, T., contribution for Chapter 6: Capillary Electromigration Techniques in Metabolomics) “Chromatographic Methods in Metabolomics” RSC Chromatography Monographs 18, pp.114-137, RSC Publishing, 2013
    Amazon.com [Publisher]
  • Alterman, M. A., Hunziker, P., Ed. (Hirayama, A., Soga, T., contribution for Chapter 8: Amino Acid Analysis by Capillary Electrophoresis-Mass Spectrometry) “Amino Acid Analysis: Methods and Protocols” Methods in Molecular Biology 828, pp.77-82, Humana Press, 2012.
    Amazon.com [Publisher]
  • Smolke, C. D., Ed. (Monton, M.R., Soga, T., contribution for Chapter 14: Monitoring and Measuring the Metabolome) “The Metabolic Pathway Engineering Handbook: Tools and Applications” pp.14-1-14-12, CRC Press, 2009.
    Amazon.com [Publisher]
  • Weckwerth, W., Ed. (Soga, T., contribution for Chapter 8: Capillary Electrophoresis-Mass Spectrometry for Metabolomics) “Metabolomics: Methods and Protocols” Methods in Molecular Biology 358, pp.129-137, Humana Press, 2006.
    Amazon.com [Publisher]
  • Tomita, M., Nishioka T., Ed. (Soga, T., contribution for Chapter 2: Development and Application of Capillary Electrophoresis-Mass Spectrometry Methods to Metabolomics) “Metabolomics: The Frontier of Systems Biology” pp.7-24, Springer, 2005.
    Amazon.com [Publisher]
  • El Rassi, Z., Ed. (Soga, T., contribution for Chapter 14: Analysis of Carbohydrates in Food and Beverages by HPLC and CE ) “Carbohydrate Analysis by Modern Chromatography and Electrophoresis” Journal of Chromatography Library 66, pp.483-502, Elsevier Science Publishers, 2002.
    Amazon.com [Publisher]

Patents

  • Soga, T., Sugimoto, M., Suematsu M., Honma, M., Yamamoto, T., Suzuki, H., “Method for Measuring Liver Disease Markers And Test Method for Pharmaceutical Preparation", EPC Patent No. EP2381259 (2016), PCT/JP2009/069950.
  • Soga, T., Sugimoto, M., Suematsu M., Saito, T., Kawata, S., “Liver Disease Marker”, JP Patent No.5809136 (2015), PCT/JP2011/061340.
  • Soga, T., Sugimoto, M., Suematsu M., Saito, T., Kawata, S., “Liver Disease Marker, Method And Apparatus For Measuring Same, And Test Method For Pharmaceutical Preparation”, CN Patent No. ZL201180030202.5 (2015), PCT/JP2011/061340.
  • Soga, T., Sugimoto, M., Suematsu M., Honma, M., Yamamoto, T., Suzuki, H.,Oxidative stress Marker, Method And Apparatus For Measuring Same, And Test Method For Pharmaceutical Preparation”, JP Patent No. 5676275 (2015), PCT/JP2009/069950.
  • Abe, T., Soga, T. ,“Novel renal disease marker substance in human” JP Patent No. 5757626 (2015), PCT/JP2010/005434.
  • Abe, T., Soga, T. ,“Human Renal Disease Marker Substance” US Patent No. US8,709,816 (2014), PCT/JP2010/005434.
  • Soga, T., Sugimoto, M., Suematsu M., Honma, M., Yamamoto, T., Suzuki, H., “Liver Disease Marker, Method And Apparatus For Measuring Same, And Test Method For Pharmaceutical Preparation”, CN Patent No. ZL200980152582.2 (2014), PCT/JP2009/069950.
  • Soga, T., Suematsu, M., “Method for Determination of Oxidative Stress”, US Patent No. US8,309,056 (2012), Division of PCT/JP2007/050517.
  • Soga, T., Suematsu, M., “Method for Determination of Oxidative Stress”, JP Patent No. 4840804 (2011).
  • Soga, T., Suematsu, M., “Method for Determination of Oxidative Stress”, US Patent No. US7,964,177 (2011), PCT/JP2007/050517.
  • Soga, T., Suematsu, M., “Method for Determination of Oxidative Stress”, EPC Patent No. EP1975621 (2010), PCT/JP2007/050517.
  • Tomita, M., Itoh, A., Soga, T., Ohhashi, N., "Method for Identifying Functions and Binding Substances of Gene Products", JP Patent No.4114075 (2008).
  • Tomita, M., Itoh, A., Soga, T., "Method and Kit for Identifying Functions and Binding Substances of Gene Products", US2007/0172825, EP1717587, WO/2005/078449, PCT/JP2005/001858.
  • Sugimoto, M., Soga, T., Tomita, M., "Method for Predicting The Migration Time of Ionic Compounds by Electrophoretic measurement", US2007/0256935, PCT/JP2005/15325.
  • Sugimoto, M., Soga, T., Tomita, M., "Method for Predicting The Migration Time of Ionic Compounds by Electrophoretic measurement", JP Patent No.3871689 (2006).
  • Soga, T., "Apparatus and Method for Anion Analysis", JP Patent 3341765 (2002).
  • Soga, T., "Capillary Electrophoresis Apparatus and Method for Anions, Amino Acids and Carbohydrate Analysis", JP Patent 3038184 (2000).
  • Soga, T., "Apparatus and Method for Anion Analysis", JP Patent 2912232 (1999).
  • Soga, T., "Apparatus and Method for Catecholamine Analysis", JP Patent 2833058 (1998).
  • Soga, T., Inoue, Y., "Capillary Electrophoresis Apparatus and Its Method", EP078329